HK1072372A1 - Alpha-1 proteinase inhibitor preparation - Google Patents

Alpha-1 proteinase inhibitor preparation

Info

Publication number
HK1072372A1
HK1072372A1 HK05105079.8A HK05105079A HK1072372A1 HK 1072372 A1 HK1072372 A1 HK 1072372A1 HK 05105079 A HK05105079 A HK 05105079A HK 1072372 A1 HK1072372 A1 HK 1072372A1
Authority
HK
Hong Kong
Prior art keywords
alpha
proteinase inhibitor
cation
chromatography
active
Prior art date
Application number
HK05105079.8A
Other languages
English (en)
Inventor
Wytold R Lebing
Sharon X Chen
Original Assignee
Bayer Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Corp filed Critical Bayer Corp
Publication of HK1072372A1 publication Critical patent/HK1072372A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8121—Serpins
    • C07K14/8125—Alpha-1-antitrypsin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/827—Proteins from mammals or birds
    • Y10S530/829—Blood
    • Y10S530/83—Plasma; serum

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pulmonology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
HK05105079.8A 1994-08-24 2005-06-17 Alpha-1 proteinase inhibitor preparation HK1072372A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/295,119 US5610285A (en) 1994-08-24 1994-08-24 Purification of α-1 proteinase inhibitor using novel chromatographic separation conditions

Publications (1)

Publication Number Publication Date
HK1072372A1 true HK1072372A1 (en) 2005-08-26

Family

ID=23136291

Family Applications (1)

Application Number Title Priority Date Filing Date
HK05105079.8A HK1072372A1 (en) 1994-08-24 2005-06-17 Alpha-1 proteinase inhibitor preparation

Country Status (13)

Country Link
US (1) US5610285A (el)
EP (1) EP0698615B1 (el)
JP (1) JP3770414B2 (el)
KR (1) KR100451266B1 (el)
CN (2) CN100548372C (el)
AT (1) ATE187462T1 (el)
CA (2) CA2692337A1 (el)
DE (1) DE69513751T2 (el)
DK (1) DK0698615T3 (el)
ES (1) ES2139794T3 (el)
GR (1) GR3032728T3 (el)
HK (1) HK1072372A1 (el)
PT (1) PT698615E (el)

Families Citing this family (48)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0871671A1 (en) * 1995-09-07 1998-10-21 PPL Therapeutics (Scotland) Limited Purification of alpha-1 proteinase inhibitor
SE9600796D0 (sv) * 1996-02-29 1996-02-29 Pharmacia Biotech Ab A method of preparing a liquid mixture
US5616693A (en) * 1996-07-01 1997-04-01 Alpha Therapeutic Corporation Process for seperating alpha-1-proteinase inhibitor from COHN IV1 +1V4 paste
GB2318732A (en) 1996-11-01 1998-05-06 Johnson & Johnson Medical Wound healing compositions containing alpha-1-antitrypsin
AT407114B (de) * 1997-06-10 2000-12-27 Immuno Ag Alpha 1-antitrypsin-präparation sowie verfahren zu deren herstellung
AUPP521298A0 (en) * 1998-08-12 1998-09-03 Life Therapeutics Limited Purification of fibrinogen
US6093804A (en) * 1998-09-24 2000-07-25 American National Red Cross Method for purification of alpha-1 proteinase inhibitor
US20050224355A1 (en) * 1999-12-23 2005-10-13 Brendon Conlan Removal of biological contaminants
AUPP790698A0 (en) 1998-12-23 1999-01-28 Life Therapeutics Limited Separation of microorganisms
AUPP790898A0 (en) 1998-12-23 1999-01-28 Life Therapeutics Limited Renal dialysis
US7704958B1 (en) 1999-03-05 2010-04-27 Bio Holding, Inc. Methods and compositions for inhibiting apoptosis using serine protease inhibitors
AU3864000A (en) * 1999-03-05 2000-09-21 Trustees Of University Technology Corporation, The Inhibitors of serine protease activity, methods and compositions for treatment of herpes viruses
US6849605B1 (en) * 1999-03-05 2005-02-01 The Trustees Of University Technology Corporation Inhibitors of serine protease activity, methods and compositions for treatment of viral infections
AU3511500A (en) 1999-03-05 2000-09-21 Trustees Of University Technology Corporation, The Inhibitors of serine protease activity, methods and compositions for treatment of nitric oxide-induced clinical conditions
AUPP971399A0 (en) 1999-04-12 1999-05-06 Life Therapeutics Limited Separation of plasma components
US6462180B1 (en) * 1999-11-24 2002-10-08 Bayer Corporation Method of preparing α-1 proteinase inhibitor
US7077942B1 (en) 1999-12-23 2006-07-18 Gradipore Limited Removal of biological contaminants
AUPQ691400A0 (en) * 2000-04-14 2000-05-11 Life Therapeutics Limited Separation of micromolecules
ATE449200T1 (de) 2000-04-18 2009-12-15 Gradipore Ltd Trennung und behandlung von proben durch elektrophorese
AUPQ697300A0 (en) * 2000-04-18 2000-05-11 Life Therapeutics Limited Separation apparatus
US6923896B2 (en) * 2000-09-22 2005-08-02 The Texas A&M University System Electrophoresis apparatus and method
DE60142520D1 (de) * 2000-10-06 2010-08-19 Arturus Capital Ltd Multi-port-elektrophorese-trennvorrichtung und entsprechendes verfahren
AU2001245240A1 (en) 2000-12-14 2002-06-24 Talecris Biotherapeutics, Inc. Method of preparing alpha-1 proteinase inhibitor
AUPR222300A0 (en) * 2000-12-21 2001-01-25 Life Therapeutics Limited Electrophoresis device and method
US7777006B2 (en) 2002-12-31 2010-08-17 Csl Behring L.L.C. Method for purification of alpha-1-antitrypsin
US20040220242A1 (en) * 2003-05-02 2004-11-04 Leland Shapiro Inhibitors of serine protease activity, methods and compositions for treatment of nitric oxide induced clinical conditions
EP3192872A1 (en) * 2003-08-26 2017-07-19 The Regents of the University of Colorado, a body corporate Inhibitors of serine protease activity and their use in methods and compositions for treatment of bacterial infections
DK1664123T4 (da) * 2003-09-22 2012-03-05 Kamada Ltd Storskalafremstilling af alfa-1-proteinaseinhibitor og anvendelse deraf
CN1314447C (zh) * 2004-04-12 2007-05-09 爱华生物科技(香港)有限公司 一种具有抑制蛋白酶作用的药物的制备方法
ES2516690T5 (es) * 2005-06-07 2017-11-21 The Regents Of The University Of Colorado, A Body Corporate Inhibidores de la actividad de serina proteasa y su uso en métodos y composiciones para el tratamiento de rechazo de injertos y promoción de supervivencia de injertos
US7807435B2 (en) * 2005-08-11 2010-10-05 Baxter International Inc. Method for the purification of alpha-1 proteinase inhibitor (a1PI)
US20080124303A1 (en) * 2005-12-12 2008-05-29 Cavit Sciences, Inc Methods and compositions for treatment of viral infections
WO2008033890A2 (en) 2006-09-12 2008-03-20 Beth Israel Deaconess Medical Center, Inc. Compositions containing alpha-1-antitrypsin and methods for use
AU2008256411B2 (en) * 2007-06-01 2013-08-22 F. Hoffmann-La Roche Ag Immunoglobulin purification
CN101778860B (zh) 2007-08-17 2013-07-10 Csl百灵有限公司 α-1-抗胰蛋白酶和载脂蛋白A-I的纯化方法
BRPI0915948A2 (pt) * 2008-07-18 2019-04-09 Talecris Biotherapeutics Inc método de preparar inibidor de alfa-1 proteinase
KR101104637B1 (ko) * 2010-02-26 2012-01-12 한국철도기술연구원 무개화차의 컨테이너 고정장치
WO2011150284A2 (en) 2010-05-26 2011-12-01 Baxter International Inc. Removal of serine proteases by treatment with finely divided silicon dioxide
AU2010202125B1 (en) 2010-05-26 2010-09-02 Takeda Pharmaceutical Company Limited A method to produce an immunoglobulin preparation with improved yield
US9938353B2 (en) 2011-06-24 2018-04-10 The Regents Of The University Of Colorado, A Body Corporate Compositions, methods and uses for alpha-1 antitrypsin fusion molecules
CN103889436A (zh) 2011-12-30 2014-06-25 基立福有限公司 用于延迟肺部症状加重的发作或进展的α1-蛋白酶抑制剂
CA2896951A1 (en) 2012-01-10 2013-07-18 The Regents Of The University Of Colorado, A Body Corporate Compositions, methods and uses for alpha-1 antitrypsin fusion molecules
WO2014137903A2 (en) 2013-03-08 2014-09-12 Genzyme Corporation Integrated continuous manufacturing of therapeutic protein drug substances
EP2978442B1 (en) 2013-03-29 2020-03-18 The Regents of the University of Colorado, a body corporate Alpha 1 antitrypsin of use for preparing a subject for transplant
TWI709569B (zh) 2014-01-17 2020-11-11 美商健臻公司 無菌層析樹脂及其用於製造方法的用途
TWI709570B (zh) 2014-01-17 2020-11-11 美商健臻公司 無菌層析法及製法
WO2016071376A2 (en) 2014-11-06 2016-05-12 F. Hoffmann-La Roche Ag Fc-region variants with modified fcrn-binding and methods of use
KR20210049155A (ko) 2018-08-31 2021-05-04 젠자임 코포레이션 멸균 크로마토그래피 수지 및 제조 공정에서 이의 용도

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1189674B (de) * 1963-06-12 1965-03-25 Behringwerke Ag Verfahren zur Isolierung von alpha-Antitrypsin
US4379087A (en) * 1982-06-17 1983-04-05 Cutter Laboratories, Inc. Method of preparing alpha-1-proteinase inhibitor
US4752576A (en) * 1984-06-14 1988-06-21 Chiron Corporation Expression of α-1 antitrypsin in yeast
US4656254A (en) * 1985-12-02 1987-04-07 Miles Laboratories, Inc. Method of preparing alpha-1-proteinase inhibitor and antithrombin III
US4629567A (en) * 1986-03-07 1986-12-16 Smithkline-Rit Alpha-1-antiprotease purification
US4749783A (en) 1986-07-11 1988-06-07 Miles Laboratories, Inc. Viral inactivation and purification of active proteins
FR2610633B1 (fr) * 1987-02-05 1992-09-18 Lille Transfusion Sanguine Procede d'obtention d'un concentre d'a 1-antitrypsine a partir de plasma humain et son utilisation a titre de medicament
US5319072A (en) * 1992-01-10 1994-06-07 Alpha Therapeutic Corporation Human antithrombin-III preparation

Also Published As

Publication number Publication date
AU3011195A (en) 1996-03-07
US5610285A (en) 1997-03-11
JP3770414B2 (ja) 2006-04-26
KR100451266B1 (ko) 2004-12-23
DE69513751T2 (de) 2000-04-27
CN100548372C (zh) 2009-10-14
CA2156007C (en) 2010-03-09
GR3032728T3 (en) 2000-06-30
KR960007617A (ko) 1996-03-22
CN1125231A (zh) 1996-06-26
ES2139794T3 (es) 2000-02-16
CA2692337A1 (en) 1996-02-25
AU700638B2 (en) 1999-01-07
CA2156007A1 (en) 1996-02-25
DE69513751D1 (de) 2000-01-13
JPH08176198A (ja) 1996-07-09
DK0698615T3 (da) 2000-05-15
ATE187462T1 (de) 1999-12-15
PT698615E (pt) 2000-05-31
EP0698615A1 (en) 1996-02-28
CN1161371C (zh) 2004-08-11
EP0698615B1 (en) 1999-12-08
CN1572321A (zh) 2005-02-02

Similar Documents

Publication Publication Date Title
HK1072372A1 (en) Alpha-1 proteinase inhibitor preparation
IL228987A0 (en) Purification of proteins using ion exchange chromatography
ES2155477T3 (es) Purificacion cromatografica y procedimiento de separacion de acidos nucleicos.
EP1308456A3 (en) Antibody purification by ion exchange chromatography
MY108512A (en) Method of purifying protein
AU3687593A (en) A method of producing a factor VIII preparation
CA2143510A1 (en) Method for the Isolation and Purification of Vitamin K-Dependent Proteins
KR960004367A (ko) α1-안티카이모트립신의 제조방법
EP0282363A3 (en) Method for preparation of a concentrate of alpha-1-antitrypsin from a human plasma fraction, and its use as a pharmaceutical
EP0720618A4 (en) METHOD FOR CLEANING "BASIC" FIBROBLAST GROWTH FACTOR
PT840746E (pt) Metodo para purificacao de proteinas
UA35599C2 (uk) Спосіб очищення гемоглобіну з сирого розчину
ES2053606T3 (es) Metodo de preparacion de un inhibidor de alfa-1-proteinasa de alta pureza.
GR3025944T3 (en) Purification of factor xiii.
ATE398171T1 (de) Hyaluronidase enthaltendes präparat und pharmazeutische verwendung davon
KR900004933A (ko) 조직 플라스미노겐 액티베이터의 정제방법
REBEYROTTE et al. The Use of the Technique of Isoelectric Focusing in the Study of Certain Proteases
KR960023063A (ko) 재조합 인간 과립구 대식세포 콜로니 자극인자의 개선된 정제방법
Sawabu et al. Purification and Some Properties of Novel γ‐Glutamyl Transpeptidase Isoenzyme Occurring in Sera of Patients with Hepatoma
KR920012436A (ko) 인간 인슐린 유사 성장인자-i의 정제 방법

Legal Events

Date Code Title Description
PE Patent expired

Effective date: 20150822