HK1007495A1 - Low toxicity drug-lipid systems - Google Patents

Low toxicity drug-lipid systems

Info

Publication number
HK1007495A1
HK1007495A1 HK98106740A HK98106740A HK1007495A1 HK 1007495 A1 HK1007495 A1 HK 1007495A1 HK 98106740 A HK98106740 A HK 98106740A HK 98106740 A HK98106740 A HK 98106740A HK 1007495 A1 HK1007495 A1 HK 1007495A1
Authority
HK
Hong Kong
Prior art keywords
lipid
compositions
hdlcs
drug
lipid complexes
Prior art date
Application number
HK98106740A
Other languages
English (en)
Inventor
Lawrence Bonl
Anthony G Durning
Pieter R Cullis
Andrew S Janoff
John J Kearns
Robert Klimchak
Original Assignee
Liposome Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27361805&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HK1007495(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Liposome Co Inc filed Critical Liposome Co Inc
Publication of HK1007495A1 publication Critical patent/HK1007495A1/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/543—Lipids, e.g. triglycerides; Polyamines, e.g. spermine or spermidine
    • A61K47/544—Phospholipids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A61K9/1277—Processes for preparing; Proliposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • G—PHYSICS
    • G03—PHOTOGRAPHY; CINEMATOGRAPHY; ANALOGOUS TECHNIQUES USING WAVES OTHER THAN OPTICAL WAVES; ELECTROGRAPHY; HOLOGRAPHY
    • G03B—APPARATUS OR ARRANGEMENTS FOR TAKING PHOTOGRAPHS OR FOR PROJECTING OR VIEWING THEM; APPARATUS OR ARRANGEMENTS EMPLOYING ANALOGOUS TECHNIQUES USING WAVES OTHER THAN OPTICAL WAVES; ACCESSORIES THEREFOR
    • G03B2227/00—Photographic printing apparatus
    • G03B2227/32—Projection printing apparatus, e.g. enlarging apparatus, copying camera
    • G03B2227/325—Microcapsule copiers

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Dispersion Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Saccharide Compounds (AREA)
  • Vehicle Step Arrangements And Article Storage (AREA)
  • Catalysts (AREA)
  • Vehicle Interior And Exterior Ornaments, Soundproofing, And Insulation (AREA)
HK98106740A 1987-03-05 1998-06-25 Low toxicity drug-lipid systems HK1007495A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US2215787A 1987-03-05 1987-03-05
US6990887A 1987-07-06 1987-07-06
US7930987A 1987-07-29 1987-07-29

Publications (1)

Publication Number Publication Date
HK1007495A1 true HK1007495A1 (en) 1999-04-16

Family

ID=27361805

Family Applications (1)

Application Number Title Priority Date Filing Date
HK98106740A HK1007495A1 (en) 1987-03-05 1998-06-25 Low toxicity drug-lipid systems

Country Status (20)

Country Link
EP (1) EP0282405B2 (sv)
KR (1) KR970002870B1 (sv)
CN (1) CN1044093C (sv)
AT (1) ATE118169T1 (sv)
AU (1) AU622405B2 (sv)
CA (1) CA1338701C (sv)
DE (1) DE3852961T3 (sv)
DK (1) DK176010B1 (sv)
ES (1) ES2070131T5 (sv)
FI (1) FI102724B (sv)
GR (1) GR3015916T3 (sv)
HK (1) HK1007495A1 (sv)
IE (1) IE67152B1 (sv)
IL (1) IL85607A (sv)
LU (1) LU88684I2 (sv)
NL (1) NL990004I1 (sv)
NO (4) NO179995C (sv)
NZ (1) NZ223660A (sv)
PT (1) PT86913B (sv)
WO (1) WO1988006443A1 (sv)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5830498A (en) * 1987-10-16 1998-11-03 Board Of Regents, The University Of Texas System Liposomal-polyene preliposomal powder and method for its preparation
US5178875A (en) * 1991-01-14 1993-01-12 The Board Of Regents, The University Of Texas System Liposomal-polyene preliposomal powder and method for its preparation
AU598958B2 (en) 1987-11-12 1990-07-05 Vestar, Inc. Improved amphotericin b liposome preparation
EP0467954B1 (en) * 1989-03-31 1996-05-01 The Regents Of The University Of California Preparation of liposome and lipid complex compositions
US5188951A (en) * 1990-04-17 1993-02-23 The Liposome Company, Inc. Enzymatic synthesis of soluble phosphatides from phospholipids
US5556637A (en) * 1990-08-06 1996-09-17 A. Nattermann & Cie. Gmbh Water containing liposome system
DE4108903A1 (de) * 1990-08-06 1992-02-13 Nattermann A & Cie Pharmazeutisches produkt
US5534502A (en) * 1990-11-06 1996-07-09 Nippon Shinyaku Co. Ltd. Process for producing fat emulsion
EP0556392A4 (en) * 1990-11-06 1994-03-17 Nippon Shinyaku Co Ltd PROCESS FOR PRODUCING A FATTY EMULSION.
WO1993003737A1 (en) * 1991-08-14 1993-03-04 Liposome Technology, Inc. Hiv-treatment method with low-toxicity amphotericin b
WO1994027580A1 (en) * 1993-05-21 1994-12-08 The Liposome Company, Inc. Reduction of liposome-induced adverse physiological reactions
US5716526A (en) * 1994-01-14 1998-02-10 The Liposome Company, Inc. Method of separating materials from liposomes or lipid complexes
US5902604A (en) * 1995-06-06 1999-05-11 Board Of Regents, The University Of Texas System Submicron liposome suspensions obtained from preliposome lyophilizates
GB2326337A (en) * 1997-06-20 1998-12-23 Phares Pharma Holland Homogeneous lipid compositions for drug delivery
US6165997A (en) * 1997-11-20 2000-12-26 Statens Serum Institut Phospholipids having antimicrobial activity with or without the presence of antimicrobials
US20070178147A1 (en) * 2005-12-08 2007-08-02 Desai Narendra R Liposomal compositions
KR101132626B1 (ko) * 2009-10-12 2012-04-02 주식회사 녹십자 난용성 약물의 전달을 위한 고밀도지단백 나노입자의 제조방법
RU2595865C2 (ru) 2010-08-20 2016-08-27 Др. Редди'З Лабораториз, Лтд. Фосфолипидный депо-препарат
CN103179972A (zh) 2010-10-22 2013-06-26 雷迪博士实验室公司 储存稳定的粘性磷脂贮库制剂在治疗伤口中的用途
CN104427976B (zh) 2012-05-10 2018-04-24 佩因拉佛姆有限公司 疏水的活性成分的储库制剂及其制备方法
CN107708672A (zh) 2015-06-15 2018-02-16 华盛顿大学 用于延长血液和淋巴组织中的药物水平的多药脂质纳米颗粒组合物和相关方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4310506A (en) * 1979-02-22 1982-01-12 California Institute Of Technology Means of preparation and applications of liposomes containing high concentrations of entrapped ionic species
FR2521565B1 (fr) * 1982-02-17 1985-07-05 Dior Sa Parfums Christian Melange pulverulent de constituants lipidiques et de constituants hydrophobes, procede pour le preparer, phases lamellaires lipidiques hydratees et procede de fabrication, compositions pharmaceutiques ou cosmetiques comportant des phases lamellaires lipidiques hydratees
US4604376A (en) * 1982-04-21 1986-08-05 Research Corporation Enteric compounds and complexes
US4436746A (en) * 1982-09-30 1984-03-13 Ciba-Geigy Corporation Thromboxane synthetase inhibitory N-substituted-2-(1-imidazolyl)indoles
US4622219A (en) * 1983-06-17 1986-11-11 Haynes Duncan H Method of inducing local anesthesia using microdroplets of a general anesthetic
IL78930A0 (en) * 1985-07-29 1986-09-30 Abbott Lab Lyophilized emulsion compositions for parenteral administration
IL78929A0 (en) * 1985-07-29 1986-09-30 Abbott Lab Microemulsion compositions for parenteral administration

Also Published As

Publication number Publication date
DE3852961T3 (de) 1998-12-24
ES2070131T5 (es) 1998-10-01
EP0282405A2 (en) 1988-09-14
NO179995B (no) 1996-10-21
NO944071D0 (no) 1994-10-26
DK176010B1 (da) 2005-11-28
NO884391L (no) 1988-11-24
EP0282405B1 (en) 1995-02-08
FI102724B1 (sv) 1999-02-15
PT86913A (pt) 1989-03-30
AU622405B2 (en) 1992-04-09
AU1799088A (en) 1988-09-26
NO944071L (no) 1988-11-24
CN1044093C (zh) 1999-07-14
FI102724B (sv) 1999-02-15
IE67152B1 (en) 1996-03-06
NO180147B (no) 1996-11-18
PT86913B (pt) 1993-07-30
ES2070131T3 (es) 1995-06-01
IL85607A (en) 1992-08-18
LU88684I2 (fr) 1996-04-29
IE880600L (en) 1988-09-05
NO884391D0 (no) 1988-10-04
DK98089D0 (da) 1989-03-01
FI894161A0 (fi) 1989-09-04
NO180147C (no) 1997-02-26
NO1998013I1 (no) 1998-03-25
ATE118169T1 (de) 1995-02-15
NZ223660A (en) 1990-11-27
CN88101864A (zh) 1988-09-28
WO1988006443A1 (en) 1988-09-07
DE3852961T2 (de) 1995-07-06
CA1338701C (en) 1996-11-12
DE3852961D1 (de) 1995-03-23
GR3015916T3 (en) 1995-07-31
NL990004I1 (nl) 1999-04-01
KR970002870B1 (ko) 1997-03-12
KR890700341A (ko) 1989-04-24
NO1998012I1 (no) 1998-03-25
DK98089A (da) 1989-03-01
IL85607A0 (en) 1988-08-31
EP0282405B2 (en) 1998-07-22
NO179995C (no) 1997-01-29
EP0282405A3 (en) 1989-01-04

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Legal Events

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PF Patent in force
PE Patent expired

Effective date: 20080303