ZA200701272B - Radicals and their use as paramagnetic agents in a dynamic nuclear polarisation process - Google Patents
Radicals and their use as paramagnetic agents in a dynamic nuclear polarisation process Download PDFInfo
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- ZA200701272B ZA200701272B ZA200701272A ZA200701272A ZA200701272B ZA 200701272 B ZA200701272 B ZA 200701272B ZA 200701272 A ZA200701272 A ZA 200701272A ZA 200701272 A ZA200701272 A ZA 200701272A ZA 200701272 B ZA200701272 B ZA 200701272B
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- 239000007858 starting material Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 229940124530 sulfonamide Drugs 0.000 description 1
- 150000003456 sulfonamides Chemical class 0.000 description 1
- 239000011593 sulfur Substances 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- OHSJPLSEQNCRLW-UHFFFAOYSA-N triphenylmethyl radical Chemical compound C1=CC=CC=C1[C](C=1C=CC=CC=1)C1=CC=CC=C1 OHSJPLSEQNCRLW-UHFFFAOYSA-N 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 238000003260 vortexing Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves
- A61B5/055—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/20—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations containing free radicals, e.g. trityl radical for overhauser
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
- G01R33/00—Arrangements or instruments for measuring magnetic variables
- G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
- G01R33/00—Arrangements or instruments for measuring magnetic variables
- G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
- G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
- G01R33/48—NMR imaging systems
- G01R33/54—Signal processing systems, e.g. using pulse sequences ; Generation or control of pulse sequences; Operator console
- G01R33/56—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution
- G01R33/5601—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution involving use of a contrast agent for contrast manipulation, e.g. a paramagnetic, super-paramagnetic, ferromagnetic or hyperpolarised contrast agent
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
- G01R33/00—Arrangements or instruments for measuring magnetic variables
- G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
- G01R33/62—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using double resonance
Landscapes
- Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Radiology & Medical Imaging (AREA)
- Condensed Matter Physics & Semiconductors (AREA)
- General Physics & Mathematics (AREA)
- Animal Behavior & Ethology (AREA)
- High Energy & Nuclear Physics (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Signal Processing (AREA)
- Biomedical Technology (AREA)
- Pathology (AREA)
- Biophysics (AREA)
- Heart & Thoracic Surgery (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Surgery (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Magnetic Resonance Imaging Apparatus (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NO20043227 | 2004-07-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA200701272B true ZA200701272B (en) | 2008-04-30 |
Family
ID=35502005
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA200701272A ZA200701272B (en) | 2004-07-30 | 2007-02-13 | Radicals and their use as paramagnetic agents in a dynamic nuclear polarisation process |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US8431723B2 (pt) |
| EP (1) | EP1805186B1 (pt) |
| JP (1) | JP5535435B2 (pt) |
| KR (3) | KR20070061805A (pt) |
| CN (1) | CN101027310B (pt) |
| AU (1) | AU2005267670B2 (pt) |
| BR (1) | BRPI0513880A (pt) |
| CA (1) | CA2575473C (pt) |
| DK (1) | DK1805186T3 (pt) |
| ES (1) | ES2545377T3 (pt) |
| HK (1) | HK1107692A1 (pt) |
| IL (1) | IL180895A (pt) |
| MX (1) | MX2007001034A (pt) |
| NO (1) | NO339934B1 (pt) |
| PL (1) | PL1805186T3 (pt) |
| RU (1) | RU2374253C2 (pt) |
| WO (1) | WO2006011811A2 (pt) |
| ZA (1) | ZA200701272B (pt) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2005267668B2 (en) * | 2004-07-30 | 2011-10-20 | Ge Healthcare As | Method of producing a composition, composition and its use |
| EP1954321B1 (en) | 2005-12-01 | 2011-11-23 | Ge Healthcare As | Method of dynamic nuclear polarisation (dnp) using a trityl radical and a paramagnetic metal ion |
| EP1962912B1 (en) * | 2005-12-16 | 2012-09-26 | Ge Healthcare As | Method to produce hyperpolarised carboxylates of organic amines |
| JP5269791B2 (ja) | 2006-08-30 | 2013-08-21 | ジーイー・ヘルスケア・アクスイェ・セルスカプ | 動的核分極（ｄｎｐ）方法並びに該方法で使用するための化合物及び組成物 |
| JP2008084485A (ja) * | 2006-09-28 | 2008-04-10 | Toshiba Corp | 不揮発性半導体記憶装置及びデータ読出方法 |
| US20100092391A1 (en) | 2007-01-11 | 2010-04-15 | Huntington Medical Research Institutes | Imaging agents and methods of use thereof |
| US9227173B2 (en) | 2007-06-22 | 2016-01-05 | General Electric Company | Methods for dynamic filtration of pharmaceutical products |
| EP2902041A1 (en) | 2007-12-19 | 2015-08-05 | GE Healthcare Limited | Composition and method for generating a metabolic profile using 13C-MR detection |
| WO2009129265A1 (en) | 2008-04-14 | 2009-10-22 | Huntington Medical Research Institutes | Methods and apparatus for pasadena hyperpolarization |
| US8968703B2 (en) | 2009-09-10 | 2015-03-03 | Ge Healthcare Limited | 13C-MR detection using hyperpolarised 13C-fructose |
| JP5150822B2 (ja) * | 2009-10-29 | 2013-02-27 | 国立大学法人九州大学 | 生体内因性分子の検出方法 |
| FR2967158A1 (fr) | 2010-11-08 | 2012-05-11 | Phosphoenix Sarl | Nouveaux radicaux triarylmethyle: leur preparation et application |
| WO2012066542A1 (en) * | 2010-11-16 | 2012-05-24 | Aspect Magnet Technologies Ltd. | System and method for generating invasively hyperpolarized images |
| GB2498181A (en) | 2011-12-29 | 2013-07-10 | Bruker Biospin Gmbh | Device and method for rapid dynamic nuclear polarisation |
| KR102255333B1 (ko) * | 2013-01-31 | 2021-05-26 | 브라코 이미징 에스.피.에이. | Mr에서 대사 마커로서 사용되는 과분극화된 에스테르 |
| US9874622B2 (en) | 2013-09-27 | 2018-01-23 | General Electric Company | Hyperpolarized media transport vessel |
| WO2018158891A1 (ja) * | 2017-03-01 | 2018-09-07 | 国立大学法人九州大学 | 生体計測方法 |
| CN108794510B (zh) * | 2018-07-25 | 2021-08-06 | 天津医科大学 | 一种由三芳基甲基自由基与氮氧自由基组成的双自由基化合物及其盐、其制备方法和应用 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK0515458T3 (da) | 1990-02-12 | 1995-09-25 | Nycomed Innovation Ab | Triarylmethylradikaler og anvendelse af inerte, frie carbon-radikaler ved MRI |
| US5728370A (en) * | 1993-04-02 | 1998-03-17 | Nycomed Imaging As | Free Radicals |
| GB9704669D0 (en) * | 1997-03-06 | 1997-04-23 | Nycomed Imaging As | Free radicals |
| DE69815305T2 (de) * | 1997-03-06 | 2004-04-29 | Amersham Health As | Triarylmethylfreie radikale als bildverbesserungsmittel |
| US6278893B1 (en) | 1998-01-05 | 2001-08-21 | Nycomed Imaging As | Method of magnetic resonance imaging of a sample with ex vivo polarization of an MR imaging agent |
-
2005
- 2005-07-28 KR KR1020077004778A patent/KR20070061805A/ko not_active Application Discontinuation
- 2005-07-28 WO PCT/NO2005/000283 patent/WO2006011811A2/en active Application Filing
- 2005-07-28 AU AU2005267670A patent/AU2005267670B2/en not_active Ceased
- 2005-07-28 CA CA2575473A patent/CA2575473C/en active Active
- 2005-07-28 KR KR1020137005589A patent/KR101413934B1/ko not_active IP Right Cessation
- 2005-07-28 DK DK05771195.4T patent/DK1805186T3/en active
- 2005-07-28 PL PL05771195T patent/PL1805186T3/pl unknown
- 2005-07-28 RU RU2007102844/04A patent/RU2374253C2/ru not_active IP Right Cessation
- 2005-07-28 BR BRPI0513880-9A patent/BRPI0513880A/pt not_active Application Discontinuation
- 2005-07-28 CN CN2005800325159A patent/CN101027310B/zh active Active
- 2005-07-28 KR KR1020147006039A patent/KR101554832B1/ko active IP Right Grant
- 2005-07-28 US US11/572,654 patent/US8431723B2/en active Active
- 2005-07-28 EP EP05771195.4A patent/EP1805186B1/en active Active
- 2005-07-28 ES ES05771195.4T patent/ES2545377T3/es active Active
- 2005-07-28 JP JP2007523506A patent/JP5535435B2/ja active Active
- 2005-07-28 MX MX2007001034A patent/MX2007001034A/es active IP Right Grant
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2007
- 2007-01-23 IL IL180895A patent/IL180895A/en active IP Right Grant
- 2007-02-13 ZA ZA200701272A patent/ZA200701272B/en unknown
- 2007-02-27 NO NO20071116A patent/NO339934B1/no not_active IP Right Cessation
- 2007-12-05 HK HK07113303.8A patent/HK1107692A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| IL180895A (en) | 2013-03-24 |
| KR20070061805A (ko) | 2007-06-14 |
| JP2008508267A (ja) | 2008-03-21 |
| RU2374253C2 (ru) | 2009-11-27 |
| NO339934B1 (no) | 2017-02-20 |
| HK1107692A1 (en) | 2008-04-11 |
| NO20071116L (no) | 2007-04-30 |
| US20090214432A1 (en) | 2009-08-27 |
| IL180895A0 (en) | 2007-07-04 |
| AU2005267670A1 (en) | 2006-02-02 |
| MX2007001034A (es) | 2007-07-25 |
| CN101027310A (zh) | 2007-08-29 |
| JP5535435B2 (ja) | 2014-07-02 |
| KR101554832B1 (ko) | 2015-09-21 |
| KR101413934B1 (ko) | 2014-06-30 |
| EP1805186A2 (en) | 2007-07-11 |
| AU2005267670B2 (en) | 2011-03-03 |
| BRPI0513880A (pt) | 2008-05-20 |
| CA2575473A1 (en) | 2006-02-02 |
| WO2006011811A2 (en) | 2006-02-02 |
| KR20140146042A (ko) | 2014-12-24 |
| KR20130045378A (ko) | 2013-05-03 |
| EP1805186B1 (en) | 2015-05-27 |
| CA2575473C (en) | 2013-02-19 |
| RU2007102844A (ru) | 2008-09-10 |
| PL1805186T3 (pl) | 2015-10-30 |
| WO2006011811A3 (en) | 2006-06-01 |
| US8431723B2 (en) | 2013-04-30 |
| DK1805186T3 (en) | 2015-08-24 |
| ES2545377T3 (es) | 2015-09-10 |
| CN101027310B (zh) | 2012-08-22 |
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