HK1047290A1 - Kahalalide f and related compounds - Google Patents

Kahalalide f and related compounds

Info

Publication number
HK1047290A1
HK1047290A1 HK02108862A HK02108862A HK1047290A1 HK 1047290 A1 HK1047290 A1 HK 1047290A1 HK 02108862 A HK02108862 A HK 02108862A HK 02108862 A HK02108862 A HK 02108862A HK 1047290 A1 HK1047290 A1 HK 1047290A1
Authority
HK
Hong Kong
Prior art keywords
kahalalide
related compounds
leads
preparing
biological activity
Prior art date
Application number
HK02108862A
Other languages
English (en)
Inventor
Fernando Albericio
Ernest Giralt
Jose Carlos Jimenez
Angel Lopez
Ignacio Manzanares
Ignacio Rodrigues
Miriam Royo
Original Assignee
Pharma Mar Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharma Mar Sa filed Critical Pharma Mar Sa
Publication of HK1047290A1 publication Critical patent/HK1047290A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K11/00—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Optical Record Carriers And Manufacture Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Silver Salt Photography Or Processing Solution Therefor (AREA)
  • Detergent Compositions (AREA)
  • Steroid Compounds (AREA)
HK02108862A 2000-02-09 2002-12-05 Kahalalide f and related compounds HK1047290A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0002952.0A GB0002952D0 (en) 2000-02-09 2000-02-09 Process for producing kahalalide F compounds
PCT/GB2001/000576 WO2001058934A2 (en) 2000-02-09 2001-02-09 Kahalalide f and related compounds

Publications (1)

Publication Number Publication Date
HK1047290A1 true HK1047290A1 (en) 2003-02-14

Family

ID=9885232

Family Applications (1)

Application Number Title Priority Date Filing Date
HK02108862A HK1047290A1 (en) 2000-02-09 2002-12-05 Kahalalide f and related compounds

Country Status (28)

Country Link
US (2) US7482429B2 (pt)
EP (3) EP1254162B1 (pt)
JP (1) JP5188665B2 (pt)
KR (1) KR100871489B1 (pt)
CN (2) CN101597326B (pt)
AT (1) ATE371667T1 (pt)
AU (1) AU783542B2 (pt)
BG (1) BG65926B1 (pt)
BR (1) BR0108213A (pt)
CA (1) CA2399187C (pt)
CY (1) CY1106992T1 (pt)
CZ (1) CZ304258B6 (pt)
DE (1) DE60130192T2 (pt)
DK (1) DK1254162T3 (pt)
ES (1) ES2292558T3 (pt)
GB (1) GB0002952D0 (pt)
HK (1) HK1047290A1 (pt)
HU (1) HUP0301817A3 (pt)
IL (2) IL150981A0 (pt)
MX (1) MXPA02007760A (pt)
NO (1) NO331847B1 (pt)
NZ (1) NZ520488A (pt)
PL (1) PL207121B1 (pt)
PT (1) PT1254162E (pt)
RU (1) RU2280039C2 (pt)
SK (1) SK11242002A3 (pt)
UA (1) UA76949C2 (pt)
WO (1) WO2001058934A2 (pt)

Families Citing this family (24)

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US6274551B1 (en) * 1994-02-03 2001-08-14 Pharmamar, S.A. Cytotoxic and antiviral compound
GB0002952D0 (en) * 2000-02-09 2000-03-29 Pharma Mar Sa Process for producing kahalalide F compounds
ATE314084T1 (de) 2000-10-31 2006-01-15 Pharma Mar Sa Kahalalid f formulierung
US20050054555A1 (en) * 2001-10-19 2005-03-10 Jose Jimeno Kahalalide compounds for use in cancer therapy
GB0304367D0 (en) * 2003-02-26 2003-04-02 Pharma Mar Sau Methods for treating psoriasis
US7507708B2 (en) 2003-02-26 2009-03-24 Pharma Mar, S.A.U. Antitumoral compounds
GB0321066D0 (en) 2003-09-09 2003-10-08 Pharma Mar Sau New antitumoral compounds
GB0408958D0 (en) * 2004-04-22 2004-05-26 Pharma Mar Sa Convergent synthesis for kahalalide compounds
CN100396696C (zh) * 2004-04-23 2008-06-25 中国科学院海洋研究所 一种海洋绿藻在提取抗肿瘤活性环肽组分中的应用
NZ584695A (en) * 2007-10-19 2011-06-30 Pharma Mar Sa Improved antitumoral treatments using PM02734 and an EGFR tyrosine kinase inhibitor (erlotinib)
EP2252315A1 (en) * 2008-01-30 2010-11-24 Pharma Mar, S.A. Improved antitumoral treatments
CA2717117A1 (en) * 2008-03-07 2009-09-11 Pharma Mar, S.A. Improved antitumoral treatments
CN103641891B (zh) * 2013-05-23 2017-03-22 深圳翰宇药业股份有限公司 一种制备Kahalalide F的方法
ES2930848T3 (es) * 2015-09-23 2022-12-22 Xwpharma Ltd Profármacos de ácido gamma-hidroxibutírico, composiciones y usos de los mismos
AU2017406159B2 (en) 2017-03-30 2020-05-21 XWPharma Ltd. Bicyclic heteroaryl derivatives and preparation and uses thereof
JOP20190254A1 (ar) 2017-04-27 2019-10-27 Pharma Mar Sa مركبات مضادة للأورام
EP3856719B1 (en) 2018-09-30 2023-06-07 XWPharma Ltd. Compounds as neuronal histamine receptor-3 antagonists and uses thereof
CN115244028A (zh) 2019-12-20 2022-10-25 凯瑞康宁生物工程有限公司 4-缬氨酰氧基丁酸的合成方法
CA3182394A1 (en) 2020-06-18 2021-12-23 Sami Karaborni Controlled release granulations of water-soluble active pharmaceutical ingredients
KR20230008190A (ko) 2020-06-18 2023-01-13 엑스더블유파마 리미티드 수용성 원료의약품의 약학적 과립화제
WO2022020621A1 (en) 2020-07-24 2022-01-27 XWPharma Ltd. Pharmaceutical compositions and pharmacokinetics of a gamma-hydroxybutyric acid derivative
JP2023544420A (ja) 2020-10-05 2023-10-23 エックスダブリューファーマ リミテッド ガンマ－ヒドロキシ酪酸誘導体の調節放出組成物
JP2024511991A (ja) 2021-03-19 2024-03-18 エックスダブリューファーマ リミテッド ガンマ－ヒドロキシ酪酸誘導体の組み合わされた放出製剤の薬物動態
WO2023205245A1 (en) * 2022-04-21 2023-10-26 Zevra Therapeutics, Inc. Gamma-hydroxybutyrate delivering compounds and processes for making and using them

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CU22545A1 (es) * 1994-11-18 1999-03-31 Centro Inmunologia Molecular Obtención de un anticuerpo quimérico y humanizado contra el receptor del factor de crecimiento epidérmico para uso diagnóstico y terapéutico
US4943533A (en) * 1984-03-01 1990-07-24 The Regents Of The University Of California Hybrid cell lines that produce monoclonal antibodies to epidermal growth factor receptor
JPS6178719A (ja) * 1984-09-25 1986-04-22 Tanabe Seiyaku Co Ltd 総合輸液剤
GR870129B (en) * 1987-01-27 1987-02-04 Giatzidis Ippokratis Stable bicarbonate - glycylglycine dialysate for hemodialysis and peritoneal dialysis
US5399363A (en) * 1991-01-25 1995-03-21 Eastman Kodak Company Surface modified anticancer nanoparticles
CZ282603B6 (cs) * 1991-03-06 1997-08-13 Merck Patent Gesellschaft Mit Beschränkter Haftun G Humanizované a chimerické monoklonální protilátky
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GB9302046D0 (en) * 1993-02-03 1993-03-24 Pharma Mar Sa Antiumoral compound-v
US6274551B1 (en) * 1994-02-03 2001-08-14 Pharmamar, S.A. Cytotoxic and antiviral compound
US5932189A (en) * 1994-07-29 1999-08-03 Diatech, Inc. Cyclic peptide somatostatin analogs
US5705511A (en) * 1994-10-14 1998-01-06 Cephalon, Inc. Fused pyrrolocarbazoles
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US5747498A (en) * 1996-05-28 1998-05-05 Pfizer Inc. Alkynyl and azido-substituted 4-anilinoquinazolines
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DK0912559T3 (da) * 1996-07-13 2003-03-10 Glaxo Group Ltd Kondenserede heterocykliske forbindelser som proteintyrosinkinaseinhibitorer
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US7311924B2 (en) * 1999-04-01 2007-12-25 Hana Biosciences, Inc. Compositions and methods for treating cancer
UA74803C2 (uk) * 1999-11-11 2006-02-15 Осі Фармасьютікалз, Інк. Стійкий поліморф гідрохлориду n-(3-етинілфеніл)-6,7-біс(2-метоксіетокси)-4-хіназолінаміну, спосіб його одержання (варіанти) та фармацевтичне застосування
GB0002952D0 (en) * 2000-02-09 2000-03-29 Pharma Mar Sa Process for producing kahalalide F compounds
AU2001255575B2 (en) * 2000-04-28 2006-08-31 The Trustees Of The University Of Pennsylvania Recombinant aav vectors with aav5 capsids and aav5 vectors pseudotyped in heterologous capsids
US6440465B1 (en) * 2000-05-01 2002-08-27 Bioderm, Inc. Topical composition for the treatment of psoriasis and related skin disorders
ATE314084T1 (de) 2000-10-31 2006-01-15 Pharma Mar Sa Kahalalid f formulierung
US20050054555A1 (en) 2001-10-19 2005-03-10 Jose Jimeno Kahalalide compounds for use in cancer therapy
GB0304367D0 (en) * 2003-02-26 2003-04-02 Pharma Mar Sau Methods for treating psoriasis
US7507708B2 (en) * 2003-02-26 2009-03-24 Pharma Mar, S.A.U. Antitumoral compounds
GB0321066D0 (en) * 2003-09-09 2003-10-08 Pharma Mar Sau New antitumoral compounds
GB0408958D0 (en) * 2004-04-22 2004-05-26 Pharma Mar Sa Convergent synthesis for kahalalide compounds

Also Published As

Publication number Publication date
EP2258715A1 (en) 2010-12-08
UA76949C2 (en) 2006-10-16
NO20023749L (no) 2002-10-07
ES2292558T3 (es) 2008-03-16
NZ520488A (en) 2005-03-24
CZ304258B6 (cs) 2014-02-05
WO2001058934A2 (en) 2001-08-16
DE60130192T2 (de) 2008-05-21
PT1254162E (pt) 2007-12-03
KR20020092951A (ko) 2002-12-12
AU783542B2 (en) 2005-11-10
EP1254162B1 (en) 2007-08-29
NO331847B1 (no) 2012-04-23
AU3208601A (en) 2001-08-20
RU2280039C2 (ru) 2006-07-20
PL207121B1 (pl) 2010-11-30
CN101597326B (zh) 2014-07-09
WO2001058934A3 (en) 2002-03-21
DK1254162T3 (da) 2008-01-02
HUP0301817A3 (en) 2011-10-28
JP5188665B2 (ja) 2013-04-24
PL356800A1 (en) 2004-07-12
IL150981A (en) 2013-05-30
BG65926B1 (bg) 2010-05-31
US20080318849A1 (en) 2008-12-25
SK11242002A3 (sk) 2003-06-03
ATE371667T1 (de) 2007-09-15
CN101597326A (zh) 2009-12-09
CZ20022740A3 (cs) 2003-01-15
US20040214755A1 (en) 2004-10-28
IL150981A0 (en) 2003-02-12
MXPA02007760A (es) 2002-10-23
JP2003522198A (ja) 2003-07-22
KR100871489B1 (ko) 2008-12-05
EP1829889A3 (en) 2007-09-26
EP1829889A2 (en) 2007-09-05
HUP0301817A2 (hu) 2003-09-29
CN1422278A (zh) 2003-06-04
NO20023749D0 (no) 2002-08-08
BG107020A (bg) 2003-05-30
DE60130192D1 (de) 2007-10-11
EP1254162A2 (en) 2002-11-06
GB0002952D0 (en) 2000-03-29
US7482429B2 (en) 2009-01-27
RU2002123877A (ru) 2004-01-10
CY1106992T1 (el) 2012-09-26
CA2399187A1 (en) 2001-08-16
BR0108213A (pt) 2003-03-05
CA2399187C (en) 2011-04-19

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Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20150209