HK1069976A1 - Aqueous based pharmaceutical formulations of water-soluble prodrugs of propofol - Google Patents

Aqueous based pharmaceutical formulations of water-soluble prodrugs of propofol

Info

Publication number
HK1069976A1
HK1069976A1 HK05102397.0A HK05102397A HK1069976A1 HK 1069976 A1 HK1069976 A1 HK 1069976A1 HK 05102397 A HK05102397 A HK 05102397A HK 1069976 A1 HK1069976 A1 HK 1069976A1
Authority
HK
Hong Kong
Prior art keywords
formulations
propofol
water
aqueous based
pharmaceutical formulations
Prior art date
Application number
HK05102397.0A
Other languages
English (en)
Inventor
Tracey L Rogers
Jeffrey A Williamson
Christophor A Rhodes
Original Assignee
Eisai Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eisai Corp filed Critical Eisai Corp
Publication of HK1069976A1 publication Critical patent/HK1069976A1/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/661—Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion or mevinphos
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P23/00—Anaesthetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Inorganic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Anesthesiology (AREA)
  • Dermatology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
HK05102397.0A 2001-12-28 2005-03-18 Aqueous based pharmaceutical formulations of water-soluble prodrugs of propofol HK1069976A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US34275501P 2001-12-28 2001-12-28
PCT/US2002/041468 WO2003057153A2 (en) 2001-12-28 2002-12-26 Aqueous based pharmaceutical formulations of water-soluble prodrugs of propofol

Publications (1)

Publication Number Publication Date
HK1069976A1 true HK1069976A1 (en) 2005-06-10

Family

ID=23343142

Family Applications (1)

Application Number Title Priority Date Filing Date
HK05102397.0A HK1069976A1 (en) 2001-12-28 2005-03-18 Aqueous based pharmaceutical formulations of water-soluble prodrugs of propofol

Country Status (22)

Country Link
US (1) US20050042280A1 (xx)
EP (1) EP1458355B1 (xx)
JP (2) JP2005517679A (xx)
KR (2) KR20040080444A (xx)
CN (1) CN1329036C (xx)
AT (1) ATE430571T1 (xx)
AU (1) AU2002364238B2 (xx)
BR (1) BR0215303A (xx)
CA (1) CA2470500C (xx)
DE (1) DE60232271D1 (xx)
ES (1) ES2325918T3 (xx)
HK (1) HK1069976A1 (xx)
HU (1) HU229293B1 (xx)
IL (3) IL162692A0 (xx)
MX (1) MXPA04006325A (xx)
NO (1) NO334424B1 (xx)
NZ (1) NZ533536A (xx)
PL (1) PL205271B1 (xx)
RU (1) RU2316317C2 (xx)
UA (1) UA76802C2 (xx)
WO (1) WO2003057153A2 (xx)
ZA (1) ZA200404616B (xx)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2543166A1 (en) 2003-10-24 2005-05-19 Auspex Pharmaceuticals, Inc. Ph sensitive prodrugs of 2,6-diisopropylphenol
WO2007028104A2 (en) 2005-09-02 2007-03-08 Auspex Pharmaceuticals, Inc. Novel therapeutic agents for the treatment of cancer, metabolic diseases and skin disorders
WO2008045189A2 (en) * 2006-10-05 2008-04-17 Eisai Corporation Of North America Aqueous based pharmaceutical formulations of water-soluble prodrugs of propofol
EP2301908B8 (en) 2007-05-09 2014-09-03 Sowood Healthcare LLC (-)-stereoisomer of 2,6-di-sec-butylphenol and analogs thereof for promoting antiemetic effect, treatment of nausea and vomiting and treatment of migraine
JP2010526827A (ja) 2007-05-09 2010-08-05 ファーマコフォア，インク． 治療用化合物
US20090098209A1 (en) * 2007-10-15 2009-04-16 University Of Kansas Pharmaceutical compositions containing water-soluble derivatives of propofol and methods of administering same via pulmonary administration
GB0905834D0 (en) 2009-04-03 2009-05-20 Seps Pharma Nv Phosphonyl-containing phenolic derivatives useful as medicaments
UY34072A (es) 2011-05-17 2013-01-03 Novartis Ag Derivados sustituidos de indol
CN110063947A (zh) * 2018-01-24 2019-07-30 四川海思科制药有限公司 苯酚衍生物用于制备麻醉药物中的用途
US11628178B2 (en) 2019-03-26 2023-04-18 Epalex Corporation Fospropofol methods and compositions
US11478490B1 (en) 2021-03-30 2022-10-25 Epalex Corporation Fospropofol formulations
US11439653B1 (en) 2021-03-30 2022-09-13 Epalex Corporation Fospropofol formulations
US11547714B2 (en) 2020-02-05 2023-01-10 Epalex Corporation Fospropofol salts, methods and compositions
CN114129578A (zh) * 2021-09-28 2022-03-04 瑞普（天津）生物药业有限公司 甲磷丙泊酚钠在制备宠物麻醉、镇静药物中的应用

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2829151A (en) * 1952-11-03 1958-04-01 Dow Chemical Co Chlorotoloxy-ethyl phosphates
US3271314A (en) * 1958-12-04 1966-09-06 Ethyl Corp 2, 6-diisopropylphenol
GB1146173A (en) * 1966-06-18 1969-03-19 Geigy Uk Ltd Production of triaryl phosphates
US3723578A (en) * 1970-10-13 1973-03-27 Gaf Corp Phosphate esters of ethers of thiol substituted phenols
US4171272A (en) * 1977-12-02 1979-10-16 Fmc Corporation Turbine lubricant
FR2601259B1 (fr) * 1986-07-11 1990-06-22 Rhone Poulenc Chimie Nouvelles compositions tensio-actives a base d'esters phosphoriques leur procede de preparation et leur application a la formulation de matieres actives.
MY103951A (en) * 1988-01-12 1993-10-30 Kao Corp Detergent composition
US5091211A (en) * 1989-08-17 1992-02-25 Lord Corporation Coating method utilizing phosphoric acid esters
US5110503A (en) * 1990-05-15 1992-05-05 Elliot Cohen Demulsifying
DK0553074T3 (da) * 1990-10-17 1996-07-01 Tomen Corp Fremgangsmåde og sammensætning til at fremme optagelse og transport af bioaktive midler i planter
EP0673373A1 (en) * 1992-12-11 1995-09-27 Smithkline Beecham Plc Bicyclic compounds with pharmaceutical activity
US5646176A (en) * 1992-12-24 1997-07-08 Bristol-Myers Squibb Company Phosphonooxymethyl ethers of taxane derivatives
KR960008645B1 (ko) * 1993-09-08 1996-06-28 동국제약 주식회사 오르토-이소프로필화 페놀 유도체의 제조방법
US5731356A (en) * 1994-03-22 1998-03-24 Zeneca Limited Pharmaceutical compositions of propofol and edetate
IT1270093B (it) * 1994-09-28 1997-04-28 Zambon Spa Processo per la purificazione di 2,6-diisopropilfenolo
US5804682A (en) * 1995-11-29 1998-09-08 Henkel Corporation Aqueous dispersions of polyamides
US5637625A (en) * 1996-03-19 1997-06-10 Research Triangle Pharmaceuticals Ltd. Propofol microdroplet formulations
US5723538A (en) * 1996-06-14 1998-03-03 Henkel Corporation Aqueous dispersions of polyamides
US5746973A (en) * 1996-07-10 1998-05-05 Naraghi; Ali Method for reducing odorant depletion
US6254853B1 (en) * 1998-05-08 2001-07-03 Vyrex Corporation Water soluble pro-drugs of propofol
US6204257B1 (en) * 1998-08-07 2001-03-20 Universtiy Of Kansas Water soluble prodrugs of hindered alcohols
US6177477B1 (en) * 1999-03-24 2001-01-23 American Home Products Corporation Propofol formulation containing TRIS
DK1265612T3 (da) * 2000-02-04 2004-08-09 Lilly Co Eli Farmaceutisk præparat omfattende pemetrexed samt monothioglycerol, l-cystein eller thioglycolsyre
IL152774A0 (en) * 2000-05-25 2003-06-24 Astrazeneca Ab Pharmaceutical composition comprising a free-radical scavenging sedative agent and a metal ion chelating agent
IN187686B (xx) * 2000-06-21 2002-06-08 Bharat Serums & Vaccines Ltd
US6362234B1 (en) * 2000-08-15 2002-03-26 Vyrex Corporation Water-soluble prodrugs of propofol for treatment of migrane
US7034013B2 (en) * 2001-03-20 2006-04-25 Cydex, Inc. Formulations containing propofol and a sulfoalkyl ether cyclodextrin

Also Published As

Publication number Publication date
CN1329036C (zh) 2007-08-01
NZ533536A (en) 2006-11-30
HUP0500439A2 (hu) 2005-08-29
BR0215303A (pt) 2005-04-05
HU229293B1 (hu) 2013-10-28
WO2003057153A3 (en) 2004-01-29
PL205271B1 (pl) 2010-03-31
MXPA04006325A (es) 2005-03-31
IL208697A0 (en) 2010-12-30
US20050042280A1 (en) 2005-02-24
KR20040080444A (ko) 2004-09-18
NO334424B1 (no) 2014-03-03
AU2002364238B2 (en) 2007-01-18
IL162692A (en) 2011-03-31
RU2004119056A (ru) 2005-04-20
UA76802C2 (uk) 2006-09-15
IL162692A0 (en) 2005-11-20
CA2470500C (en) 2012-05-15
EP1458355B1 (en) 2009-05-06
PL372324A1 (en) 2005-07-11
AU2002364238A1 (en) 2003-07-24
EP1458355A2 (en) 2004-09-22
JP2005517679A (ja) 2005-06-16
ZA200404616B (en) 2005-10-26
JP2010235622A (ja) 2010-10-21
ES2325918T3 (es) 2009-09-24
DE60232271D1 (de) 2009-06-18
RU2316317C2 (ru) 2008-02-10
EP1458355A4 (en) 2005-04-20
NO20042459L (no) 2004-08-25
KR20100112632A (ko) 2010-10-19
CN1607938A (zh) 2005-04-20
CA2470500A1 (en) 2003-07-17
ATE430571T1 (de) 2009-05-15
WO2003057153A2 (en) 2003-07-17

Similar Documents

Publication Publication Date Title
IL208697A0 (en) Aqueous based pharmaceutical formulations of water-soluble prodrugs of propofol
CY1108532T1 (el) Ενωσεις και συνθεσεις για την παροχη δραστικων παραγοντων
TW200633716A (en) Compositions and methods for stabilizing active pharmaceutical ingredients
DK1133316T3 (da) Adenovirus-formulering til genterapi
DE60236541D1 (de) Inhibitoren von 11-beta-hydroxysteroiddehydrogenase typ 1
NO20025590D0 (no) Fenylglycin-derivater
DK1273299T3 (da) Minoxidilinindeholdende praparater
WO2008045189A3 (en) Aqueous based pharmaceutical formulations of water-soluble prodrugs of propofol
YU87202A (sh) Derivati arilmetilamina koji se koriste kao inhibitori triptaze
MXPA03011480A (es) Una preparacion farmaceutica acuosa de cilostazol para uso parenteral.
RS50046B (sr) Farmaceutske kompozicije tizoksanida i nitazoksanida
MXPA04001256A (es) Productos de combinacion de derivados de propanolamina aril substituidos con otros ingredientes activos y su uso.
ATE367165T1 (de) Xanthangummi enthaltende reepithelialisierende pharmazeutische zubereitungen
MY138172A (en) Pharmaceutical compositions based on azetidine derivatives
ES2180319T3 (es) Utilizacion de derivados de metilenbisoxazolidina y composiciones de los mismos.
MXPA03011128A (es) Composicion de sabor y fragancia.
GEP20094648B (en) Anti-parasiticidal composition
AU3548901A (en) Veterinary compositions for the treatment of parasitic diseases
CO5261624A1 (es) Novedosos derivados fenilheteroalquilamina, procesos para su preparacion, composiciones farmaceuticas que comprenden dichos derivados novedosos y su uso en terapia
MXPA04005033A (es) Composicion farmaceutica que comprende una combinacion de metformina y acido 4-oxobutanoico y el uso de la misma para el tratamiento contra diabetes.
WO2005011565A3 (fr) Vernis a ongles a action antimycosique
ES2156763A1 (es) Formulacion estables de solucion de apomorfina.
DE60112578D1 (de) Pharmazeutische diclofenac-verbindung basierend auf vitamin e, papain und hyaluronidase
HRP20070054T3 (en) Fungicidal mixtures
HRPK20040924B3 (en) Preparation based on curcumae longae rhizomae roots

Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20151226