HK1064097A1 - Bicyclic Ä1,2,4Ü -triazole adenosine a2a receptor antagonists - Google Patents

Bicyclic Ä1,2,4Ü -triazole adenosine a2a receptor antagonists

Info

Publication number
HK1064097A1
HK1064097A1 HK04106857A HK04106857A HK1064097A1 HK 1064097 A1 HK1064097 A1 HK 1064097A1 HK 04106857 A HK04106857 A HK 04106857A HK 04106857 A HK04106857 A HK 04106857A HK 1064097 A1 HK1064097 A1 HK 1064097A1
Authority
HK
Hong Kong
Prior art keywords
adenosine
triazole
bicyclic
receptor antagonists
antagonists
Prior art date
Application number
HK04106857A
Other languages
English (en)
Inventor
Bernard R Neustadt
Hong Liu
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of HK1064097A1 publication Critical patent/HK1064097A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
HK04106857A 2001-11-30 2004-09-10 Bicyclic Ä1,2,4Ü -triazole adenosine a2a receptor antagonists HK1064097A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US33438501P 2001-11-30 2001-11-30
PCT/US2002/037915 WO2003048163A1 (en) 2001-11-30 2002-11-26 [1,2,4]-TRIAZOLE BICYCLIC ADENOSINE A2a RECEPTOR ANTAGONISTS

Publications (1)

Publication Number Publication Date
HK1064097A1 true HK1064097A1 (en) 2005-01-21

Family

ID=23306955

Family Applications (1)

Application Number Title Priority Date Filing Date
HK04106857A HK1064097A1 (en) 2001-11-30 2004-09-10 Bicyclic Ä1,2,4Ü -triazole adenosine a2a receptor antagonists

Country Status (19)

Country Link
US (2) US6875772B2 (sk)
EP (1) EP1453836B1 (sk)
JP (2) JP4429724B2 (sk)
KR (1) KR20050044600A (sk)
CN (1) CN1688581A (sk)
AR (1) AR037681A1 (sk)
AT (1) ATE358130T1 (sk)
AU (1) AU2002352933A1 (sk)
CA (1) CA2468658C (sk)
DE (1) DE60219196T2 (sk)
ES (1) ES2283625T3 (sk)
HK (1) HK1064097A1 (sk)
HU (1) HUP0402324A3 (sk)
IL (1) IL161573A0 (sk)
MX (1) MXPA04005158A (sk)
PE (1) PE20030653A1 (sk)
TW (1) TW200300689A (sk)
WO (1) WO2003048163A1 (sk)
ZA (1) ZA200404168B (sk)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PE20030739A1 (es) 2001-11-30 2003-08-28 Schering Corp Antagonistas del receptor de adenosina a2a
US6875772B2 (en) * 2001-11-30 2005-04-05 Schering Corporation [1,2,4]-Triazole bicyclic adeonsine A2a receptor antagonists
CN101492383A (zh) * 2002-03-12 2009-07-29 惠氏公司 制备手性1,4-二取代哌嗪的方法
CA2500228A1 (en) * 2002-09-24 2004-04-08 Kyowa Hakko Kogyo Co., Ltd. [1,2,4]-triazolo[1,5-c]pyrimidine derivative
CN101310724A (zh) 2002-12-19 2008-11-26 先灵公司 腺苷A2a受体拮抗剂的应用
WO2004092170A2 (en) 2003-04-09 2004-10-28 Biogen Idec Ma Inc. Triazolotriazines and pyrazolotriazines useful as a2a adenosine receptor antagon ists
ATE418555T1 (de) 2003-04-09 2009-01-15 Biogen Idec Inc A2a-adenosinrezeptorantagonisten
EP1618109A2 (en) * 2003-04-09 2006-01-25 Biogen Idec MA Inc. Triazolo[1,5-c]pyrimidines and pyrazolo[1,5-c]pyrimidines useful as a2a adenosine receptor antagonists
WO2004092177A1 (en) 2003-04-09 2004-10-28 Biogen Idec Ma Inc. Triazolopyrazines and methods of making and using the same
TW200507850A (en) * 2003-07-25 2005-03-01 Kyowa Hakko Kogyo Kk Pharmaceutical composition
JPWO2006129626A1 (ja) * 2005-05-30 2009-01-08 協和醗酵工業株式会社 ［１，２，４］トリアゾロ［１，５−ｃ］ピリミジン誘導体の製造法
ATE556712T1 (de) 2005-06-07 2012-05-15 Kyowa Hakko Kirin Co Ltd A2a antagonisten zur behandlung von motorischen störungen
EP1896415A1 (en) * 2005-06-08 2008-03-12 NeuroSearch A/S Novel n-phenyl-piperidine derivatives and their use as monoamine neurotransmitter re-uptake inhibitors
WO2007027987A2 (en) 2005-09-02 2007-03-08 Mount Cook Biosciences, Inc. Method of treating parkinson's disease with diarylmethylpiperazine compounds exhibiting delta receptor agonist activity
ES2273599B1 (es) 2005-10-14 2008-06-01 Universidad De Barcelona Compuestos para el tratamiento de la fibrilacion auricular.
US7615556B2 (en) * 2006-01-27 2009-11-10 Bristol-Myers Squibb Company Piperazinyl derivatives as modulators of chemokine receptor activity
US20110064671A1 (en) 2008-03-10 2011-03-17 Cornell University Modulation of blood brain barrier permeability
WO2010008775A1 (en) * 2008-06-23 2010-01-21 Ligand Pharmaceuticals Inc. Aminopyridopyrazinone derivatives for treating neurodegenerative diseases
GB201214106D0 (en) * 2012-08-07 2012-09-19 Univ Strathclyde Immunomodulatory compounds
EP3436013A4 (en) 2016-03-31 2019-11-13 Versi Group, LLC COMPOSITIONS BASED ON OPIACE RECEPTOR DELTA / OPAACEOUS RECEPTOR DELTA OPTIONAL AGONIST, AND METHODS FOR TREATING PARKINSON'S DISEASE
CN106866582A (zh) * 2017-01-10 2017-06-20 广州隽沐生物科技有限公司 一种氟班色林中间体的制备方法
CN111164084B (zh) * 2018-06-26 2023-05-23 浙江春禾医药科技有限公司 可用作a2a受体拮抗剂的三唑并三嗪衍生物
WO2020227156A1 (en) * 2019-05-03 2020-11-12 Nektar Therapeutics Adenosine 2 receptor antagonists
BR112023021918A2 (pt) * 2021-04-23 2023-12-19 Chong Kun Dang Pharmaceutical Corp Composto como antagonista do receptor de adenosina a2a e composição farmacêutica compreendendo o mesmo

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1264901B1 (it) 1993-06-29 1996-10-17 Schering Plough S P A Analoghi eterociclici di 1,2,4-triazolo(15-c)pirimidine ad attivita' antagonista per il recettore a2 dell'adenosina
CA2144330A1 (en) * 1993-07-27 1995-02-09 Fumio Suzuki A therapeutic agent for parkinson's disease
IT1277392B1 (it) 1995-07-28 1997-11-10 Schering Plough S P A Analoghi eterociclici di 1,2,4-triazolo(1,5-c]pirimidine ad attivita' antagonista per il recettore a2a dell'adenosina
DE69820866T2 (de) * 1997-03-24 2004-12-30 Kyowa Hakko Kogyo Co., Ltd. [1,2,4]TRIAZOLO[1,5-c]PYRIMIDIN-DERIVATE
IT1291372B1 (it) 1997-05-21 1999-01-07 Schering Plough S P A Uso di analoghi eterociclici di 1,2,4-triazolo (1,5-c) pirimidine per la preparazione di medicamenti utili per il trattamento delle malattie
AU2639299A (en) 1998-02-24 1999-09-15 Kyowa Hakko Kogyo Co. Ltd. Remedies/preventives for parkinson's disease
WO2000017201A1 (fr) * 1998-09-22 2000-03-30 Kyowa Hakko Kogyo Co., Ltd. DERIVES DE [1,2,4]TRIAZOLO[1,5-c]PYRIMIDINE
US6355653B1 (en) 1999-09-06 2002-03-12 Hoffmann-La Roche Inc. Amino-triazolopyridine derivatives
JP2002037787A (ja) * 2000-05-16 2002-02-06 Kyowa Hakko Kogyo Co Ltd ［１，２，４］トリアゾロ［１，５−ｃ］ピリミジン誘導体の製造法
TWI288137B (en) 2000-05-26 2007-10-11 Schering Corp Adenosine A2a receptor antagonists
MXPA04003474A (es) * 2001-10-15 2004-07-30 Schering Corp Imidazo (4,3-e)-1,2,4-triazolo(1,5-c) pirimidinas como antagonistas del receptor de adenosina a2a.
US6875772B2 (en) * 2001-11-30 2005-04-05 Schering Corporation [1,2,4]-Triazole bicyclic adeonsine A2a receptor antagonists

Also Published As

Publication number Publication date
DE60219196T2 (de) 2008-01-03
IL161573A0 (en) 2004-09-27
KR20050044600A (ko) 2005-05-12
TW200300689A (en) 2003-06-16
US20030191130A1 (en) 2003-10-09
AR037681A1 (es) 2004-12-01
CA2468658A1 (en) 2003-06-12
US20050113380A1 (en) 2005-05-26
PE20030653A1 (es) 2003-08-04
JP4429724B2 (ja) 2010-03-10
AU2002352933A1 (en) 2003-06-17
JP2010018634A (ja) 2010-01-28
WO2003048163A1 (en) 2003-06-12
JP2005511697A (ja) 2005-04-28
CN1688581A (zh) 2005-10-26
MXPA04005158A (es) 2004-08-11
DE60219196D1 (de) 2007-05-10
ES2283625T3 (es) 2007-11-01
HUP0402324A2 (hu) 2005-02-28
US7078408B2 (en) 2006-07-18
ZA200404168B (en) 2005-09-02
US6875772B2 (en) 2005-04-05
EP1453836A1 (en) 2004-09-08
ATE358130T1 (de) 2007-04-15
CA2468658C (en) 2009-04-14
EP1453836B1 (en) 2007-03-28
HUP0402324A3 (en) 2008-09-29

Similar Documents

Publication Publication Date Title
HK1064097A1 (en) Bicyclic Ä1,2,4Ü -triazole adenosine a2a receptor antagonists
HK1063780A1 (en) Adenosine a2a receptor antagonists
IL161572A0 (en) Adenosine a2a receptor antagonists
IL152726A0 (en) Adenosine a2a receptor antagonists
HUP0401925A3 (en) A2b adenosine receptor antagonists
MXPA03004439A (es) Aminotiazoles y su uso como antagonistas del receptor de adenosina.
HUP0401437A3 (en) Adenosine a3 receptor agonists
PL353969A1 (en) Substituted 2-thio-3,5-dicyano-4-aryl-6-aminopyridines and the use thereof as adenosine receptor ligands
IL175759A0 (en) A2b adenosine receptor antagonists
MXPA03008967A (es) Antagonistas receptores de 8-heteroarilo xantina adenosina a-2b.
HK1062300A1 (en) 4-Amino-5-phenyl-7-cyclobutyl-pyrrolo (2,3-d)pyrimidine derivatives
PL373953A1 (en) 7-amino-benzothiazole derivatives as adenosine receptor ligands
ZA200408755B (en) Condensed purine derivatives as A1 adenosine receptor antagonists.
HK1049835A1 (en) Selective antagonists of a2b adenosine receptors a2b.
HRP20040672A2 (en) Triazolo-quinolin derivatives useful as adenosine receptor ligands
PL370565A1 (en) 5-methoxy-8-aryl-[1,2,4] triazolo [1,5-a] pyridine derivatives as adenosine receptor antagonists
AU2002359524A8 (en) P2x7 receptor antagonists
AU4980999A (en) A3 adenosine receptor antagonists
EP1636230A4 (en) ADENOSINE A1 RECEPTOR ANTAGONISTS
IL156087A0 (en) Histamine receptor antagonists
IL158063A0 (en) Crf receptor antagonists
SI1444233T1 (sl) Antagonisti adenozinskega receptorja A2B
SI1401837T1 (sl) Purinski derivati kot antagonisti adenozinskega receptorja A2B
AU2002226519A1 (en) Pyrrolo(2,3-d)pyrimidine and their use as purinergic receptor antagonists
HUP0203369A3 (en) Polycycloalkylpurines as adenosine receptor antagonists, process for their preparation and their use

Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20101126