HK1011693A1 - Fluorinated 17-beta substituted -4-AZA-5-alpha-andostran-3ONE derivatives - Google Patents

Fluorinated 17-beta substituted -4-AZA-5-alpha-andostran-3ONE derivatives

Info

Publication number
HK1011693A1
HK1011693A1 HK98112739A HK98112739A HK1011693A1 HK 1011693 A1 HK1011693 A1 HK 1011693A1 HK 98112739 A HK98112739 A HK 98112739A HK 98112739 A HK98112739 A HK 98112739A HK 1011693 A1 HK1011693 A1 HK 1011693A1
Authority
HK
Hong Kong
Prior art keywords
hydrogen
fluorine
alkyl
andostran
3one
Prior art date
Application number
HK98112739A
Other languages
English (en)
Inventor
Achille Panzeri
Marcella Nesi
Enrico Di Salle
Original Assignee
Pharmacia & Upjohn Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia & Upjohn Spa filed Critical Pharmacia & Upjohn Spa
Publication of HK1011693A1 publication Critical patent/HK1011693A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J73/00—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms
    • C07J73/001—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom
    • C07J73/005—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom by nitrogen as hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/08—Antiseborrheics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/28—Antiandrogens

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Lubricants (AREA)
  • Glass Compositions (AREA)
  • Percussion Or Vibration Massage (AREA)
HK98112739A 1992-07-31 1998-12-03 Fluorinated 17-beta substituted -4-AZA-5-alpha-andostran-3ONE derivatives HK1011693A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB929216284A GB9216284D0 (en) 1992-07-31 1992-07-31 Fluorinated 17beta-substituted 4-aza-5alpha-androstane-3-one derivatives
PCT/EP1993/002037 WO1994003475A1 (en) 1992-07-31 1993-07-29 FLUORINATED 17β-SUBSTITUTED 4-AZA-5α-ANDROSTAN-3-ONE DERIVATIVES

Publications (1)

Publication Number Publication Date
HK1011693A1 true HK1011693A1 (en) 1999-07-16

Family

ID=10719598

Family Applications (1)

Application Number Title Priority Date Filing Date
HK98112739A HK1011693A1 (en) 1992-07-31 1998-12-03 Fluorinated 17-beta substituted -4-AZA-5-alpha-andostran-3ONE derivatives

Country Status (29)

Country Link
US (1) US5407939A (xx)
EP (1) EP0607400B1 (xx)
JP (1) JP3325025B2 (xx)
KR (1) KR100311547B1 (xx)
CN (1) CN1041096C (xx)
AT (1) ATE159951T1 (xx)
AU (1) AU660562B2 (xx)
CA (1) CA2120343A1 (xx)
CZ (1) CZ286240B6 (xx)
DE (1) DE69315050T2 (xx)
DK (1) DK0607400T3 (xx)
ES (1) ES2110620T3 (xx)
FI (1) FI113778B (xx)
GB (1) GB9216284D0 (xx)
GR (1) GR3025546T3 (xx)
HK (1) HK1011693A1 (xx)
HU (2) HUT67043A (xx)
IL (1) IL106520A (xx)
MX (1) MX9304579A (xx)
MY (1) MY109633A (xx)
NO (1) NO305401B1 (xx)
NZ (1) NZ254787A (xx)
PH (1) PH29938A (xx)
PL (1) PL178591B1 (xx)
RU (1) RU2125061C1 (xx)
TW (1) TW286319B (xx)
UA (1) UA41291C2 (xx)
WO (1) WO1994003475A1 (xx)
ZA (1) ZA935481B (xx)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2151239A1 (en) * 1992-12-18 1994-07-07 Glenn J. Gormley Method of treatment of chronic prostatitis with 17b-n- monosubstituted-carbamoyl-4-aza-5a-androst-1-en-3-ones
DK0705272T3 (da) * 1993-06-24 2002-05-27 Richter Gedeon Vegyeszet Særlig fremgangsmåde til fremstilling af 17beta-substituerede 4-azaandrostanderivater
TW369521B (en) * 1993-09-17 1999-09-11 Smithkline Beecham Corp Androstenone derivative
WO1995011254A1 (en) * 1993-10-21 1995-04-27 Merck & Co., Inc. 16-substituted-4-aza-androstane 5-alpha-reductase isozyme 1 inhibitors
GB9415178D0 (en) * 1994-07-28 1994-09-21 Erba Carlo Spa 4-azasteroids with side-chain fluoroketones
US5541322A (en) * 1994-10-14 1996-07-30 Glaxo Wellcome Inc. Synthesis of 6-azaandrostenones
US5543417A (en) * 1994-10-21 1996-08-06 Merck & Co., Inc. Combination method of treating acne using 4-AZA-5α-cholestan-ones and 4-AZA-5α-androstan-ones as selective 5α-reductase inhibitors with anti-bacterial, keratolytic, or anti-inflammatory agents
US5595996A (en) * 1994-10-25 1997-01-21 Merck & Co., Inc. 7-substituted 4-aza cholanic acid derivatives and their use
IT1275594B1 (it) * 1995-07-21 1997-08-06 Pharmacia S P A Ora Pharmacia Epimeri del (22rs)-n-(1,1,1-trifluoro-2-fenilprop-2-il)-3-osso -4-aza-5alfa-androst-1-ene-17beta-carbossammide
GB9518858D0 (en) * 1995-09-14 1995-11-15 Pharmacia Spa Phenylsubstituted 4-azasteroid fluoroderivatives
GB9727522D0 (en) * 1997-12-31 1998-02-25 Pharmacia & Upjohn Spa Process for preparing carboxamido-4-azasteroids
US6645974B2 (en) * 2001-07-31 2003-11-11 Merck & Co., Inc. Androgen receptor modulators and methods for use thereof
PL372920A1 (en) * 2002-03-13 2005-08-08 Merck & Co,Inc. Fluorinated 4-azasteroid derivatives as androgen receptor modulators
CN100528168C (zh) * 2003-06-30 2009-08-19 麦克公司 作为雄激素受体调节剂的17-乙酰氨基-4-氮杂甾类衍生物
CA2530182A1 (en) 2003-06-30 2005-01-20 Merck & Co., Inc. 17-acetamido-4-azasteroid derivatives as androgen receptor modulators
JP2007521293A (ja) * 2003-06-30 2007-08-02 メルク　エンド　カムパニー　インコーポレーテッド アンドロゲン受容体モジュレータとしての１７−アセトアミド−４−アザステロイド誘導体
WO2005004807A2 (en) * 2003-06-30 2005-01-20 Merck & Co., Inc. 17-acetamido-4-azasteroid derivatives as androgen receptor modulators
US7446110B2 (en) * 2003-09-10 2008-11-04 Merck & Co., Inc. 17-Heterocyclic-4-azasteroid derivatives as androgen receptor modulators
CA2537663A1 (en) 2003-09-10 2005-03-24 Merck & Co., Inc. 17-heterocyclic-4-azasteroid derivatives as androgen receptor modulators
US20080125399A1 (en) * 2004-04-08 2008-05-29 Jiabing Wang 17 Beta-Acetamide-4-Azasteroids As Androgen Receptor Modulators
CN102282133A (zh) * 2008-10-28 2011-12-14 生物马林药物股份有限公司 十氢-1h-茚并喹啉酮和十氢-3h-环戊并菲啶酮cyp17抑制剂

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ211145A (en) * 1984-02-27 1988-10-28 Merck & Co Inc 4-aza-5-alpha-androst-1-en-3-ones and pharmaceutical compositions
GB8505862D0 (en) * 1985-03-07 1985-04-11 Erba Farmitalia Steroidic 5alpha-reductase inhibitors
GB9002922D0 (en) * 1990-02-09 1990-04-04 Erba Carlo Spa 17 beta-substituted-4-aza-5 alpha-androstan-3-one derivatives and process for their preparation
IE76452B1 (en) * 1990-10-29 1997-10-22 Sankyo Co Azasteroid compounds for the treatment of prostatic hypertrophy their preparation and use
US5304562A (en) * 1991-10-09 1994-04-19 Ciba-Geigy Corporation 17β-substituted Aza-androstane derivatives
AUPP930799A0 (en) * 1999-03-18 1999-04-15 University Of Sydney, The Optical planar waveguide device and method of its fabrication

Also Published As

Publication number Publication date
IL106520A0 (en) 1993-11-15
RU2125061C1 (ru) 1999-01-20
ES2110620T3 (es) 1998-02-16
UA41291C2 (uk) 2001-09-17
HUT67043A (en) 1995-01-30
DE69315050T2 (de) 1998-03-05
DK0607400T3 (da) 1998-01-26
FI941424A0 (fi) 1994-03-28
HU9400914D0 (en) 1994-06-28
AU660562B2 (en) 1995-06-29
JPH06511497A (ja) 1994-12-22
ATE159951T1 (de) 1997-11-15
US5407939A (en) 1995-04-18
GB9216284D0 (en) 1992-09-16
NO941080L (no) 1994-05-18
TW286319B (xx) 1996-09-21
ZA935481B (en) 1994-05-16
DE69315050D1 (de) 1997-12-11
NZ254787A (en) 1995-11-27
MY109633A (en) 1997-03-31
NO941080D0 (no) 1994-03-24
JP3325025B2 (ja) 2002-09-17
HU211238A9 (en) 1995-11-28
CZ286240B6 (cs) 2000-02-16
CN1041096C (zh) 1998-12-09
GR3025546T3 (en) 1998-03-31
NO305401B1 (no) 1999-05-25
CZ153893A3 (en) 1994-02-16
CA2120343A1 (en) 1994-02-17
MX9304579A (es) 1994-02-28
PH29938A (en) 1996-09-16
PL178591B1 (pl) 2000-05-31
CN1085224A (zh) 1994-04-13
EP0607400A1 (en) 1994-07-27
FI113778B (fi) 2004-06-15
WO1994003475A1 (en) 1994-02-17
KR100311547B1 (ko) 2002-06-20
AU4704893A (en) 1994-03-03
EP0607400B1 (en) 1997-11-05
FI941424A (fi) 1994-05-27
IL106520A (en) 1997-11-20

Similar Documents

Publication Publication Date Title
HK1011693A1 (en) Fluorinated 17-beta substituted -4-AZA-5-alpha-andostran-3ONE derivatives
AU3051295A (en) 4-Amino-3,5- Dihalophenylsulphurpentafluoride
AU537414B2 (en) Pyroglutamic acid derivatives
AU596389B2 (en) 1-arylpyrazoles
ES2001106A6 (es) Procedimiento para la obtencion de 1-aril-pirazoles
CA2003172A1 (en) Certain 2-(2',3',4'-trisubstituted benzoyl)-1,3-cyclohexanediones
ATE386724T1 (de) Substituierte hexahydrobenzo(a) phenanthridine
MY103245A (en) Antiarrhythmic agents
EP0696585A4 (xx)
AU572668B2 (en) 5-acylamino-1-phenylpyrazoles
ES480873A1 (es) Un procedimiento para la obtencion de triazolidin-3-onas o- tionas.
ES8801669A1 (es) Un procedimiento para preparar nuevos compuestos de 2-oxa-0 aza-pregnano.
ES2001102A6 (es) Un procedimiento para la preparacion de un derivado de indeno.
TW358809B (en) Phenylamidinothiophene compound and anti-inflammatory agent containing the same
EP0443474A3 (en) 1-phenoxycarbonyl-2-pyrrolidinone derivatives and nootropic agents
MX9706627A (es) Derivado de tiazolidinona opticamente activo.

Legal Events

Date Code Title Description
PF Patent in force
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20060729