HK1035368A1 - Prodrugs of proton pump inhibitors - Google Patents

Prodrugs of proton pump inhibitors

Info

Publication number
HK1035368A1
HK1035368A1 HK01105985A HK01105985A HK1035368A1 HK 1035368 A1 HK1035368 A1 HK 1035368A1 HK 01105985 A HK01105985 A HK 01105985A HK 01105985 A HK01105985 A HK 01105985A HK 1035368 A1 HK1035368 A1 HK 1035368A1
Authority
HK
Hong Kong
Prior art keywords
proton pump
prodrugs
pump inhibitor
drugs
inhibitor drugs
Prior art date
Application number
HK01105985A
Other languages
English (en)
Inventor
Michael E Garst
George Sachs
Jai Moo Shin
Original Assignee
Univ California
U S Government Represented By
Winston Pharmaceuticals Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/131,481 external-priority patent/US6093734A/en
Application filed by Univ California, U S Government Represented By, Winston Pharmaceuticals Llc filed Critical Univ California
Publication of HK1035368A1 publication Critical patent/HK1035368A1/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D235/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/28Sulfur atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65583Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Steroid Compounds (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyridine Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Reciprocating Pumps (AREA)
  • Fertilizing (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
HK01105985A 1998-08-10 2001-08-24 Prodrugs of proton pump inhibitors HK1035368A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US09/131,481 US6093734A (en) 1998-08-10 1998-08-10 Prodrugs of proton pump inhibitors
US36438199A 1999-07-29 1999-07-29
PCT/US1999/018048 WO2000009498A1 (fr) 1998-08-10 1999-08-09 Promedicaments d'inhibiteurs de la pompe a protons

Publications (1)

Publication Number Publication Date
HK1035368A1 true HK1035368A1 (en) 2001-11-23

Family

ID=26829517

Family Applications (1)

Application Number Title Priority Date Filing Date
HK01105985A HK1035368A1 (en) 1998-08-10 2001-08-24 Prodrugs of proton pump inhibitors

Country Status (28)

Country Link
US (1) US6559167B1 (fr)
EP (1) EP1105387B1 (fr)
JP (1) JP4346243B2 (fr)
KR (1) KR100472126B1 (fr)
CN (1) CN100396675C (fr)
AT (1) ATE231857T1 (fr)
AU (1) AU752292B2 (fr)
BG (1) BG64870B1 (fr)
BR (1) BR9912937A (fr)
CA (1) CA2338311C (fr)
DE (1) DE69905171T2 (fr)
DK (1) DK1105387T3 (fr)
ES (1) ES2192394T3 (fr)
FI (1) FI20010248A (fr)
HK (1) HK1035368A1 (fr)
HR (1) HRP20010106A2 (fr)
HU (1) HUP0103464A3 (fr)
ID (1) ID28273A (fr)
IL (2) IL141083A0 (fr)
IS (1) IS5826A (fr)
MX (1) MXPA01001464A (fr)
NO (1) NO322490B1 (fr)
NZ (1) NZ510180A (fr)
PL (1) PL346000A1 (fr)
TR (1) TR200100431T2 (fr)
UA (1) UA67788C2 (fr)
WO (1) WO2000009498A1 (fr)
YU (1) YU10101A (fr)

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WO2003043614A2 (fr) * 2001-11-19 2003-05-30 Altana Pharma Ag Agents utiles pour le traitement des troubles des voies aeriennes
MXPA05000657A (es) * 2002-07-19 2005-08-19 Winston Pharmaceuticals Llc Profarmacos de los inhibidores de bomba de protones.
JP2006188432A (ja) * 2003-02-25 2006-07-20 Zeria Pharmaceut Co Ltd 四環系スルフェンアミド化合物
WO2005016917A1 (fr) 2003-07-15 2005-02-24 Allergan, Inc. Procede de preparation de promedicaments isomeriquement purs d'inhibiteurs de la pompe a protons
KR20060118421A (ko) * 2003-08-29 2006-11-23 다이노젠 파마세우티컬스, 인코포레이티드 위장 운동 장애의 치료에 유용한 조성물
TWI372066B (en) * 2003-10-01 2012-09-11 Wyeth Corp Pantoprazole multiparticulate formulations
WO2005039640A1 (fr) * 2003-10-03 2005-05-06 Allergan Inc. Compositions contenant des peptides en trefle et/ou des mucoadhesifs et des promedicaments d'un inhibiteur de pompe a proton
US20050075371A1 (en) * 2003-10-03 2005-04-07 Allergan, Inc. Methods and compositions for the oral administration of prodrugs of proton pump inhibitors
US20070161679A1 (en) * 2004-02-18 2007-07-12 Allergan, Inc. Method and compositions for the intravenous administration of compounds related to proton pump inhibitors
AU2005216862A1 (en) * 2004-02-18 2005-09-09 Allergan, Inc. Compositions comprising prodrugs of proton pump inhibitors
CA2561700A1 (fr) * 2004-04-16 2005-12-15 Santarus, Inc. Combinaison d'un inhibiteur de la pompe a protons, d'un agent tampon et d'un agent prokinetique
ATE437869T1 (de) * 2004-04-28 2009-08-15 Hetero Drugs Ltd Verfahren zur herstellung von pyridinylmethyl-1h- benzimidazolverbindungen in enantiomerenangereicherter form oder als einzelne enantiomere
US7365206B2 (en) * 2004-05-28 2008-04-29 Hetero Drugs Limited Stereoselective synthesis of benzimidazole sulfoxides
BRPI0512261A (pt) * 2004-06-17 2008-02-26 Wyeth Corp antagonistas de receptor de hormÈnio liberador de gonadotropina
RU2007101509A (ru) * 2004-06-17 2008-07-27 Уайт (Us) Способ получения антагонистов рецепторов гормона, высвобождающего гонадотропин
AU2005286593A1 (en) * 2004-09-23 2006-03-30 Reddy Us Therapeutics, Inc. Novel pyridine compounds, process for their preparation and compositions containing them
MX2007005765A (es) * 2004-11-23 2007-07-19 Wyeth Corp Antagonistas del receptor de la hormona que libera gonadotropina.
US7582634B2 (en) * 2005-02-18 2009-09-01 Wyeth 7-substituted imidazo[4,5-c]pyridine antagonists of gonadotropin releasing hormone receptor
US7534796B2 (en) * 2005-02-18 2009-05-19 Wyeth Imidazo[4,5-b]pyridine antagonists of gonadotropin releasing hormone receptor
US7538113B2 (en) * 2005-02-18 2009-05-26 Wyeth 4-substituted imidazo[4,5-c]pyridine antagonists of gonadotropin releasing hormone receptor
US20060189619A1 (en) * 2005-02-24 2006-08-24 Wyeth 3-({4-[2-(4-Tert-butylphenyl)-1h-benzimidazol-4-yl]piperazin-1-yl}methyl)pyrido[2,3-b]]pyrazi ne compounds
US20070015782A1 (en) 2005-04-15 2007-01-18 Eisai Co., Ltd. Benzimidazole compound
US9040564B2 (en) 2005-04-28 2015-05-26 Eisai R&D Management Co., Ltd. Stabilized composition
US7531542B2 (en) 2005-05-18 2009-05-12 Wyeth Benzooxazole and benzothiazole antagonists of gonadotropin releasing hormone receptor
US7582636B2 (en) * 2005-05-26 2009-09-01 Wyeth Piperazinylimidazopyridine and piperazinyltriazolopyridine antagonists of Gonadotropin Releasing Hormone receptor
US20090036406A1 (en) * 2005-06-13 2009-02-05 Takeda Pharmaceutical Company Limited Injection
WO2007073301A1 (fr) * 2005-12-23 2007-06-28 Astrazeneca Ab Derives du benzoimidazole en tant que promedicaments d'inhibiteurs de la pompe a protons
US20100317689A1 (en) * 2006-09-19 2010-12-16 Garst Michael E Prodrugs of proton pump inhibitors including the 1h-imidazo[4,5-b] pyridine moiety
WO2008036211A1 (fr) * 2006-09-19 2008-03-27 Alevium Pharmaceuticals, Inc. Promédicaments d'inhibiteurs de pompes à protons comprenant le groupe fonctionnel (1h-pyrrol-1-yl)-1h-benzimidazole
CA2667682A1 (fr) 2006-10-27 2008-05-15 The Curators Of The University Of Missouri Compositions comprenant des agents d'inhibition de la pompe a protons labiles d'acide, au moins un autre agent pharmaceutiquement actif et leurs procedes d'utilisation
CN101497622B (zh) * 2008-01-30 2011-04-27 山东轩竹医药科技有限公司 吡啶甲基亚磺酰基咪唑并吡啶衍生物
CA2716367C (fr) 2008-02-20 2015-05-26 The Curators Of The University Of Missouri Composition comprenant une combinaison d'omeprazole et de lansoprazole, et un agent tampon, et ses methodes d'utilisation
UA100192C2 (en) * 2008-11-11 2012-11-26 УАЙТ ЭлЭлСи 1-(arylsulfonyl)-4-(piperazin-1-yl)-1h-benzimidazoles as 5-hydroxytryptamine-6 ligands
EP2921479B1 (fr) * 2012-11-19 2017-02-01 Jiangsu Hansoh Pharmaceutical Co., Ltd. Dérivé pyrrole sulfonamide, procédé de préparation et application médicale associés
CN105143187B (zh) 2013-02-28 2018-04-03 武田药品工业株式会社 制备磺酰氯化合物的方法
EP3762368B1 (fr) 2018-03-08 2022-01-26 Incyte Corporation Composés d'aminopyrazine diol utilisés comme inhibiteurs de pi3k-y
US11046658B2 (en) 2018-07-02 2021-06-29 Incyte Corporation Aminopyrazine derivatives as PI3K-γ inhibitors
WO2021234002A1 (fr) 2020-05-20 2021-11-25 F. Hoffmann-La Roche Ag Réactif pour la spectrométrie de masse

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JPS6150978A (ja) * 1984-08-16 1986-03-13 Takeda Chem Ind Ltd ピリジン誘導体およびその製造法
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US5708017A (en) * 1995-04-04 1998-01-13 Merck & Co., Inc. Stable, ready-to-use pharmaceutical paste composition containing proton pump inhibitors
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Also Published As

Publication number Publication date
PL346000A1 (en) 2002-01-14
KR20010103566A (ko) 2001-11-23
ATE231857T1 (de) 2003-02-15
AU752292B2 (en) 2002-09-12
KR100472126B1 (ko) 2005-03-08
US6559167B1 (en) 2003-05-06
HUP0103464A2 (hu) 2002-02-28
EP1105387A1 (fr) 2001-06-13
AU5551899A (en) 2000-03-06
TR200100431T2 (tr) 2001-06-21
DE69905171T2 (de) 2003-11-20
CN100396675C (zh) 2008-06-25
BR9912937A (pt) 2001-05-08
CN1312806A (zh) 2001-09-12
BG105191A (en) 2001-12-29
EP1105387B1 (fr) 2003-01-29
UA67788C2 (uk) 2004-07-15
HRP20010106A2 (en) 2002-02-28
IL141083A0 (en) 2002-02-10
IS5826A (is) 2001-01-29
CA2338311C (fr) 2007-01-23
IL141083A (en) 2006-07-05
CA2338311A1 (fr) 2000-02-24
DK1105387T3 (da) 2003-06-23
HUP0103464A3 (en) 2002-11-28
JP2003534232A (ja) 2003-11-18
NZ510180A (en) 2002-11-26
ID28273A (id) 2001-05-10
NO322490B1 (no) 2006-10-09
YU10101A (sh) 2003-10-31
NO20010693D0 (no) 2001-02-09
DE69905171D1 (de) 2003-03-06
MXPA01001464A (es) 2002-05-08
BG64870B1 (bg) 2006-07-31
FI20010248A (fi) 2001-02-09
ES2192394T3 (es) 2003-10-01
JP4346243B2 (ja) 2009-10-21
NO20010693L (no) 2001-03-05
WO2000009498A1 (fr) 2000-02-24

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Legal Events

Date Code Title Description
PF Patent in force
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20110809