FI972240A - Förhindrade N-oxidestrar av rapamycin och deras användning som läkemedel - Google Patents
Förhindrade N-oxidestrar av rapamycin och deras användning som läkemedel Download PDFInfo
- Publication number
- FI972240A FI972240A FI972240A FI972240A FI972240A FI 972240 A FI972240 A FI 972240A FI 972240 A FI972240 A FI 972240A FI 972240 A FI972240 A FI 972240A FI 972240 A FI972240 A FI 972240A
- Authority
- FI
- Finland
- Prior art keywords
- rapamycin
- drugs
- prevent
- alkyl
- oxide esters
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/18—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/345,972 US5491231A (en) | 1994-11-28 | 1994-11-28 | Hindered N-oxide esters of rapamycin |
PCT/US1995/015318 WO1996016967A1 (en) | 1994-11-28 | 1995-11-22 | Hindered n-oxide esters of rapamycin and their use as medicaments |
Publications (2)
Publication Number | Publication Date |
---|---|
FI972240A true FI972240A (sv) | 1997-05-27 |
FI972240A0 FI972240A0 (sv) | 1997-05-27 |
Family
ID=23357367
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
FI972240A FI972240A0 (sv) | 1994-11-28 | 1997-05-27 | Förhindrade N-oxidestrar av rapamycin och deras användning som läkemedel |
Country Status (19)
Country | Link |
---|---|
US (5) | US5491231A (sv) |
EP (1) | EP0794955B1 (sv) |
JP (1) | JPH10509977A (sv) |
KR (1) | KR100377278B1 (sv) |
AT (1) | ATE203539T1 (sv) |
AU (1) | AU712998B2 (sv) |
BR (1) | BR9509825A (sv) |
CA (1) | CA2205577A1 (sv) |
DE (1) | DE69521907T2 (sv) |
DK (1) | DK0794955T3 (sv) |
ES (1) | ES2158959T3 (sv) |
FI (1) | FI972240A0 (sv) |
GR (1) | GR3036712T3 (sv) |
HK (1) | HK1002281A1 (sv) |
HU (1) | HUT77139A (sv) |
MX (1) | MX9703893A (sv) |
NZ (1) | NZ297661A (sv) |
PT (1) | PT794955E (sv) |
WO (1) | WO1996016967A1 (sv) |
Families Citing this family (95)
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US6015809A (en) * | 1998-08-17 | 2000-01-18 | American Home Products Corporation | Photocyclized rapamycin |
US6331547B1 (en) | 1999-08-18 | 2001-12-18 | American Home Products Corporation | Water soluble SDZ RAD esters |
US6277983B1 (en) | 2000-09-27 | 2001-08-21 | American Home Products Corporation | Regioselective synthesis of rapamycin derivatives |
US8236048B2 (en) | 2000-05-12 | 2012-08-07 | Cordis Corporation | Drug/drug delivery systems for the prevention and treatment of vascular disease |
US20050002986A1 (en) * | 2000-05-12 | 2005-01-06 | Robert Falotico | Drug/drug delivery systems for the prevention and treatment of vascular disease |
US7300662B2 (en) * | 2000-05-12 | 2007-11-27 | Cordis Corporation | Drug/drug delivery systems for the prevention and treatment of vascular disease |
US6670355B2 (en) | 2000-06-16 | 2003-12-30 | Wyeth | Method of treating cardiovascular disease |
ATE278421T1 (de) | 2000-08-11 | 2004-10-15 | Wyeth Corp | Verfahren zur behandlung eines östrogenrezeptor positives karzinoms |
EP1319008B1 (en) | 2000-09-19 | 2008-10-15 | Wyeth | Water soluble rapamycin esters |
US6399625B1 (en) | 2000-09-27 | 2002-06-04 | Wyeth | 1-oxorapamycins |
US8303609B2 (en) * | 2000-09-29 | 2012-11-06 | Cordis Corporation | Coated medical devices |
US6399626B1 (en) | 2000-10-02 | 2002-06-04 | Wyeth | Hydroxyesters of 7-desmethylrapamycin |
US6440991B1 (en) | 2000-10-02 | 2002-08-27 | Wyeth | Ethers of 7-desmethlrapamycin |
US7829084B2 (en) * | 2001-01-17 | 2010-11-09 | Trubion Pharmaceuticals, Inc. | Binding constructs and methods for use thereof |
US7754208B2 (en) | 2001-01-17 | 2010-07-13 | Trubion Pharmaceuticals, Inc. | Binding domain-immunoglobulin fusion proteins |
CN100522967C (zh) | 2002-02-01 | 2009-08-05 | 阿里亚德基因治疗公司 | 含磷化合物及其应用 |
RU2344821C2 (ru) | 2002-07-30 | 2009-01-27 | Уайт | Парентеральные композиции, содержащие гидроксиэфиры рапамицина |
AU2003293529A1 (en) | 2002-12-16 | 2004-07-29 | Nitromed, Inc. | Nitrosated and nitrosylated rapamycin compounds, compositions and methods of use |
NZ541846A (en) * | 2003-01-27 | 2008-12-24 | Endocyte Inc | Vitamin receptor binding drug delivery conjugates |
US7349971B2 (en) * | 2004-02-05 | 2008-03-25 | Scenera Technologies, Llc | System for transmitting data utilizing multiple communication applications simultaneously in response to user request without specifying recipient's communication information |
DE602005010228D1 (de) * | 2004-04-14 | 2008-11-20 | Wyeth Corp | Verfahren zur herstellung von rapamycin-42-estern und fk-506-32-estern mit dicarbonsäure, vorstufen für rapamycinkonjugate und antikörper |
AU2005238493A1 (en) * | 2004-04-27 | 2005-11-10 | Wyeth | Labeling of rapamycin using rapamycin-specific methylases |
EP1768662A2 (en) | 2004-06-24 | 2007-04-04 | Novartis Vaccines and Diagnostics, Inc. | Small molecule immunopotentiators and assays for their detection |
JP5149620B2 (ja) | 2004-07-23 | 2013-02-20 | エンドサイト,インコーポレイテッド | 2価リンカーおよびその結合体 |
MX2007005153A (es) * | 2004-10-28 | 2007-06-26 | Wyeth Corp | Uso de un inhibidor del mtor en el tratamiento de leiomioma del utero. |
GB0503936D0 (en) | 2005-02-25 | 2005-04-06 | San Raffaele Centro Fond | Method |
CN101175757B (zh) * | 2005-03-16 | 2012-11-14 | 恩多塞特公司 | 蝶酸及其缀合物的合成和纯化 |
SI1912675T1 (sl) | 2005-07-25 | 2014-07-31 | Emergent Product Development Seattle, Llc | zmanjšanje števila celic B z uporabo molekul, ki se specifično vežejo na CD37 in CD20 |
BRPI0615354A2 (pt) * | 2005-08-19 | 2011-05-17 | Endocyte Inc | conjugado de liberação de fármaco de ligação de receptor, composição farmacêutica que o compreende, bem como seu uso |
KR101354828B1 (ko) | 2005-11-04 | 2014-02-18 | 와이어쓰 엘엘씨 | mTOR 저해자, 헤르셉틴, 및/또는 HKI-272의항신생물성 조합 |
EP1962819A1 (en) * | 2005-12-20 | 2008-09-03 | Wyeth | Control of cci-779 dosage form stability through control of drug substance impurities |
US7678901B2 (en) * | 2006-02-28 | 2010-03-16 | Wyeth | Rapamycin analogs containing an antioxidant moiety |
US20080051691A1 (en) * | 2006-08-28 | 2008-02-28 | Wyeth | Implantable shunt or catheter enabling gradual delivery of therapeutic agents |
CA2669415A1 (en) * | 2006-11-14 | 2008-05-22 | Ariad Pharmaceuticals, Inc. | Solid dosage form comprising ap23573 |
US9700704B2 (en) | 2006-11-20 | 2017-07-11 | Lutonix, Inc. | Drug releasing coatings for balloon catheters |
US9737640B2 (en) | 2006-11-20 | 2017-08-22 | Lutonix, Inc. | Drug releasing coatings for medical devices |
US8414525B2 (en) | 2006-11-20 | 2013-04-09 | Lutonix, Inc. | Drug releasing coatings for medical devices |
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US20080276935A1 (en) | 2006-11-20 | 2008-11-13 | Lixiao Wang | Treatment of asthma and chronic obstructive pulmonary disease with anti-proliferate and anti-inflammatory drugs |
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CA2937492C (en) | 2008-11-11 | 2019-08-13 | The Board Of Regents Of The University Of Texas System | Inhibition of mammalian target of rapamycin |
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KR20120115237A (ko) | 2009-10-30 | 2012-10-17 | 어리어드 파마슈티칼스, 인코포레이티드 | 암 치료 방법 및 조성물 |
US9283211B1 (en) | 2009-11-11 | 2016-03-15 | Rapamycin Holdings, Llc | Oral rapamycin preparation and use for stomatitis |
US20130195919A1 (en) | 2010-03-05 | 2013-08-01 | President And Fellows Of Harvard College | Induced dendritic cell compositions and uses thereof |
EP2563391B1 (en) | 2010-04-27 | 2020-08-26 | Roche Glycart AG | Combination therapy of an afucosylated cd20 antibody with a mtor inhibitor |
WO2012149014A1 (en) | 2011-04-25 | 2012-11-01 | OSI Pharmaceuticals, LLC | Use of emt gene signatures in cancer drug discovery, diagnostics, and treatment |
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US10080805B2 (en) | 2012-02-24 | 2018-09-25 | Purdue Research Foundation | Cholecystokinin B receptor targeting for imaging and therapy |
US20140080175A1 (en) | 2012-03-29 | 2014-03-20 | Endocyte, Inc. | Processes for preparing tubulysin derivatives and conjugates thereof |
EP2906214A1 (en) | 2012-10-12 | 2015-08-19 | The Board of Regents of The University of Texas System | Use of mtor inhibitors to treat vascular cognitive impairment |
IN2015DN04147A (sv) | 2012-10-16 | 2015-10-16 | Endocyte Inc | |
US20150258127A1 (en) | 2012-10-31 | 2015-09-17 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for preventing antiphospholipid syndrome (aps) |
WO2014160328A1 (en) | 2013-03-13 | 2014-10-02 | The Board Of Regents Of The University Of Texas System | Mtor inhibitors for prevention of intestinal polyp growth |
BR112015023098A2 (pt) | 2013-03-14 | 2017-07-18 | Univ Jefferson | agentes de infrarregulação do receptor de andrógeno e usos dos mesmos |
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US20200129486A1 (en) | 2017-06-26 | 2020-04-30 | Inserm (Institut National De La Santé Et De La Recherche Medicale) | Methods and pharmaceutical compositions for the treatment of olmsted syndrome |
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CN113164563A (zh) | 2018-07-23 | 2021-07-23 | 因柯利尔疗法公司 | 神经性病症的治疗方法 |
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ZA737247B (en) * | 1972-09-29 | 1975-04-30 | Ayerst Mckenna & Harrison | Rapamycin and process of preparation |
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US5023264A (en) * | 1990-07-16 | 1991-06-11 | American Home Products Corporation | Rapamycin oximes |
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-
1994
- 1994-11-28 US US08/345,972 patent/US5491231A/en not_active Expired - Lifetime
-
1995
- 1995-05-24 US US08/450,769 patent/US5521194A/en not_active Expired - Lifetime
- 1995-05-24 US US08/448,843 patent/US5559122A/en not_active Expired - Lifetime
- 1995-05-24 US US08/449,167 patent/US5508290A/en not_active Expired - Lifetime
- 1995-05-24 US US08/449,168 patent/US5508285A/en not_active Expired - Lifetime
- 1995-11-22 EP EP95941467A patent/EP0794955B1/en not_active Expired - Lifetime
- 1995-11-22 HU HU9701851A patent/HUT77139A/hu unknown
- 1995-11-22 CA CA002205577A patent/CA2205577A1/en not_active Abandoned
- 1995-11-22 JP JP8518953A patent/JPH10509977A/ja not_active Withdrawn
- 1995-11-22 AU AU42877/96A patent/AU712998B2/en not_active Ceased
- 1995-11-22 KR KR1019970703519A patent/KR100377278B1/ko not_active IP Right Cessation
- 1995-11-22 ES ES95941467T patent/ES2158959T3/es not_active Expired - Lifetime
- 1995-11-22 AT AT95941467T patent/ATE203539T1/de not_active IP Right Cessation
- 1995-11-22 PT PT95941467T patent/PT794955E/pt unknown
- 1995-11-22 MX MX9703893A patent/MX9703893A/es not_active IP Right Cessation
- 1995-11-22 BR BR9509825A patent/BR9509825A/pt active Search and Examination
- 1995-11-22 DK DK95941467T patent/DK0794955T3/da active
- 1995-11-22 NZ NZ297661A patent/NZ297661A/xx unknown
- 1995-11-22 DE DE69521907T patent/DE69521907T2/de not_active Expired - Fee Related
- 1995-11-22 WO PCT/US1995/015318 patent/WO1996016967A1/en active IP Right Grant
-
1997
- 1997-05-27 FI FI972240A patent/FI972240A0/sv unknown
-
1998
- 1998-02-19 HK HK98101292A patent/HK1002281A1/xx not_active IP Right Cessation
-
2001
- 2001-09-26 GR GR20010401569T patent/GR3036712T3/el not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
MX9703893A (es) | 1997-08-30 |
DE69521907T2 (de) | 2001-11-29 |
DE69521907D1 (de) | 2001-08-30 |
EP0794955A1 (en) | 1997-09-17 |
US5521194A (en) | 1996-05-28 |
HUT77139A (hu) | 1998-03-02 |
US5559122A (en) | 1996-09-24 |
ATE203539T1 (de) | 2001-08-15 |
EP0794955B1 (en) | 2001-07-25 |
BR9509825A (pt) | 1997-09-30 |
KR100377278B1 (ko) | 2003-10-04 |
ES2158959T3 (es) | 2001-09-16 |
FI972240A0 (sv) | 1997-05-27 |
US5508290A (en) | 1996-04-16 |
JPH10509977A (ja) | 1998-09-29 |
AU4287796A (en) | 1996-06-19 |
CA2205577A1 (en) | 1996-06-06 |
DK0794955T3 (da) | 2001-09-24 |
US5491231A (en) | 1996-02-13 |
NZ297661A (en) | 2000-01-28 |
WO1996016967A1 (en) | 1996-06-06 |
GR3036712T3 (en) | 2001-12-31 |
AU712998B2 (en) | 1999-11-18 |
PT794955E (pt) | 2001-12-28 |
US5508285A (en) | 1996-04-16 |
HK1002281A1 (en) | 1998-08-14 |
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