HK1100441A1 - Derivatives of pyridine and quinoline - Google Patents

Derivatives of pyridine and quinoline

Info

Publication number
HK1100441A1
HK1100441A1 HK07108357.3A HK07108357A HK1100441A1 HK 1100441 A1 HK1100441 A1 HK 1100441A1 HK 07108357 A HK07108357 A HK 07108357A HK 1100441 A1 HK1100441 A1 HK 1100441A1
Authority
HK
Hong Kong
Prior art keywords
quinoline
pyridine
derivatives
blocking
diseases
Prior art date
Application number
HK07108357.3A
Other languages
English (en)
Inventor
Sanjuan Juan Carlos Lacal
Rosa Joaquin Campos
Meza Miguel Angel Gallo
Ubeda Antonio Espinosa
Original Assignee
Consejo Superior Investigacion
Univ Granada
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Consejo Superior Investigacion, Univ Granada filed Critical Consejo Superior Investigacion
Publication of HK1100441A1 publication Critical patent/HK1100441A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C07D215/42—Nitrogen atoms attached in position 4
    • C07D215/44—Nitrogen atoms attached in position 4 with aryl radicals attached to said nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
HK07108357.3A 2004-01-14 2007-07-31 Derivatives of pyridine and quinoline HK1100441A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ES200400072A ES2237332B1 (es) 2004-01-14 2004-01-14 Derivados de piridinio y quinolinio.
PCT/ES2005/070002 WO2005068429A1 (fr) 2004-01-14 2005-01-11 Derives de pyridine et de quinoline

Publications (1)

Publication Number Publication Date
HK1100441A1 true HK1100441A1 (en) 2007-09-21

Family

ID=34778265

Family Applications (1)

Application Number Title Priority Date Filing Date
HK07108357.3A HK1100441A1 (en) 2004-01-14 2007-07-31 Derivatives of pyridine and quinoline

Country Status (16)

Country Link
US (1) US7781458B2 (fr)
EP (2) EP2085386A3 (fr)
JP (2) JP5047627B2 (fr)
KR (1) KR101157206B1 (fr)
CN (1) CN1910153B (fr)
AT (1) ATE461918T1 (fr)
BR (1) BRPI0506486A (fr)
CA (1) CA2553328C (fr)
DE (1) DE602005020112D1 (fr)
DK (1) DK1710236T3 (fr)
ES (2) ES2237332B1 (fr)
HK (1) HK1100441A1 (fr)
MX (1) MXPA06007940A (fr)
PL (1) PL1710236T3 (fr)
PT (1) PT1710236E (fr)
WO (1) WO2005068429A1 (fr)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8586613B2 (en) * 2004-01-14 2013-11-19 Universidad De Granada Pyridinium and quinolinium derivatives
AU2009265121A1 (en) 2008-07-04 2010-01-07 Traslational Cancer Drugs Pharma, S.L. Methods for the treatment and diagnosis of cancer
US20100068302A1 (en) * 2008-09-17 2010-03-18 Traslational Cancer Drugs Pharma, S.L. Methods and compositions for the treatment of cancer
US20110212994A1 (en) * 2009-06-26 2011-09-01 Brian Clem Small Molecule Choline Kinase Inhibitors, Screening Assays, and Methods for Safe and Effective Treatment of Neoplastic Disorders
WO2012041493A1 (fr) * 2010-09-28 2012-04-05 Julius-Maximilians-Universität Würzburg Sels d'aminoquinoline, leurs procédés de production et leur utilisation en tant qu'agents actifs pour des applications biotechnologiques et médicales contre les toxines binaires
EP2468259A1 (fr) * 2010-12-23 2012-06-27 Traslational Cancer Drugs Pharma, S.L. Compositions pharmaceutiques de dérivés de pyridinium et de quinolinium
JP2014527397A (ja) 2011-06-20 2014-10-16 トラスラショナル、キャンサー、ドラッグス、ファーマ、ソシエダッド、リミターダＴｒａｓｌａｔｉｏｎａｌ Ｃａｎｃｅｒ Ｄｒｕｇｓ Ｐｈａｒｍａ， Ｓ．Ｌ． 癌患者の化学療法に対する臨床応答を予測する方法
CA2849442A1 (fr) * 2011-09-22 2013-03-28 Vertex Pharmaceuticals Incorporated Composes utiles en tant qu'inhibiteurs de la choline kinase
ES2472367B1 (es) * 2012-12-28 2015-06-02 Universidad De Granada Inhibidores no simétricos de colina quinasa con actividad antitumoral y antimalárica
WO2015028662A1 (fr) 2013-08-30 2015-03-05 Consejo Superior De Investigaciones Cientificas (Csic) Compositions et méthodes de caractérisation et de traitement de la polyarthrite rhumatoïde
ES2482290B1 (es) * 2014-06-05 2015-05-19 Universidad De Granada Inhibidores polares simétricos de colina cinasa con actividad antitumoral
ES2899114T3 (es) 2016-07-25 2022-03-10 Nerviano Medical Sciences Srl Análogos de purina y 3-deazapurina como inhibidores de colina cinasa
US11117901B2 (en) 2017-07-11 2021-09-14 Nerviano Medical Sciences S.R.L. Substituted pyrazolo[4,3-h]quinazolines as choline kinase inhibitors

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4206215A (en) * 1976-02-25 1980-06-03 Sterling Drug Inc. Antimicrobial bis-[4-(substituted-amino)-1-pyridinium]alkanes
GB1533952A (en) * 1976-02-25 1978-11-29 Sterling Drug Inc Anti-microbial bis-pyridinium compounds
FR2498187A1 (fr) * 1981-01-16 1982-07-23 Rhone Poulenc Sante Procede de preparation d'amino-4 chloro-7 quinoleines
IL89026A (en) * 1988-01-29 1993-02-21 Lilly Co Eli Substituted quinolines and cinnolines, process for their preparation and fungicidal, insecticidal and miticidal compositions containing them
ES2117950B1 (es) * 1996-08-02 1999-09-16 Univ Granada Nuevos compuestos que bloquean la biosintesis de fosforilcolina y su uso como segundo mensajero en proliferacion celular.

Also Published As

Publication number Publication date
EP1710236B1 (fr) 2010-03-24
JP5619805B2 (ja) 2014-11-05
WO2005068429A1 (fr) 2005-07-28
JP5047627B2 (ja) 2012-10-10
PL1710236T3 (pl) 2010-08-31
CN1910153A (zh) 2007-02-07
CA2553328C (fr) 2012-05-15
MXPA06007940A (es) 2007-01-23
US20070185170A1 (en) 2007-08-09
KR20060110364A (ko) 2006-10-24
EP2085386A3 (fr) 2009-10-28
EP2085386A2 (fr) 2009-08-05
ATE461918T1 (de) 2010-04-15
JP2007517837A (ja) 2007-07-05
EP1710236A1 (fr) 2006-10-11
DK1710236T3 (da) 2010-07-12
CA2553328A1 (fr) 2005-07-28
CN1910153B (zh) 2010-05-26
ES2343418T3 (es) 2010-07-30
US7781458B2 (en) 2010-08-24
BRPI0506486A (pt) 2007-02-13
PT1710236E (pt) 2010-06-18
DE602005020112D1 (de) 2010-05-06
ES2237332B1 (es) 2006-11-01
JP2012149077A (ja) 2012-08-09
ES2237332A1 (es) 2005-07-16
KR101157206B1 (ko) 2012-07-06

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Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20170111