HK1009154A1 - Neural transplantation using pluripotent neuroepithelial cells - Google Patents

Neural transplantation using pluripotent neuroepithelial cells

Info

Publication number
HK1009154A1
HK1009154A1 HK98110007A HK98110007A HK1009154A1 HK 1009154 A1 HK1009154 A1 HK 1009154A1 HK 98110007 A HK98110007 A HK 98110007A HK 98110007 A HK98110007 A HK 98110007A HK 1009154 A1 HK1009154 A1 HK 1009154A1
Authority
HK
Hong Kong
Prior art keywords
neuroepithelial cells
pluripotent neuroepithelial
neural transplantation
cells
pluripotent
Prior art date
Application number
HK98110007A
Other languages
English (en)
Inventor
John Sinden
Jeffrey Alan Gray
Helen Hodges
Timothy Kershaw
Fiza Rashid-Doubell
Original Assignee
Reneuron Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Reneuron Ltd filed Critical Reneuron Ltd
Publication of HK1009154A1 publication Critical patent/HK1009154A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/30—Nerves; Brain; Eyes; Corneal cells; Cerebrospinal fluid; Neuronal stem cells; Neuronal precursor cells; Glial cells; Oligodendrocytes; Schwann cells; Astroglia; Astrocytes; Choroid plexus; Spinal cord tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0618—Cells of the nervous system
    • C12N5/0623—Stem cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/05—Inorganic components
    • C12N2500/10—Metals; Metal chelators
    • C12N2500/20—Transition metals
    • C12N2500/24—Iron; Fe chelators; Transferrin
    • C12N2500/25—Insulin-transferrin; Insulin-transferrin-selenium
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/90—Serum-free medium, which may still contain naturally-sourced components
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/115—Basic fibroblast growth factor (bFGF, FGF-2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/24—Interferons [IFN]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/30—Hormones
    • C12N2501/38—Hormones with nuclear receptors
    • C12N2501/39—Steroid hormones
    • C12N2501/392—Sexual steroids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/30—Hormones
    • C12N2501/38—Hormones with nuclear receptors
    • C12N2501/395—Thyroid hormones
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/90—Polysaccharides
    • C12N2501/91—Heparin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Organic Chemistry (AREA)
  • Developmental Biology & Embryology (AREA)
  • Neurology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Ophthalmology & Optometry (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Urology & Nephrology (AREA)
  • Physics & Mathematics (AREA)
  • Hospice & Palliative Care (AREA)
  • Food Science & Technology (AREA)
  • Psychiatry (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
HK98110007A 1995-09-12 1998-08-19 Neural transplantation using pluripotent neuroepithelial cells HK1009154A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9518606.0A GB9518606D0 (en) 1995-09-12 1995-09-12 Neural transplantation
PCT/GB1996/002251 WO1997010329A1 (fr) 1995-09-12 1996-09-12 Transplantation neurale a l'aide de cellules neuroepitheliales pluripotentes

Publications (1)

Publication Number Publication Date
HK1009154A1 true HK1009154A1 (en) 1999-05-28

Family

ID=10780583

Family Applications (1)

Application Number Title Priority Date Filing Date
HK98110007A HK1009154A1 (en) 1995-09-12 1998-08-19 Neural transplantation using pluripotent neuroepithelial cells

Country Status (21)

Country Link
US (3) US7048921B2 (fr)
EP (1) EP0850298B1 (fr)
JP (1) JP4280872B2 (fr)
KR (1) KR19990044606A (fr)
CN (1) CN1193345A (fr)
AT (1) ATE242316T1 (fr)
AU (1) AU711563B2 (fr)
CA (1) CA2231436C (fr)
CZ (1) CZ296669B6 (fr)
DE (1) DE69628566T2 (fr)
DK (1) DK0850298T3 (fr)
ES (1) ES2196172T3 (fr)
GB (1) GB9518606D0 (fr)
HK (1) HK1009154A1 (fr)
HU (1) HUP9802091A3 (fr)
NO (1) NO981072L (fr)
PL (1) PL186777B1 (fr)
PT (1) PT850298E (fr)
RU (1) RU2185833C2 (fr)
SK (1) SK285816B6 (fr)
WO (1) WO1997010329A1 (fr)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ138397A3 (en) 1994-11-08 1997-10-15 Bradley Michael John Stringer Human cellular lines
GB9518606D0 (en) 1995-09-12 1995-11-15 Inst Of Psychiatry Neural transplantation
GB9904281D0 (en) * 1999-02-24 1999-04-21 Reneuron Ltd Transplantation
GB9907243D0 (en) 1999-03-29 1999-05-26 Reneuron Ltd Therapy
KR100801764B1 (ko) * 1999-09-17 2008-02-05 레뉴런 리미티드 세포의 조건부 불멸화
US6399384B1 (en) * 1999-09-17 2002-06-04 Reneuron Limited Conditional immortalization of cells
US6465215B1 (en) 1999-12-14 2002-10-15 Reneuron Limited Identification of cells for transplantation
GB0005856D0 (en) * 2000-03-10 2000-05-03 Reneuron Ltd Genetic constructs
GB0125773D0 (en) * 2001-10-26 2001-12-19 Reneuron Ltd Constructs
DE602005002430T2 (de) 2004-09-30 2008-06-19 Reneuron Ltd., Guildford Zelllinie
CA2725953A1 (fr) * 2007-05-29 2008-12-11 Christopher B. Reid Procedes de production et d'utilisations de populations de cellules multipotentes, pluripotentes, differentiees et resistantes au vih
GB0822246D0 (en) 2008-12-05 2009-01-14 Reneuron Ltd Composition
GB0902034D0 (en) 2009-02-06 2009-03-11 Reneuron Ltd Method
GB201011589D0 (en) * 2010-07-09 2010-08-25 Reneuron Ltd Therapeutic cells
US20150232662A1 (en) * 2014-02-20 2015-08-20 Sabic Innovative Plastics Ip B.V. Thermoplastic composition and article
US20170173114A1 (en) * 2014-05-07 2017-06-22 Joslin Diabetes Center, Inc. Methods and compositions for induction of ucp1 expression
CN116590345B (zh) * 2023-05-06 2024-01-30 北京中医药大学 永生化小鼠足细胞系及其制备方法、分化方法和应用

Family Cites Families (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1662A (en) * 1840-06-27 ariel nobris
US146821A (en) * 1874-01-27 Improvement in nose-pieces of nail-plate feeders
US28510A (en) * 1860-05-29 John e
US147873A (en) * 1874-02-24 Improvement in nasal yokes for animals
US203483A (en) * 1878-05-07 Improvement in honey-boxes
US913443A (en) * 1908-08-13 1909-02-23 Webster Full Expansion Rotary Engine Company Rotary engine.
NZ226750A (en) * 1987-10-29 1990-09-26 Amrad Corp Ltd Immortalisation of neural precursor cells by introducing a retrovirus vector containing a myc-oncogene
EP0428519B1 (fr) 1988-04-12 1993-06-16 Massachusetts Institute Of Technology Procede de manipulation des types cellulaires d'eucaryotes
US5270191A (en) 1988-04-12 1993-12-14 Massachusetts Institute Of Technology Method for manipulation of the cell types of eukaryotes
EP0395106B1 (fr) * 1989-04-27 1994-07-06 Ajinomoto Co., Inc. Déméthylallosamidine et procédé pour sa production
US5399493A (en) 1989-06-15 1995-03-21 The Regents Of The University Of Michigan Methods and compositions for the optimization of human hematopoietic progenitor cell cultures
WO1991009936A1 (fr) * 1989-12-26 1991-07-11 Hana Biologics, Inc. Produit cellulaire progeniteur neuronal proliferee et procede
US5612211A (en) 1990-06-08 1997-03-18 New York University Stimulation, production and culturing of hematopoietic progenitor cells by fibroblast growth factors
RU2028089C1 (ru) * 1990-10-16 1995-02-09 Украинский научно-исследовательский институт нейрохирургии Способ лечения апаллического синдрома
US5851832A (en) 1991-07-08 1998-12-22 Neurospheres, Ltd. In vitro growth and proliferation of multipotent neural stem cells and their progeny
ATE240389T1 (de) * 1991-07-08 2003-05-15 Neurospheres Holdings Ltd Auf wachstumsfaktoren reagierende neurale vorläuferzellen, die in vitro vermehrt werden können.
KR950700403A (ko) 1992-03-04 1995-01-16 죤 제이. 쉬바르츠 조혈 간세포의 배양 및 그것의 유전공학(culturing of hematopoietic stem cells and their genetic engineering)
US5753491A (en) 1993-04-13 1998-05-19 Us Health Use of neuro-derived fetal cell lines for transplantation therapy
DK0696205T3 (da) 1993-04-13 2002-05-13 Us Gov Health & Human Serv Anvendelse af neuro-afledte fetale cellelinier til transplantationsterapi
CZ138397A3 (en) 1994-11-08 1997-10-15 Bradley Michael John Stringer Human cellular lines
CN1170435A (zh) * 1994-11-14 1998-01-14 纽罗斯菲里斯控股有限公司 神经干细胞增殖的调节
US5843780A (en) 1995-01-20 1998-12-01 Wisconsin Alumni Research Foundation Primate embryonic stem cells
GB9517263D0 (en) * 1995-08-23 1995-10-25 Cancer Res Campaign Tech Expression systems
GB9518606D0 (en) * 1995-09-12 1995-11-15 Inst Of Psychiatry Neural transplantation
US5588692A (en) * 1995-10-11 1996-12-31 General Motors Corporation Push-out vehicle side door
NZ334016A (en) 1996-08-19 2000-08-25 Univ Massachusetts Embryonic stem cell lines produced by cross species nuclear transplantation
SE9604322D0 (sv) * 1996-11-25 1996-11-25 Astra Ab Bacterial antigens and vaccine compositions II
US20020123143A1 (en) 1997-08-22 2002-09-05 Jean Toma Multipotent stem cells from peripheral tissues and uses thereof
WO1999056759A1 (fr) * 1998-05-07 1999-11-11 University Of South Florida Cellules de moelle osseuse comme source de neurones utile pour reparer la moelle epiniere et le cerveau
US5958767A (en) 1998-08-14 1999-09-28 The Children's Medical Center Corp. Engraftable human neural stem cells
GB9904281D0 (en) 1999-02-24 1999-04-21 Reneuron Ltd Transplantation
GB9907243D0 (en) * 1999-03-29 1999-05-26 Reneuron Ltd Therapy
US6399384B1 (en) 1999-09-17 2002-06-04 Reneuron Limited Conditional immortalization of cells
US6465215B1 (en) * 1999-12-14 2002-10-15 Reneuron Limited Identification of cells for transplantation
JP2004500824A (ja) * 2000-03-09 2004-01-15 クリオ−セル　インターナショナル　インコーポレーティッド 脳および脊髄の修復のための神経組織源としてのヒト臍帯血
US7250294B2 (en) 2000-05-17 2007-07-31 Geron Corporation Screening small molecule drugs using neural cells differentiated from human embryonic stem cells
AU2001264763A1 (en) 2000-06-05 2001-12-17 University Of South Florida Human mesenchymal progenitor cell
US7049072B2 (en) * 2000-06-05 2006-05-23 University Of South Florida Gene expression analysis of pluri-differentiated mesenchymal progenitor cells and methods for diagnosing a leukemic disease state
WO2003029432A2 (fr) 2001-10-03 2003-04-10 University Of South Florida Cellule souche mesenchymateuse humaine
GB0125773D0 (en) * 2001-10-26 2001-12-19 Reneuron Ltd Constructs
DE602005002430T2 (de) * 2004-09-30 2008-06-19 Reneuron Ltd., Guildford Zelllinie

Also Published As

Publication number Publication date
US7048921B2 (en) 2006-05-23
RU2185833C2 (ru) 2002-07-27
PL186777B1 (pl) 2004-02-27
HUP9802091A3 (en) 2001-01-29
DE69628566D1 (de) 2003-07-10
JP4280872B2 (ja) 2009-06-17
CA2231436A1 (fr) 1997-03-20
EP0850298A1 (fr) 1998-07-01
US20030147873A1 (en) 2003-08-07
CZ296669B6 (cs) 2006-05-17
EP0850298B1 (fr) 2003-06-04
SK285816B6 (sk) 2007-09-06
PL325646A1 (en) 1998-08-03
NO981072D0 (no) 1998-03-11
KR19990044606A (ko) 1999-06-25
JPH11513242A (ja) 1999-11-16
ATE242316T1 (de) 2003-06-15
US20010001662A1 (en) 2001-05-24
PT850298E (pt) 2003-09-30
AU6937596A (en) 1997-04-01
NO981072L (no) 1998-05-12
HUP9802091A2 (hu) 1998-12-28
DE69628566T2 (de) 2004-05-06
ES2196172T3 (es) 2003-12-16
CA2231436C (fr) 2007-07-17
WO1997010329A1 (fr) 1997-03-20
CZ55898A3 (cs) 1998-06-17
SK30698A3 (en) 1999-01-11
CN1193345A (zh) 1998-09-16
DK0850298T3 (da) 2003-09-15
US20060051326A1 (en) 2006-03-09
US7371374B2 (en) 2008-05-13
AU711563B2 (en) 1999-10-14
GB9518606D0 (en) 1995-11-15

Similar Documents

Publication Publication Date Title
HK1009154A1 (en) Neural transplantation using pluripotent neuroepithelial cells
WO2001036589A3 (fr) Systeme immunitaire humain ex vivo
WO1997012960A3 (fr) Support solide de culture de cellules et en particulier de cellules hepatiques, reacteur biologique utilisant ledit support et leur emploi dans un systeme de foie bio-artificiel
DE69609222D1 (de) Partikel auf Polyaminosäure(n)basis zur Verwendung als Wirkstoffträger sowie deren Herstellungsverfahren
IL143283A0 (en) Medicinal product and method for treatment of conditions affecting neural stem cells or progenitor cells
BG104095A (en) Male tissue preferable regulatory section and method for its application
IL121790A0 (en) Method for preventing and treating sensorineural hearing loss and vestibular disorders using glial cell line-derived neurotrophic factor (GDNF) protein product
MX340738B (es) Terapia para deficiencia de a-galactosidasa a.
GB9308271D0 (en) Method of isolating and/or enriching and/or selectively propagating pluripotential animal cells and animals for use in said method
HUT64595A (en) Method for producing mammalian cytokine, il-11
AU5267698A (en) Ascending-dose dosage form
MY113045A (en) Waste treatment plant and process
GR3005297T3 (fr)
MX9702126A (es) Modelos in vitro de funcion y disfuncion del snc.
ES8403157A1 (es) Un metodo de preparar sustancias biologicamente activas que tienen actividad anti-tumoral.
DE69637709D1 (de) Durch elektroporation vermittelter molekulartransfer in intakten pflanzen
WO1999029279A3 (fr) Survie a long terme et regeneration de neurones du systeme nerveux central
ATE290385T1 (de) Arzneimittel zur förderung der neuronalen zelldifferenzierung, die cyclische glycerophosphate und deren analoga enthalten
IL90414A (en) Combination of angiotensin converting enzyme inhibitors with potassium channel modulators and use thereof in pharmaceuticals
AU5391886A (en) Method and device for the in vitro culture of plant cells and organs, as well as for the micropropagation and regeneration of complete plants
PL310950A1 (en) Novel imidazole quinoxalinones, method of obtaining them and their application
AU7577091A (en) Process for the artificial stimulation of cells and cyte culture device
EP0723454A4 (fr) Nouveaux tripeptides de traitement du systeme immunitaire et du snc
WO2003040304A3 (fr) Procede de proliferation dans des regions neurogenes
EP0142109A3 (en) Macromolecules extracted from cultured mesenchymal cells for the treatment of degenerative diseases

Legal Events

Date Code Title Description
PF Patent in force
PE Patent expired

Effective date: 20160911