HK1049159B - 新的茚並吲哚酮化合物，其製備方法和含有這種化合物的藥物組合物 - Google Patents

新的茚並吲哚酮化合物，其製備方法和含有這種化合物的藥物組合物 Download PDF

Info

Publication number
HK1049159B
HK1049159B HK03101148.6A HK03101148A HK1049159B HK 1049159 B HK1049159 B HK 1049159B HK 03101148 A HK03101148 A HK 03101148A HK 1049159 B HK1049159 B HK 1049159B
Authority
HK
Hong Kong
Prior art keywords
formula
compound
indol
group
indeno
Prior art date
Application number
HK03101148.6A
Other languages
English (en)
Chinese (zh)
Other versions
HK1049159A1 (en
Inventor
M‧维尔兹比奇
M‧維爾兹比奇
M-F‧伯萨德
A‧罗西奥
M-F‧伯薩德
J-A‧保廷
P‧德拉格朗吉
A‧羅西奧
Original Assignee
瑟维尔实验室
瑟維爾實驗室
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 瑟维尔实验室, 瑟維爾實驗室 filed Critical 瑟维尔实验室
Publication of HK1049159A1 publication Critical patent/HK1049159A1/xx
Publication of HK1049159B publication Critical patent/HK1049159B/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Reproductive Health (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychology (AREA)
  • Anesthesiology (AREA)
  • Emergency Medicine (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Child & Adolescent Psychology (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
HK03101148.6A 2001-03-19 2003-02-18 新的茚並吲哚酮化合物，其製備方法和含有這種化合物的藥物組合物 HK1049159B (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0103667 2001-03-19
FR0103667A FR2822153B1 (fr) 2001-03-19 2001-03-19 Nouveaux derives d'indenoindolones, leur procede de preparation et les compositions pharmaceutiques qui les contiennent

Publications (2)

Publication Number Publication Date
HK1049159A1 HK1049159A1 (en) 2003-05-02
HK1049159B true HK1049159B (zh) 2005-07-29

Family

ID=8861264

Family Applications (1)

Application Number Title Priority Date Filing Date
HK03101148.6A HK1049159B (zh) 2001-03-19 2003-02-18 新的茚並吲哚酮化合物，其製備方法和含有這種化合物的藥物組合物

Country Status (24)

Country Link
US (1) US6844445B2 (enExample)
EP (1) EP1245565B1 (enExample)
JP (1) JP3886829B2 (enExample)
KR (1) KR100453979B1 (enExample)
CN (1) CN1185214C (enExample)
AR (1) AR034861A1 (enExample)
AT (1) ATE250578T1 (enExample)
AU (1) AU780027B2 (enExample)
BR (1) BR0200871A (enExample)
CA (1) CA2378628C (enExample)
DE (1) DE60200041T2 (enExample)
DK (1) DK1245565T3 (enExample)
EA (1) EA004711B1 (enExample)
ES (1) ES2207629T3 (enExample)
FR (1) FR2822153B1 (enExample)
HK (1) HK1049159B (enExample)
HU (1) HU226674B1 (enExample)
MX (1) MXPA02002816A (enExample)
NO (1) NO321890B1 (enExample)
NZ (1) NZ517855A (enExample)
PL (1) PL352866A1 (enExample)
PT (1) PT1245565E (enExample)
SI (1) SI1245565T1 (enExample)
ZA (1) ZA200202220B (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102006047231B4 (de) * 2006-10-04 2009-02-12 Hemmerling, Hans-Jörg, Dr. Substituierte Indeno[1,2-b]indolderivate als neue Hemmstoffe der Protein Kinase CK2 und ihre Verwendung als Tumor Therapeutika, Cytostatika und Diagnostika
ES2580702B1 (es) 2015-02-25 2017-06-08 Palobiofarma, S.L. Derivados de 2-aminopiridina como antagonistas del receptor A2b de adenosina y ligandos del receptor MT3 de melatonina
SG11202002032SA (en) 2017-09-22 2020-04-29 Jubilant Epipad LLC Heterocyclic compounds as pad inhibitors
CN111225915B (zh) 2017-10-18 2023-03-07 朱比兰特埃皮帕德有限公司 作为pad抑制剂的咪唑并吡啶化合物
AU2018362046B2 (en) 2017-11-06 2023-04-13 Jubilant Prodel LLC Pyrimidine derivatives as inhibitors of PD1/PD-L1 activation
AU2018372211B2 (en) 2017-11-24 2023-02-02 Jubilant Episcribe LLC, Heterocyclic compounds as PRMT5 inhibitors
CA3093527A1 (en) 2018-03-13 2019-09-19 Jubilant Prodel LLC Bicyclic compounds as inhibitors of pd1/pd-l1 interaction/activation

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
YU166291A (sh) * 1990-10-16 1994-04-05 University Of Bath Claverton Down Indenoindol jedinjenja

Also Published As

Publication number Publication date
EP1245565A1 (fr) 2002-10-02
PL352866A1 (en) 2002-09-23
CA2378628C (fr) 2007-07-10
SI1245565T1 (en) 2003-12-31
NO20021330D0 (no) 2002-03-18
KR100453979B1 (ko) 2004-10-20
PT1245565E (pt) 2003-12-31
HU226674B1 (en) 2009-06-29
MXPA02002816A (es) 2004-11-12
AU780027B2 (en) 2005-02-24
KR20020074420A (ko) 2002-09-30
US6844445B2 (en) 2005-01-18
NO20021330L (no) 2002-09-20
DK1245565T3 (da) 2004-01-12
US20020173531A1 (en) 2002-11-21
EA200200263A2 (ru) 2002-10-31
EP1245565B1 (fr) 2003-09-24
JP3886829B2 (ja) 2007-02-28
CN1375490A (zh) 2002-10-23
HU0201024D0 (enExample) 2002-05-29
NO321890B1 (no) 2006-07-17
ES2207629T3 (es) 2004-06-01
DE60200041T2 (de) 2004-06-09
EA004711B1 (ru) 2004-06-24
EA200200263A3 (ru) 2002-12-26
FR2822153B1 (fr) 2003-10-31
AU2746902A (en) 2002-09-26
CA2378628A1 (fr) 2002-09-19
FR2822153A1 (fr) 2002-09-20
DE60200041D1 (de) 2003-10-30
AR034861A1 (es) 2004-03-24
CN1185214C (zh) 2005-01-19
BR0200871A (pt) 2003-01-07
JP2002322150A (ja) 2002-11-08
ZA200202220B (en) 2002-10-10
NZ517855A (en) 2002-10-25
HUP0201024A2 (hu) 2002-11-28
ATE250578T1 (de) 2003-10-15
HK1049159A1 (en) 2003-05-02
HUP0201024A3 (en) 2003-12-29

Similar Documents

Publication Publication Date Title
CN1118451C (zh) 褪黑激素的酰化衍生物及其作为药物的类似物
CN1097054C (zh) 三环类吡唑衍生物及其组合物
CN101041629A (zh) 阿戈美拉汀的新合成方法、新晶型及其药物组合物
CN85101761A (zh) 新型色胺衍生物的制备方法和应用
CN1105360A (zh) 1-[2h-1-苯并吡喃-2-酮-8-基]-哌嗪衍生物
HK1049159A1 (en) New indenoindolone compounds, a process for their preparation and pharmaceutical compositions containing them
CN1159316C (zh) 异吲哚并吲哚酮化合物、它们的制备方法和含有它们的药物组合物
CN1139588C (zh) 新的氟化咪唑啉苯并二噁烷,其制备及其治疗用途
CN1809574A (zh) 喹啉3－氨基苯并二氢吡喃衍生物
CN1050358C (zh) 新四环哌嗪和1,4-噁嗪化合物,其制备和药物组合物
CN1254476C (zh) 二氢咪唑并[5,1－a]－β－咔啉衍生物,其制备方法和作为药物的用途
CN1671708A (zh) 新的环烷二酮衍生物、它们的制备方法和它们的药物应用
HK1071896A (en) 2-(aminomethyl)-tetrahydro-9-oxa-1,3-diaza-cyclopenta[a]naphthalenyl derivatives with antipsychotic activity
CN1555376A (zh) 具有抗精神病药活性的2-(氨甲基)-四氢-9-氧杂-1,3-二氮杂-环戊二烯并[a]萘基衍生物
HK1072423A (en) 2-(aminomethyl)-tetrahydro-9-oxa-1,3-diaza-cyclopenta[a]naphthalenyl derivatives with antipsychotic activity
HK1083507A (en) Novel derivatives of cycloalcanodiones, method for the production thereof and their pharmacological applications
HK1016987B (en) Chromene compounds a process for their preparation and pharmaceutical compositions containing them
HK1034710A (en) Benzylpiperazinyl-and benzylpiperidinyl ethanone derivatives, their preparation and their use as dopamine d4 receptor antagonists
HK1016987A1 (en) Chromene compounds a process for their preparation and pharmaceutical compositions containing them
HK1031727A (en) 1-(2-naphthyl) and 1-(2-azanaphthyl)-4-(1-phenylmethyl) piperazines being dopamine d4 receptor subtype ligands

Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20100318