HK1012023A1 - Platelet-activating factor acetylhydrolase - Google Patents

Platelet-activating factor acetylhydrolase

Info

Publication number
HK1012023A1
HK1012023A1 HK98113001A HK98113001A HK1012023A1 HK 1012023 A1 HK1012023 A1 HK 1012023A1 HK 98113001 A HK98113001 A HK 98113001A HK 98113001 A HK98113001 A HK 98113001A HK 1012023 A1 HK1012023 A1 HK 1012023A1
Authority
HK
Hong Kong
Prior art keywords
platelet
activating factor
factor acetylhydrolase
acetylhydrolase
expected
Prior art date
Application number
HK98113001A
Other languages
English (en)
Inventor
Laurence S Cousens
Christine D Eberhardt
Patrick Gray
Trong Hai Le
Larry W Tjoelker
Cheryl L Wilder
Original Assignee
Icos Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Icos Corp filed Critical Icos Corp
Publication of HK1012023A1 publication Critical patent/HK1012023A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/16—Central respiratory analeptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/06—Antiabortive agents; Labour repressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/18—Carboxylic ester hydrolases (3.1.1)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Pulmonology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Immunology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cardiology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Dermatology (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Vascular Medicine (AREA)
  • Pregnancy & Childbirth (AREA)
  • Oncology (AREA)
HK98113001A 1993-10-06 1998-12-09 Platelet-activating factor acetylhydrolase HK1012023A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US13380393A 1993-10-06 1993-10-06
PCT/US1994/011340 WO1995009921A1 (fr) 1993-10-06 1994-10-06 Facteur d'activation des plaquettes-acetylhydrolase

Publications (1)

Publication Number Publication Date
HK1012023A1 true HK1012023A1 (en) 1999-07-23

Family

ID=22460373

Family Applications (2)

Application Number Title Priority Date Filing Date
HK98113001A HK1012023A1 (en) 1993-10-06 1998-12-09 Platelet-activating factor acetylhydrolase
HK01107638A HK1038587A1 (en) 1993-10-06 2001-11-01 Platelet-activating factor acetylhydrolase

Family Applications After (1)

Application Number Title Priority Date Filing Date
HK01107638A HK1038587A1 (en) 1993-10-06 2001-11-01 Platelet-activating factor acetylhydrolase

Country Status (12)

Country Link
US (5) US5641669A (fr)
EP (3) EP1634953A3 (fr)
JP (3) JP3613398B2 (fr)
AT (2) ATE315655T1 (fr)
CA (1) CA2151045C (fr)
DE (2) DE69434609T2 (fr)
DK (2) DK1096016T3 (fr)
ES (2) ES2159573T3 (fr)
GR (1) GR3036535T3 (fr)
HK (2) HK1012023A1 (fr)
PT (1) PT673426E (fr)
WO (1) WO1995009921A1 (fr)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69423436T2 (de) 1993-06-25 2000-09-07 Smithkline Beecham Plc An lipoprotein gebundene phospholipase a2, inhibitoren davon und deren verwendung für diagnose und therapie
JP3563091B2 (ja) * 1993-08-03 2004-09-08 第一サントリーファーマ株式会社 酸化リン脂質分解酵素およびその遺伝子
US6146625A (en) * 1993-10-06 2000-11-14 Icos Corporation Platelet-activating factor acetylhydrolase
WO1997012984A1 (fr) * 1995-09-29 1997-04-10 Smithkline Beecham Plc COMPOSE PRESENTANT UNE HOMOLOGIE DE SEQUENCE AVEC UNE PHOSPHOLIPASE A2 ASSOCIEE A UNE LIPOPROTEINE (Lp-PLA2) OU ACETYLE HYDROLASE DU FACTEUR D'ACTIVATION DES PLAQUETTES
JP2002515728A (ja) * 1995-09-29 2002-05-28 スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー 新規用途
EP0869943A1 (fr) * 1995-12-08 1998-10-14 Smithkline Beecham Plc Derives de beta-lactame monocycliques utilises dans le traitement de l'atherosclerose
US6891084B1 (en) * 1996-04-26 2005-05-10 Ajinomoto Co., Inc. DNA encoding raffinose synthase from soybean
US6166292A (en) * 1996-04-26 2000-12-26 Ajinomoto Co., Inc. Raffinose synthetase gene, method of producing raffinose and transgenic plant
HUP9901359A3 (en) * 1996-04-26 2000-03-28 Smithkline Beecham Plc Azetidinone derivatives for the treatment of atherosclerosis, process for their producing and pharmaceutical compositions containing them
JPH1017600A (ja) * 1996-06-28 1998-01-20 Suntory Ltd 血小板活性化因子アセチルヒドロラーゼおよびその遺伝子
IL129262A0 (en) * 1997-08-13 2000-02-17 Icos Corp Truncated platelet-activating factor acetylhydrolase
WO2000024910A1 (fr) * 1998-10-28 2000-05-04 Smithkline Beecham Plc Procede de purification de phospholipase a2 associee a une lipoproteine de faible densite (ldl-pla2) au moyen d'une chromatographie par affinite avec un metal immobilise
GB9923790D0 (en) * 1999-10-08 1999-12-08 Isis Innovation Immunoregulatory compositions
CZ304450B6 (cs) 2000-02-16 2014-05-14 Smithkline Beecham P. L. C. Pyrimidinový derivát
GB0024808D0 (en) 2000-10-10 2000-11-22 Smithkline Beecham Plc Novel compounds
GB0027181D0 (en) * 2000-11-04 2000-12-27 S P A New use
AU2002320049A1 (en) * 2001-05-30 2002-12-09 James W. Ryan Isolated genomic polynucleotide fragments that encode human lipoprotein-associated phospholipase a2
US7475248B2 (en) 2002-04-29 2009-01-06 International Business Machines Corporation Enhanced message security
US7273620B1 (en) 2002-05-20 2007-09-25 University Of British Columbia Triggered release of liposomal drugs following mixing of cationic and anionic liposomes
JP4892350B2 (ja) 2003-05-28 2012-03-07 グラクソ グループ リミテッド Ｌｐ−ＰＬＡ２活性のハイスループットアッセイ
JP5155564B2 (ja) 2004-02-03 2013-03-06 ディアデクサス インコーポレーテッド Ｌｐ−ＰＬＡ２活性を検出する方法
US7741020B2 (en) 2004-04-16 2010-06-22 Glaxo Group Limited Methods for detecting Lp-PLA2 activity and inhibition of Lp-PLA2 activity
US20150017671A1 (en) 2004-04-16 2015-01-15 Yaping Shou Methods for detecting lp-pla2 activity and inhibition of lp-pla2 activity
JP2007145814A (ja) * 2005-10-28 2007-06-14 Bizen Chemical Co Ltd 血小板活性化因子受容体拮抗剤および組成物
CA2649295A1 (fr) * 2006-04-21 2007-11-01 Wyeth Procedes de criblage a haut debit de lignees cellulaires
BRPI0721697A2 (pt) 2007-05-11 2014-08-05 Univ Jefferson " métodos para tratar e/ou prevenir uma doença ou distúrbio neurodegenerativo em um indivíduo, para tratar e/ou prevenir um indivíduo com ou em risco de demência vascular, para tratar e/ou prevenir uma doença ou distúrbio associado com uma barreira hematoencefálica anormal em um indivíduo, para diminuir o acúmulo beta amilóide no cérebro de um indivíduo, para tratar e/ou prevenir mal de alzheimer em um indivíduo e para prevenir ou reduzir o risco de desenvolver mal de alzhheimer, e, uso de um agente que inibe a expressão e/ou atividade da proteína lp-pla2."
AU2008251467B2 (en) 2007-05-11 2014-07-31 The Trustees Of The University Of Pennsylvania Methods of treatment of skin ulcers
US8257697B2 (en) 2007-10-31 2012-09-04 Allertech Laboratory Inc. Use of platelet activating factor acetylhydrolase as biomarker for anaphylaxis
JP2009005705A (ja) * 2008-07-02 2009-01-15 Icos Corp 血小板活性化因子アセチルヒドロラーゼ
JP5596964B2 (ja) * 2008-12-02 2014-09-24 協和メデックス株式会社 リポ蛋白中成分の分別定量用標準品の製造方法
WO2012080497A2 (fr) 2010-12-17 2012-06-21 Glaxo Group Limited Procédés de traitement et de prévention de maladies oculaires
US20140283157A1 (en) 2013-03-15 2014-09-18 Diadexus, Inc. Lipoprotein-associated phospholipase a2 antibody compositions and methods of use
CN105542010B (zh) * 2015-12-31 2020-11-03 武汉华美生物工程有限公司 脂蛋白相关磷脂酶a2单克隆抗体、抗体对及制备方法、用途

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US5019508A (en) * 1987-08-27 1991-05-28 Biotechnology Research Partners, Ltd. Synovial phospholipases
US6565841B1 (en) * 1991-03-15 2003-05-20 Amgen, Inc. Pulmonary administration of granulocyte colony stimulating factor
US5279957A (en) * 1992-04-30 1994-01-18 Washington University cDNA encoding human phospholipase A2 polypeptide
DE69423436T2 (de) * 1993-06-25 2000-09-07 Smithkline Beecham Plc An lipoprotein gebundene phospholipase a2, inhibitoren davon und deren verwendung für diagnose und therapie
GB9313144D0 (en) 1993-06-25 1993-08-11 Smithkline Beecham Plc Compounds
GB9400413D0 (en) 1994-01-11 1994-03-09 Smithkline Beecham Plc Compounds

Also Published As

Publication number Publication date
JPH08504603A (ja) 1996-05-21
DK1096016T3 (da) 2006-05-29
ATE315655T1 (de) 2006-02-15
US5532152A (en) 1996-07-02
EP1634953A2 (fr) 2006-03-15
US5698403A (en) 1997-12-16
US5605801A (en) 1997-02-25
EP0673426B1 (fr) 2001-06-06
ES2159573T3 (es) 2001-10-16
ATE201905T1 (de) 2001-06-15
DE69434609T2 (de) 2006-09-21
JP3759941B2 (ja) 2006-03-29
CA2151045C (fr) 2002-04-30
US5641669A (en) 1997-06-24
HK1038587A1 (en) 2002-03-22
EP1096016B1 (fr) 2006-01-11
US20050100540A1 (en) 2005-05-12
EP0673426A1 (fr) 1995-09-27
JP3613398B2 (ja) 2005-01-26
DK0673426T3 (da) 2001-08-27
EP1096016A1 (fr) 2001-05-02
CA2151045A1 (fr) 1995-04-13
ES2258955T3 (es) 2006-09-16
EP1634953A3 (fr) 2006-06-28
JP2006056901A (ja) 2006-03-02
PT673426E (pt) 2001-11-30
JP2004129671A (ja) 2004-04-30
GR3036535T3 (en) 2001-12-31
DE69427392T2 (de) 2002-05-23
DE69434609D1 (de) 2006-04-06
WO1995009921A1 (fr) 1995-04-13
DE69427392D1 (de) 2001-07-12

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Effective date: 20141005