JPH11513242A - 多能性感覚上皮細胞を用いる神経移植 - Google Patents
多能性感覚上皮細胞を用いる神経移植Info
- Publication number
- JPH11513242A JPH11513242A JP9511756A JP51175697A JPH11513242A JP H11513242 A JPH11513242 A JP H11513242A JP 9511756 A JP9511756 A JP 9511756A JP 51175697 A JP51175697 A JP 51175697A JP H11513242 A JPH11513242 A JP H11513242A
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- Prior art keywords
- cells
- cell
- pluripotent
- invention according
- sensory epithelial
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Abstract
Description
Claims (1)
- 【特許請求の範囲】 1. 治療的有効量の多能性感覚上皮細胞を大脳内移植することを包含する行動 的および/または精神的欠損の処置方法。 2. 認識機能に関するテストを移植の前と後の両方で行なう請求項1に記載の 方法。 3. 治療的使用、特に行動的および/または精神的欠損の処置に使用するため の多能性感覚上皮細胞。 4. 行動的および/または精神的欠損の処置のための医薬製造における多能性 感覚上皮細胞の使用。 5. 細胞が条件的不死である請求項1〜4のいずれか1つに記載の発明。 6. 細胞が単離されている請求項3または4に記載の発明。 7. 治療的使用、特に行動的および/または精神的欠損の処置に使用するため の条件的不死の多能性感覚上皮細胞系。 8. 処置または治療的使用がヒトの処置である、請求項1〜7のいずれか1つ に記載の発明。 9. 処置または治療的使用がヒトの処置であり使用される細胞がヒト細胞であ る、請求項8に記載の発明。 10. 細胞が単一の細胞系からのものである、請求項 1〜9のいずれか1つに記載の発明。 11. 細胞が2種以上の細胞系からの細胞の混合物である、請求項1〜9のい ずれか1つに記載の発明。 12. 細胞が高度の潜在的能力(potency)を有する、請求項1〜11のいずれ か1つに記載の発明。 13. 細胞の増殖がインビトロで許容および非許容の両方の条件下にFGF2添加 によって増加される、請求項1〜12のいずれか1つに記載の発明。 14. 細胞が、条件的不死性を提供し、必要に応じてクローン化を可能にする のに必要な外因性DNAを含むことにおいてのみ自然に見い出されるものと異なる 、請求項1〜13のいずれか1つに記載の発明。 15. 行動的および/または精神的欠損が患者の脳への血液供給の一時的消失 の結果である、請求項1〜14のいずれか1つに記載の発明。 16. 単離されたヒトの多能性感覚上皮細胞。 17. ヒトの条件的不死多能性感覚上皮細胞系。 18. ヒトの条件的不死多能性感覚上皮細胞の産生方法であって、 (a)ヒト胎児から感覚上皮細胞を得る工程、該細胞は発生経路の十分に早い段階 にあるので、それらは様々な異なる脳細胞タイプに分化する能力を有する、 (b)それらの細胞に、適切な調節性エレメントの制御下で細胞に条件的不死を生 じさせ得る配列を含むDNAを導入する工程、および (c)細胞をインビトロで許容条件下で維持する工程、 を包含する方法。 19. 1種以上の細胞系を得るために細胞のクローン化工程をさらに含む請求 項18に記載の方法。 20. 上記請求項のいずれか1つに記載の細胞および薬学的に許容される担体 を含む薬学的組成物。 21. 条件的不死多能性感覚上皮細胞系の細胞のポピュレーションをインビト ロで維持し、細胞の一部分を許容条件下で成長因子の存在下または非存在下に培 養し、細胞の増殖を測定することを包含する、テスト方法。 22. 細胞の一部分を非許容条件下で成長因子の存在下または非存在下に培養 し、細胞の増殖を測定することをさらに包含する、請求項21に記載のテスト方 法。 23. 請求項1或いはそれに従属するあらゆる請求項による処置を受けた哺乳 動物。
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GBGB9518606.0A GB9518606D0 (en) | 1995-09-12 | 1995-09-12 | Neural transplantation |
GB9518606.0 | 1995-09-12 | ||
PCT/GB1996/002251 WO1997010329A1 (en) | 1995-09-12 | 1996-09-12 | Neural transplantation using pluripotent neuroepithelial cells |
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JPH11513242A true JPH11513242A (ja) | 1999-11-16 |
JP4280872B2 JP4280872B2 (ja) | 2009-06-17 |
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JP51175697A Expired - Lifetime JP4280872B2 (ja) | 1995-09-12 | 1996-09-12 | 多能性感覚上皮細胞を用いる神経移植 |
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US (3) | US7048921B2 (ja) |
EP (1) | EP0850298B1 (ja) |
JP (1) | JP4280872B2 (ja) |
KR (1) | KR19990044606A (ja) |
CN (1) | CN1193345A (ja) |
AT (1) | ATE242316T1 (ja) |
AU (1) | AU711563B2 (ja) |
CA (1) | CA2231436C (ja) |
CZ (1) | CZ296669B6 (ja) |
DE (1) | DE69628566T2 (ja) |
DK (1) | DK0850298T3 (ja) |
ES (1) | ES2196172T3 (ja) |
GB (1) | GB9518606D0 (ja) |
HK (1) | HK1009154A1 (ja) |
HU (1) | HUP9802091A3 (ja) |
NO (1) | NO981072L (ja) |
PL (1) | PL186777B1 (ja) |
PT (1) | PT850298E (ja) |
RU (1) | RU2185833C2 (ja) |
SK (1) | SK285816B6 (ja) |
WO (1) | WO1997010329A1 (ja) |
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CZ138397A3 (en) | 1994-11-08 | 1997-10-15 | Bradley Michael John Stringer | Human cellular lines |
GB9518606D0 (en) | 1995-09-12 | 1995-11-15 | Inst Of Psychiatry | Neural transplantation |
GB9904281D0 (en) * | 1999-02-24 | 1999-04-21 | Reneuron Ltd | Transplantation |
GB9907243D0 (en) | 1999-03-29 | 1999-05-26 | Reneuron Ltd | Therapy |
KR100801764B1 (ko) * | 1999-09-17 | 2008-02-05 | 레뉴런 리미티드 | 세포의 조건부 불멸화 |
US6399384B1 (en) * | 1999-09-17 | 2002-06-04 | Reneuron Limited | Conditional immortalization of cells |
US6465215B1 (en) | 1999-12-14 | 2002-10-15 | Reneuron Limited | Identification of cells for transplantation |
GB0005856D0 (en) * | 2000-03-10 | 2000-05-03 | Reneuron Ltd | Genetic constructs |
GB0125773D0 (en) * | 2001-10-26 | 2001-12-19 | Reneuron Ltd | Constructs |
DE602005002430T2 (de) | 2004-09-30 | 2008-06-19 | Reneuron Ltd., Guildford | Zelllinie |
CA2725953A1 (en) * | 2007-05-29 | 2008-12-11 | Christopher B. Reid | Methods for production and uses of multipotent cell populations, pluripotent cell populations, neuronal cell populations, and muscle cell populations |
GB0822246D0 (en) | 2008-12-05 | 2009-01-14 | Reneuron Ltd | Composition |
GB0902034D0 (en) | 2009-02-06 | 2009-03-11 | Reneuron Ltd | Method |
GB201011589D0 (en) * | 2010-07-09 | 2010-08-25 | Reneuron Ltd | Therapeutic cells |
US20150232662A1 (en) * | 2014-02-20 | 2015-08-20 | Sabic Innovative Plastics Ip B.V. | Thermoplastic composition and article |
US20170173114A1 (en) * | 2014-05-07 | 2017-06-22 | Joslin Diabetes Center, Inc. | Methods and compositions for induction of ucp1 expression |
CN116590345B (zh) * | 2023-05-06 | 2024-01-30 | 北京中医药大学 | 永生化小鼠足细胞系及其制备方法、分化方法和应用 |
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US7048921B2 (en) | 2006-05-23 |
RU2185833C2 (ru) | 2002-07-27 |
PL186777B1 (pl) | 2004-02-27 |
HUP9802091A3 (en) | 2001-01-29 |
DE69628566D1 (de) | 2003-07-10 |
JP4280872B2 (ja) | 2009-06-17 |
CA2231436A1 (en) | 1997-03-20 |
EP0850298A1 (en) | 1998-07-01 |
US20030147873A1 (en) | 2003-08-07 |
CZ296669B6 (cs) | 2006-05-17 |
EP0850298B1 (en) | 2003-06-04 |
SK285816B6 (sk) | 2007-09-06 |
PL325646A1 (en) | 1998-08-03 |
NO981072D0 (no) | 1998-03-11 |
KR19990044606A (ko) | 1999-06-25 |
ATE242316T1 (de) | 2003-06-15 |
US20010001662A1 (en) | 2001-05-24 |
PT850298E (pt) | 2003-09-30 |
AU6937596A (en) | 1997-04-01 |
NO981072L (no) | 1998-05-12 |
HUP9802091A2 (hu) | 1998-12-28 |
DE69628566T2 (de) | 2004-05-06 |
ES2196172T3 (es) | 2003-12-16 |
CA2231436C (en) | 2007-07-17 |
WO1997010329A1 (en) | 1997-03-20 |
CZ55898A3 (cs) | 1998-06-17 |
SK30698A3 (en) | 1999-01-11 |
CN1193345A (zh) | 1998-09-16 |
DK0850298T3 (da) | 2003-09-15 |
US20060051326A1 (en) | 2006-03-09 |
US7371374B2 (en) | 2008-05-13 |
AU711563B2 (en) | 1999-10-14 |
GB9518606D0 (en) | 1995-11-15 |
HK1009154A1 (en) | 1999-05-28 |
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