DE69628566D1 - Neurale transplantation durch verwendung von pluripotenten neuroepithelzellen - Google Patents

Neurale transplantation durch verwendung von pluripotenten neuroepithelzellen

Info

Publication number
DE69628566D1
DE69628566D1 DE69628566T DE69628566T DE69628566D1 DE 69628566 D1 DE69628566 D1 DE 69628566D1 DE 69628566 T DE69628566 T DE 69628566T DE 69628566 T DE69628566 T DE 69628566T DE 69628566 D1 DE69628566 D1 DE 69628566D1
Authority
DE
Germany
Prior art keywords
cells
pluripotental
neuroepithelic
neural transplantation
cell lines
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69628566T
Other languages
English (en)
Other versions
DE69628566T2 (de
Inventor
John Sinden
Alan Gray
Helen Hodges
Timothy Kershaw
Fiza Rashid-Doubell
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Reneuron Ltd
Original Assignee
Reneuron Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Reneuron Ltd filed Critical Reneuron Ltd
Publication of DE69628566D1 publication Critical patent/DE69628566D1/de
Application granted granted Critical
Publication of DE69628566T2 publication Critical patent/DE69628566T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/30—Nerves; Brain; Eyes; Corneal cells; Cerebrospinal fluid; Neuronal stem cells; Neuronal precursor cells; Glial cells; Oligodendrocytes; Schwann cells; Astroglia; Astrocytes; Choroid plexus; Spinal cord tissue
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0618—Cells of the nervous system
    • C12N5/0623—Stem cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/05—Inorganic components
    • C12N2500/10—Metals; Metal chelators
    • C12N2500/20—Transition metals
    • C12N2500/24—Iron; Fe chelators; Transferrin
    • C12N2500/25—Insulin-transferrin; Insulin-transferrin-selenium
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/90—Serum-free medium, which may still contain naturally-sourced components
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/115—Basic fibroblast growth factor (bFGF, FGF-2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/20—Cytokines; Chemokines
    • C12N2501/24—Interferons [IFN]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/30—Hormones
    • C12N2501/38—Hormones with nuclear receptors
    • C12N2501/39—Steroid hormones
    • C12N2501/392—Sexual steroids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/30—Hormones
    • C12N2501/38—Hormones with nuclear receptors
    • C12N2501/395—Thyroid hormones
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/90—Polysaccharides
    • C12N2501/91—Heparin
DE69628566T 1995-09-12 1996-09-12 Neurale transplantation durch verwendung von pluripotenten neuroepithelzellen Expired - Lifetime DE69628566T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB9518606 1995-09-12
GBGB9518606.0A GB9518606D0 (en) 1995-09-12 1995-09-12 Neural transplantation
PCT/GB1996/002251 WO1997010329A1 (en) 1995-09-12 1996-09-12 Neural transplantation using pluripotent neuroepithelial cells

Publications (2)

Publication Number Publication Date
DE69628566D1 true DE69628566D1 (de) 2003-07-10
DE69628566T2 DE69628566T2 (de) 2004-05-06

Family

ID=10780583

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69628566T Expired - Lifetime DE69628566T2 (de) 1995-09-12 1996-09-12 Neurale transplantation durch verwendung von pluripotenten neuroepithelzellen

Country Status (21)

Country Link
US (3) US7048921B2 (de)
EP (1) EP0850298B1 (de)
JP (1) JP4280872B2 (de)
KR (1) KR19990044606A (de)
CN (1) CN1193345A (de)
AT (1) ATE242316T1 (de)
AU (1) AU711563B2 (de)
CA (1) CA2231436C (de)
CZ (1) CZ296669B6 (de)
DE (1) DE69628566T2 (de)
DK (1) DK0850298T3 (de)
ES (1) ES2196172T3 (de)
GB (1) GB9518606D0 (de)
HK (1) HK1009154A1 (de)
HU (1) HUP9802091A3 (de)
NO (1) NO981072L (de)
PL (1) PL186777B1 (de)
PT (1) PT850298E (de)
RU (1) RU2185833C2 (de)
SK (1) SK285816B6 (de)
WO (1) WO1997010329A1 (de)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2217285T3 (es) 1994-11-08 2004-11-01 Cellfactors Plc Metodo para producir una linea celular neural humana.
GB9518606D0 (en) 1995-09-12 1995-11-15 Inst Of Psychiatry Neural transplantation
GB9904281D0 (en) * 1999-02-24 1999-04-21 Reneuron Ltd Transplantation
GB9907243D0 (en) 1999-03-29 1999-05-26 Reneuron Ltd Therapy
US6399384B1 (en) * 1999-09-17 2002-06-04 Reneuron Limited Conditional immortalization of cells
KR100801764B1 (ko) * 1999-09-17 2008-02-05 레뉴런 리미티드 세포의 조건부 불멸화
US6465215B1 (en) 1999-12-14 2002-10-15 Reneuron Limited Identification of cells for transplantation
GB0005856D0 (en) * 2000-03-10 2000-05-03 Reneuron Ltd Genetic constructs
GB0125773D0 (en) * 2001-10-26 2001-12-19 Reneuron Ltd Constructs
DK1645626T3 (da) 2004-09-30 2008-01-21 Reneuron Ltd Cellelinie
SG10201509679XA (en) * 2007-05-29 2015-12-30 Christopher B Reid Methods for production and uses of multipotent cell populations
GB0822246D0 (en) 2008-12-05 2009-01-14 Reneuron Ltd Composition
GB0902034D0 (en) 2009-02-06 2009-03-11 Reneuron Ltd Method
GB201011589D0 (en) * 2010-07-09 2010-08-25 Reneuron Ltd Therapeutic cells
US20150232662A1 (en) * 2014-02-20 2015-08-20 Sabic Innovative Plastics Ip B.V. Thermoplastic composition and article
US20170173114A1 (en) * 2014-05-07 2017-06-22 Joslin Diabetes Center, Inc. Methods and compositions for induction of ucp1 expression
CN116590345B (zh) * 2023-05-06 2024-01-30 北京中医药大学 永生化小鼠足细胞系及其制备方法、分化方法和应用

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US1662A (en) * 1840-06-27 ariel nobris
US146821A (en) * 1874-01-27 Improvement in nose-pieces of nail-plate feeders
US28510A (en) * 1860-05-29 John e
US913443A (en) * 1908-08-13 1909-02-23 Webster Full Expansion Rotary Engine Company Rotary engine.
NZ226750A (en) * 1987-10-29 1990-09-26 Amrad Corp Ltd Immortalisation of neural precursor cells by introducing a retrovirus vector containing a myc-oncogene
ATE90724T1 (de) 1988-04-12 1993-07-15 Massachusetts Inst Technology Verfahren zur manipulation des zelltyps von eukaryonten.
US5270191A (en) 1988-04-12 1993-12-14 Massachusetts Institute Of Technology Method for manipulation of the cell types of eukaryotes
DE69010388T2 (de) * 1989-04-27 1994-10-20 Ajinomoto Kk Demethylallosamidin und ein Verfahren zu seiner Herstellung.
US5399493A (en) 1989-06-15 1995-03-21 The Regents Of The University Of Michigan Methods and compositions for the optimization of human hematopoietic progenitor cell cultures
WO1991009936A1 (en) * 1989-12-26 1991-07-11 Hana Biologics, Inc. Proliferated neuron progenitor cell product and process
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US5851832A (en) 1991-07-08 1998-12-22 Neurospheres, Ltd. In vitro growth and proliferation of multipotent neural stem cells and their progeny
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JPH08509215A (ja) 1993-04-13 1996-10-01 アメリカ合衆国 移植治療のための神経由来胎児セルラインの使用
US5753491A (en) 1993-04-13 1998-05-19 Us Health Use of neuro-derived fetal cell lines for transplantation therapy
ES2217285T3 (es) 1994-11-08 2004-11-01 Cellfactors Plc Metodo para producir una linea celular neural humana.
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GB9907243D0 (en) * 1999-03-29 1999-05-26 Reneuron Ltd Therapy
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US6465215B1 (en) * 1999-12-14 2002-10-15 Reneuron Limited Identification of cells for transplantation
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DK1645626T3 (da) * 2004-09-30 2008-01-21 Reneuron Ltd Cellelinie

Also Published As

Publication number Publication date
CA2231436A1 (en) 1997-03-20
US7371374B2 (en) 2008-05-13
EP0850298A1 (de) 1998-07-01
US20010001662A1 (en) 2001-05-24
CZ296669B6 (cs) 2006-05-17
HUP9802091A3 (en) 2001-01-29
RU2185833C2 (ru) 2002-07-27
HK1009154A1 (en) 1999-05-28
WO1997010329A1 (en) 1997-03-20
PL186777B1 (pl) 2004-02-27
GB9518606D0 (en) 1995-11-15
JP4280872B2 (ja) 2009-06-17
ATE242316T1 (de) 2003-06-15
DK0850298T3 (da) 2003-09-15
PL325646A1 (en) 1998-08-03
AU6937596A (en) 1997-04-01
JPH11513242A (ja) 1999-11-16
ES2196172T3 (es) 2003-12-16
EP0850298B1 (de) 2003-06-04
US20060051326A1 (en) 2006-03-09
SK285816B6 (sk) 2007-09-06
CZ55898A3 (cs) 1998-06-17
AU711563B2 (en) 1999-10-14
SK30698A3 (en) 1999-01-11
NO981072L (no) 1998-05-12
DE69628566T2 (de) 2004-05-06
US20030147873A1 (en) 2003-08-07
NO981072D0 (no) 1998-03-11
CN1193345A (zh) 1998-09-16
KR19990044606A (ko) 1999-06-25
PT850298E (pt) 2003-09-30
HUP9802091A2 (hu) 1998-12-28
CA2231436C (en) 2007-07-17
US7048921B2 (en) 2006-05-23

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