AU2003231819B2 - Novel chimeric CD154 - Google Patents

Novel chimeric CD154 Download PDF

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Publication number
AU2003231819B2
AU2003231819B2 AU2003231819A AU2003231819A AU2003231819B2 AU 2003231819 B2 AU2003231819 B2 AU 2003231819B2 AU 2003231819 A AU2003231819 A AU 2003231819A AU 2003231819 A AU2003231819 A AU 2003231819A AU 2003231819 B2 AU2003231819 B2 AU 2003231819B2
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AU
Australia
Prior art keywords
human
cell
chimeric
cells
expression
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
AU2003231819A
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English (en)
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AU2003231819A1 (en
Inventor
Mark J. Cantwell
Thomas J. Kipps
Charles E. Prussak
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University of California
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University of California
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Publication date
Application filed by University of California filed Critical University of California
Publication of AU2003231819A1 publication Critical patent/AU2003231819A1/en
Application granted granted Critical
Publication of AU2003231819B2 publication Critical patent/AU2003231819B2/en
Anticipated expiration legal-status Critical
Expired legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70575—NGF/TNF-superfamily, e.g. CD70, CD95L, CD153, CD154
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Toxicology (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Detergent Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Polyoxymethylene Polymers And Polymers With Carbon-To-Carbon Bonds (AREA)
AU2003231819A 2002-05-23 2003-05-23 Novel chimeric CD154 Expired AU2003231819B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US10/154,759 US7495090B2 (en) 2002-05-23 2002-05-23 Nucleic acids encoding chimeric CD154 polypeptides
US10/154,759 2002-05-23
PCT/US2003/016305 WO2003099340A1 (en) 2002-05-23 2003-05-23 Novel chimeric cd154

Publications (2)

Publication Number Publication Date
AU2003231819A1 AU2003231819A1 (en) 2003-12-12
AU2003231819B2 true AU2003231819B2 (en) 2008-07-10

Family

ID=29548954

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2003231819A Expired AU2003231819B2 (en) 2002-05-23 2003-05-23 Novel chimeric CD154

Country Status (14)

Country Link
US (3) US7495090B2 (da)
EP (1) EP1509253B1 (da)
JP (1) JP4454493B2 (da)
CN (1) CN100482283C (da)
AT (1) ATE458058T1 (da)
AU (1) AU2003231819B2 (da)
CA (1) CA2486918C (da)
DE (1) DE60331307D1 (da)
DK (1) DK1509253T3 (da)
ES (1) ES2341331T3 (da)
HK (1) HK1076711A1 (da)
IL (1) IL165347A (da)
PT (1) PT1509253E (da)
WO (1) WO2003099340A1 (da)

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US7495090B2 (en) * 2002-05-23 2009-02-24 The Regents Of The University Of California Nucleic acids encoding chimeric CD154 polypeptides
CN101522210B (zh) 2006-09-18 2017-03-22 阿肯色大学评议会 增强免疫应答的组合物和方法
JP2010511731A (ja) * 2006-12-05 2010-04-15 メムジェン エルエルシー キメラｉｓｆ３５を利用した化学療法剤に対する癌感受性増強方法
NZ585776A (en) * 2007-10-30 2012-07-27 Univ Arkansas Compositions and methods of enhancing immune responses to flagellated bacterium
PL2214701T3 (pl) * 2007-11-01 2017-01-31 The Board Of Trustees Of The University Of Arkansas Kompozycje i sposoby wzmacniania odpowiedzi odpornościowych na Eimeria
UA110024C2 (uk) 2010-01-21 2015-11-10 Вакцинний вектор і спосіб посилення імунної відповіді
KR102007132B1 (ko) 2010-06-09 2019-08-05 더 보드 오브 트러스티스 오브 더 유니버시티 오브 아칸소 캄필로박터 감염을 감소시키기 위한 백신 및 방법
US9562088B2 (en) 2010-10-19 2017-02-07 The Regents Of The University Of Colorado, A Body Corporate Pegylated CD154 peptides and methods of inhibiting CD40 interacations with CD154
WO2014132142A2 (en) * 2013-01-30 2014-09-04 King Abdullah University Of Science And Technology Method of detaching adherent cells for flow cytometry
NZ711019A (en) 2013-02-14 2019-07-26 Univ Arkansas Compositions and methods of enhancing immune responses to eimeria or limiting eimeria infection
EP2968423A4 (en) 2013-03-15 2016-11-09 Univ Arkansas COMPOSITIONS AND METHODS FOR INCREASING IMMUNE REACTIONS AGAINST ENTERAL PATHOGENES
MA41044A (fr) 2014-10-08 2017-08-15 Novartis Ag Compositions et procédés d'utilisation pour une réponse immunitaire accrue et traitement contre le cancer
CR20170143A (es) 2014-10-14 2017-06-19 Dana Farber Cancer Inst Inc Moléculas de anticuerpo que se unen a pd-l1 y usos de las mismas
PT3317301T (pt) 2015-07-29 2021-07-09 Novartis Ag Terapias de associação compreendendo moléculas de anticorpo contra lag-3
WO2017019896A1 (en) 2015-07-29 2017-02-02 Novartis Ag Combination therapies comprising antibody molecules to pd-1
US20180207273A1 (en) 2015-07-29 2018-07-26 Novartis Ag Combination therapies comprising antibody molecules to tim-3
WO2017024146A1 (en) 2015-08-05 2017-02-09 Janssen Biotech, Inc. Anti-cd154 antibodies and methods of using them
US20180244750A1 (en) * 2015-11-02 2018-08-30 Memgen, Llc Methods for treatment of cancer
LT3370733T (lt) 2015-11-02 2021-10-25 Board Of Regents, The University Of Texas System Cd40 aktyvinimo ir imuninės kontrolės taškų blokados būdai
AU2016369537B2 (en) 2015-12-17 2024-03-14 Novartis Ag Antibody molecules to PD-1 and uses thereof
BR112018072592A2 (pt) 2016-05-03 2019-04-16 The Board Of Trustees Of The University Of Arkansas vetor de vacina de levedura que inclui polipeptídeos imunoestimulantes e antigênicos, e métodos de uso dos mesmos
US11298420B2 (en) 2016-12-21 2022-04-12 Memgen, Llc Armed oncolytic viruses
CN110650745A (zh) * 2016-12-21 2020-01-03 曼珍有限责任公司 武装复制型溶瘤腺病毒
US20200353044A1 (en) * 2017-04-12 2020-11-12 Memgen, Llc Methods of cd40 and toll like receptor immune activation
SG11202006494VA (en) * 2018-01-05 2020-08-28 Op T Llc Therapeutic peptides and methods for treating autoimmune related disease
MX2020013901A (es) * 2018-06-19 2021-05-27 H Lee Moffitt Cancer Ct & Res Virus oncolítico o antígeno que presenta terapia contra el cáncer mediada por células usando interferón tipo i y lingado de cd40.
SG11202109225WA (en) 2019-03-08 2021-09-29 Obsidian Therapeutics Inc Cd40l compositions and methods for tunable regulation
US11793854B2 (en) 2019-03-21 2023-10-24 Op-T Llc Methods for reducing symptoms of multiple sclerosis using a six-amino acid long peptide that inhibits CD40-CD150 interaction
US20220259284A1 (en) 2019-06-12 2022-08-18 Obsidian Therapeutics, Inc. Ca2 compositions and methods for tunable regulation
US12048734B2 (en) 2020-04-17 2024-07-30 Op-T Llc Bioactive peptides and methods of use thereof
WO2022056302A1 (en) * 2020-09-11 2022-03-17 Memgen, Inc. Enhancing immunity using chimeric cd40 ligand and coronavirus vaccine
WO2022060904A1 (en) 2020-09-16 2022-03-24 Obsidian Therapeutics, Inc. Compositions and methods for expression of t-cell receptors with small molecule-regulated cd40l in t cells

Citations (1)

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WO1998026061A2 (en) * 1996-12-09 1998-06-18 University Of California Expression vectors containing accessory molecule ligand genes and their use for immunomodulation and treatment of malignancies and autoimmune disease

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Patent Citations (1)

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Publication number Priority date Publication date Assignee Title
WO1998026061A2 (en) * 1996-12-09 1998-06-18 University Of California Expression vectors containing accessory molecule ligand genes and their use for immunomodulation and treatment of malignancies and autoimmune disease

Also Published As

Publication number Publication date
AU2003231819A1 (en) 2003-12-12
EP1509253A4 (en) 2005-12-21
DE60331307D1 (de) 2010-04-01
US20030220473A1 (en) 2003-11-27
US7928213B2 (en) 2011-04-19
ES2341331T3 (es) 2010-06-18
JP4454493B2 (ja) 2010-04-21
PT1509253E (pt) 2010-05-21
CN100482283C (zh) 2009-04-29
WO2003099340A1 (en) 2003-12-04
EP1509253A1 (en) 2005-03-02
IL165347A (en) 2012-05-31
US8138310B2 (en) 2012-03-20
CA2486918C (en) 2013-08-27
EP1509253B1 (en) 2010-02-17
JP2005537785A (ja) 2005-12-15
US20110177556A1 (en) 2011-07-21
CN1671423A (zh) 2005-09-21
ATE458058T1 (de) 2010-03-15
CA2486918A1 (en) 2003-12-04
US7495090B2 (en) 2009-02-24
HK1076711A1 (en) 2006-01-27
US20100297695A1 (en) 2010-11-25
IL165347A0 (en) 2006-01-15
DK1509253T3 (da) 2010-06-07

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