HK1002281A1 - Hindered n-oxide esters of rapamycin and their use as medicaments - Google Patents
Hindered n-oxide esters of rapamycin and their use as medicamentsInfo
- Publication number
- HK1002281A1 HK1002281A1 HK98101292A HK98101292A HK1002281A1 HK 1002281 A1 HK1002281 A1 HK 1002281A1 HK 98101292 A HK98101292 A HK 98101292A HK 98101292 A HK98101292 A HK 98101292A HK 1002281 A1 HK1002281 A1 HK 1002281A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- rapamycin
- medicaments
- hindered
- alkyl
- oxide esters
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/18—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Transplantation (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/345,972 US5491231A (en) | 1994-11-28 | 1994-11-28 | Hindered N-oxide esters of rapamycin |
PCT/US1995/015318 WO1996016967A1 (en) | 1994-11-28 | 1995-11-22 | Hindered n-oxide esters of rapamycin and their use as medicaments |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1002281A1 true HK1002281A1 (en) | 1998-08-14 |
Family
ID=23357367
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK98101292A HK1002281A1 (en) | 1994-11-28 | 1998-02-19 | Hindered n-oxide esters of rapamycin and their use as medicaments |
Country Status (19)
Country | Link |
---|---|
US (5) | US5491231A (sv) |
EP (1) | EP0794955B1 (sv) |
JP (1) | JPH10509977A (sv) |
KR (1) | KR100377278B1 (sv) |
AT (1) | ATE203539T1 (sv) |
AU (1) | AU712998B2 (sv) |
BR (1) | BR9509825A (sv) |
CA (1) | CA2205577A1 (sv) |
DE (1) | DE69521907T2 (sv) |
DK (1) | DK0794955T3 (sv) |
ES (1) | ES2158959T3 (sv) |
FI (1) | FI972240A (sv) |
GR (1) | GR3036712T3 (sv) |
HK (1) | HK1002281A1 (sv) |
HU (1) | HUT77139A (sv) |
MX (1) | MX9703893A (sv) |
NZ (1) | NZ297661A (sv) |
PT (1) | PT794955E (sv) |
WO (1) | WO1996016967A1 (sv) |
Families Citing this family (95)
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US6015809A (en) * | 1998-08-17 | 2000-01-18 | American Home Products Corporation | Photocyclized rapamycin |
US6331547B1 (en) | 1999-08-18 | 2001-12-18 | American Home Products Corporation | Water soluble SDZ RAD esters |
US6277983B1 (en) | 2000-09-27 | 2001-08-21 | American Home Products Corporation | Regioselective synthesis of rapamycin derivatives |
US20050002986A1 (en) * | 2000-05-12 | 2005-01-06 | Robert Falotico | Drug/drug delivery systems for the prevention and treatment of vascular disease |
US7300662B2 (en) * | 2000-05-12 | 2007-11-27 | Cordis Corporation | Drug/drug delivery systems for the prevention and treatment of vascular disease |
US8236048B2 (en) | 2000-05-12 | 2012-08-07 | Cordis Corporation | Drug/drug delivery systems for the prevention and treatment of vascular disease |
US6670355B2 (en) * | 2000-06-16 | 2003-12-30 | Wyeth | Method of treating cardiovascular disease |
US6511986B2 (en) | 2000-08-11 | 2003-01-28 | Wyeth | Method of treating estrogen receptor positive carcinoma |
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US6399625B1 (en) | 2000-09-27 | 2002-06-04 | Wyeth | 1-oxorapamycins |
AU2001294869B2 (en) * | 2000-09-29 | 2006-06-15 | Cardinal Health 529, Llc | Coated medical devices |
US6399626B1 (en) | 2000-10-02 | 2002-06-04 | Wyeth | Hydroxyesters of 7-desmethylrapamycin |
US6440991B1 (en) | 2000-10-02 | 2002-08-27 | Wyeth | Ethers of 7-desmethlrapamycin |
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ATE385795T1 (de) | 2002-07-30 | 2008-03-15 | Wyeth Corp | Parenterale formulierungen mit einem rapamycin hydroxyester |
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CN1946852A (zh) * | 2004-04-27 | 2007-04-11 | 惠氏公司 | 利用雷帕霉素特异性甲基化酶标记雷帕霉素 |
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US9283211B1 (en) | 2009-11-11 | 2016-03-15 | Rapamycin Holdings, Llc | Oral rapamycin preparation and use for stomatitis |
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WO2019012024A1 (en) | 2017-07-13 | 2019-01-17 | INSERM (Institut National de la Santé et de la Recherche Médicale) | METHODS FOR INCREASING EXPANSION AND IMMUNOSUPPRESSIVE CAPACITY OF A CD8 + CD45RCBAS TREGS POPULATION / - |
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-
1994
- 1994-11-28 US US08/345,972 patent/US5491231A/en not_active Expired - Lifetime
-
1995
- 1995-05-24 US US08/448,843 patent/US5559122A/en not_active Expired - Lifetime
- 1995-05-24 US US08/449,168 patent/US5508285A/en not_active Expired - Lifetime
- 1995-05-24 US US08/449,167 patent/US5508290A/en not_active Expired - Lifetime
- 1995-05-24 US US08/450,769 patent/US5521194A/en not_active Expired - Lifetime
- 1995-11-22 JP JP8518953A patent/JPH10509977A/ja not_active Withdrawn
- 1995-11-22 PT PT95941467T patent/PT794955E/pt unknown
- 1995-11-22 KR KR1019970703519A patent/KR100377278B1/ko not_active IP Right Cessation
- 1995-11-22 DE DE69521907T patent/DE69521907T2/de not_active Expired - Fee Related
- 1995-11-22 NZ NZ297661A patent/NZ297661A/xx unknown
- 1995-11-22 DK DK95941467T patent/DK0794955T3/da active
- 1995-11-22 ES ES95941467T patent/ES2158959T3/es not_active Expired - Lifetime
- 1995-11-22 WO PCT/US1995/015318 patent/WO1996016967A1/en active IP Right Grant
- 1995-11-22 BR BR9509825A patent/BR9509825A/pt active Search and Examination
- 1995-11-22 AT AT95941467T patent/ATE203539T1/de not_active IP Right Cessation
- 1995-11-22 HU HU9701851A patent/HUT77139A/hu unknown
- 1995-11-22 EP EP95941467A patent/EP0794955B1/en not_active Expired - Lifetime
- 1995-11-22 MX MX9703893A patent/MX9703893A/es not_active IP Right Cessation
- 1995-11-22 AU AU42877/96A patent/AU712998B2/en not_active Ceased
- 1995-11-22 CA CA002205577A patent/CA2205577A1/en not_active Abandoned
-
1997
- 1997-05-27 FI FI972240A patent/FI972240A/sv unknown
-
1998
- 1998-02-19 HK HK98101292A patent/HK1002281A1/xx not_active IP Right Cessation
-
2001
- 2001-09-26 GR GR20010401569T patent/GR3036712T3/el not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
FI972240A0 (sv) | 1997-05-27 |
JPH10509977A (ja) | 1998-09-29 |
US5521194A (en) | 1996-05-28 |
WO1996016967A1 (en) | 1996-06-06 |
DE69521907T2 (de) | 2001-11-29 |
AU4287796A (en) | 1996-06-19 |
FI972240A (sv) | 1997-05-27 |
CA2205577A1 (en) | 1996-06-06 |
HUT77139A (hu) | 1998-03-02 |
NZ297661A (en) | 2000-01-28 |
US5508285A (en) | 1996-04-16 |
US5491231A (en) | 1996-02-13 |
GR3036712T3 (en) | 2001-12-31 |
ATE203539T1 (de) | 2001-08-15 |
DE69521907D1 (de) | 2001-08-30 |
ES2158959T3 (es) | 2001-09-16 |
MX9703893A (es) | 1997-08-30 |
US5508290A (en) | 1996-04-16 |
BR9509825A (pt) | 1997-09-30 |
KR100377278B1 (ko) | 2003-10-04 |
PT794955E (pt) | 2001-12-28 |
US5559122A (en) | 1996-09-24 |
DK0794955T3 (da) | 2001-09-24 |
EP0794955A1 (en) | 1997-09-17 |
EP0794955B1 (en) | 2001-07-25 |
AU712998B2 (en) | 1999-11-18 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PF | Patent in force | ||
PC | Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee) |
Effective date: 20041122 |