HK1058193A1 - Treatment of gastrointestinal stromal tumors - Google Patents

Treatment of gastrointestinal stromal tumors

Info

Publication number
HK1058193A1
HK1058193A1 HK03109439A HK03109439A HK1058193A1 HK 1058193 A1 HK1058193 A1 HK 1058193A1 HK 03109439 A HK03109439 A HK 03109439A HK 03109439 A HK03109439 A HK 03109439A HK 1058193 A1 HK1058193 A1 HK 1058193A1
Authority
HK
Hong Kong
Prior art keywords
treatment
gastrointestinal stromal
stromal tumors
methylpiperazin
ylamino
Prior art date
Application number
HK03109439A
Other languages
English (en)
Inventor
Elisabeth Buchdunger
Renaud Capdeville
George Daniel Demetri
Sasa Dimitrijevic
Brian J Druker
Jonathan A Fletcher
Heikki Joensuu
Sandra Leta Silberman
David Tuveson
Michael C Heinrich
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22920224&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HK1058193(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of HK1058193A1 publication Critical patent/HK1058193A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Farming Of Fish And Shellfish (AREA)
HK03109439A 2000-10-27 2003-12-29 Treatment of gastrointestinal stromal tumors HK1058193A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US24381000P 2000-10-27 2000-10-27
PCT/EP2001/012442 WO2002034727A2 (en) 2000-10-27 2001-10-26 Treatment of gastrointestinal stromal tumors

Publications (1)

Publication Number Publication Date
HK1058193A1 true HK1058193A1 (en) 2004-05-07

Family

ID=22920224

Family Applications (1)

Application Number Title Priority Date Filing Date
HK03109439A HK1058193A1 (en) 2000-10-27 2003-12-29 Treatment of gastrointestinal stromal tumors

Country Status (26)

Country Link
US (1) US6958335B2 (zh)
EP (1) EP1332137B1 (zh)
JP (1) JP4386635B2 (zh)
KR (1) KR100885129B1 (zh)
CN (1) CN1276754C (zh)
AT (1) ATE321556T1 (zh)
AU (2) AU2002218262B2 (zh)
BR (1) BRPI0114870B8 (zh)
CA (1) CA2424470C (zh)
CY (1) CY1105055T1 (zh)
CZ (1) CZ303944B6 (zh)
DE (1) DE60118430T2 (zh)
DK (1) DK1332137T3 (zh)
ES (1) ES2260317T3 (zh)
HK (1) HK1058193A1 (zh)
HU (1) HU229106B1 (zh)
IL (2) IL155029A0 (zh)
MX (1) MXPA03003703A (zh)
NO (1) NO324948B1 (zh)
NZ (1) NZ525254A (zh)
PL (1) PL209733B1 (zh)
PT (1) PT1332137E (zh)
RU (1) RU2301066C2 (zh)
SK (1) SK287335B6 (zh)
WO (1) WO2002034727A2 (zh)
ZA (1) ZA200302155B (zh)

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KR20030094415A (ko) * 2001-05-16 2003-12-11 노파르티스 아게 Ν-｛5-[4-(4-메틸-피페라지노-메틸)-벤조일아미도]-2-메틸페닐｝-4-(3-피리딜)-2-피리미딘-아민 및 화학치료제를포함하는 배합물
EP1401412A2 (en) * 2001-06-29 2004-03-31 AB Science Use of potent, selective and non toxic c-kit inhibitors for treating tumor angiogenesis
CA2452392A1 (en) * 2001-06-29 2003-01-16 Ab Science Use of tyrosine kinase inhibitors for treating inflammatory bowel diseases (ibd)
ATE330608T1 (de) * 2001-06-29 2006-07-15 Ab Science Die verwendung von n-phenyl-2-pyrimidine-amine derivaten zur behandlung von entzündlichen erkrankungen
WO2003002106A2 (en) * 2001-06-29 2003-01-09 Ab Science Use of tyrosine kinase inhibitions for treating allergic diseases
WO2003003006A2 (en) * 2001-06-29 2003-01-09 Ab Science New potent, selective and non toxic c-kit inhibitors
EP1461032B1 (en) * 2001-09-20 2008-07-16 AB Science Use of c-kit inhibitors for promoting hair growth
DE60228278D1 (de) * 2001-09-20 2008-09-25 Ab Science Die verwendung von potenten, selektiven und nontoxischen c-kithemmern zur behandlung von interstitieller blasenentzündung
CA2477111A1 (en) * 2002-02-27 2003-09-04 Ab Science Use of tyrosine kinase inhibitors for treating cns disorders
FR2844452A1 (fr) * 2002-09-18 2004-03-19 Inst Gustave Roussy Igr Utilisation d'inhibiteurs specifiques de tyrosine kinases pour l'immunomodulation
US7202257B2 (en) 2003-12-24 2007-04-10 Deciphera Pharmaceuticals, Llc Anti-inflammatory medicaments
US7144911B2 (en) 2002-12-31 2006-12-05 Deciphera Pharmaceuticals Llc Anti-inflammatory medicaments
US7279576B2 (en) 2002-12-31 2007-10-09 Deciphera Pharmaceuticals, Llc Anti-cancer medicaments
AU2004273605B2 (en) * 2003-09-19 2008-07-31 Novartis Ag Treatment of gastrointestinal stromal tumors with imatinib and midostaurin
WO2007089716A2 (en) * 2006-02-01 2007-08-09 The Regents Of The University Of California Use of aminopyrimidine compounds in the treatment of immune disorders
JP5563300B2 (ja) * 2006-09-11 2014-07-30 キュリス，インコーポレイテッド 亜鉛結合部分を含むチロシンキナーゼインヒビター
EP2061772A4 (en) * 2006-09-11 2011-06-29 Curis Inc MULTIFUNCTIONAL SMALL MOLECULES AS PROLIFERATION-ACTIVE ACTIVE SUBSTANCES
US8642067B2 (en) 2007-04-02 2014-02-04 Allergen, Inc. Methods and compositions for intraocular administration to treat ocular conditions
US20090082361A1 (en) * 2007-09-26 2009-03-26 Protia, Llc Deuterium-enriched imatinib
CN101584696A (zh) 2008-05-21 2009-11-25 上海艾力斯医药科技有限公司 包含喹唑啉衍生物的组合物及制备方法、用途
US8530492B2 (en) 2009-04-17 2013-09-10 Nektar Therapeutics Oligomer-protein tyrosine kinase inhibitor conjugates
EP2680850B1 (en) 2011-03-04 2018-05-23 Newgen Therapeutics, Inc. Alkyne substituted quinazoline compound and methods of use
WO2012155339A1 (zh) 2011-05-17 2012-11-22 江苏康缘药业股份有限公司 4-苯胺-6-丁烯酰胺-7-烷醚喹唑啉衍生物及其制备方法和用途
WO2013124774A1 (en) 2012-02-21 2013-08-29 Ranbaxy Laboratories Limited Stable dosage forms of imatinib mesylate
US8461179B1 (en) 2012-06-07 2013-06-11 Deciphera Pharmaceuticals, Llc Dihydronaphthyridines and related compounds useful as kinase inhibitors for the treatment of proliferative diseases
CN104736144B (zh) 2012-07-27 2019-02-01 艾祖米科技有限公司 外排抑制剂组合物和使用此组合物治疗的方法
US20150044288A1 (en) 2013-07-31 2015-02-12 Windward Pharma, Inc. Aerosol tyrosine kinase inhibitor compounds and uses thereof
US11285152B2 (en) 2017-07-20 2022-03-29 Kashiv Biosciences, Llc Stable oral pharmaceutical composition of imatinib
MX2020008016A (es) 2018-01-31 2020-11-09 Deciphera Pharmaceuticals Llc Terapia de combinación para el tratamiento de tumores del estroma gastrointestinal.
TW202122082A (zh) 2019-08-12 2021-06-16 美商迪賽孚爾製藥有限公司 治療胃腸道基質瘤方法
BR112022002609A2 (pt) 2019-08-12 2022-08-09 Deciphera Pharmaceuticals Llc Métodos de tratamento de tumores estromais gastrointestinais
FI4084778T3 (fi) 2019-12-30 2023-12-18 Deciphera Pharmaceuticals Llc Amorfisia kinaasi-inhibiittoriformulaatioita ja menetelmiä niiden käyttämiseksi
AU2020417282B2 (en) 2019-12-30 2023-08-31 Deciphera Pharmaceuticals, Llc Compositions of 1-(4-bromo-5-(1-ethyl-7-(methylamino)-2-oxo-1,2-dihydro-1,6-naphthyridin-3-yl)-2-fluorophenyl)-3-phenylurea
KR102535840B1 (ko) 2020-07-31 2023-05-23 (주)파로스아이바이오 2,3,5-치환된 싸이오펜 화합물의 위장관기질종양 예방, 개선 또는 치료 용도
US11779572B1 (en) 2022-09-02 2023-10-10 Deciphera Pharmaceuticals, Llc Methods of treating gastrointestinal stromal tumors

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW225528B (zh) * 1992-04-03 1994-06-21 Ciba Geigy Ag
CO4940418A1 (es) * 1997-07-18 2000-07-24 Novartis Ag Modificacion de cristal de un derivado de n-fenil-2- pirimidinamina, procesos para su fabricacion y su uso
WO2000012084A1 (en) * 1998-08-31 2000-03-09 Sugen, Inc. Geometrically restricted 2-indolinone derivatives as modulators of protein kinase activity

Also Published As

Publication number Publication date
DE60118430D1 (de) 2006-05-18
IL155029A0 (en) 2003-10-31
EP1332137B1 (en) 2006-03-29
DE60118430T2 (de) 2006-10-26
NZ525254A (en) 2006-02-24
DK1332137T3 (da) 2006-07-17
CZ303944B6 (cs) 2013-07-10
AU2002218262B2 (en) 2005-09-29
WO2002034727A2 (en) 2002-05-02
ES2260317T3 (es) 2006-11-01
CY1105055T1 (el) 2010-03-03
MXPA03003703A (es) 2005-01-25
SK287335B6 (sk) 2010-07-07
BR0114870A (pt) 2004-02-17
KR100885129B1 (ko) 2009-02-23
HUP0301512A2 (hu) 2003-11-28
ATE321556T1 (de) 2006-04-15
PT1332137E (pt) 2006-07-31
US6958335B2 (en) 2005-10-25
CN1622808A (zh) 2005-06-01
AU1826202A (en) 2002-05-06
BRPI0114870B8 (pt) 2021-05-25
CZ20031152A3 (en) 2004-04-14
EP1332137A2 (en) 2003-08-06
IL155029A (en) 2009-09-22
ZA200302155B (en) 2004-04-22
HU229106B1 (en) 2013-07-29
SK5182003A3 (en) 2004-02-03
PL209733B1 (pl) 2011-10-31
CN1276754C (zh) 2006-09-27
NO20031833D0 (no) 2003-04-24
WO2002034727A3 (en) 2003-03-27
RU2301066C2 (ru) 2007-06-20
PL362148A1 (en) 2004-10-18
CA2424470A1 (en) 2002-05-02
NO324948B1 (no) 2008-01-07
CA2424470C (en) 2009-06-09
US20040023976A1 (en) 2004-02-05
KR20030051656A (ko) 2003-06-25
BRPI0114870B1 (pt) 2020-06-16
NO20031833L (no) 2003-04-24
JP4386635B2 (ja) 2009-12-16
JP2004512328A (ja) 2004-04-22

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Effective date: 20211025