HK1052932A1 - 1,5-Disubstituted-3,4-dihydro-1h-pyrimido Ä4,5-dÜpyrimidin-2-one compounds and their use in treatingcsbp/p38 kinase mediated diseases - Google Patents

1,5-Disubstituted-3,4-dihydro-1h-pyrimido Ä4,5-dÜpyrimidin-2-one compounds and their use in treatingcsbp/p38 kinase mediated diseases

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Publication number
HK1052932A1
HK1052932A1 HK03103782A HK03103782A HK1052932A1 HK 1052932 A1 HK1052932 A1 HK 1052932A1 HK 03103782 A HK03103782 A HK 03103782A HK 03103782 A HK03103782 A HK 03103782A HK 1052932 A1 HK1052932 A1 HK 1052932A1
Authority
HK
Hong Kong
Prior art keywords
treatingcsbp
düpyrimidin
pyrimido
disubstituted
dihydro
Prior art date
Application number
HK03103782A
Other languages
English (en)
Inventor
Jerry L Adams
Jeffrey C Boehm
Ralph F Hall
John J Taggart
Original Assignee
Smithkline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp
Publication of HK1052932A1 publication Critical patent/HK1052932A1/xx

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/16—Emollients or protectives, e.g. against radiation
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
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    • A—HUMAN NECESSITIES
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    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
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    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
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    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
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    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P9/00—Drugs for disorders of the cardiovascular system
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    • A—HUMAN NECESSITIES
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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HK03103782A 2000-03-02 2003-05-27 1,5-Disubstituted-3,4-dihydro-1h-pyrimido Ä4,5-dÜpyrimidin-2-one compounds and their use in treatingcsbp/p38 kinase mediated diseases HK1052932A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US18641900P 2000-03-02 2000-03-02
PCT/US2001/006688 WO2001064679A1 (fr) 2000-03-02 2001-03-02 Composes de 3,4 dihydro-1h-pyrimido[4,5-d]pyrimidin-2-one a disubstitution en position 1,5 et leur utilisation pour traiter des maladies mediees par des kinases csbp/p38

Publications (1)

Publication Number Publication Date
HK1052932A1 true HK1052932A1 (en) 2003-10-03

Family

ID=22684876

Family Applications (1)

Application Number Title Priority Date Filing Date
HK03103782A HK1052932A1 (en) 2000-03-02 2003-05-27 1,5-Disubstituted-3,4-dihydro-1h-pyrimido Ä4,5-dÜpyrimidin-2-one compounds and their use in treatingcsbp/p38 kinase mediated diseases

Country Status (26)

Country Link
EP (1) EP1265900B1 (fr)
JP (1) JP2003525295A (fr)
KR (1) KR100806978B1 (fr)
CN (1) CN100482664C (fr)
AR (2) AR030053A1 (fr)
AT (1) ATE362473T1 (fr)
AU (2) AU3999201A (fr)
BR (1) BR0108715A (fr)
CA (1) CA2402092C (fr)
CY (1) CY1106816T1 (fr)
CZ (1) CZ20022933A3 (fr)
DE (1) DE60128457T2 (fr)
DK (1) DK1265900T3 (fr)
ES (1) ES2287107T3 (fr)
HK (1) HK1052932A1 (fr)
HU (1) HUP0204431A3 (fr)
IL (3) IL151426A0 (fr)
MX (1) MXPA02008588A (fr)
MY (1) MY141144A (fr)
NO (1) NO326409B1 (fr)
NZ (1) NZ520914A (fr)
PL (1) PL358280A1 (fr)
PT (1) PT1265900E (fr)
TW (1) TWI290926B (fr)
WO (1) WO2001064679A1 (fr)
ZA (1) ZA200207017B (fr)

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DE69939168D1 (de) 1998-05-26 2008-09-04 Warner Lambert Co Bicyclische pyrimidine und bicyclische 3,4-dihydropyrimidine als inhibitoren der zellvermehrung
DK1333833T3 (da) * 2000-10-23 2011-12-12 Glaxosmithkline Llc Ny trisubstitueret 8H-pyridol[2,3-d]pyrimidin-7-on-forbindelse til behandling af CSBP/RK/p38-kinnasemedierede sygdomme
EP1345603A4 (fr) 2000-12-20 2004-09-08 Merck & Co Inc Agents inhibiteurs de p38 kinase (halo-benzo carbonyl)heterocyclo- fusionnes phenyl
GB0124848D0 (en) 2001-10-16 2001-12-05 Celltech R&D Ltd Chemical compounds
DK1474395T3 (da) 2002-02-12 2008-02-11 Smithkline Beecham Corp Nicotinamidderivater, der er nyttige som p38-inhibitorer
JP4359146B2 (ja) * 2002-02-13 2009-11-04 エフ．ホフマン−ラ ロシュ アーゲー 新規なピリジン−およびピリミジン−誘導体
CA2482022A1 (fr) * 2002-04-19 2003-10-30 Smithkline Beecham Corporation Nouveaux composes
GB0214268D0 (en) * 2002-06-20 2002-07-31 Celltech R&D Ltd Chemical compounds
PA8577501A1 (es) 2002-07-25 2004-02-07 Warner Lambert Co Inhibidores de quinasas
GB0218800D0 (en) * 2002-08-13 2002-09-18 Celltech R&D Ltd Chemical compounds
US7084270B2 (en) 2002-08-14 2006-08-01 Hoffman-La Roche Inc. Pyrimido compounds having antiproliferative activity
AU2003262911A1 (en) 2002-08-29 2004-03-19 Scios Inc. Methods of promoting osteogenesis
US7112676B2 (en) 2002-11-04 2006-09-26 Hoffmann-La Roche Inc. Pyrimido compounds having antiproliferative activity
US7384937B2 (en) 2002-11-06 2008-06-10 Bristol-Myers Squibb Co. Fused heterocyclic compounds and use thereof
US7098332B2 (en) 2002-12-20 2006-08-29 Hoffmann-La Roche Inc. 5,8-Dihydro-6H-pyrido[2,3-d]pyrimidin-7-ones
CA2521124A1 (fr) 2003-04-10 2004-10-21 F. Hoffmann-La Roche Ag Composes pyrimido
WO2005030091A2 (fr) 2003-09-25 2005-04-07 Scios Inc. Stents et protheses intra-luminales contenant des inhibiteurs de kinase map
PT1699800E (pt) * 2003-12-23 2010-04-12 Novartis Ag Inibidores de quinase p-38 heterocíclicos bicíclicos
AU2005316668B2 (en) * 2004-12-13 2012-09-06 Millennium Pharmaceuticals, Inc. Pyrido pyrimidinones, dihydro pyrimido pyrimidinones and pteridinones useful as RAF kinase inhibitors
EP1676574A3 (fr) 2004-12-30 2006-07-26 Johnson & Johnson Vision Care, Inc. Procédé favorisant la survie des tissus ou cellules griffées
JP5201817B2 (ja) * 2005-10-28 2013-06-05 大塚製薬株式会社 医薬組成物
JP2009542818A (ja) * 2006-06-16 2009-12-03 グラクソ グループ リミテッド 新規化合物
JP2009542817A (ja) * 2006-06-16 2009-12-03 グラクソ グループ リミテッド 新規化合物
KR101040394B1 (ko) * 2010-05-18 2011-06-09 (주)이성산업 역화 방지 기능을 갖는 야외용 가스 히터
CN102816162B (zh) * 2011-06-10 2016-04-27 中国科学院广州生物医药与健康研究院 嘧啶并嘧啶酮类化合物及其药用组合物和应用
BR112015022191A8 (pt) 2013-03-15 2018-01-23 Celgene Avilomics Res Inc compostos heteroarila e usos dos mesmos
US9321786B2 (en) 2013-03-15 2016-04-26 Celgene Avilomics Research, Inc. Heteroaryl compounds and uses thereof
MY181020A (en) 2013-03-15 2020-12-16 Sanofi Sa Heteroaryl compounds and uses thereof
RU2663999C2 (ru) * 2013-10-16 2018-08-14 Шанхай Инли Фармасьютикал Ко., Лтд Конденсированное гетероциклическое соединение, способ его получения, его фармацевтическая композиция и применения
US20190060286A1 (en) 2016-02-29 2019-02-28 University Of Florida Research Foundation, Incorpo Chemotherapeutic Methods
US10342786B2 (en) 2017-10-05 2019-07-09 Fulcrum Therapeutics, Inc. P38 kinase inhibitors reduce DUX4 and downstream gene expression for the treatment of FSHD
WO2019071147A1 (fr) 2017-10-05 2019-04-11 Fulcrum Therapeutics, Inc. Inhibiteurs de la kinase p38 réduisant l'expression du gène dux4 et des gènes aval pour le traitement de la fshd
IL312076A (en) 2021-10-20 2024-06-01 Insilico Medicine Ip Ltd Methionine adenosyltransferase 2A inhibitors and their uses

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JPS60226882A (ja) * 1984-04-24 1985-11-12 Nippon Zoki Pharmaceut Co Ltd 新規ピリミドピリミジン誘導体
ES2191183T3 (es) * 1996-08-06 2003-09-01 Pfizer Derivados 6,6- o 6,7-biciclicos que contienen pirido o pirimido sustituidos.
DE69939168D1 (de) * 1998-05-26 2008-09-04 Warner Lambert Co Bicyclische pyrimidine und bicyclische 3,4-dihydropyrimidine als inhibitoren der zellvermehrung
EP1086085A1 (fr) * 1998-06-12 2001-03-28 Vertex Pharmaceuticals Incorporated INHIBITEURS DE p38
JP3593035B2 (ja) * 1998-10-23 2004-11-24 エフ．ホフマン−ラ ロシュ アーゲー 二環式窒素複素環化合物

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MXPA02008588A (es) 2003-02-24
IL189865A0 (en) 2008-08-07
MY141144A (en) 2010-03-15
NZ520914A (en) 2004-03-26
EP1265900A1 (fr) 2002-12-18
CN1422273A (zh) 2003-06-04
NO20024134L (no) 2002-10-24
WO2001064679A1 (fr) 2001-09-07
HUP0204431A1 (hu) 2003-04-28
EP1265900B1 (fr) 2007-05-16
CY1106816T1 (el) 2012-01-25
PL358280A1 (en) 2004-08-09
ES2287107T3 (es) 2007-12-16
EP1265900A4 (fr) 2004-11-10
CA2402092A1 (fr) 2001-09-07
BR0108715A (pt) 2004-04-27
AR030053A1 (es) 2003-08-13
IL151426A (en) 2011-01-31
ATE362473T1 (de) 2007-06-15
KR100806978B1 (ko) 2008-02-25
CN100482664C (zh) 2009-04-29
CZ20022933A3 (cs) 2003-02-12
NO326409B1 (no) 2008-12-01
DE60128457T2 (de) 2008-01-17
DK1265900T3 (da) 2007-09-24
NO20024134D0 (no) 2002-08-30
TWI290926B (en) 2007-12-11
HUP0204431A3 (en) 2006-01-30
ZA200207017B (en) 2004-02-26
AR040075A2 (es) 2005-03-16
JP2003525295A (ja) 2003-08-26
KR20020082858A (ko) 2002-10-31
AU3999201A (en) 2001-09-12
IL151426A0 (en) 2003-04-10
PT1265900E (pt) 2007-08-22
CA2402092C (fr) 2012-01-24
DE60128457D1 (de) 2007-06-28
AU2001239992B2 (en) 2005-09-01

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