HK1076711A1 - Chimeric cd154 - Google Patents

Chimeric cd154

Info

Publication number
HK1076711A1
HK1076711A1 HK05107749.4A HK05107749A HK1076711A1 HK 1076711 A1 HK1076711 A1 HK 1076711A1 HK 05107749 A HK05107749 A HK 05107749A HK 1076711 A1 HK1076711 A1 HK 1076711A1
Authority
HK
Hong Kong
Prior art keywords
chimeric
human
sequence encoding
vector
polynucleotide sequence
Prior art date
Application number
HK05107749.4A
Other languages
English (en)
Inventor
Charles E Prussak
Thomas J Kipps
Mark J Cantwell
Original Assignee
Univ California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ California filed Critical Univ California
Publication of HK1076711A1 publication Critical patent/HK1076711A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70575—NGF/TNF-superfamily, e.g. CD70, CD95L, CD153, CD154
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Detergent Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Polyoxymethylene Polymers And Polymers With Carbon-To-Carbon Bonds (AREA)
HK05107749.4A 2002-05-23 2005-09-02 Chimeric cd154 HK1076711A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/154,759 US7495090B2 (en) 2002-05-23 2002-05-23 Nucleic acids encoding chimeric CD154 polypeptides
PCT/US2003/016305 WO2003099340A1 (en) 2002-05-23 2003-05-23 Novel chimeric cd154

Publications (1)

Publication Number Publication Date
HK1076711A1 true HK1076711A1 (en) 2006-01-27

Family

ID=29548954

Family Applications (1)

Application Number Title Priority Date Filing Date
HK05107749.4A HK1076711A1 (en) 2002-05-23 2005-09-02 Chimeric cd154

Country Status (14)

Country Link
US (3) US7495090B2 (da)
EP (1) EP1509253B1 (da)
JP (1) JP4454493B2 (da)
CN (1) CN100482283C (da)
AT (1) ATE458058T1 (da)
AU (1) AU2003231819B2 (da)
CA (1) CA2486918C (da)
DE (1) DE60331307D1 (da)
DK (1) DK1509253T3 (da)
ES (1) ES2341331T3 (da)
HK (1) HK1076711A1 (da)
IL (1) IL165347A (da)
PT (1) PT1509253E (da)
WO (1) WO2003099340A1 (da)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7070771B1 (en) * 1996-12-09 2006-07-04 Regents Of The University Of California Methods of expressing chimeric mouse and human CD40 ligand in human CD40+ cells
US7786282B2 (en) * 2001-12-06 2010-08-31 The Regents Of The University Of California Nucleic acid molecules encoding TNF-α ligand polypeptides having a CD154 domain
US7495090B2 (en) * 2002-05-23 2009-02-24 The Regents Of The University Of California Nucleic acids encoding chimeric CD154 polypeptides
CN101522210B (zh) 2006-09-18 2017-03-22 阿肯色大学评议会 增强免疫应答的组合物和方法
US20080318886A1 (en) * 2006-12-05 2008-12-25 Prussak Charles E Methods of Increasing Cancer Sensitivity to Chemotherapeutic Agents Using Chimeric ISF35
CA2704457A1 (en) * 2007-10-30 2009-05-07 Walter Bottje Compositions and methods of enhancing immune responses to flagellated bacterium
PL3097926T3 (pl) * 2007-11-01 2020-04-30 The Board Of Trustees Of The University Of Arkansas Kompozycje i sposoby wzmacniania odpowiedzi odpornościowych na Eimeria
US8956618B2 (en) 2010-01-21 2015-02-17 The Texas A&M University System Vaccine vectors and methods of enhancing immune responses
NZ702839A (en) 2010-06-09 2016-04-29 Univ Arkansas Vaccine and methods to reduce campylobacter infection
EP3421487B1 (en) 2010-10-19 2023-06-28 The Regents of the University of Colorado, a body corporate Peptides for modulating t-cell activity and uses thereof
US20150368620A1 (en) * 2013-01-30 2015-12-24 King Abdullah University Of Science And Technology Method of detaching adherent cells for flow cytometry
SG11201506398SA (en) 2013-02-14 2015-09-29 Univ Arkansas Compositions and methods of enhancing immune responses to eimeria or limiting eimeria infection
JP6530742B2 (ja) 2013-03-15 2019-06-12 ザ ボード オブ トラスティーズ オブ ザ ユニバーシティ オブ アーカンソー 腸内病原体の免疫応答を強化する組成物及び方法
MA41044A (fr) 2014-10-08 2017-08-15 Novartis Ag Compositions et procédés d'utilisation pour une réponse immunitaire accrue et traitement contre le cancer
TN2017000129A1 (en) 2014-10-14 2018-10-19 Dana Farber Cancer Inst Inc Antibody molecules to pd-l1 and uses thereof
US20180340025A1 (en) 2015-07-29 2018-11-29 Novartis Ag Combination therapies comprising antibody molecules to lag-3
JP6878405B2 (ja) 2015-07-29 2021-05-26 ノバルティス アーゲー Ｐｄ−１に対する抗体分子を含む組み合わせ治療
WO2017019897A1 (en) 2015-07-29 2017-02-02 Novartis Ag Combination therapies comprising antibody molecules to tim-3
ES2944982T3 (es) 2015-08-05 2023-06-27 Janssen Biotech Inc Anticuerpos anti-CD154 y métodos para utilizarlos
LT3370733T (lt) * 2015-11-02 2021-10-25 Board Of Regents, The University Of Texas System Cd40 aktyvinimo ir imuninės kontrolės taškų blokados būdai
WO2017079297A1 (en) 2015-11-02 2017-05-11 Memgen Llc Methods for treatment of cancer
JP2019503349A (ja) 2015-12-17 2019-02-07 ノバルティス アーゲー Ｐｄ−１に対する抗体分子およびその使用
AR108688A1 (es) 2016-05-03 2018-09-19 Univ Arkansas Vector de vacuna de levadura que incluye polipéptidos inmunoestimuladores y antigénicos, métodos para su uso
AU2017379835A1 (en) * 2016-12-21 2019-07-11 Dnatrix Armed replication-competent oncolytic adenoviruses
US11298420B2 (en) 2016-12-21 2022-04-12 Memgen, Llc Armed oncolytic viruses
EP3609581A4 (en) * 2017-04-12 2021-01-13 Memgen LLC PROCEDURE FOR CD40 AND TOLL-LIKE RECEPTOR IMMUNACTIVATION
JP2021510174A (ja) * 2018-01-05 2021-04-15 オーピー−ティー エルエルシー 自己免疫関連疾患を治療するための治療用ペプチドおよび方法
AU2019288277A1 (en) * 2018-06-19 2021-01-28 H. Lee Moffitt Cancer Center And Research Institute, Inc. Oncolytic virus or antigen presenting cell mediated cancer therapy using type I interferon and CD40-ligand
MX2021010831A (es) 2019-03-08 2021-12-15 Obsidian Therapeutics Inc Composiciones de ligando del cumulo de diferenciación 40 (cd40l) y métodos para regulación ajustable.
US11793854B2 (en) 2019-03-21 2023-10-24 Op-T Llc Methods for reducing symptoms of multiple sclerosis using a six-amino acid long peptide that inhibits CD40-CD150 interaction
CN114450308A (zh) 2019-06-12 2022-05-06 黑曜石疗法公司 用于调节性调控的ca2组合物和方法
CA3192417A1 (en) * 2020-09-11 2022-03-17 Memgen, Inc. Enhancing immunity using chimeric cd40 ligand and coronavirus vaccine
WO2022060904A1 (en) 2020-09-16 2022-03-24 Obsidian Therapeutics, Inc. Compositions and methods for expression of t-cell receptors with small molecule-regulated cd40l in t cells

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2002A (en) * 1841-03-12 Tor and planter for plowing
US22017A (en) * 1858-11-09 Pen-fountain
DE3879395T2 (de) 1987-05-29 1993-06-24 Sagami Chem Res Fusionsprotein, enthaltend lymphotoxin.
DK0491878T3 (da) 1989-08-16 1997-06-23 Chiron Corp Præparater til inhibering af proteinhormondannelse og anvendelser deraf
US5962406A (en) * 1991-10-25 1999-10-05 Immunex Corporation Recombinant soluble CD40 ligand polypeptide and pharmaceutical composition containing the same
US5716805A (en) * 1991-10-25 1998-02-10 Immunex Corporation Methods of preparing soluble, oligomeric proteins
DK0667901T4 (da) 1991-10-25 2008-11-10 Immunex Corp Hidtil ukendt cytokin
WO1994004680A1 (en) 1992-08-21 1994-03-03 Schering Corporation Human interleukin-13
ATE256180T1 (de) 1993-01-22 2003-12-15 Immunex Corp Detektion und behandlung von mutationen in einem gen für einen cd40-liganden
US5830463A (en) 1993-07-07 1998-11-03 University Technology Corporation Yeast-based delivery vehicles
US5861310A (en) * 1993-11-03 1999-01-19 Dana-Farber Cancer Institute Tumor cells modified to express B7-2 with increased immunogenicity and uses therefor
JPH08127594A (ja) 1993-11-10 1996-05-21 Mochida Pharmaceut Co Ltd Ｆａｓ抗原に結合する新規蛋白質およびそれをコードするＤＮＡ
AU1059095A (en) 1993-11-24 1995-06-13 Australian National University, The Treatment of viral disease with cd40l peptide
AU705484B2 (en) 1994-01-07 1999-05-20 Mochida Pharmaceutical Co., Ltd. Ligand that binds fas antigen
EP0763057B1 (en) * 1994-04-28 2005-11-09 Boehringer Ingelheim Pharmaceuticals Inc. Method for proliferating and differentiating b cells, and uses thereof
US5759536A (en) 1994-05-27 1998-06-02 University Technology Corporation Use of fas ligand to supress T-lymphocyte-mediated immune responses
GB9425060D0 (en) 1994-12-13 1995-02-08 Univ Birmingham Carcinoma treatment
US5888764A (en) 1995-01-20 1999-03-30 Uab Research Foundation Human fas gene promoter region
US6544523B1 (en) 1996-11-13 2003-04-08 Chiron Corporation Mutant forms of Fas ligand and uses thereof
US7070771B1 (en) * 1996-12-09 2006-07-04 Regents Of The University Of California Methods of expressing chimeric mouse and human CD40 ligand in human CD40+ cells
CA2304130C (en) 1997-09-17 2008-10-28 Mochida Pharmaceutical Co., Ltd. Novel fas ligand derivative
US6451759B1 (en) * 1998-01-14 2002-09-17 The Regents Of The University Of California Noncleavable Fas ligand
US7300774B1 (en) * 1999-12-09 2007-11-27 The Regents Of The University Of California Multimeric fusion proteins of the TNF superfamily ligands
US20020022017A1 (en) 2000-04-12 2002-02-21 Hua Yu Regulation of systemic immune responses utilizing soluble CD40
US7495090B2 (en) * 2002-05-23 2009-02-24 The Regents Of The University Of California Nucleic acids encoding chimeric CD154 polypeptides
GB2392158B (en) * 2002-08-21 2005-02-16 Proimmune Ltd Chimeric MHC protein and oligomer thereof

Also Published As

Publication number Publication date
EP1509253B1 (en) 2010-02-17
IL165347A0 (en) 2006-01-15
US8138310B2 (en) 2012-03-20
CN1671423A (zh) 2005-09-21
DK1509253T3 (da) 2010-06-07
US20100297695A1 (en) 2010-11-25
IL165347A (en) 2012-05-31
US7928213B2 (en) 2011-04-19
US7495090B2 (en) 2009-02-24
JP2005537785A (ja) 2005-12-15
AU2003231819B2 (en) 2008-07-10
ATE458058T1 (de) 2010-03-15
JP4454493B2 (ja) 2010-04-21
DE60331307D1 (de) 2010-04-01
ES2341331T3 (es) 2010-06-18
CN100482283C (zh) 2009-04-29
CA2486918A1 (en) 2003-12-04
CA2486918C (en) 2013-08-27
EP1509253A4 (en) 2005-12-21
EP1509253A1 (en) 2005-03-02
US20030220473A1 (en) 2003-11-27
AU2003231819A1 (en) 2003-12-12
WO2003099340A1 (en) 2003-12-04
US20110177556A1 (en) 2011-07-21
PT1509253E (pt) 2010-05-21

Similar Documents

Publication Publication Date Title
HK1076711A1 (en) Chimeric cd154
WO2002095014A3 (en) Polypeptides having cellobiase activity and polynucleotides encoding same
PT1240325E (pt) Polipéptidos homólogos de il-17 e il-17r e suas utilizações terapêuticas
IL161769A0 (en) Anbtimicrobial polypeptides from pseudoplectania nigrella
ATE352626T1 (de) Polypeptide mit galaktoseoxidaseaktivität und dafür kodierende nukleisäuren
UA97946C2 (ru) Моноклональное антитело, специфически связывающееся с внеклеточным доменом ilt7 человека
UA92580C2 (ru) Антитело, которое специфически связывается с cd22, и его терапевтическое и диагностическое применение
AU2003291962A1 (en) Polypeptides having cellobiohydrolase ii activity and polynucleotides encoding same
WO2005044996A3 (en) Chimeric receptors with 4-1bb stimulatory signaling domain
DK1131444T3 (da) Polypeptider med lysophospholipase aktivitet og nucleinsyre som koder for disse
ATE414775T1 (de) Polypeptide mit prolyldipeptidylaminopeptidase- aktivität und dafür kodierende nukleinsäuren
AU2003238444A1 (en) The frog prince, a transposon vector for gene transfer in vertebrates
MX2022008955A (es) Variantes de mananasas y polinucleotidos que las codifican.
ZA202210127B (en) Codon optimized gla genes and uses thereof
DK1756273T3 (da) Signalpeptid til frembringelse af et polypeptid
NO20085086L (no) Fettsyresyntetase, polynukleotid som koder denne og anvendelse derav
IL165007A0 (en) Nucleic acids, polypeptides, compositions, and methods for modulating apoptosis
EP0972054A4 (en) INCREASING IMMUNE RESPONSE USING TARGETED MOLECULES
KR100717353B1 (ko) 피키아 파스토리스 유래의 자동 유도성 ｎｐｓ 프로모터 및이를 이용한 이종 단백질의 제조방법
ZA948973B (en) Tyrosinase-activator protein fusion enzyme
SG161106A1 (en) Inhibitor proteins of a protease and use thereof
EP1572133A4 (en) METHOD FOR IDENTIFYING MODULATORS OF THE HUMAN OREXIN-2 RECEPTOR
Wittenbrink et al. Differential NKG2D binding to highly related human NKG2D ligands ULBP2 and RAET1G is determined by a single amino acid in the α2 domain
DK1226236T3 (da) Polypeptider, der har glucanotransferase-aktivitet, og nucleinsyrer, som koder disse
AU2002304915A1 (en) Cation conducting gabaa receptors and their use

Legal Events

Date Code Title Description
PE Patent expired

Effective date: 20230518