HK1074059A1 - Enzymatic processes for the production of 4-substituted 3-hydroxybutyric acid derivatives - Google Patents
Enzymatic processes for the production of 4-substituted 3-hydroxybutyric acid derivativesInfo
- Publication number
- HK1074059A1 HK1074059A1 HK05108017.7A HK05108017A HK1074059A1 HK 1074059 A1 HK1074059 A1 HK 1074059A1 HK 05108017 A HK05108017 A HK 05108017A HK 1074059 A1 HK1074059 A1 HK 1074059A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- acid derivatives
- hydroxybutyric acid
- substituted
- production
- enzymatic processes
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/002—Nitriles (-CN)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/02—Amides, e.g. chloramphenicol or polyamides; Imides or polyimides; Urethanes, i.e. compounds comprising N-C=O structural element or polyurethanes
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US40243602P | 2002-08-09 | 2002-08-09 | |
PCT/US2003/025263 WO2004015132A2 (fr) | 2002-08-09 | 2003-08-11 | Production par voie enzymatique de derives de 3-acide hydroxybutyrique substitue en position 4 |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1074059A1 true HK1074059A1 (en) | 2005-10-28 |
Family
ID=31715856
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK05108017.7A HK1074059A1 (en) | 2002-08-09 | 2005-09-13 | Enzymatic processes for the production of 4-substituted 3-hydroxybutyric acid derivatives |
Country Status (12)
Country | Link |
---|---|
US (1) | US7125693B2 (fr) |
EP (1) | EP1537222B1 (fr) |
JP (2) | JP4578240B2 (fr) |
AT (1) | ATE501264T1 (fr) |
AU (1) | AU2003258187A1 (fr) |
BR (1) | BR0305767A (fr) |
CA (1) | CA2493941A1 (fr) |
DE (1) | DE60336324D1 (fr) |
HK (1) | HK1074059A1 (fr) |
MX (1) | MXPA05001537A (fr) |
NO (1) | NO20041379L (fr) |
WO (1) | WO2004015132A2 (fr) |
Families Citing this family (30)
Publication number | Priority date | Publication date | Assignee | Title |
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DE60336324D1 (de) | 2002-08-09 | 2011-04-21 | Codexis Inc | Enzymatische verfahren zur herstellung 4-substituierter 3-hydroxybuttersäure-derivate |
KR20060064620A (ko) * | 2003-08-11 | 2006-06-13 | 코덱시스, 인코포레이티드 | 개선된 글루코스 데히드로게나제 폴리펩티드 및 관련폴리뉴클레오티드 |
US7824898B2 (en) | 2003-08-11 | 2010-11-02 | Codexis, Inc. | Halohydrin dehalogenases and related polynucleotides |
US7588928B2 (en) * | 2003-08-11 | 2009-09-15 | Codexis, Inc. | Halohydrin dehalogenases and related polynucleotides |
KR20060071397A (ko) * | 2003-08-11 | 2006-06-26 | 코덱시스, 인코포레이티드 | 4-치환된 3-히드록시부티르산 유도체 및 이웃자리 시아노,히드록시 치환된 카르복실산 에스테르의 효소적 제조 방법 |
US7541171B2 (en) | 2003-08-11 | 2009-06-02 | Codexis, Inc. | Halohydrin dehalogenases and related polynucleotides |
CA2533838A1 (fr) * | 2003-08-11 | 2005-02-24 | Codexis, Inc. | Polypeptides cetoreductase ameliores et polynucleotides associes |
JP2008537477A (ja) * | 2005-02-23 | 2008-09-18 | コデクシス, インコーポレイテッド | 改良されたハロヒドリンデハロゲナーゼおよび関連のポリヌクレオチド |
ITMI20051971A1 (it) * | 2005-10-18 | 2007-04-19 | Dipharma Spa | Procedimento per la preparazione di - modafinil |
AU2008229076B2 (en) | 2007-03-16 | 2014-05-15 | Genomatica, Inc. | Compositions and methods for the biosynthesis of 1,4-butanediol and its precursors |
US7947483B2 (en) | 2007-08-10 | 2011-05-24 | Genomatica, Inc. | Methods and organisms for the growth-coupled production of 1,4-butanediol |
EP3514242A3 (fr) | 2008-09-10 | 2019-08-28 | Genomatica, Inc. | Microorganismes pour la production de 1,4-butanediol |
SG172231A1 (en) | 2008-12-18 | 2011-07-28 | Codexis Inc | Recombinant halohydrin dehalogenase polypeptides |
CN102459138A (zh) | 2009-06-04 | 2012-05-16 | 基因组股份公司 | 分离发酵液成分的方法 |
VN29801A1 (fr) | 2009-06-04 | 2012-05-25 | ||
CN102482648B (zh) | 2009-06-22 | 2014-12-10 | 科德克希思公司 | 酮还原酶介导的产生α氯代醇的立体选择性途径 |
CN102762735B (zh) | 2009-10-13 | 2016-08-03 | 基因组股份公司 | 生产1,4-丁二醇、4-羟基丁醛、4-羟基丁酰-coa、腐胺和相关化合物的微生物及其相关方法 |
WO2011066076A1 (fr) | 2009-11-25 | 2011-06-03 | Genomatica, Inc. | Micro-organismes et procédés pour la coproduction de 1,4-butanediol et de gamma-butyrolactone |
US9080192B2 (en) | 2010-02-10 | 2015-07-14 | Codexis, Inc. | Processes using amino acid dehydrogenases and ketoreductase-based cofactor regenerating system |
US8637286B2 (en) | 2010-02-23 | 2014-01-28 | Genomatica, Inc. | Methods for increasing product yields |
US8048661B2 (en) | 2010-02-23 | 2011-11-01 | Genomatica, Inc. | Microbial organisms comprising exogenous nucleic acids encoding reductive TCA pathway enzymes |
US8420364B2 (en) | 2010-06-30 | 2013-04-16 | Codexis, Inc. | Highly stable beta-class carbonic anhydrases useful in carbon capture systems |
CN102168117B (zh) * | 2011-01-12 | 2014-05-07 | 江苏阿尔法药业有限公司 | 一种制备(r)-4-氰基-3-羟基丁酸乙酯的方法 |
JP5705580B2 (ja) | 2011-02-21 | 2015-04-22 | 公益財団法人微生物化学研究会 | チオアミド化合物、チオアミド化合物の製造方法、[(4r,6r)−6−アミノエチル−1,3−ジオキサン−4−イル]アセテート誘導体の製造方法、及びアトルバスタチンの製造方法 |
CN102676597A (zh) * | 2011-03-16 | 2012-09-19 | 苏州国镝医药科技有限公司 | 生物酶手性合成立普妥中间体ats-5 |
CN104685058B (zh) | 2012-06-04 | 2020-07-07 | 基因组股份公司 | 制造4-羟基丁酸酯、1,4-丁二醇和相关化合物的微生物和方法 |
CN103695486A (zh) * | 2014-01-03 | 2014-04-02 | 黄冈华阳药业有限公司 | 一种(3r,5r)-6-氰基-3,5-二羟基己酸叔丁酯的生物制备方法 |
CN105368886A (zh) * | 2015-12-11 | 2016-03-02 | 江苏万年长药业有限公司 | 一种树脂固定卤醇脱卤酶催化合成(r)-4-氰基-3-羟基丁酸乙酯的工艺 |
CN109439700A (zh) * | 2018-11-09 | 2019-03-08 | 浙江宏元药业股份有限公司 | 一种脱卤酶高效催化合成他汀类药物中间体的方法 |
CN111876448A (zh) * | 2020-08-03 | 2020-11-03 | 连云港宏业化工有限公司 | 4-氰基-3-羟基丁酸乙酯合成方法 |
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US5155251A (en) * | 1991-10-11 | 1992-10-13 | Warner-Lambert Company | Process for the synthesis of (5R)-1,1-dimethylethyl-6-cyano-5-hydroxy-3-oxo-hexanoate |
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JPH08336393A (ja) * | 1995-04-13 | 1996-12-24 | Mitsubishi Chem Corp | 光学活性なγ−置換−β−ヒドロキシ酪酸エステルの製造法 |
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US5891685A (en) * | 1996-06-03 | 1999-04-06 | Mitsubishi Chemical Corporation | Method for producing ester of (S)-γ-halogenated-β-hydroxybutyric acid |
US5908953A (en) * | 1996-12-18 | 1999-06-01 | Mitsubishi Chemical Corporation | Method for producing (R)-4-cyano-3-hydroxybutyric acid lower alkyl ester |
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KR100313668B1 (ko) * | 1999-02-03 | 2001-11-26 | 박영구 | (r)-4-시아노-3-히드록시부티르산 에스테르의 제조방법 |
WO2001004336A1 (fr) * | 1999-07-09 | 2001-01-18 | Forschungszentrum Jülich GmbH | Procede de reduction d'acides cetocarboxyliques et de leurs esters |
US6645746B1 (en) * | 1999-12-03 | 2003-11-11 | Kaneka Corporation | Carbonyl reductase, gene thereof and method of using the same |
EP1158054A1 (fr) | 2000-05-25 | 2001-11-28 | Rijksuniversiteit te Groningen | Conversion enzymatique d'époxydes |
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DE60105734T2 (de) * | 2000-10-31 | 2006-02-16 | Sumitomo Chemical Co. Ltd. | Verfahren zur Herstellung von 4-Cyano-4-Oxobuttersäureester und 4-Cyano-3-Hydroxybuttersäureester |
JP4603171B2 (ja) * | 2001-01-22 | 2010-12-22 | ダイセル化学工業株式会社 | (s)−4−ハロ−3−ヒドロキシ酪酸エステルの製造に有用な酵素をコードする遺伝子、その取得方法、およびこれを利用した光学活性アルコールの製造方法 |
MXPA03011813A (es) | 2001-07-02 | 2004-07-01 | Kaneka Corp | Metodo para la modificacion de enzimas y variantes de oxido reductasa. |
DE60336324D1 (de) | 2002-08-09 | 2011-04-21 | Codexis Inc | Enzymatische verfahren zur herstellung 4-substituierter 3-hydroxybuttersäure-derivate |
KR20060071397A (ko) | 2003-08-11 | 2006-06-26 | 코덱시스, 인코포레이티드 | 4-치환된 3-히드록시부티르산 유도체 및 이웃자리 시아노,히드록시 치환된 카르복실산 에스테르의 효소적 제조 방법 |
US7824898B2 (en) | 2003-08-11 | 2010-11-02 | Codexis, Inc. | Halohydrin dehalogenases and related polynucleotides |
KR20060064620A (ko) * | 2003-08-11 | 2006-06-13 | 코덱시스, 인코포레이티드 | 개선된 글루코스 데히드로게나제 폴리펩티드 및 관련폴리뉴클레오티드 |
US7541171B2 (en) * | 2003-08-11 | 2009-06-02 | Codexis, Inc. | Halohydrin dehalogenases and related polynucleotides |
CA2533838A1 (fr) | 2003-08-11 | 2005-02-24 | Codexis, Inc. | Polypeptides cetoreductase ameliores et polynucleotides associes |
-
2003
- 2003-08-11 DE DE60336324T patent/DE60336324D1/de not_active Expired - Lifetime
- 2003-08-11 US US10/639,159 patent/US7125693B2/en active Active
- 2003-08-11 AU AU2003258187A patent/AU2003258187A1/en not_active Abandoned
- 2003-08-11 JP JP2004528083A patent/JP4578240B2/ja not_active Expired - Lifetime
- 2003-08-11 EP EP03785237A patent/EP1537222B1/fr not_active Expired - Lifetime
- 2003-08-11 BR BR0305767-4A patent/BR0305767A/pt not_active IP Right Cessation
- 2003-08-11 CA CA002493941A patent/CA2493941A1/fr not_active Abandoned
- 2003-08-11 MX MXPA05001537A patent/MXPA05001537A/es unknown
- 2003-08-11 AT AT03785237T patent/ATE501264T1/de not_active IP Right Cessation
- 2003-08-11 WO PCT/US2003/025263 patent/WO2004015132A2/fr active Application Filing
-
2004
- 2004-04-02 NO NO20041379A patent/NO20041379L/no not_active Application Discontinuation
-
2005
- 2005-09-13 HK HK05108017.7A patent/HK1074059A1/xx not_active IP Right Cessation
-
2010
- 2010-05-19 JP JP2010115827A patent/JP2010172348A/ja not_active Withdrawn
Also Published As
Publication number | Publication date |
---|---|
US7125693B2 (en) | 2006-10-24 |
WO2004015132A3 (fr) | 2005-04-14 |
JP4578240B2 (ja) | 2010-11-10 |
JP2005535330A (ja) | 2005-11-24 |
ATE501264T1 (de) | 2011-03-15 |
AU2003258187A8 (en) | 2004-02-25 |
NO20041379L (no) | 2004-06-01 |
EP1537222B1 (fr) | 2011-03-09 |
AU2003258187A1 (en) | 2004-02-25 |
MXPA05001537A (es) | 2005-11-17 |
DE60336324D1 (de) | 2011-04-21 |
EP1537222A2 (fr) | 2005-06-08 |
EP1537222A4 (fr) | 2008-10-01 |
WO2004015132A2 (fr) | 2004-02-19 |
US20040137585A1 (en) | 2004-07-15 |
JP2010172348A (ja) | 2010-08-12 |
CA2493941A1 (fr) | 2004-02-19 |
BR0305767A (pt) | 2005-05-24 |
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Effective date: 20230810 |