SK285816B6 - Podmienene nesmrteľná pluripotentná neuroepiteliálna bunková línia na terapeutické použitie, farmaceutický prostriedok a použitie podmienene nesmrteľných pluripotentných neuroepiteliálnych buniek na výrobu liečiva - Google Patents

Podmienene nesmrteľná pluripotentná neuroepiteliálna bunková línia na terapeutické použitie, farmaceutický prostriedok a použitie podmienene nesmrteľných pluripotentných neuroepiteliálnych buniek na výrobu liečiva Download PDF

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Publication number
SK285816B6
SK285816B6 SK306-98A SK30698A SK285816B6 SK 285816 B6 SK285816 B6 SK 285816B6 SK 30698 A SK30698 A SK 30698A SK 285816 B6 SK285816 B6 SK 285816B6
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Slovakia
Prior art keywords
cells
cell
brain
treatment
transplantation
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SK306-98A
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English (en)
Slovak (sk)
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SK30698A3 (en
Inventor
John Sinden
Jeffrey Alan Gray
Helen Hodges
Timothy Kershaw
Fiza Rashid-Doubell
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Reneuron Limited
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Application filed by Reneuron Limited filed Critical Reneuron Limited
Publication of SK30698A3 publication Critical patent/SK30698A3/sk
Publication of SK285816B6 publication Critical patent/SK285816B6/sk

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/30—Nerves; Brain; Eyes; Corneal cells; Cerebrospinal fluid; Neuronal stem cells; Neuronal precursor cells; Glial cells; Oligodendrocytes; Schwann cells; Astroglia; Astrocytes; Choroid plexus; Spinal cord tissue
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0618—Cells of the nervous system
    • C12N5/0623—Stem cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/05—Inorganic components
    • C12N2500/10—Metals; Metal chelators
    • C12N2500/20—Transition metals
    • C12N2500/24—Iron; Fe chelators; Transferrin
    • C12N2500/25—Insulin-transferrin; Insulin-transferrin-selenium
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/90—Serum-free medium, which may still contain naturally-sourced components
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/115—Basic fibroblast growth factor (bFGF, FGF-2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/24—Interferons [IFN]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/30—Hormones
    • C12N2501/38—Hormones with nuclear receptors
    • C12N2501/39—Steroid hormones
    • C12N2501/392—Sexual steroids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/30—Hormones
    • C12N2501/38—Hormones with nuclear receptors
    • C12N2501/395—Thyroid hormones
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/90—Polysaccharides
    • C12N2501/91—Heparin

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurology (AREA)
  • Organic Chemistry (AREA)
  • Neurosurgery (AREA)
  • Developmental Biology & Embryology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Immunology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Physics & Mathematics (AREA)
  • Hospice & Palliative Care (AREA)
  • Food Science & Technology (AREA)
  • Psychiatry (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
SK306-98A 1995-09-12 1996-09-12 Podmienene nesmrteľná pluripotentná neuroepiteliálna bunková línia na terapeutické použitie, farmaceutický prostriedok a použitie podmienene nesmrteľných pluripotentných neuroepiteliálnych buniek na výrobu liečiva SK285816B6 (sk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9518606.0A GB9518606D0 (en) 1995-09-12 1995-09-12 Neural transplantation
PCT/GB1996/002251 WO1997010329A1 (fr) 1995-09-12 1996-09-12 Transplantation neurale a l'aide de cellules neuroepitheliales pluripotentes

Publications (2)

Publication Number Publication Date
SK30698A3 SK30698A3 (en) 1999-01-11
SK285816B6 true SK285816B6 (sk) 2007-09-06

Family

ID=10780583

Family Applications (1)

Application Number Title Priority Date Filing Date
SK306-98A SK285816B6 (sk) 1995-09-12 1996-09-12 Podmienene nesmrteľná pluripotentná neuroepiteliálna bunková línia na terapeutické použitie, farmaceutický prostriedok a použitie podmienene nesmrteľných pluripotentných neuroepiteliálnych buniek na výrobu liečiva

Country Status (21)

Country Link
US (3) US7048921B2 (fr)
EP (1) EP0850298B1 (fr)
JP (1) JP4280872B2 (fr)
KR (1) KR19990044606A (fr)
CN (1) CN1193345A (fr)
AT (1) ATE242316T1 (fr)
AU (1) AU711563B2 (fr)
CA (1) CA2231436C (fr)
CZ (1) CZ296669B6 (fr)
DE (1) DE69628566T2 (fr)
DK (1) DK0850298T3 (fr)
ES (1) ES2196172T3 (fr)
GB (1) GB9518606D0 (fr)
HK (1) HK1009154A1 (fr)
HU (1) HUP9802091A3 (fr)
NO (1) NO981072L (fr)
PL (1) PL186777B1 (fr)
PT (1) PT850298E (fr)
RU (1) RU2185833C2 (fr)
SK (1) SK285816B6 (fr)
WO (1) WO1997010329A1 (fr)

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EP0792351B1 (fr) 1994-11-08 2004-03-10 Cellfactors PLC Methode pour la production d' une lignee cellulaire neuronale humaine
GB9518606D0 (en) * 1995-09-12 1995-11-15 Inst Of Psychiatry Neural transplantation
GB9904281D0 (en) * 1999-02-24 1999-04-21 Reneuron Ltd Transplantation
GB9907243D0 (en) 1999-03-29 1999-05-26 Reneuron Ltd Therapy
KR100801764B1 (ko) * 1999-09-17 2008-02-05 레뉴런 리미티드 세포의 조건부 불멸화
US6399384B1 (en) * 1999-09-17 2002-06-04 Reneuron Limited Conditional immortalization of cells
US6465215B1 (en) 1999-12-14 2002-10-15 Reneuron Limited Identification of cells for transplantation
GB0005856D0 (en) * 2000-03-10 2000-05-03 Reneuron Ltd Genetic constructs
GB0125773D0 (en) * 2001-10-26 2001-12-19 Reneuron Ltd Constructs
DE602005002430T2 (de) 2004-09-30 2008-06-19 Reneuron Ltd., Guildford Zelllinie
EP3128015A3 (fr) * 2007-05-29 2017-05-03 Christopher B. Reid Procédé destiné à obtenir une population de cellules capables de différenciation in vivo
GB0822246D0 (en) 2008-12-05 2009-01-14 Reneuron Ltd Composition
GB0902034D0 (en) 2009-02-06 2009-03-11 Reneuron Ltd Method
GB201011589D0 (en) * 2010-07-09 2010-08-25 Reneuron Ltd Therapeutic cells
US20150232662A1 (en) * 2014-02-20 2015-08-20 Sabic Innovative Plastics Ip B.V. Thermoplastic composition and article
US20170173114A1 (en) * 2014-05-07 2017-06-22 Joslin Diabetes Center, Inc. Methods and compositions for induction of ucp1 expression
CN116590345B (zh) * 2023-05-06 2024-01-30 北京中医药大学 永生化小鼠足细胞系及其制备方法、分化方法和应用

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US6465215B1 (en) * 1999-12-14 2002-10-15 Reneuron Limited Identification of cells for transplantation
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Also Published As

Publication number Publication date
US20030147873A1 (en) 2003-08-07
GB9518606D0 (en) 1995-11-15
KR19990044606A (ko) 1999-06-25
CA2231436C (fr) 2007-07-17
WO1997010329A1 (fr) 1997-03-20
AU6937596A (en) 1997-04-01
ATE242316T1 (de) 2003-06-15
CA2231436A1 (fr) 1997-03-20
US7048921B2 (en) 2006-05-23
NO981072D0 (no) 1998-03-11
JP4280872B2 (ja) 2009-06-17
PL186777B1 (pl) 2004-02-27
JPH11513242A (ja) 1999-11-16
PT850298E (pt) 2003-09-30
NO981072L (no) 1998-05-12
EP0850298B1 (fr) 2003-06-04
HUP9802091A2 (hu) 1998-12-28
AU711563B2 (en) 1999-10-14
US7371374B2 (en) 2008-05-13
HK1009154A1 (en) 1999-05-28
PL325646A1 (en) 1998-08-03
DE69628566D1 (de) 2003-07-10
CZ296669B6 (cs) 2006-05-17
DK0850298T3 (da) 2003-09-15
ES2196172T3 (es) 2003-12-16
US20060051326A1 (en) 2006-03-09
HUP9802091A3 (en) 2001-01-29
EP0850298A1 (fr) 1998-07-01
US20010001662A1 (en) 2001-05-24
CN1193345A (zh) 1998-09-16
RU2185833C2 (ru) 2002-07-27
CZ55898A3 (cs) 1998-06-17
SK30698A3 (en) 1999-01-11
DE69628566T2 (de) 2004-05-06

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