MX9401165A - Compuestos inmunomoduladores macrociclicos y composiciones farmaceuticas que los incluyen. - Google Patents

Compuestos inmunomoduladores macrociclicos y composiciones farmaceuticas que los incluyen.

Info

Publication number
MX9401165A
MX9401165A MX9401165A MX9401165A MX9401165A MX 9401165 A MX9401165 A MX 9401165A MX 9401165 A MX9401165 A MX 9401165A MX 9401165 A MX9401165 A MX 9401165A MX 9401165 A MX9401165 A MX 9401165A
Authority
MX
Mexico
Prior art keywords
cr4r5
nr1cr2r3
macrocyclic
ocr2r3
mnr6
Prior art date
Application number
MX9401165A
Other languages
English (en)
Inventor
Robert Michael Kearney
Jerauld Stanley Skotnicki
Amedeo Arturo Failli
Robert John Steffan
Original Assignee
American Home Prod
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Home Prod filed Critical American Home Prod
Publication of MX9401165A publication Critical patent/MX9401165A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Transplantation (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Esta invención proporciona un compuesto de la estructura (I): en donde X se selecciona del grupo que consiste de -NR1CR2R3(CR4R5)mS-, -NR1CR2R3(CR4R5)mO-, OCR2R3(CR4R5)mO-, -NR1CR2R3(CR4R5)p-, -OCR2R3(CR4R5)p-, -NR1CR2R3(CR4R5)mNR6-, -OCR2R3(CR4R5)mNR6-, -SCR2R3(CR4R5)mNR6-, -SCR2R3(CR4R5)mS-, y -NR1; R1, R2, R3, R4, R5 y R6 son cada uno, independientemente, hidrógeno, alquilo, flúor, trifluorometilo, arilo, arilalquilo, o cualquier par tomado conjuntamente para formar un anillo de 3 a 6 miembros; m1-6; y p0-6 o una sal farmacéuticamente aceptable del mismo, la cual es útil como un agente inmunosupresor, antiinflamatorio, antimicótico, antiproliferativo y antitumoral. Esta invención también cubre los derivados de I y el uso de I en combinación con otros agentes inmunorreguladores.
MX9401165A 1993-02-16 1994-02-15 Compuestos inmunomoduladores macrociclicos y composiciones farmaceuticas que los incluyen. MX9401165A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/017,586 US5252579A (en) 1993-02-16 1993-02-16 Macrocyclic immunomodulators

Publications (1)

Publication Number Publication Date
MX9401165A true MX9401165A (es) 1994-08-31

Family

ID=21783418

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9401165A MX9401165A (es) 1993-02-16 1994-02-15 Compuestos inmunomoduladores macrociclicos y composiciones farmaceuticas que los incluyen.

Country Status (8)

Country Link
US (1) US5252579A (es)
EP (1) EP0613901A3 (es)
JP (1) JPH06293774A (es)
KR (1) KR940019711A (es)
CA (1) CA2115295A1 (es)
HU (1) HUT70765A (es)
MX (1) MX9401165A (es)
TW (1) TW261617B (es)

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US6333340B1 (en) 1998-08-14 2001-12-25 Gpi Nil Holdings, Inc. Small molecule sulfonamides for vision and memory disorders
US7265150B1 (en) * 1998-08-14 2007-09-04 Gpi Nil Holdings Inc. Carboxylic acids and carboxylic acid isosteres of N-heterocyclic compounds for vision and memory disorders
US6337340B1 (en) 1998-08-14 2002-01-08 Gpi Nil Holdings, Inc. Carboxylic acids and isosteres of heterocyclic ring compounds having multiple heteroatoms for vision and memory disorders
US6506788B1 (en) 1998-08-14 2003-01-14 Gpi Nil Holdings, Inc. N-linked urea or carbamate of heterocyclic thioesters for vision and memory disorders
US6399648B1 (en) 1998-08-14 2002-06-04 Gpi Nil Holdings, Inc. N-oxides of heterocyclic ester, amide, thioester, or ketone for vision and memory disorders
US6376517B1 (en) 1998-08-14 2002-04-23 Gpi Nil Holdings, Inc. Pipecolic acid derivatives for vision and memory disorders
US7338976B1 (en) 1998-08-14 2008-03-04 Gpi Nil Holdings, Inc. Heterocyclic esters or amides for vision and memory disorders
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US9737640B2 (en) 2006-11-20 2017-08-22 Lutonix, Inc. Drug releasing coatings for medical devices
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EP3193902A4 (en) 2014-09-11 2018-03-28 The Regents of The University of California mTORC1 INHIBITORS
CN112368289B (zh) 2018-05-01 2024-02-20 锐新医药公司 作为mtor抑制剂的c26-连接的雷帕霉素类似物
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Also Published As

Publication number Publication date
EP0613901A2 (en) 1994-09-07
KR940019711A (ko) 1994-09-14
JPH06293774A (ja) 1994-10-21
TW261617B (es) 1995-11-01
US5252579A (en) 1993-10-12
HU9400423D0 (en) 1994-05-30
EP0613901A3 (en) 1995-04-12
CA2115295A1 (en) 1994-08-17
HUT70765A (en) 1995-10-30

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