MX9703893A - N-oxido-esteres impedidos de rapamicina y sus usos como medicamentos. - Google Patents

N-oxido-esteres impedidos de rapamicina y sus usos como medicamentos.

Info

Publication number
MX9703893A
MX9703893A MX9703893A MX9703893A MX9703893A MX 9703893 A MX9703893 A MX 9703893A MX 9703893 A MX9703893 A MX 9703893A MX 9703893 A MX9703893 A MX 9703893A MX 9703893 A MX9703893 A MX 9703893A
Authority
MX
Mexico
Prior art keywords
rapamycin
medicaments
hindered
alkyl
oxide esters
Prior art date
Application number
MX9703893A
Other languages
English (en)
Other versions
MXPA97003893A (es
Inventor
Frances Christy Nelson
Guy Alan Schiehser
Original Assignee
American Home Prod
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Home Prod filed Critical American Home Prod
Publication of MXPA97003893A publication Critical patent/MXPA97003893A/es
Publication of MX9703893A publication Critical patent/MX9703893A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Transplantation (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Se describe un compuesto de la estructura (I), en donde R y R1 son cada uno independientemente, a), b), o hidrogeno; R2 y R3 son cada uno, independientemente, alquilo, arilalquilo, o R2 y R3 pueden ser tomados conjuntamente para formar un anillo cicloalquílico; R4 es un radical N-oxido heterocíclico, el cual puede estar opcionalmente sustituido; R5 es alquilo o arialquilo; R6 y R7 son tomados conjuntamente para formar un N-oxido saturado N-alquil-heterocíclico, el cual puede estar opcionalmente sustituido; k = 0 - 1, m = 0 -1; n = 1 -6; con la condicion de que R y R1 no sean ambos hidrogeno, el cual es util como un agente inmunosupresor, antiinflamatorio, antimicotico, antiproliferativo y antitumoral.
MX9703893A 1994-11-28 1995-11-22 N-oxido-esteres impedidos de rapamicina y sus usos como medicamentos. MX9703893A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08345972 1994-11-28
US08/345,972 US5491231A (en) 1994-11-28 1994-11-28 Hindered N-oxide esters of rapamycin
PCT/US1995/015318 WO1996016967A1 (en) 1994-11-28 1995-11-22 Hindered n-oxide esters of rapamycin and their use as medicaments

Publications (2)

Publication Number Publication Date
MXPA97003893A MXPA97003893A (es) 1997-08-01
MX9703893A true MX9703893A (es) 1997-08-30

Family

ID=23357367

Family Applications (1)

Application Number Title Priority Date Filing Date
MX9703893A MX9703893A (es) 1994-11-28 1995-11-22 N-oxido-esteres impedidos de rapamicina y sus usos como medicamentos.

Country Status (19)

Country Link
US (5) US5491231A (es)
EP (1) EP0794955B1 (es)
JP (1) JPH10509977A (es)
KR (1) KR100377278B1 (es)
AT (1) ATE203539T1 (es)
AU (1) AU712998B2 (es)
BR (1) BR9509825A (es)
CA (1) CA2205577A1 (es)
DE (1) DE69521907T2 (es)
DK (1) DK0794955T3 (es)
ES (1) ES2158959T3 (es)
FI (1) FI972240A (es)
GR (1) GR3036712T3 (es)
HK (1) HK1002281A1 (es)
HU (1) HUT77139A (es)
MX (1) MX9703893A (es)
NZ (1) NZ297661A (es)
PT (1) PT794955E (es)
WO (1) WO1996016967A1 (es)

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US5385910A (en) * 1993-11-22 1995-01-31 American Home Products Corporation Gem-distributed esters of rapamycin

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DK0794955T3 (da) 2001-09-24
EP0794955A1 (en) 1997-09-17
AU712998B2 (en) 1999-11-18
PT794955E (pt) 2001-12-28
NZ297661A (en) 2000-01-28
BR9509825A (pt) 1997-09-30
EP0794955B1 (en) 2001-07-25
ES2158959T3 (es) 2001-09-16
WO1996016967A1 (en) 1996-06-06
HUT77139A (hu) 1998-03-02
FI972240A0 (fi) 1997-05-27
US5508290A (en) 1996-04-16
US5559122A (en) 1996-09-24
JPH10509977A (ja) 1998-09-29
US5491231A (en) 1996-02-13
AU4287796A (en) 1996-06-19
DE69521907D1 (de) 2001-08-30
ATE203539T1 (de) 2001-08-15
CA2205577A1 (en) 1996-06-06
US5521194A (en) 1996-05-28
GR3036712T3 (en) 2001-12-31
HK1002281A1 (en) 1998-08-14
KR100377278B1 (ko) 2003-10-04
US5508285A (en) 1996-04-16
DE69521907T2 (de) 2001-11-29
FI972240A (fi) 1997-05-27

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