HK1068630A1 - Method of mycophenolate mofetil preparation - Google Patents

Method of mycophenolate mofetil preparation

Info

Publication number
HK1068630A1
HK1068630A1 HK05101061A HK05101061A HK1068630A1 HK 1068630 A1 HK1068630 A1 HK 1068630A1 HK 05101061 A HK05101061 A HK 05101061A HK 05101061 A HK05101061 A HK 05101061A HK 1068630 A1 HK1068630 A1 HK 1068630A1
Authority
HK
Hong Kong
Prior art keywords
mycophenolate mofetil
preparation
mofetil preparation
mycophenolate
mofetil
Prior art date
Application number
HK05101061A
Other languages
English (en)
Inventor
Miloslav Chudlik
Ales Husek
Original Assignee
Ivax Pharmaceuticals Sro
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ivax Pharmaceuticals Sro filed Critical Ivax Pharmaceuticals Sro
Publication of HK1068630A1 publication Critical patent/HK1068630A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
    • C07D307/88—Benzo [c] furans; Hydrogenated benzo [c] furans with one oxygen atom directly attached in position 1 or 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Saccharide Compounds (AREA)
  • Furan Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
HK05101061A 2001-06-08 2005-02-18 Method of mycophenolate mofetil preparation HK1068630A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CZ20012071A CZ292123B6 (cs) 2001-06-08 2001-06-08 Způsob přípravy mykofenolátu mofetilu
PCT/US2002/018274 WO2002100855A1 (en) 2001-06-08 2002-06-08 Method of mycophenolate mofetil preparation

Publications (1)

Publication Number Publication Date
HK1068630A1 true HK1068630A1 (en) 2005-04-29

Family

ID=5473426

Family Applications (1)

Application Number Title Priority Date Filing Date
HK05101061A HK1068630A1 (en) 2001-06-08 2005-02-18 Method of mycophenolate mofetil preparation

Country Status (17)

Country Link
US (1) US20050085635A1 (ja)
EP (1) EP1421081A4 (ja)
JP (1) JP2004534063A (ja)
KR (1) KR20040030660A (ja)
CN (1) CN1253450C (ja)
AR (1) AR041777A1 (ja)
BR (1) BR0210931A (ja)
CA (1) CA2450013A1 (ja)
CZ (1) CZ292123B6 (ja)
HK (1) HK1068630A1 (ja)
HU (1) HUP0400189A3 (ja)
NZ (1) NZ530013A (ja)
PL (1) PL364366A1 (ja)
RU (1) RU2283313C2 (ja)
SK (1) SK285663B6 (ja)
TW (1) TWI241299B (ja)
WO (1) WO2002100855A1 (ja)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1667987B1 (en) * 2003-09-11 2008-07-23 Sandoz AG Process for the production of mycophenolate mofetil
US7683188B2 (en) 2004-04-26 2010-03-23 TEVA Gyógyszergyár Zártkōrūen Mūkōdō Részvénytársaság Process for preparation of mycophenolic acid and ester derivatives thereof
CA2555454C (en) 2004-04-27 2009-12-15 Sandor Molnar Mycophenolate mofetil impurity
CN101014584A (zh) 2004-07-20 2007-08-08 特瓦药厂私人有限公司 结晶霉酚酸钠的制备方法
ITMI20041703A1 (it) * 2004-09-03 2004-12-03 Poli Ind Chimica Spa Metodo di preparazione del mofetil micofenolato per transesterificazione enzimatica
CN1328272C (zh) * 2005-08-22 2007-07-25 鲁南制药集团股份有限公司 一种工业化生产霉酚酸莫啡酯的方法
CN100402516C (zh) * 2005-10-18 2008-07-16 深圳市东阳光实业发展有限公司 一种霉酚酸莫啡酯的制备方法
DK2032712T3 (da) * 2006-06-29 2010-05-25 Ivax Pharmaceuticals Sro Regulering af syremetabolitproduktion
CN1974564B (zh) * 2006-12-15 2010-05-12 丽珠集团新北江制药股份有限公司 一种霉酚酸莫啡酯的制备方法
US20080188653A1 (en) 2007-02-04 2008-08-07 Formosa Laboratories, Inc. Process for Preparation of Mycophenolate Mofetil
CN100484930C (zh) * 2007-03-16 2009-05-06 重庆大新药业股份有限公司 一种吗替麦考酚酯的制备方法
TW200904982A (en) * 2007-04-11 2009-02-01 Teva Gyogyszergyar Zartkoruen Mukodo Reszvenytarsasag Method for reducing impurity level in mycophenolic acid fermentation
WO2009000834A1 (en) * 2007-06-27 2008-12-31 Dsm Ip Assets B.V. Method for the purification of mycophenolate mofetil
WO2009003878A1 (en) * 2007-06-29 2009-01-08 Dsm Ip Assets B.V. Method for the preparation of mycophenolate mofetil
WO2009010503A1 (en) * 2007-07-18 2009-01-22 Dsm Ip Assets B.V. Mycophenolic acid recycling in a method for the preparation of mycophenolate mofetil
CN101671706B (zh) * 2009-09-05 2013-09-18 山东新时代药业有限公司 一种霉酚酸发酵过程中补糖方法
CN103265514B (zh) * 2013-06-08 2016-01-13 重庆理工大学 一种制备吗替麦考酚酯的方法
CN107056736A (zh) * 2017-05-08 2017-08-18 福建省微生物研究所 一种吗替麦考酚酯的制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4748173A (en) * 1987-01-30 1988-05-31 Syntex (U.S.A.) Inc. Heterocyclic aminoalkyl esters of mycophenolic acid and derivatives thereof and pharmaceutical compositions
HU203678B (en) * 1988-09-26 1991-09-30 Richter Gedeon Vegyeszet Method for increased dewatering condensation reaction mixtures
US5247083A (en) * 1992-07-10 1993-09-21 Syntex (U.S.A.) Inc. Direct esterification of mycophenolic acid

Also Published As

Publication number Publication date
WO2002100855A1 (en) 2002-12-19
BR0210931A (pt) 2004-06-08
HUP0400189A3 (en) 2007-05-29
CA2450013A1 (en) 2002-12-19
CZ20012071A3 (cs) 2003-01-15
CZ292123B6 (cs) 2003-08-13
SK285663B6 (sk) 2007-05-03
RU2004100227A (ru) 2005-06-27
KR20040030660A (ko) 2004-04-09
NZ530013A (en) 2005-05-27
SK15062003A3 (en) 2004-11-03
CN1253450C (zh) 2006-04-26
EP1421081A4 (en) 2004-11-03
HUP0400189A2 (hu) 2004-07-28
AR041777A1 (es) 2005-06-01
JP2004534063A (ja) 2004-11-11
RU2283313C2 (ru) 2006-09-10
PL364366A1 (en) 2004-12-13
EP1421081A1 (en) 2004-05-26
TWI241299B (en) 2005-10-11
US20050085635A1 (en) 2005-04-21
CN1520411A (zh) 2004-08-11

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Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20100608