GR3024707T3 - Digitoxigenin and dihydrodigitoxigenin 3beta-derivatives and pharmaceutical compositions comprising same for the treatment of cardiovascular disorders - Google Patents
Digitoxigenin and dihydrodigitoxigenin 3beta-derivatives and pharmaceutical compositions comprising same for the treatment of cardiovascular disordersInfo
- Publication number
- GR3024707T3 GR3024707T3 GR970402351T GR970402351T GR3024707T3 GR 3024707 T3 GR3024707 T3 GR 3024707T3 GR 970402351 T GR970402351 T GR 970402351T GR 970402351 T GR970402351 T GR 970402351T GR 3024707 T3 GR3024707 T3 GR 3024707T3
- Authority
- GR
- Greece
- Prior art keywords
- dihydrodigitoxigenin
- digitoxigenin
- derivatives
- treatment
- pharmaceutical compositions
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J19/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 by a lactone ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
- C07J31/003—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring the S atom directly linked to a ring carbon atom of the cyclopenta(a)hydrophenanthrene skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0055—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of at least three carbon atoms which may or may not be branched, e.g. cholane or cholestane derivatives, optionally cyclised, e.g. 17-beta-phenyl or 17-beta-furyl derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0088—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 containing unsubstituted amino radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
Abstract
Digitoxigenin and dihydrodigitoxigenin 3 beta -derivatives, a process for their preparation and pharmaceutical compositions containing same for the treatment of cardiovascular disorders such as heart failure and hypertension are disclosed.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE4221635A DE4221635C1 (en) | 1992-07-01 | 1992-07-01 | 3beta-digitoxigenin and 3beta-dihydrodigitoxigenin derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
GR3024707T3 true GR3024707T3 (en) | 1997-12-31 |
Family
ID=6462264
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GR970402351T GR3024707T3 (en) | 1992-07-01 | 1997-09-11 | Digitoxigenin and dihydrodigitoxigenin 3beta-derivatives and pharmaceutical compositions comprising same for the treatment of cardiovascular disorders |
Country Status (8)
Country | Link |
---|---|
US (1) | US5478817A (en) |
EP (1) | EP0576913B1 (en) |
JP (1) | JPH0665285A (en) |
AT (1) | ATE157670T1 (en) |
DE (2) | DE4221635C1 (en) |
DK (1) | DK0576913T3 (en) |
ES (1) | ES2106922T3 (en) |
GR (1) | GR3024707T3 (en) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7361478B2 (en) * | 2001-11-20 | 2008-04-22 | Allergan, Inc. | High-throughput screen for identifying selective persistent sodium channels channel blockers |
US20040064050A1 (en) * | 2002-09-20 | 2004-04-01 | Jun Liu | System and method for screening tissue |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2004543A1 (en) * | 1970-02-02 | 1971-08-12 | Knoll Ag, Chemische Fabriken, 6700 Ludwigshafen | Alkoxymethyl ethers of cardiovascular steroids |
DE2517293C2 (en) * | 1975-04-18 | 1984-02-16 | Knoll Ag, 6700 Ludwigshafen | Novel cardenolide β-glycosides, their preparation and uses |
FR2310766A1 (en) * | 1975-05-16 | 1976-12-10 | Nativelle Sa Ets | CARDENOLIDE DERIVATIVES, PROCESS OF PREPARATION AND APPLICATION AS A MEDICINAL PRODUCT |
DE2833472A1 (en) * | 1978-07-29 | 1980-03-06 | Beiersdorf Ag | Digitoxigenin mono:digitoxoside derivs. and isomers - useful as cardiotonic agents |
US4259240A (en) * | 1979-09-28 | 1981-03-31 | Advance Biofactures Corporation | Synthesis of furyl intermediates, and cardenolides and their isomers prepared therefrom |
GB8600491D0 (en) * | 1986-01-09 | 1986-02-12 | Erba Farmitalia | Aminoglycoside norcholanic acid derivatives |
GB8916635D0 (en) * | 1989-07-20 | 1989-09-06 | Erba Carlo Spa | Cardanolactam derivatives |
-
1992
- 1992-07-01 DE DE4221635A patent/DE4221635C1/en not_active Expired - Fee Related
-
1993
- 1993-06-16 DE DE69313534T patent/DE69313534T2/en not_active Expired - Fee Related
- 1993-06-16 ES ES93109610T patent/ES2106922T3/en not_active Expired - Lifetime
- 1993-06-16 DK DK93109610.1T patent/DK0576913T3/en active
- 1993-06-16 AT AT93109610T patent/ATE157670T1/en not_active IP Right Cessation
- 1993-06-16 EP EP93109610A patent/EP0576913B1/en not_active Expired - Lifetime
- 1993-06-23 US US08/079,942 patent/US5478817A/en not_active Expired - Fee Related
- 1993-06-30 JP JP5161239A patent/JPH0665285A/en active Pending
-
1997
- 1997-09-11 GR GR970402351T patent/GR3024707T3/en unknown
Also Published As
Publication number | Publication date |
---|---|
DE69313534D1 (en) | 1997-10-09 |
JPH0665285A (en) | 1994-03-08 |
EP0576913A3 (en) | 1995-04-19 |
DE4221635C1 (en) | 1994-05-05 |
DK0576913T3 (en) | 1997-11-03 |
ATE157670T1 (en) | 1997-09-15 |
EP0576913B1 (en) | 1997-09-03 |
DE69313534T2 (en) | 1998-02-19 |
US5478817A (en) | 1995-12-26 |
EP0576913A2 (en) | 1994-01-05 |
ES2106922T3 (en) | 1997-11-16 |
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