HK1005878A1 - 17B-aryl and 17B-heterocyclyl-5-beta 14-beta-andostane derivatives active on the cardiovascular system processes for their preparation and pharmaceutical compositions containing same - Google Patents
17B-aryl and 17B-heterocyclyl-5-beta 14-beta-andostane derivatives active on the cardiovascular system processes for their preparation and pharmaceutical compositions containing sameInfo
- Publication number
- HK1005878A1 HK1005878A1 HK98104947A HK98104947A HK1005878A1 HK 1005878 A1 HK1005878 A1 HK 1005878A1 HK 98104947 A HK98104947 A HK 98104947A HK 98104947 A HK98104947 A HK 98104947A HK 1005878 A1 HK1005878 A1 HK 1005878A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- beta
- heterocyclyl
- aryl
- preparation
- pharmaceutical compositions
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 210000000748 cardiovascular system Anatomy 0.000 title 1
- 230000026676 system process Effects 0.000 title 1
- 208000024172 Cardiovascular disease Diseases 0.000 abstract 1
- 206010019280 Heart failures Diseases 0.000 abstract 1
- 206010020772 Hypertension Diseases 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000008177 pharmaceutical agent Substances 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
- C07J31/003—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring the S atom directly linked to a ring carbon atom of the cyclopenta(a)hydrophenanthrene skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0003—Androstane derivatives
- C07J1/0011—Androstane derivatives substituted in position 17 by a keto group
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J17/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
- C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J33/00—Normal steroids having a sulfur-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J33/002—Normal steroids having a sulfur-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0055—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0088—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing unsubstituted amino radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE4232638A DE4232638C2 (de) | 1992-09-29 | 1992-09-29 | 17-Phenyl-5beta-14beta-androstanderivate, Verfahren zu deren Herstellung und diese enthaltende pharmazeutische Zusammensetzungen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HK1005878A1 true HK1005878A1 (en) | 1999-01-29 |
Family
ID=6469142
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HK98104947A HK1005878A1 (en) | 1992-09-29 | 1998-06-05 | 17B-aryl and 17B-heterocyclyl-5-beta 14-beta-andostane derivatives active on the cardiovascular system processes for their preparation and pharmaceutical compositions containing same |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US5567694A (xx) |
| EP (1) | EP0590272B1 (xx) |
| JP (1) | JPH06192286A (xx) |
| KR (1) | KR940007055A (xx) |
| AT (1) | ATE147077T1 (xx) |
| CA (1) | CA2106917A1 (xx) |
| DE (2) | DE4232638C2 (xx) |
| DK (1) | DK0590272T3 (xx) |
| ES (1) | ES2095531T3 (xx) |
| GR (1) | GR3022376T3 (xx) |
| HK (1) | HK1005878A1 (xx) |
| ZA (1) | ZA937085B (xx) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5510340A (en) * | 1992-06-12 | 1996-04-23 | Sri International | Antihypercholesterolemic compounds and related pharmaceutical compositions and methods of use |
| DE4232681C2 (de) * | 1992-09-29 | 1994-11-24 | Sigma Tau Ind Farmaceuti | 17-Phenyl- und 17-Furyl-14beta,5alpha-androstan- und androsten- Derivate, Verfahren zu deren Herstellung und diese enthaltende pharmazeutische Zusammensetzung |
| US20040242618A1 (en) | 2003-04-01 | 2004-12-02 | Lardy Henry A. | Antiandrogens with marginal agonist activity and methods of use |
| CN101291950B (zh) * | 2005-09-15 | 2013-01-02 | 科学与工业研究会 | 咪唑基取代的类固醇和茚满-1-酮衍生物 |
| SI2160190T1 (sl) * | 2007-06-07 | 2015-12-31 | Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. | Derivati 5 beta, 14 beta-androstana, uporabni za zdravljenje bolezni zaradi fibroze organov |
| US20120028945A1 (en) | 2009-03-23 | 2012-02-02 | Patrizia Ferrari | 5-Beta, 14-Beta-Androstane Derivatives Useful For The Treatment Of Proteinuria, Glomerulosclerosis And Renal Failure |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2614046C2 (de) * | 1976-04-01 | 1984-08-02 | Boehringer Mannheim Gmbh, 6800 Mannheim | Neue 17α-Hydroxy-Cardenolid-Glykoside, Verfahren zu deren Herstellung und diese enthaltende Arzneimittel |
| FR2407940A1 (fr) * | 1977-11-08 | 1979-06-01 | Roussel Uclaf | Nouveaux derives steroides 17 a-aryle, ou 17 a-heteroaryle, leur procede de preparation et leur application comme medicament |
| DE3223735A1 (de) * | 1982-06-25 | 1983-12-29 | Boehringer Mannheim Gmbh, 6800 Mannheim | Neue derivate von 17(alpha)-hydroxy-digitoxigenin-digitoxosiden, verfahren zu ihrer herstellung und ihre verwendung als arzneitmittel |
| JPH0368596A (ja) * | 1989-08-09 | 1991-03-25 | Snow Brand Milk Prod Co Ltd | １４α‐ヒドロキシ‐４‐アンドロステン‐３，６，１７‐トリオンの製造方法 |
-
1992
- 1992-09-29 DE DE4232638A patent/DE4232638C2/de not_active Expired - Fee Related
-
1993
- 1993-08-04 DK DK93112500.9T patent/DK0590272T3/da active
- 1993-08-04 AT AT93112500T patent/ATE147077T1/de active
- 1993-08-04 ES ES93112500T patent/ES2095531T3/es not_active Expired - Lifetime
- 1993-08-04 DE DE69307071T patent/DE69307071T2/de not_active Expired - Fee Related
- 1993-08-04 EP EP93112500A patent/EP0590272B1/en not_active Expired - Lifetime
- 1993-09-24 ZA ZA937085A patent/ZA937085B/xx unknown
- 1993-09-24 CA CA002106917A patent/CA2106917A1/en not_active Abandoned
- 1993-09-27 KR KR1019930019824A patent/KR940007055A/ko not_active Application Discontinuation
- 1993-09-29 JP JP5243359A patent/JPH06192286A/ja active Pending
- 1993-09-29 US US08/128,114 patent/US5567694A/en not_active Expired - Fee Related
-
1997
- 1997-01-23 GR GR970400113T patent/GR3022376T3/el unknown
-
1998
- 1998-06-05 HK HK98104947A patent/HK1005878A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| DE69307071T2 (de) | 1997-05-22 |
| EP0590272B1 (en) | 1997-01-02 |
| DK0590272T3 (da) | 1997-04-14 |
| KR940007055A (ko) | 1994-04-26 |
| ATE147077T1 (de) | 1997-01-15 |
| DE4232638A1 (de) | 1994-03-31 |
| JPH06192286A (ja) | 1994-07-12 |
| ZA937085B (en) | 1994-08-11 |
| EP0590272A2 (en) | 1994-04-06 |
| DE4232638C2 (de) | 1994-11-17 |
| CA2106917A1 (en) | 1994-03-30 |
| ES2095531T3 (es) | 1997-02-16 |
| US5567694A (en) | 1996-10-22 |
| DE69307071D1 (de) | 1997-02-13 |
| EP0590272A3 (en) | 1994-07-06 |
| GR3022376T3 (en) | 1997-04-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PC | Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee) |