HK1089159A1 - Inhibitors of nucleoside metabolism - Google Patents

Inhibitors of nucleoside metabolism

Info

Publication number
HK1089159A1
HK1089159A1 HK06109456A HK06109456A HK1089159A1 HK 1089159 A1 HK1089159 A1 HK 1089159A1 HK 06109456 A HK06109456 A HK 06109456A HK 06109456 A HK06109456 A HK 06109456A HK 1089159 A1 HK1089159 A1 HK 1089159A1
Authority
HK
Hong Kong
Prior art keywords
sub
compounds
halogen
chosen
hydroxy
Prior art date
Application number
HK06109456A
Other languages
English (en)
Inventor
Richard Hubert Furneaux
Peter Charles Tyler
Vern L Schramm
Original Assignee
Einstein Coll Med
Ind Res Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Einstein Coll Med, Ind Res Ltd filed Critical Einstein Coll Med
Publication of HK1089159A1 publication Critical patent/HK1089159A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Transplantation (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
HK06109456A 1997-10-14 2006-08-25 Inhibitors of nucleoside metabolism HK1089159A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/949,388 US5985848A (en) 1997-10-14 1997-10-14 Inhibitors of nucleoside metabolism

Publications (1)

Publication Number Publication Date
HK1089159A1 true HK1089159A1 (en) 2006-11-24

Family

ID=25489007

Family Applications (1)

Application Number Title Priority Date Filing Date
HK06109456A HK1089159A1 (en) 1997-10-14 2006-08-25 Inhibitors of nucleoside metabolism

Country Status (14)

Country Link
US (7) US5985848A (ja)
EP (1) EP1023308B1 (ja)
JP (1) JP4451983B2 (ja)
KR (1) KR100637479B1 (ja)
CN (2) CN100393722C (ja)
AT (1) ATE304019T1 (ja)
AU (1) AU749098B2 (ja)
CA (1) CA2305760C (ja)
DE (1) DE69831499T2 (ja)
DK (1) DK1023308T3 (ja)
ES (1) ES2249844T3 (ja)
HK (1) HK1089159A1 (ja)
PT (1) PT1023308E (ja)
WO (1) WO1999019338A1 (ja)

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JP2009527550A (ja) * 2006-02-24 2009-07-30 アルバート アインシュタイン カレッジ オブ メディシン オブ イエシバ ユニバーシティ 癌を処置する方法
CN101094080B (zh) * 2006-06-22 2012-06-20 华为技术有限公司 一种即按即通系统中的计费方法
CN101528749B (zh) 2006-09-07 2013-07-31 工业研究有限公司 核苷磷酸化酶和水解酶的无环胺抑制剂
EP2049543B1 (en) 2006-09-07 2014-11-05 Callaghan Innovation Research Limited Acyclic amine inhibitors of 5'-methylthioadenosine phosphorylase and nucleosidase
WO2008079028A1 (en) * 2006-12-22 2008-07-03 Industrial Research Limited Azetidine analogues of nucleosidase and phosphorylase inhibitors
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UA103195C2 (uk) 2008-08-11 2013-09-25 Глаксосмитклайн Ллк Похідні пурину для застосування у лікуванні алергій, запальних та інфекційних захворювань
EP2348854A4 (en) * 2008-09-22 2012-03-14 Einstein Coll Med METHOD AND COMPOSITIONS FOR THE TREATMENT OF BACTERIAL INFECTIONS BY INHIBITING THE "QUORUM SENSING
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US10112946B2 (en) 2011-07-22 2018-10-30 Glaxosmithkline Llc Composition
US9682093B2 (en) 2012-03-30 2017-06-20 Charles R. Drew University Of Medicine And Science Compositions and methods for treating or preventing metabolic syndrome disorders
AR090699A1 (es) 2012-04-18 2014-12-03 Biocryst Pharm Inc Compuestos inhibidores de la actividad de la arn polimerasa viral
WO2014025842A1 (en) 2012-08-07 2014-02-13 Albert Einstein College Of Medicine Of Yeshiva University Treatment of helicobacter pylori infections
US9555036B2 (en) 2012-08-24 2017-01-31 Glaxosmithkline Llc Pyrazolopyrimidine compounds
BR112015011447A2 (pt) * 2012-11-20 2017-07-11 Glaxosmithkline Llc composto da fórmula i, composição farmacêutica e de vacina, e, uso de um composto
CN104780922B (zh) 2012-11-20 2016-09-07 葛兰素史克有限责任公司 干扰素诱导剂化合物
KR20150085081A (ko) 2012-11-20 2015-07-22 글락소스미스클라인 엘엘씨 신규 화합물
ES2499965B2 (es) * 2013-03-27 2015-03-31 Universidad De Alicante Procedimiento de síntesis de compuestos homólogos de azanucleósidos
US9452217B2 (en) 2013-06-22 2016-09-27 Nitor Therapeutics Methods for potentiating immune response for the treatment of infectious diseases and cancer
BR112016019469B1 (pt) 2014-02-12 2022-12-06 Albert Einstein College Of Medicine, Inc. Tratamento de infecções por h. pylori utilizando -se inibidores de mtan
AU2016205995A1 (en) * 2015-01-07 2017-07-27 Euro-Celtique S.A. Process for manufacture of Forodesine
CA3016588A1 (en) 2016-03-06 2017-09-14 Biocryst Pharmaceuticals, Inc. Methods and compositions for treatment of zika virus infection
WO2018005830A1 (en) 2016-06-29 2018-01-04 Otonomy, Inc. Triglyceride otic formulations and uses thereof
WO2020186187A1 (en) 2019-03-13 2020-09-17 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Methods for treating bladder and urethra dysfunction and disease
KR20240050362A (ko) 2021-08-20 2024-04-18 시오노기 앤드 컴파니, 리미티드 바이러스 증식 억제 작용을 갖는 뉴클레오사이드 유도체 및 그들의 프로드러그
GB202218782D0 (en) 2022-12-13 2023-01-25 Mehrling Thomas Purine nucleoside phosphorylase inhibitor for metabolic syndrome

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Also Published As

Publication number Publication date
US6228847B1 (en) 2001-05-08
AU1086699A (en) 1999-05-03
ATE304019T1 (de) 2005-09-15
CA2305760A1 (en) 1999-04-22
KR100637479B1 (ko) 2006-10-20
EP1023308A4 (en) 2002-05-29
US20050026936A1 (en) 2005-02-03
DK1023308T3 (da) 2006-01-23
US7211653B2 (en) 2007-05-01
US20030096830A1 (en) 2003-05-22
PT1023308E (pt) 2005-11-30
CA2305760C (en) 2008-06-03
CN1220695C (zh) 2005-09-28
US6492347B2 (en) 2002-12-10
US6066722A (en) 2000-05-23
ES2249844T3 (es) 2006-04-01
DE69831499T2 (de) 2006-06-14
CN100393722C (zh) 2008-06-11
JP2001519437A (ja) 2001-10-23
DE69831499D1 (de) 2005-10-13
CN1757646A (zh) 2006-04-12
EP1023308A1 (en) 2000-08-02
US7390890B2 (en) 2008-06-24
EP1023308B1 (en) 2005-09-07
CN1279686A (zh) 2001-01-10
KR20010031082A (ko) 2001-04-16
AU749098B2 (en) 2002-06-20
JP4451983B2 (ja) 2010-04-14
WO1999019338A1 (en) 1999-04-22
US5985848A (en) 1999-11-16
US20020061898A1 (en) 2002-05-23
US20070197561A1 (en) 2007-08-23
US6803455B2 (en) 2004-10-12

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Effective date: 20181013