HK1035490A1 - Targeted liposome gene delivery. - Google Patents

Targeted liposome gene delivery.

Info

Publication number
HK1035490A1
HK1035490A1 HK01106017A HK01106017A HK1035490A1 HK 1035490 A1 HK1035490 A1 HK 1035490A1 HK 01106017 A HK01106017 A HK 01106017A HK 01106017 A HK01106017 A HK 01106017A HK 1035490 A1 HK1035490 A1 HK 1035490A1
Authority
HK
Hong Kong
Prior art keywords
gene delivery
targeted liposome
liposome gene
virus
targeted
Prior art date
Application number
HK01106017A
Other languages
English (en)
Inventor
Esther H Chang
Liang Xu
Kathleen Pirollo
Original Assignee
Univ Georgetown
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Georgetown filed Critical Univ Georgetown
Publication of HK1035490A1 publication Critical patent/HK1035490A1/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
    • A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers with substantial amounts of non-phosphatidyl, i.e. non-acylglycerophosphate, surfactants as bilayer-forming substances, e.g. cationic lipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/0008—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition
    • A61K48/0025—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'non-active' part of the composition delivered, e.g. wherein such 'non-active' part is not delivered simultaneously with the 'active' part of the composition wherein the non-active part clearly interacts with the delivered nucleic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/88—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using amphiphile liposome vesicle
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biotechnology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
HK01106017A 1997-11-19 2001-08-27 Targeted liposome gene delivery. HK1035490A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US6618897P 1997-11-19 1997-11-19
US8317598P 1998-04-27 1998-04-27
PCT/US1998/024657 WO1999025320A1 (fr) 1997-11-19 1998-11-19 Apport cible de gene dans un liposome vecteur

Publications (1)

Publication Number Publication Date
HK1035490A1 true HK1035490A1 (en) 2001-11-30

Family

ID=26746455

Family Applications (3)

Application Number Title Priority Date Filing Date
HK01106017A HK1035490A1 (en) 1997-11-19 2001-08-27 Targeted liposome gene delivery.
HK02104922.3A HK1045641B (zh) 1997-11-19 2002-07-02 指定脂質體遺傳因子傳送
HK05110310.7A HK1078608A1 (en) 1997-11-19 2005-11-17 Targeted liposome gene delivery

Family Applications After (2)

Application Number Title Priority Date Filing Date
HK02104922.3A HK1045641B (zh) 1997-11-19 2002-07-02 指定脂質體遺傳因子傳送
HK05110310.7A HK1078608A1 (en) 1997-11-19 2005-11-17 Targeted liposome gene delivery

Country Status (12)

Country Link
EP (2) EP1166775B1 (fr)
JP (2) JP2001522871A (fr)
CN (3) CN1616665B (fr)
AT (2) ATE295722T1 (fr)
AU (1) AU759164C (fr)
CA (1) CA2308584C (fr)
DE (2) DE69830249T2 (fr)
DK (1) DK1166775T3 (fr)
ES (1) ES2339421T3 (fr)
HK (3) HK1035490A1 (fr)
PT (1) PT1166775E (fr)
WO (1) WO1999025320A1 (fr)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8617514B2 (en) 1999-02-22 2013-12-31 Georgetown University Tumor-targeted nanodelivery systems to improve early MRI detection of cancer
US7780882B2 (en) 1999-02-22 2010-08-24 Georgetown University Simplified and improved method for preparing an antibody or an antibody fragment targeted immunoliposome for systemic administration of a therapeutic or diagnostic agent
US9034329B2 (en) 1999-02-22 2015-05-19 Georgetown University Preparation of antibody or an antibody fragment-targeted immunoliposomes for systemic administration of therapeutic or diagnostic agents and uses thereof
ATE350012T1 (de) 1999-02-22 2007-01-15 Univ Georgetown Immunoliposome mit einem targeting- antikörperfragment zur systemischen genverabreichung
US7109165B2 (en) * 2001-05-18 2006-09-19 Sirna Therapeutics, Inc. Conjugates and compositions for cellular delivery
WO2004066908A2 (fr) * 2003-01-17 2004-08-12 Sanofi Pasteur Composition comprenant lipides cationiques et un polynucleotide ou un polpeptide et methode pour leur delivrance ciblee
CA2513769A1 (fr) * 2003-01-28 2004-08-12 Georgetown University Procede pour l'evaluation de l'efficacite de certains traitements du cancer
CN1327899C (zh) * 2003-05-10 2007-07-25 彭朝晖 腺病毒载体与p53基因的基因重组体的应用
JP4987474B2 (ja) * 2003-06-04 2012-07-25 ジョージタウン・ユニバーシティ リポソーム複合体の安定性および使用期限を改良するための方法
US8627821B2 (en) 2005-01-10 2014-01-14 Pulmatrix, Inc. Method and device for decreasing contamination
WO2007061141A1 (fr) * 2005-11-24 2007-05-31 Genomidea, Inc. Paramyxovirus mutant et procede pour la production de celui-ci
WO2007142781A1 (fr) 2006-05-15 2007-12-13 Georgetown University Préparation d'immunoliposomes ciblés sur un anticorps ou sur des fragments d'anticorps, destinée à une administration systémique d'agents thérapeutiques ou diagnostiques et utilisations
CN102133404B (zh) * 2011-03-23 2013-01-16 成都诺恩生物科技有限公司 一种肿瘤靶向治疗药物载体、其制备方法及其应用
RU2014130080A (ru) 2011-12-22 2016-02-10 Нуво Рисерч Гмбх Липосомальные композиции хлоритов или хлоратов
EP2711000B1 (fr) 2012-09-19 2019-04-03 Georgetown University Liposomes ciblés
US20140120157A1 (en) 2012-09-19 2014-05-01 Georgetown University Targeted liposomes
CA2901616A1 (fr) 2013-03-14 2014-10-02 Georgetown University Traitement apres l'exposition a un agent neurotoxique
BR112018007173B1 (pt) 2015-10-08 2021-02-02 Technion Research & Development Foundation Ltd composição compreendendo àcidos nucléicos ou proteínas p53 de elefante e uso da composição para inibir câncer
JP2020500020A (ja) 2016-11-14 2020-01-09 ノバルティス アーゲー 融合誘導性タンパク質ｍｉｎｉｏｎに関連する組成物、方法、および治療上の使用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5635380A (en) * 1994-01-18 1997-06-03 Vanderbilt University Enhancement of nucleic acid transfer by coupling virus to nucleic acid via lipids
US5928944A (en) * 1994-02-04 1999-07-27 The United States Of America As Represented By The Department Of Health And Human Services Method of adenoviral-medicated cell transfection
MX9701860A (es) * 1994-09-13 1997-06-28 Theratech Inc Suministro intracelular de agentes quimicos, a un tipo especifico de celula.
US20020051767A1 (en) * 1995-09-13 2002-05-02 Yawen L. Chiang Cancer treatment
JPH09110722A (ja) * 1995-10-20 1997-04-28 Toray Ind Inc 抗腫瘍活性物質の腫瘍細胞内導入用イムノリポソーム及びその調製法
DE69736385T2 (de) * 1996-02-09 2007-08-23 Pi-Wan Cheng Kationisches lipid und rezeptorligand erleichterte gabe von biologisch aktiven molekuelen
JP3956402B2 (ja) * 1996-03-04 2007-08-08 日本油脂株式会社 アンホテリシンｂ運搬体

Also Published As

Publication number Publication date
EP1166775A2 (fr) 2002-01-02
AU759164C (en) 2007-03-29
CA2308584C (fr) 2011-07-19
EP1166775B1 (fr) 2010-03-03
HK1045641A1 (en) 2002-12-06
JP2001522871A (ja) 2001-11-20
ATE459340T1 (de) 2010-03-15
CN1191094C (zh) 2005-03-02
CN1286630A (zh) 2001-03-07
WO1999025320A1 (fr) 1999-05-27
EP1032369A1 (fr) 2000-09-06
AU759164B2 (en) 2003-04-10
CN1616665B (zh) 2010-10-06
DE69830249D1 (de) 2005-06-23
DE69830249T2 (de) 2006-05-04
EP1032369B1 (fr) 2005-05-18
ATE295722T1 (de) 2005-06-15
AU1464299A (en) 1999-06-07
CN1616665A (zh) 2005-05-18
ES2339421T3 (es) 2010-05-20
PT1166775E (pt) 2010-04-16
EP1166775A3 (fr) 2003-06-25
JP2010263920A (ja) 2010-11-25
DK1166775T3 (da) 2010-05-03
HK1045641B (zh) 2010-10-29
CA2308584A1 (fr) 1999-05-27
CN1904055A (zh) 2007-01-31
HK1078608A1 (en) 2006-03-17
DE69841536D1 (de) 2010-04-15

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Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20171119