HK1107692A1 - 基團及其在動態核極化方法中作為順磁化劑的應用 - Google Patents

基團及其在動態核極化方法中作為順磁化劑的應用

Info

Publication number
HK1107692A1
HK1107692A1 HK07113303.8A HK07113303A HK1107692A1 HK 1107692 A1 HK1107692 A1 HK 1107692A1 HK 07113303 A HK07113303 A HK 07113303A HK 1107692 A1 HK1107692 A1 HK 1107692A1
Authority
HK
Hong Kong
Prior art keywords
radicals
dynamic nuclear
paramagnetic agents
nuclear polarisation
polarisation process
Prior art date
Application number
HK07113303.8A
Other languages
English (en)
Inventor
Mikkel Thaning
Original Assignee
Ge Healthcare As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ge Healthcare As filed Critical Ge Healthcare As
Publication of HK1107692A1 publication Critical patent/HK1107692A1/zh

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/06Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D519/00Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/05Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves 
    • A61B5/055Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves  involving electronic [EMR] or nuclear [NMR] magnetic resonance, e.g. magnetic resonance imaging
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/06Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/20Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations containing free radicals, e.g. trityl radical for overhauser
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01RMEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00Arrangements or instruments for measuring magnetic variables
    • G01R33/20Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01RMEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00Arrangements or instruments for measuring magnetic variables
    • G01R33/20Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/48NMR imaging systems
    • G01R33/54Signal processing systems, e.g. using pulse sequences ; Generation or control of pulse sequences; Operator console
    • G01R33/56Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution
    • G01R33/5601Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution involving use of a contrast agent for contrast manipulation, e.g. a paramagnetic, super-paramagnetic, ferromagnetic or hyperpolarised contrast agent
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01RMEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00Arrangements or instruments for measuring magnetic variables
    • G01R33/20Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/62Arrangements or instruments for measuring magnetic variables involving magnetic resonance using double resonance

Landscapes

  • Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Radiology & Medical Imaging (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • General Physics & Mathematics (AREA)
  • Animal Behavior & Ethology (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Signal Processing (AREA)
  • Biomedical Technology (AREA)
  • Pathology (AREA)
  • Biophysics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Surgery (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
HK07113303.8A 2004-07-30 2007-12-05 基團及其在動態核極化方法中作為順磁化劑的應用 HK1107692A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
NO20043227 2004-07-30
PCT/NO2005/000283 WO2006011811A2 (en) 2004-07-30 2005-07-28 Radicals and their use as paramagnetic agents in a dynamic nuclear polarisation process

Publications (1)

Publication Number Publication Date
HK1107692A1 true HK1107692A1 (zh) 2008-04-11

Family

ID=35502005

Family Applications (1)

Application Number Title Priority Date Filing Date
HK07113303.8A HK1107692A1 (zh) 2004-07-30 2007-12-05 基團及其在動態核極化方法中作為順磁化劑的應用

Country Status (18)

Country Link
US (1) US8431723B2 (zh)
EP (1) EP1805186B1 (zh)
JP (1) JP5535435B2 (zh)
KR (3) KR20070061805A (zh)
CN (1) CN101027310B (zh)
AU (1) AU2005267670B2 (zh)
BR (1) BRPI0513880A (zh)
CA (1) CA2575473C (zh)
DK (1) DK1805186T3 (zh)
ES (1) ES2545377T3 (zh)
HK (1) HK1107692A1 (zh)
IL (1) IL180895A (zh)
MX (1) MX2007001034A (zh)
NO (1) NO339934B1 (zh)
PL (1) PL1805186T3 (zh)
RU (1) RU2374253C2 (zh)
WO (1) WO2006011811A2 (zh)
ZA (1) ZA200701272B (zh)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9023320B2 (en) * 2004-07-30 2015-05-05 Ge Healthcare As Method of producing a composition, composition and its use
ES2375089T3 (es) 2005-12-01 2012-02-24 Ge Healthcare As Procedimiento de la polarización nuclear dinámica(dnp) que usa un radical tritilo y un ión metálico paramagnético.
ES2393750T3 (es) * 2005-12-16 2012-12-27 Ge Healthcare As Procedimiento para producir carbosilatos hiperpolarizados de aminas orgánicas
KR101502180B1 (ko) 2006-08-30 2015-03-12 지이 헬스케어 에이에스 동적 핵 분극화 방법 및 이러한 방법에서 사용되는 화합물 및 조성물
JP2008084485A (ja) * 2006-09-28 2008-04-10 Toshiba Corp 不揮発性半導体記憶装置及びデータ読出方法
WO2008086534A1 (en) * 2007-01-11 2008-07-17 Huntington Medical Research Institutes Imaging agents and methods of use thereof
US9227173B2 (en) 2007-06-22 2016-01-05 General Electric Company Methods for dynamic filtration of pharmaceutical products
EP2072061A1 (en) 2007-12-19 2009-06-24 GE Healthcare Limited Composition and method for generating a metabolic profile using 13C-MR detection
WO2009129265A1 (en) 2008-04-14 2009-10-22 Huntington Medical Research Institutes Methods and apparatus for pasadena hyperpolarization
WO2011029854A1 (en) 2009-09-10 2011-03-17 Ge Healthcare Limited 13c-mr detection using hyperpolarised 13c-fructose
US8722420B2 (en) 2009-10-29 2014-05-13 Kyushu University, National University Corporation Method for detecting an endogenous biomolecule
FR2967158A1 (fr) 2010-11-08 2012-05-11 Phosphoenix Sarl Nouveaux radicaux triarylmethyle: leur preparation et application
EP2640263A1 (en) * 2010-11-16 2013-09-25 Aspect Magnet Technologies Ltd. System and method for generating invasively hyperpolarized images
GB2498181A (en) 2011-12-29 2013-07-10 Bruker Biospin Gmbh Device and method for rapid dynamic nuclear polarisation
JP6507101B2 (ja) * 2013-01-31 2019-04-24 ブラッコ・イメージング・ソシエタ・ペル・アチオニBracco Imaging S.P.A. Mrにおける代謝マーカーとしての過分極エステル
US9874622B2 (en) 2013-09-27 2018-01-23 General Electric Company Hyperpolarized media transport vessel
WO2018158891A1 (ja) * 2017-03-01 2018-09-07 国立大学法人九州大学 生体計測方法
CN108794510B (zh) * 2018-07-25 2021-08-06 天津医科大学 一种由三芳基甲基自由基与氮氧自由基组成的双自由基化合物及其盐、其制备方法和应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3175940B2 (ja) * 1990-02-12 2001-06-11 ニコムド イノベーション アーベー トリアリールメチルラジカルおよび磁気共鳴造影法における不活性炭素フリーラジカルの用途
GB9704669D0 (en) * 1997-03-06 1997-04-23 Nycomed Imaging As Free radicals
US5728370A (en) * 1993-04-02 1998-03-17 Nycomed Imaging As Free Radicals
AU6506598A (en) * 1997-03-06 1998-09-22 Nycomed Imaging As Triarylmethyl free radicals as image enhancing agents
US6278893B1 (en) * 1998-01-05 2001-08-21 Nycomed Imaging As Method of magnetic resonance imaging of a sample with ex vivo polarization of an MR imaging agent

Also Published As

Publication number Publication date
WO2006011811A3 (en) 2006-06-01
ZA200701272B (en) 2008-04-30
KR20140146042A (ko) 2014-12-24
BRPI0513880A (pt) 2008-05-20
JP5535435B2 (ja) 2014-07-02
IL180895A (en) 2013-03-24
CN101027310B (zh) 2012-08-22
KR101413934B1 (ko) 2014-06-30
KR101554832B1 (ko) 2015-09-21
DK1805186T3 (en) 2015-08-24
ES2545377T3 (es) 2015-09-10
RU2374253C2 (ru) 2009-11-27
AU2005267670A1 (en) 2006-02-02
NO339934B1 (no) 2017-02-20
IL180895A0 (en) 2007-07-04
MX2007001034A (es) 2007-07-25
WO2006011811A2 (en) 2006-02-02
NO20071116L (no) 2007-04-30
JP2008508267A (ja) 2008-03-21
US8431723B2 (en) 2013-04-30
US20090214432A1 (en) 2009-08-27
AU2005267670B2 (en) 2011-03-03
CA2575473A1 (en) 2006-02-02
PL1805186T3 (pl) 2015-10-30
CN101027310A (zh) 2007-08-29
CA2575473C (en) 2013-02-19
EP1805186A2 (en) 2007-07-11
EP1805186B1 (en) 2015-05-27
KR20130045378A (ko) 2013-05-03
KR20070061805A (ko) 2007-06-14
RU2007102844A (ru) 2008-09-10

Similar Documents

Publication Publication Date Title
PL1805186T3 (pl) Rodniki i ich zastosowanie jako środków paramagnetycznych w procesie dynamicznej polaryzacji jądrowej
HK1205981A1 (zh) 用於三維模型印刷的組合物和方法
ZA200600716B (en) Improvements in and to processes
EP2004302A4 (en) ELECTRETS AND COMPOUNDS USEFUL IN ELECTRETS
GB0911243D0 (en) Methods and apparatus for use in a well
EP1863992A4 (en) RESIDUAL MAGNETIC DEVICES AND METHODS
PL1849154T3 (pl) Sposoby i urządzenie do zastosowania w modyfikacji dźwięku
EP1913954A4 (en) AGENTS AND METHODS BASED ON THE USE OF THE FIBRONECTIN EDA DOMAIN
PL1720408T3 (pl) Mieszaniny i sposoby indukowania odporności w roślinach
EP1812034A4 (en) COMPOSITIONS AND METHODS OF INDUCING MELANOESEES IN ONE PERSON
GB2429472B (en) Technique and apparatus for use in well testing
EP2088794A4 (en) USER DEVICE AND METHOD USED IN USER DEVICE
EP1919329A4 (en) IMPROVEMENTS IN OR RELATING TO A DISTRIBUTION APPARATUS
GB0426005D0 (en) Sram test method and sram test arrangement
EP2205342A4 (en) GENERATION AND USE OF ISOTOPE PATTERNS IN THE MASS SPECTROMETRIC PHENOTYPE COMPARISON OF ORGANISMS
GB0412817D0 (en) Improvements in and relating to image articles
GB0505170D0 (en) Improvements in and relating to padded boxes
EP1804615A4 (en) SYSTEMS AND METHODS FOR SHAPING HANDLES FOR FURNITURE
HK1126907A1 (en) A management system and management method of the timer in the software system
PL2091724T3 (pl) Uchwyty i sposób obróbki konstrukcji toroidalnych
GB0326708D0 (en) Improvements in and relating to socks
GB0512668D0 (en) System and method for use in visual modelling
ZA200802116B (en) Biphenyl drivatives and their use in treating hepatitis C
LU91261B1 (en) Article and method
EP1975058A4 (en) PROCESS FOR CONTAINING CONTAMINANT AGENTS PRESENT IN THE AQUATIC ENVIRONMENT AND DEVICE FOR IMPLEMENTING IT

Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20190725