HK1008433A1 - Methods and diagnostic kits for determining the toxicity of a compound utilizing bacterial stress promoters fused to reporter genes - Google Patents

Methods and diagnostic kits for determining the toxicity of a compound utilizing bacterial stress promoters fused to reporter genes

Info

Publication number
HK1008433A1
HK1008433A1 HK98109159A HK98109159A HK1008433A1 HK 1008433 A1 HK1008433 A1 HK 1008433A1 HK 98109159 A HK98109159 A HK 98109159A HK 98109159 A HK98109159 A HK 98109159A HK 1008433 A1 HK1008433 A1 HK 1008433A1
Authority
HK
Hong Kong
Prior art keywords
stress
methods
toxicity
diagnostic kits
compound
Prior art date
Application number
HK98109159A
Other languages
English (en)
Inventor
B Spencer Farr
Original Assignee
Harvard College
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Harvard College filed Critical Harvard College
Publication of HK1008433A1 publication Critical patent/HK1008433A1/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6888Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
    • C12Q1/689Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms for bacteria
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6897Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids involving reporter genes operably linked to promoters

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Plant Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Saccharide Compounds (AREA)
HK98109159A 1992-07-06 1998-07-14 Methods and diagnostic kits for determining the toxicity of a compound utilizing bacterial stress promoters fused to reporter genes HK1008433A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US91079392A 1992-07-06 1992-07-06
PCT/US1993/006537 WO1994001584A1 (en) 1992-07-06 1993-07-06 Methods and diagnostic kits for determining toxicity utilizing bacterial stress promoters fused to reporter genes

Publications (1)

Publication Number Publication Date
HK1008433A1 true HK1008433A1 (en) 1999-05-07

Family

ID=25429335

Family Applications (1)

Application Number Title Priority Date Filing Date
HK98109159A HK1008433A1 (en) 1992-07-06 1998-07-14 Methods and diagnostic kits for determining the toxicity of a compound utilizing bacterial stress promoters fused to reporter genes

Country Status (15)

Country Link
US (2) US5589337A (de)
EP (1) EP0651825B1 (de)
JP (1) JP3456703B2 (de)
KR (1) KR100300932B1 (de)
AT (1) ATE162225T1 (de)
AU (1) AU687353B2 (de)
CA (1) CA2139667C (de)
DE (1) DE69316368T2 (de)
DK (1) DK0651825T3 (de)
ES (1) ES2113546T3 (de)
GR (1) GR3026639T3 (de)
HK (1) HK1008433A1 (de)
NO (1) NO319372B1 (de)
SG (1) SG77101A1 (de)
WO (1) WO1994001584A1 (de)

Families Citing this family (51)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL107815A (en) * 1992-12-04 2003-12-10 Du Pont Genetic constructs comprising a stress-responsive promoter linked to a lux reporter operon and methods of use in environmental testing
JP3509100B2 (ja) * 1993-01-21 2004-03-22 プレジデント アンド フェローズ オブ ハーバード カレッジ 哺乳動物のストレスプロモーターを利用する化合物の毒性測定方法および診断用キット
GB9420735D0 (en) * 1994-10-14 1994-11-30 Karobio Ab Reporter cell line
JPH10509049A (ja) * 1994-11-23 1998-09-08 イー・アイ・デユポン・ドウ・ヌムール・アンド・カンパニー 毒物検出のための凍結乾燥生物発光細菌試薬
US6387651B1 (en) 1995-04-12 2002-05-14 Biolog, Inc. Comparative phenotype analysis of two or more microorganisms using a plurality of substrates within a microwell device
CN1209875A (zh) 1996-01-26 1999-03-03 维科公司 根据人类hiv病毒株的表型药物敏感性控制hiv阳性病人化疗的方法
JP2001503990A (ja) * 1996-11-15 2001-03-27 イー・アイ・デユポン・ドウ・ヌムール・アンド・カンパニー 環境傷害物を検出するための少量で高感度の方法
JP2001516573A (ja) * 1997-09-18 2001-10-02 スミスクライン・ビーチャム・コーポレイション 抗微生物化合物のスクリーニング方法
EP0950717A1 (de) 1998-04-14 1999-10-20 "VLAAMSE INSTELLING VOOR TECHNOLOGISCH ONDERZOEK", afgekort "V.I.T.O." Diagnostisches System und Verfahren zur Bestimmung genotoxischer Substanzen in einer Probe
US6953666B1 (en) 1998-11-06 2005-10-11 Emory University Biomarkers for oxidative stress
AU1243500A (en) * 1998-11-06 2000-05-29 Emory University Biomarkers for oxidative stress
EP1169482A1 (de) * 1999-04-10 2002-01-09 Merlin Gesellschaft für mikrobiologische Diagnostika mbH Verfahren zur genotypischen klassifizierung
US6410255B1 (en) * 1999-05-05 2002-06-25 Aurora Biosciences Corporation Optical probes and assays
US6673554B1 (en) * 1999-06-14 2004-01-06 Trellie Bioinformatics, Inc. Protein localization assays for toxicity and antidotes thereto
US6931396B1 (en) 1999-06-29 2005-08-16 Gene Logic Inc. Biological data processing
US20030232056A1 (en) * 1999-09-10 2003-12-18 Corixa Corporation Compositions and methods for the therapy and diagnosis of ovarian cancer
GB2355791B (en) * 1999-10-28 2004-10-20 Molecular Light Tech Res Ltd Detection of mRNA expression using chemiluminescent labelled probes
CA2400642A1 (en) * 2000-02-23 2001-08-30 Vertex Pharmaceuticals (San Diego) Llc Modified fluorescent proteins
US6696239B1 (en) 2000-04-20 2004-02-24 Biolog, Inc. Comparative phenotype analysis for assessment of biological active compounds such as antimicrobials
US7020561B1 (en) 2000-05-23 2006-03-28 Gene Logic, Inc. Methods and systems for efficient comparison, identification, processing, and importing of gene expression data
US20030171876A1 (en) * 2002-03-05 2003-09-11 Victor Markowitz System and method for managing gene expression data
US6667153B1 (en) 2000-06-26 2003-12-23 Susan Margaret Thomas Composition and method for detecting mutagens
AU2001280746A1 (en) * 2000-07-21 2002-02-05 Phase-1 Molecular Toxicology Canine toxicity genes
US20030119094A1 (en) * 2001-09-24 2003-06-26 Irm Llc Solubility reporter gene constructs
EP1364055A4 (de) * 2000-11-21 2004-08-25 Irm Llc Löslichkeitsreportergen-konstrukte
AU2002237879A1 (en) * 2001-01-23 2002-08-06 Gene Logic, Inc. A method and system for predicting the biological activity, including toxicology and toxicity, of substances
US7054758B2 (en) * 2001-01-30 2006-05-30 Sciona Limited Computer-assisted means for assessing lifestyle risk factors
CN100406569C (zh) * 2001-02-05 2008-07-30 潘申权 用于鉴别活性氧类物质清除剂的方法和试剂盒
WO2002073504A1 (en) * 2001-03-14 2002-09-19 Gene Logic, Inc. A system and method for retrieving and using gene expression data from multiple sources
US7211383B2 (en) * 2001-04-05 2007-05-01 Genelink, Inc. Kits and methods for assessing skin health
US20020146698A1 (en) * 2001-04-05 2002-10-10 Genelink, Inc. Kits and methods for assessing oxidative stress
US7251642B1 (en) 2001-08-06 2007-07-31 Gene Logic Inc. Analysis engine and work space manager for use with gene expression data
DE20116898U1 (de) * 2001-10-15 2002-01-17 Festo Ag & Co Mikroventil
KR20030040923A (ko) * 2001-11-17 2003-05-23 광주과학기술원 산화적 손상과 관련된 유해성 탐지를 위한 재조합발광박테리아 대장균DH5@/pSodaLux(EBHJ1)[KCTC10098BP]
KR100461757B1 (ko) * 2002-06-20 2004-12-14 광주과학기술원 화학물질의 독성과 그 유해성을 탐지할 수 있는 재조합발광 박테리아
CA2445420A1 (en) 2003-07-29 2005-01-29 Invitrogen Corporation Kinase and phosphatase assays
US7727752B2 (en) 2003-07-29 2010-06-01 Life Technologies Corporation Kinase and phosphatase assays
WO2005045426A2 (en) * 2003-11-10 2005-05-19 Aic Gene expression profiling of hazardous compounds and corresponding database clustering algorithm
GB0415963D0 (en) * 2004-07-16 2004-08-18 Cxr Biosciences Ltd Detection of cellular stress
CA2475456A1 (en) * 2004-07-20 2006-01-20 Biophys, Inc. Method and device to optimize analyte and antibody substrate binding by least energy adsorption
CA2475240A1 (en) * 2004-07-20 2006-01-20 Biophys, Inc. Method and device to measure dynamic internal calibration true dose response curves
WO2006096063A1 (en) * 2005-03-11 2006-09-14 Stichting Voor De Technische Wetenschappen Construct and method for screening, selection and identification of stress factors
US7646450B2 (en) * 2005-12-29 2010-01-12 Lg Display Co., Ltd. Light emitting diode array, method of manufacturing the same, backlight assembly having the same, and LCD having the same
ES2307395B2 (es) * 2006-09-04 2009-07-09 Universidad De Oviedo Metodo rapido de deteccion y evaluacion de agentes genotoxicos.
US7890463B2 (en) 2006-09-28 2011-02-15 Xeround Systems Ltd. Apparatus and method for a distributed storage global database
US8647642B2 (en) 2008-09-18 2014-02-11 Aviex Technologies, Llc Live bacterial vaccines resistant to carbon dioxide (CO2), acidic PH and/or osmolarity for viral infection prophylaxis or treatment
US11129906B1 (en) 2016-12-07 2021-09-28 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria
US11180535B1 (en) 2016-12-07 2021-11-23 David Gordon Bermudes Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria
EP3707273B1 (de) 2017-11-08 2024-04-10 Twinstrand Biosciences, Inc. Reagenzien und adapter zur nukleinsäuresequenzierung und verfahren zur herstellung solcher reagenzien und adapter
SG11202007648WA (en) * 2018-02-13 2020-09-29 Twinstrand Biosciences Inc Methods and reagents for detecting and assessing genotoxicity
EP3821004A4 (de) 2018-07-12 2022-04-20 Twinstrand Biosciences, Inc. Verfahren und reagenzien zur charakterisierung genomischer editierung, klonale expansion und zugehörige anwendungen

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0063522B1 (de) * 1981-04-14 1989-07-19 Institut Pasteur DNA-Replikationszellteilung hervorrufender Kupplungsmechanismus in Escherichia Coli
FR2533584B1 (fr) * 1982-09-28 1986-03-21 Pasteur Institut Procede de detection du pouvoir mutagene de substances, susceptibles d'induire la deterioration d'adn cellulaires, mettant en jeu la production d'une reponse sos
US4569916A (en) * 1984-05-21 1986-02-11 Massachusetts Institute Of Technology Assay for tumor promoting agents
EP0370813A3 (de) * 1988-11-25 1991-06-19 Exemplar Corporation Rascher Überprüfungstest der Mutagenesis und Tetratogenesis
EP0463056A1 (de) * 1989-03-17 1992-01-02 E.I. Du Pont De Nemours And Company Externe regulierung der genexpression

Also Published As

Publication number Publication date
NO950040D0 (no) 1995-01-05
ATE162225T1 (de) 1998-01-15
JP3456703B2 (ja) 2003-10-14
ES2113546T3 (es) 1998-05-01
KR950702639A (ko) 1995-07-29
NO950040L (no) 1995-03-06
US5585232A (en) 1996-12-17
KR100300932B1 (ko) 2001-10-22
AU4588493A (en) 1994-01-31
EP0651825B1 (de) 1998-01-14
DE69316368D1 (de) 1998-02-19
AU687353B2 (en) 1998-02-26
GR3026639T3 (en) 1998-07-31
JPH08501930A (ja) 1996-03-05
US5589337A (en) 1996-12-31
DE69316368T2 (de) 1998-06-25
EP0651825A1 (de) 1995-05-10
CA2139667C (en) 2005-03-29
CA2139667A1 (en) 1994-01-20
WO1994001584A1 (en) 1994-01-20
DK0651825T3 (da) 1998-09-14
NO319372B1 (no) 2005-07-25
SG77101A1 (en) 2000-12-19

Similar Documents

Publication Publication Date Title
SG77101A1 (en) Methods and diagnostic kits for determining toxicity utilizing bacterial stress promoters fused to reporter genes
Hamm et al. Unexpected host dependency of Antarctic Nanohaloarchaeota
DK0680517T3 (da) Fremgangsmåde og diagnostiske sæt til bestemmelseaf en forbindelses toksicitet under anvendelse afstress-promotorer fra pat
Cho et al. Bacterial cell wall biogenesis is mediated by SEDS and PBP polymerase families functioning semi-autonomously
Miller et al. Detection on surfaces and in Caco-2 cells of Campylobacter jejuni cells transformed with new gfp, yfp, and cfp marker plasmids
Mitchell et al. An Escherichia coli biosensor capable of detecting both genotoxic and oxidative damage
Busler et al. Protein-protein interactions among Helicobacter pylori cag proteins
BR9809516A (pt) Proteìnas com atividades inseticidas e método de uso
Irrgang et al. Well-known surface and extracellular antigens of pathogenic microorganisms among the immunodominant proteins of the infectious microalgae Prototheca zopfii
BG97042A (bg) Метод за получаване на растения,резистентни към атаките на sсlеrотiniа sсlеrотiоruм,чрез внасяне на ген,кодиращ оксалатоксидаза
Hantash et al. Membrane association of the Escherichia coli enterobactin synthase proteins EntB/G, EntE, and EntF
Farr Methods and diagnostic kits for determining toxicity utilizing E. coli stress promoters fused to reporter genes
Palva et al. Gene fusions to the ptsM/pel locus of Escherichia coli
Leister et al. Mitochondrial ribosomal proteins in Xenopus laevis/X. mulleri interspecific hybrids
Ihler et al. Selective binding of ribosomes to initiation sites on single-stranded DNA from bacterial viruses
EP0729580B1 (de) Nachweisverfahren für hdm-2-spezifische antikörper
DE19544374C1 (de) Plasmid und damit transformierter Mikroorganismus für ein Verfahren zur luminometrischen Bestimmung der mutagenen und/oder karzinogenen Potenz eines Agens
MAcDERMOT et al. beta-Bungarotoxin. Separation of two discrete proteins with different synaptic actions
Kawanishi et al. Translesion DNA synthesis across various DNA adducts produced by 3-nitrobenzanthrone in Escherichia coli
US20230332214A1 (en) Method of mapping spatial distributions of cellular components
Vandekerchove et al. Development of a capture ELISA for the detection of antibodies to enteropathogenic Escherichia coli (EPEC) in rabbit flocks using intimin-specific monoclonal antibodies
Carpio et al. Bovine DNA polymorphisms uncovered by RAPD‐PCR
Suo et al. A Mesorhizobium japonicum quorum sensing circuit that involves three linked genes and an unusual acyl-homoserine lactone signal
WO1996017066A1 (de) Screening-modell
KR100542260B1 (ko) 벤조산 및 그 유도체의 탐지를 위한 형질전환용 재조합벡터, 그 형질전환체 및 동 형질전환체를 이용한 벤조산및 그 유도체의 탐지방법

Legal Events

Date Code Title Description
PF Patent in force
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20040706