HK1092788A1 - Caspase inhibitors containing isoxazoline ring - Google Patents

Caspase inhibitors containing isoxazoline ring

Info

Publication number
HK1092788A1
HK1092788A1 HK06110041.2A HK06110041A HK1092788A1 HK 1092788 A1 HK1092788 A1 HK 1092788A1 HK 06110041 A HK06110041 A HK 06110041A HK 1092788 A1 HK1092788 A1 HK 1092788A1
Authority
HK
Hong Kong
Prior art keywords
caspase inhibitors
inhibitors containing
isoxazoline ring
containing isoxazoline
ring
Prior art date
Application number
HK06110041.2A
Other languages
English (en)
Chinese (zh)
Inventor
Hye-Kyung Chang
Jeong Hui Seong
Yeong-Soo Oh
Cheol-Won Park
Yong-Jin Jang
Tae-Kyo Park
Sung-Sub Kim
Min-Jung Kim
Mi-Jeong Park
Jung-Gyu Park
Hee-Dong Park
Kyeong-Sik Min
Tae-Soo Lee
Sang-Kyun Lee
Soo-Hyeon Kim
Hee-Kyung Jeong
Sun-Hwa Lee
Hwa-Dong Kim
Ae-Ri Kim
Ki-Sook Park
Hyun-Ik Shin
Hyeong-Wook Choi
Kyu-Woong Lee
Jae-Hoon Lee
Tae-Ho Heo
Ho Jun Kim
Tae-Sik Kwon
Original Assignee
Lg Life Sciences Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lg Life Sciences Ltd filed Critical Lg Life Sciences Ltd
Publication of HK1092788A1 publication Critical patent/HK1092788A1/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D261/00Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/04Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/55Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Oncology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Communicable Diseases (AREA)
  • Rheumatology (AREA)
  • Emergency Medicine (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Obesity (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Transplantation (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
HK06110041.2A 2003-08-27 2006-09-08 Caspase inhibitors containing isoxazoline ring HK1092788A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR20030059451 2003-08-27
PCT/KR2004/002139 WO2005021516A1 (en) 2003-08-27 2004-08-26 Caspase inhibitors containing isoxazoline ring

Publications (1)

Publication Number Publication Date
HK1092788A1 true HK1092788A1 (en) 2007-02-16

Family

ID=36102769

Family Applications (1)

Application Number Title Priority Date Filing Date
HK06110041.2A HK1092788A1 (en) 2003-08-27 2006-09-08 Caspase inhibitors containing isoxazoline ring

Country Status (27)

Country Link
US (1) US7557133B2 (tr)
EP (1) EP1660464B1 (tr)
JP (1) JP4503017B2 (tr)
KR (1) KR100594544B1 (tr)
CN (1) CN1842521B (tr)
AP (1) AP2104A (tr)
AR (1) AR045503A1 (tr)
BR (1) BRPI0413848B8 (tr)
CA (1) CA2535711C (tr)
EA (1) EA012080B1 (tr)
EC (1) ECSP066378A (tr)
EG (1) EG25751A (tr)
HK (1) HK1092788A1 (tr)
IL (1) IL173638A (tr)
MA (1) MA27999A1 (tr)
MX (1) MXPA06002267A (tr)
MY (1) MY162110A (tr)
NO (1) NO335620B1 (tr)
NZ (1) NZ545216A (tr)
OA (1) OA13244A (tr)
PE (1) PE20050371A1 (tr)
TR (1) TR200600899T2 (tr)
TW (1) TWI346110B (tr)
UA (1) UA83240C2 (tr)
UY (1) UY28494A1 (tr)
WO (1) WO2005021516A1 (tr)
ZA (1) ZA200601586B (tr)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100774999B1 (ko) * 2005-02-26 2007-11-09 주식회사 엘지생명과학 이소옥사졸린 유도체 및 그의 제조 방법
US7754909B1 (en) * 2005-04-06 2010-07-13 The Florida State University Research Foundation, Inc. Compounds and methods of arylmethylation (benzylation) as protection for alcohol groups during chemical synthesis
KR101299720B1 (ko) * 2006-08-16 2013-08-28 주식회사 엘지생명과학 3-아미노-5-플루오로-4-디알콕시펜탄산 에스테르의 새로운제조방법
KR20080042290A (ko) * 2006-11-09 2008-05-15 주식회사 엘지생명과학 피리돈 구조를 포함하는 캐스파제 저해제
EP2186804B1 (en) * 2007-08-10 2015-06-17 Nippon Soda Co., Ltd. Nitrogen-containing heterocyclic compound and pest control agent
KR20090099886A (ko) * 2008-03-18 2009-09-23 주식회사 엘지생명과학 캐스파제 저해제의 프로드럭
SG191591A1 (en) 2008-05-21 2013-07-31 New World Lab Inc Selective caspase inhibitors and uses thereof
US9034883B2 (en) 2010-11-15 2015-05-19 Boehringer Ingelheim International Gmbh Vasoprotective and cardioprotective antidiabetic therapy
CA2831704C (en) 2011-03-31 2019-10-01 Bayer Intellectual Property Gmbh Herbicidally and fungicidally active 3-phenylisoxazoline-5-carboxamides and 3-phenylisoxazoline-5-thioamides
DK2697246T3 (en) * 2011-04-15 2018-05-28 Genesis Tech Limited SELECTIVE CYSTEIN PROTEASE INHIBITORS AND USES THEREOF
AU2013322855B2 (en) * 2012-09-25 2017-06-22 Bayer Cropscience Ag Herbicidal and fungicidal 5-oxy-substituted 3-phenylisoxazoline-5-carboxamides and 5-oxy-substituted 3-phenylisoxazoline-5-thioamides
US9585392B2 (en) * 2012-09-25 2017-03-07 Bayer Cropscience Ag 3-phenylisoxazolin derivatives with herbicidal action
EP2900660B1 (de) 2012-09-25 2018-01-17 Bayer CropScience AG Herbizid und fungizid wirksame 3-heteroarylisoxazolin-5-carboxamide und 3- heteroarylisoxazolin-5-thioamide
JP2017095353A (ja) * 2014-03-27 2017-06-01 日本曹達株式会社 イソオキサゾリン−5−カルボキサミド化合物および有害生物防除剤
BR112016026560A2 (pt) 2014-05-12 2017-08-15 Conatus Pharmaceuticals Inc Método para tratar uma complicação de uma doença hepática crônica, método para tratar hipertensão portal, método para inibir uma cascata de sinalização de tnf-a e de a-fas; composição farmacêutica, kit, método de tratamento, método para tratar uma afecção
CN105753853B (zh) 2014-12-16 2020-08-04 沈阳中化农药化工研发有限公司 一种含异恶唑啉的脲嘧啶类化合物及其用途
WO2017079566A1 (en) 2015-11-05 2017-05-11 Conatus Pharmaceuticals, Inc. Caspase inhibitors for use in the treatment of liver cancer
RU2018127752A (ru) 2015-12-31 2020-01-31 Конатус Фармасьютикалз Инк. Способы применения ингибиторов каспаз при лечении заболеваний печени
KR20190062501A (ko) 2016-10-05 2019-06-05 노파르티스 아게 섬유증, 간경화 질환 또는 질병을 치료 또는 예방하기 위한 fxr 작용제를 포함하는 조합 조성물
US11434212B2 (en) * 2017-01-23 2022-09-06 Chia Tai Tianqing Pharmaceutical Group Co., Ltd. Bicyclic compound as a caspase inhibitor
BR112019026261B1 (pt) 2017-06-13 2023-12-19 Bayer Cropscience Aktiengesellschaft 3- fenilisoxazolina-5-carboxamidas e seus usos para controlar plantas indesejadas
PL3638666T3 (pl) 2017-06-13 2022-01-03 Bayer Aktiengesellschaft Chwastobójczo skuteczne 3-fenyloizoksazolino-5-karboksyamidy amidów kwasu tetrahydro- i dihydrofuranokarboksylowego
WO2019034602A1 (de) 2017-08-17 2019-02-21 Bayer Aktiengesellschaft Herbizid wirksame 3-phenyl-5-trifluormethylisoxazolin-5-carboxamide von cyclopentylcarbonsäuren und -estern
EA202091774A1 (ru) 2018-01-25 2020-12-07 Байер Акциенгезельшафт Гербицидно-активные 3-фенилизоксазолин-5-карбоксамиды производных циклопентенилкарбоновой кислоты
EP3937637B1 (de) 2019-03-12 2023-04-19 Bayer Aktiengesellschaft Herbizid wirksame 3-phenylisoxazolin-5-carboxamide von s-haltigen cyclopentenylcarbonsäureestern
EP3939976B1 (en) * 2019-04-19 2024-05-01 Lg Chem, Ltd. Prodrug of caspase inhibitor
US20220227743A1 (en) * 2019-04-30 2022-07-21 Lg Chem, Ltd. Prodrug of caspase inhibitor
TW202237143A (zh) 2020-12-10 2022-10-01 南韓商Lg化學股份有限公司 酸(Boronic Acid)化合物
WO2022123062A1 (en) 2020-12-11 2022-06-16 INSERM (Institut National de la Santé et de la Recherche Médicale) Blocking caspase and/or fasl for preventing fatal outcome in covid-19 patients

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2738486B2 (ja) 1992-11-20 1998-04-08 ファイザー製薬株式会社 抗炎症剤としての新規なイソオキサゾリン類
WO1995014681A1 (en) * 1993-11-26 1995-06-01 Pfizer Inc. Isoxazoline compounds as antiinflammatory agents
ATE187447T1 (de) * 1993-11-26 1999-12-15 Pfizer 3-phenyl-2-isoxazoline derivate als entzündugshemmende mittel
US5710159A (en) * 1996-05-09 1998-01-20 The Dupont Merck Pharmaceutical Company Integrin receptor antagonists
IL118325A0 (en) * 1995-05-25 1996-10-31 Pont Merck And Pharmaceutical Integrin receptor antagonists and pharmaceutical compositions containing them
KR100373375B1 (ko) * 1998-04-03 2003-06-12 주식회사 엘지생명과학 인터루킨-1b-컨버팅효소및아포파인/cpp-32에대한저해제
AU5762899A (en) * 1999-09-17 2001-04-24 Lg Chemical Ltd. Caspase inhibitor
DE60013147T2 (de) 1999-09-17 2005-08-11 Lg Chem Investment, Ltd. Caspase-hemmer

Also Published As

Publication number Publication date
EP1660464A1 (en) 2006-05-31
JP4503017B2 (ja) 2010-07-14
US20060223848A1 (en) 2006-10-05
UY28494A1 (es) 2005-02-28
US7557133B2 (en) 2009-07-07
PE20050371A1 (es) 2005-08-17
EP1660464A4 (en) 2008-11-26
EP1660464B1 (en) 2015-02-25
CA2535711A1 (en) 2005-03-10
UA83240C2 (ru) 2008-06-25
EA200600465A1 (ru) 2006-08-25
KR100594544B1 (ko) 2006-06-30
TR200600899T2 (tr) 2006-09-21
MXPA06002267A (es) 2006-05-17
IL173638A (en) 2011-12-29
TW200512199A (en) 2005-04-01
OA13244A (en) 2007-01-31
JP2007503429A (ja) 2007-02-22
MA27999A1 (fr) 2006-07-03
BRPI0413848B1 (pt) 2019-04-30
MY162110A (en) 2017-05-31
CA2535711C (en) 2011-07-05
ZA200601586B (en) 2007-05-30
IL173638A0 (en) 2006-07-05
TWI346110B (en) 2011-08-01
ECSP066378A (es) 2006-08-30
NO335620B1 (no) 2015-01-12
CN1842521B (zh) 2012-09-05
EA012080B1 (ru) 2009-08-28
AR045503A1 (es) 2005-11-02
CN1842521A (zh) 2006-10-04
NO20061362L (no) 2006-03-24
AP2006003509A0 (en) 2006-02-28
WO2005021516A1 (en) 2005-03-10
KR20050022364A (ko) 2005-03-07
BRPI0413848A (pt) 2006-10-24
BRPI0413848B8 (pt) 2021-05-25
EG25751A (en) 2012-06-25
AP2104A (en) 2010-02-06
NZ545216A (en) 2009-06-26
AU2004268895A1 (en) 2005-03-10

Similar Documents

Publication Publication Date Title
IL173638A0 (en) Caspase inhibitors containing isoxazoline ring
GB0315111D0 (en) Substituted 5-membered ring compounds and their use
AU153411S (en) Watchcase
ZA200505418B (en) Cathepsin S inhibitors
AU152718S (en) Wristwatch
EP1660436A4 (en) cathepsin inhibitors
PL2258188T3 (pl) Mieszaniny chwastobójcze zawierające pikolinafen
HK1139568A1 (en) Belt ring
EP1704142A4 (en) PROTEASE INHIBITORS
AU153883S (en) Ring
EP1622615A4 (en) INHIBITORS OF THE INTEGRASE OF NAPHTHYRIDINE
GB0311195D0 (en) Glyoxalase inhibitors
AU149626S (en) Ring
AU158134S (en) Ring
GB2402069B (en) Dental isolation device
AU154468S (en) Watch
GB2402749B (en) Ring dividing device
AU153829S (en) Ring
AU153832S (en) Ring
HU0300249V0 (en) Ring for penial
GB0312619D0 (en) Complement inhibitors
PL360019A1 (en) Gps
GB0303105D0 (en) Isoxazole compounds
GB0313751D0 (en) Isoxazole compounds
GB0306560D0 (en) Isoxazole compounds

Legal Events

Date Code Title Description
CHRG Changes in the register

Free format text: ADDITION OF INVENTOR: SEONG, JEONG HUI