PL1805186T3 - Rodniki i ich zastosowanie jako środków paramagnetycznych w procesie dynamicznej polaryzacji jądrowej - Google Patents

Rodniki i ich zastosowanie jako środków paramagnetycznych w procesie dynamicznej polaryzacji jądrowej

Info

Publication number
PL1805186T3
PL1805186T3 PL05771195T PL05771195T PL1805186T3 PL 1805186 T3 PL1805186 T3 PL 1805186T3 PL 05771195 T PL05771195 T PL 05771195T PL 05771195 T PL05771195 T PL 05771195T PL 1805186 T3 PL1805186 T3 PL 1805186T3
Authority
PL
Poland
Prior art keywords
radicals
dynamic nuclear
paramagnetic agents
nuclear polarisation
polarisation process
Prior art date
Application number
PL05771195T
Other languages
English (en)
Inventor
Mikkel Thaning
Original Assignee
Ge Healthcare As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ge Healthcare As filed Critical Ge Healthcare As
Publication of PL1805186T3 publication Critical patent/PL1805186T3/pl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/05—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves 
    • A61B5/055—Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves  involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/20—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations containing free radicals, e.g. trityl radical for overhauser
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/48—NMR imaging systems
    • G01R33/54—Signal processing systems, e.g. using pulse sequences ; Generation or control of pulse sequences; Operator console
    • G01R33/56—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution
    • G01R33/5601—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution involving use of a contrast agent for contrast manipulation, e.g. a paramagnetic, super-paramagnetic, ferromagnetic or hyperpolarised contrast agent
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/62—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using double resonance

Landscapes

  • Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Radiology & Medical Imaging (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • General Physics & Mathematics (AREA)
  • Animal Behavior & Ethology (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Signal Processing (AREA)
  • Biomedical Technology (AREA)
  • Pathology (AREA)
  • Biophysics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Peptides Or Proteins (AREA)
PL05771195T 2004-07-30 2005-07-28 Rodniki i ich zastosowanie jako środków paramagnetycznych w procesie dynamicznej polaryzacji jądrowej PL1805186T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
NO20043227 2004-07-30
PCT/NO2005/000283 WO2006011811A2 (en) 2004-07-30 2005-07-28 Radicals and their use as paramagnetic agents in a dynamic nuclear polarisation process
EP05771195.4A EP1805186B1 (en) 2004-07-30 2005-07-28 Radicals and their use as paramagnetic agents in a dynamic nuclear polarisation process

Publications (1)

Publication Number Publication Date
PL1805186T3 true PL1805186T3 (pl) 2015-10-30

Family

ID=35502005

Family Applications (1)

Application Number Title Priority Date Filing Date
PL05771195T PL1805186T3 (pl) 2004-07-30 2005-07-28 Rodniki i ich zastosowanie jako środków paramagnetycznych w procesie dynamicznej polaryzacji jądrowej

Country Status (18)

Country Link
US (1) US8431723B2 (pl)
EP (1) EP1805186B1 (pl)
JP (1) JP5535435B2 (pl)
KR (3) KR101554832B1 (pl)
CN (1) CN101027310B (pl)
AU (1) AU2005267670B2 (pl)
BR (1) BRPI0513880A (pl)
CA (1) CA2575473C (pl)
DK (1) DK1805186T3 (pl)
ES (1) ES2545377T3 (pl)
HK (1) HK1107692A1 (pl)
IL (1) IL180895A (pl)
MX (1) MX2007001034A (pl)
NO (1) NO339934B1 (pl)
PL (1) PL1805186T3 (pl)
RU (1) RU2374253C2 (pl)
WO (1) WO2006011811A2 (pl)
ZA (1) ZA200701272B (pl)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006011809A1 (en) * 2004-07-30 2006-02-02 Ge Healthcare As Method of producing a composition, composition and its use
ES2375089T3 (es) 2005-12-01 2012-02-24 Ge Healthcare As Procedimiento de la polarización nuclear dinámica(dnp) que usa un radical tritilo y un ión metálico paramagnético.
CN101378784B (zh) * 2005-12-16 2013-06-12 通用电气医疗集团股份有限公司 产生有机胺的超极化羧酸盐的方法
CN101506179B (zh) 2006-08-30 2012-08-22 通用电气医疗集团股份有限公司 动态核极化(dnp)的方法及用于所述方法的化合物和组合物
JP2008084485A (ja) * 2006-09-28 2008-04-10 Toshiba Corp 不揮発性半導体記憶装置及びデータ読出方法
EP2117607A4 (en) * 2007-01-11 2012-08-08 Huntington Medical Res Inst IMAGING AGENTS AND METHODS OF USE
US9227173B2 (en) 2007-06-22 2016-01-05 General Electric Company Methods for dynamic filtration of pharmaceutical products
EP2902041A1 (en) 2007-12-19 2015-08-05 GE Healthcare Limited Composition and method for generating a metabolic profile using 13C-MR detection
WO2009129265A1 (en) 2008-04-14 2009-10-22 Huntington Medical Research Institutes Methods and apparatus for pasadena hyperpolarization
SG179067A1 (en) 2009-09-10 2012-04-27 Ge Healthcare Ltd 13c-mr detection using hyperpolarised 13c-fructose
EP2494918B1 (en) 2009-10-29 2015-08-19 Kyushu University, National University Corporation Method for detecting endogenous biomolecules
FR2967158A1 (fr) 2010-11-08 2012-05-11 Phosphoenix Sarl Nouveaux radicaux triarylmethyle: leur preparation et application
EP2640263A1 (en) * 2010-11-16 2013-09-25 Aspect Magnet Technologies Ltd. System and method for generating invasively hyperpolarized images
GB2498181A (en) 2011-12-29 2013-07-10 Bruker Biospin Gmbh Device and method for rapid dynamic nuclear polarisation
JP6507101B2 (ja) * 2013-01-31 2019-04-24 ブラッコ・イメージング・ソシエタ・ペル・アチオニＢｒａｃｃｏ Ｉｍａｇｉｎｇ Ｓ．Ｐ．Ａ． Ｍｒにおける代謝マーカーとしての過分極エステル
US9874622B2 (en) 2013-09-27 2018-01-23 General Electric Company Hyperpolarized media transport vessel
WO2018158891A1 (ja) * 2017-03-01 2018-09-07 国立大学法人九州大学 生体計測方法
CN108794510B (zh) * 2018-07-25 2021-08-06 天津医科大学 一种由三芳基甲基自由基与氮氧自由基组成的双自由基化合物及其盐、其制备方法和应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU651570B2 (en) 1990-02-12 1994-07-28 Hafslund Nycomed Innovation Ab Triarylmethyl radicals and the use of inert carbon free radicals in MRI
GB9704669D0 (en) * 1997-03-06 1997-04-23 Nycomed Imaging As Free radicals
US5728370A (en) * 1993-04-02 1998-03-17 Nycomed Imaging As Free Radicals
EP0966414B1 (en) 1997-03-06 2003-06-04 Amersham Health AS Triarylmethyl free radicals as image enhancing agents
US6278893B1 (en) 1998-01-05 2001-08-21 Nycomed Imaging As Method of magnetic resonance imaging of a sample with ex vivo polarization of an MR imaging agent

Also Published As

Publication number Publication date
NO20071116L (no) 2007-04-30
MX2007001034A (es) 2007-07-25
JP5535435B2 (ja) 2014-07-02
HK1107692A1 (en) 2008-04-11
WO2006011811A3 (en) 2006-06-01
AU2005267670B2 (en) 2011-03-03
ZA200701272B (en) 2008-04-30
CA2575473C (en) 2013-02-19
KR101413934B1 (ko) 2014-06-30
EP1805186A2 (en) 2007-07-11
DK1805186T3 (en) 2015-08-24
ES2545377T3 (es) 2015-09-10
WO2006011811A2 (en) 2006-02-02
EP1805186B1 (en) 2015-05-27
RU2374253C2 (ru) 2009-11-27
US20090214432A1 (en) 2009-08-27
BRPI0513880A (pt) 2008-05-20
CN101027310A (zh) 2007-08-29
CA2575473A1 (en) 2006-02-02
IL180895A (en) 2013-03-24
KR20070061805A (ko) 2007-06-14
JP2008508267A (ja) 2008-03-21
CN101027310B (zh) 2012-08-22
RU2007102844A (ru) 2008-09-10
KR101554832B1 (ko) 2015-09-21
AU2005267670A1 (en) 2006-02-02
IL180895A0 (en) 2007-07-04
KR20130045378A (ko) 2013-05-03
KR20140146042A (ko) 2014-12-24
NO339934B1 (no) 2017-02-20
US8431723B2 (en) 2013-04-30

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