HK1000495A1 - Novel compound, process for producing the same, and antitumor agent - Google Patents

Novel compound, process for producing the same, and antitumor agent Download PDF

Info

Publication number
HK1000495A1
HK1000495A1 HK97101948A HK97101948A HK1000495A1 HK 1000495 A1 HK1000495 A1 HK 1000495A1 HK 97101948 A HK97101948 A HK 97101948A HK 97101948 A HK97101948 A HK 97101948A HK 1000495 A1 HK1000495 A1 HK 1000495A1
Authority
HK
Hong Kong
Prior art keywords
group
carboxylic acid
salts
pyridone
hydrogen atom
Prior art date
Application number
HK97101948A
Other languages
German (de)
English (en)
French (fr)
Chinese (zh)
Other versions
HK1000495B (en
Inventor
Tomita Kyoji
Chiba Katsumi
Kashimoto Shigeki
Shibamori Koh-Ichiro
Tsuzuki Yasunori
Original Assignee
Dainippon Sumitomo Pharma Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dainippon Sumitomo Pharma Co., Ltd. filed Critical Dainippon Sumitomo Pharma Co., Ltd.
Publication of HK1000495B publication Critical patent/HK1000495B/en
Publication of HK1000495A1 publication Critical patent/HK1000495A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
HK97101948A 1994-06-14 1995-06-06 Novel compound, process for producing the same, and antitumor agent HK1000495A1 (en)

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
JP15657894 1994-06-14
JP156578/94 1994-06-14
JP19792194 1994-07-28
JP197921/94 1994-07-28
JP30691494 1994-11-15
JP306914/94 1994-11-15
JP339956/94 1994-12-28
JP33995694 1994-12-28
JP81705/95 1995-03-13
JP8170595 1995-03-13
PCT/JP1995/001110 WO1995034559A1 (fr) 1994-06-14 1995-06-06 Nouveau compose, son procede de production et agent antitumoral

Publications (2)

Publication Number Publication Date
HK1000495B HK1000495B (en) 2002-07-19
HK1000495A1 true HK1000495A1 (en) 2002-07-19

Family

ID=27524935

Family Applications (1)

Application Number Title Priority Date Filing Date
HK97101948A HK1000495A1 (en) 1994-06-14 1995-06-06 Novel compound, process for producing the same, and antitumor agent

Country Status (27)

Country Link
US (1) US5817669A (forum.php)
EP (1) EP0787726B1 (forum.php)
JP (1) JP3391796B2 (forum.php)
KR (1) KR100350921B1 (forum.php)
CN (1) CN1053668C (forum.php)
AT (1) ATE209645T1 (forum.php)
AU (1) AU679859B2 (forum.php)
BR (1) BR9508037A (forum.php)
CA (1) CA2192824C (forum.php)
CZ (1) CZ292631B6 (forum.php)
DE (1) DE69524251T2 (forum.php)
DK (1) DK0787726T3 (forum.php)
ES (1) ES2163512T3 (forum.php)
FI (1) FI112485B (forum.php)
HK (1) HK1000495A1 (forum.php)
HU (1) HU220072B (forum.php)
MX (1) MX9606331A (forum.php)
NO (1) NO307255B1 (forum.php)
NZ (1) NZ287139A (forum.php)
PL (1) PL181867B1 (forum.php)
PT (1) PT787726E (forum.php)
RO (1) RO117793B1 (forum.php)
RU (1) RU2151770C1 (forum.php)
SI (1) SI0787726T1 (forum.php)
SK (1) SK281341B6 (forum.php)
TW (1) TW319769B (forum.php)
WO (1) WO1995034559A1 (forum.php)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6900205B2 (en) * 2001-09-26 2005-05-31 Bayer Pharmaceuticals Corporation 1,8-Naphthyridine derivatives and their use to treat diabetes and related disorders
US6802423B2 (en) * 2002-02-20 2004-10-12 Trans Global Foods, Inc. Disposable food delivery apparatus
WO2004091627A2 (en) * 2003-04-07 2004-10-28 Cylene Pharmaceuticals, Inc. Heterocyclic substituted 1,4-dihydro-4-oxo-1,8-naphthpyridine analogs
SG144936A1 (en) * 2003-09-10 2008-08-28 Kyorin Seiyaku Kk 7-(4-substituted-3-cyclopropylaminomethyl-1- pyrrolidinyl)quinolonecarboxylic acid derivative
DE10352979A1 (de) * 2003-11-13 2005-06-09 Merck Patent Gmbh Pyridopyrimidinone
CA2559650C (en) 2004-03-15 2013-11-19 Sunesis Pharmaceuticals, Inc. Sns-595 and methods of using the same
AU2013201203C1 (en) * 2004-03-15 2015-04-23 Sumitomo Dainippon Pharma Co., Ltd. Sns-595 and methods of using the same
WO2006040050A1 (en) * 2004-10-14 2006-04-20 F.Hoffmann-La Roche Ag Quinazolinylmethylene thiazolinones as cdk1 inhibitors
WO2006040052A1 (en) * 2004-10-14 2006-04-20 F. Hoffmann-La Roche Ag 1,5-naphthyridine azolidinones having cdk1 antiproliferative activity
RU2420524C2 (ru) * 2005-05-19 2011-06-10 Дайити Санкио Компани, Лимитед Производные три- или тетра-замещенного-3-аминопирролидина
US7563805B2 (en) * 2005-05-19 2009-07-21 Daiichi Pharmaceutical Co., Ltd. Tri-, tetra-substituted-3-aminopyrrolidine derivative
WO2007022474A2 (en) * 2005-08-19 2007-02-22 Cylene Pharmaceuticals, Inc. HUMAN RIBOSOMAL DNA(rDNA) AND RIBOSOMAL RNA (rRNA) NUCLEIC ACIDS AND USES THEREOF
KR20080041298A (ko) * 2005-09-02 2008-05-09 선에시스 파마슈티컬스 인코포레이티드 암 치료를 위한(＋)-1,4-디히드로-7-[(3ｓ,4ｓ)-3-메톡시-4-(메틸아미노)-1-피롤리디닐]-4-옥소-1-(2-티아졸릴)-1,8-나프티리딘-3-카르복실산의 사용 방법
CA2845095A1 (en) * 2005-09-02 2007-03-08 Sunesis Pharmaceuticals, Inc. Methods of using (+)-1,4-dihydro-7-[(3s,4s)-3-methoxy-4-(methylamino)-1-pyrrolidinyl]-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid for treatment of cancer
CN104873502A (zh) * 2005-09-02 2015-09-02 逊尼希思制药公司 使用(+)-1,4-二氢-7-[(3s,4s)-3-甲氧基-4-(甲氨基)-1-吡咯烷基]-4-氧代-1-(2-噻唑基)-1,8-萘啶-3-羧酸治疗癌症的方法
AU2013219242C1 (en) * 2005-09-02 2016-09-22 Sunesis Pharmaceuticals, Inc. Methods of using (+)-1,4-dihydro-7-[(3s,4s)-3-methoxy-4-(methylamino)-1-pyrrolidinyl]-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid for treatment of cancer
US8580814B2 (en) * 2006-04-03 2013-11-12 Sunesis Pharmaceuticals, Inc. Methods of using (+)-1,4-dihydro-7-[(3S,4S)-3-methoxy-4-(methylamino)-1-pyrrolidinyl]-4- oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid for treatment of cancer
RU2428983C2 (ru) * 2005-09-02 2011-09-20 Санесис Фармасьютикалз, Инк. Способы применения (+)-1,4-дигидро-7-[(3s,4s)-3-метокси-4-(метиламино)-1-пирролидинил]-4-оксо-1-(2-тиазолил)-1,8-нафтиридин-3-карбоновой кислоты для лечения рака
US7642270B2 (en) 2005-09-14 2010-01-05 Janssen Pharmaceutica N.V. 5-oxo-5,8-dihydro-pyrido-pyrimidine as inhibitors of c-fms kinase
KR20080045279A (ko) * 2005-09-14 2008-05-22 얀센 파마슈티카 엔.브이. Ｃ-ｆｍｓ 키나제 저해제로서의5-옥소-5,8-디하이드로-피리도-피리미딘
TW200800983A (en) 2005-09-14 2008-01-01 Janssen Pharmaceutica Nv 5-oxo-5,8-dihydro-pyrido-pyrimidines as inhibitors of C-FMS kinase
AU2007258280B2 (en) 2006-06-12 2013-05-02 Sunesis Pharmaceuticals, Inc. Compounds and compositions for treatment of cancer
WO2008016678A2 (en) * 2006-08-01 2008-02-07 Sunesis Pharmaceuticals, Inc. Pharmaceutical dosage forms for (+)-1,4-dihydro-7-[(3s,4s)-3-methoxy-4-(methylamino)-1-pyrrolidinyl]-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid
SI2049109T1 (sl) 2006-08-02 2016-04-29 Sunesis Pharmaceuticals, Inc. Kombinirana uporaba(+)-1,4-dihidro-7-((3s,4s)-3-metoksi-4-(metilamino)- 1-pirolidinil)-4-okso-1-(2-tiazolil)-1,8-naftiridin-3-karboksilne kisline in citarabina (ara-c) za zdravljenje levkemije
CN101909613A (zh) * 2007-10-22 2010-12-08 逊尼希思制药公司 在联合治疗中使用(+)-1,4-二氢-7-[(3s,4s)-3-甲氧基-4-(甲氨基)-1-吡咯烷基]-4-氧代-1-(2-噻唑基)-1,8-萘啶-3-羧酸的方法
EP2249831A2 (en) * 2007-12-10 2010-11-17 Sunesis Pharmaceuticals, Inc. Methods of using (+)-1,4-dihydro-7-ý(3s,4s)-3-methoxy-4-(methylamino)-1-pyrrolidinyl¨-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid for treatment of antecedent hematologic disorders
ES2646093T3 (es) * 2008-12-31 2017-12-12 Sunesis Pharmaceuticals, Inc. Método de preparación del ácido (+)-1,4-dihidro-7-[(3S,4S)-3-metoxi-4-(metilamino)-1-pirrolidinil]-4-oxo-1-(2-tiazolil)-1,8-naftiridina-3-carboxílico
CA2753261A1 (en) 2009-02-27 2010-09-02 Sunesis Pharmaceuticals, Inc. Methods of using sns-595 for treatment of cancer subjects with reduced brca2 activity
UA110465C2 (en) 2009-09-04 2016-01-12 Sunesis Pharmaceutecals Inc Stable sns-595 composition
TW201120037A (en) * 2009-10-26 2011-06-16 Sunesis Pharmaceuticals Inc Compounds and methods for treatment of cancer
BR112013029201B1 (pt) 2011-05-13 2022-08-09 Array Biopharma Inc Compostos de pirrolidinil ureia e pirrolidinil tioureia, seu processo de preparação, seu uso e composições farmacêuticas
CN103497186B (zh) * 2013-09-24 2015-02-25 浙江司太立制药股份有限公司 含有烷氧亚氨基取代的萘啶酮羧酸衍生物及其制备方法
AU2018238079B2 (en) * 2017-03-24 2022-03-03 Wakunaga Pharmaceutical Co., Ltd. Novel pyridone carboxylic acid derivative or salt thereof

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3988463A (en) * 1974-05-06 1976-10-26 Merck & Co., Inc. Method of preventing metastasis of H. Ep. No. 3
US4384001A (en) * 1978-12-21 1983-05-17 Gosalvez Mario Treatment of tumors with thiazolidine-4-carboxylic acid
US4730000A (en) * 1984-04-09 1988-03-08 Abbott Laboratories Quinoline antibacterial compounds
DE3577089D1 (de) * 1984-01-26 1990-05-17 Abbott Lab Antibakterielle chinolinderivate.
NZ210847A (en) * 1984-01-26 1988-02-29 Abbott Lab Naphthyridine and pyridopyrimidine derivatives and pharmaceutical compositions
JPS61152682A (ja) * 1984-12-27 1986-07-11 Dainippon Pharmaceut Co Ltd ピリドンカルボン酸誘導体、そのエステルおよびその塩
JPS61251667A (ja) * 1985-04-30 1986-11-08 Otsuka Pharmaceut Co Ltd ベンゾヘテロ環化合物
GR861530B (en) * 1985-06-13 1986-12-31 Schering Corp Preparation process for polycyclic quinoline of naphthyridine and pyrazinopyridine
US4851425A (en) * 1985-06-14 1989-07-25 The Upjohn Company Cyclopentapyrazole and tetrahydroindazole compounds and their use as anti-inflammatory and anti-allergic agents
JPS6233176A (ja) * 1985-08-05 1987-02-13 Toyama Chem Co Ltd １，４−ジヒドロ−４−オキソナフチリジン誘導体およびその塩
JP2704428B2 (ja) * 1988-06-15 1998-01-26 富山化学工業株式会社 キノロンカルボン酸誘導体またはその塩
DE3906365A1 (de) * 1988-07-15 1990-01-18 Bayer Ag 7-(1-pyrrolidinyl)-3-chinolon- und -naphthyridoncarbonsaeure-derivate, verfahren sowie substituierte (oxa)diazabicyclooctane und -nonane als zwischenprodukte zu ihrer herstellung, und sie enthaltende antibakterielle mittel und futterzusatzstoffe
JPH06233176A (ja) * 1993-01-29 1994-08-19 Sony Corp ビデオカメラ

Also Published As

Publication number Publication date
CN1158614A (zh) 1997-09-03
BR9508037A (pt) 1997-09-16
EP0787726B1 (en) 2001-11-28
CA2192824A1 (en) 1995-12-21
AU679859B2 (en) 1997-07-10
ES2163512T3 (es) 2002-02-01
NZ287139A (en) 1997-07-27
SK281341B6 (sk) 2001-02-12
EP0787726A1 (en) 1997-08-06
PL181867B1 (pl) 2001-09-28
AU2576795A (en) 1996-01-05
FI965020A0 (fi) 1996-12-13
DK0787726T3 (da) 2002-02-11
KR100350921B1 (ko) 2002-11-18
RO117793B1 (ro) 2002-07-30
WO1995034559A1 (fr) 1995-12-21
US5817669A (en) 1998-10-06
SK157496A3 (en) 1997-08-06
DE69524251D1 (de) 2002-01-10
RU2151770C1 (ru) 2000-06-27
CN1053668C (zh) 2000-06-21
CZ364396A3 (en) 1997-06-11
HUT75777A (en) 1997-05-28
CA2192824C (en) 2006-11-07
NO965305L (no) 1997-02-04
CZ292631B6 (cs) 2003-11-12
FI965020A7 (fi) 1996-12-16
PL317726A1 (en) 1997-04-28
JP3391796B2 (ja) 2003-03-31
ATE209645T1 (de) 2001-12-15
NO965305D0 (no) 1996-12-11
FI112485B (fi) 2003-12-15
DE69524251T2 (de) 2002-07-11
MX9606331A (es) 1997-03-29
NO307255B1 (no) 2000-03-06
PT787726E (pt) 2002-04-29
TW319769B (forum.php) 1997-11-11
HU9603455D0 (en) 1997-02-28
HU220072B (hu) 2001-10-28
SI0787726T1 (en) 2002-04-30
EP0787726A4 (forum.php) 1997-08-06

Similar Documents

Publication Publication Date Title
EP0787726B1 (en) Novel compound, process for producing the same, and antitumor agent
HK1000495B (en) Novel compound, process for producing the same, and antitumor agent
ES2246399T3 (es) 1,2,3,4-tetrahidroisoquinolinas como antagonistas derivados del receptor de urotensina ii.
CN104854101B (zh) Alk激酶抑制剂
US20090131444A1 (en) Aminopiperidine Quinolines and Their Azaisosteric Analogues with Antibacterial Activity
JP4323574B2 (ja) 抗腫瘍剤
KR20160034384A (ko) 인돌 및 피롤의 유도체, 이의 제조 방법 및 이를 함유하는 약제 조성물
JP2005538962A (ja) フェニルアミノピリミジンおよびＲｈｏ−キナーゼ阻害剤としてのその使用
EP2857402A1 (en) Pyrrole [2, 1-f][1, 2, 4]triazine derivative and antitumor effect thereof
CN112898292A (zh) 新型极光激酶抑制剂及其用途
CA2076982A1 (en) Pyridonecarboxylic acid derivatives
CN117126231A (zh) 拟肽类stat蛋白降解剂、组合物及其应用
JPS6333379A (ja) ４（３Ｈ）−オキソ−５，６，７，８−テトラヒドロピリド〔２，３−ｄ〕ピリミジン誘導体
WO2022162034A1 (en) Pyrazoleamide derivatives
WO1995021163A1 (en) Pyridonecarboxylic acid derivative substituted by bicyclic amino group, ester thereof, salt thereof, and bicyclic amine as intermediate therefor
JP5079612B2 (ja) 抗腫瘍剤
JPH0873460A (ja) １，８−ナフチリジン化合物および抗腫瘍剤
US5248692A (en) DC-89 derivatives as anti-tumor agents
HK40064179A (en) Piperazine amide derivative, preparation method therefor, and use thereof in medicine
EP4583869A2 (en) Inhibitors of enl/af9 yeats and flt3
CN119930589A (zh) 一种三环类化合物、药物组合物和应用
KR100359151B1 (ko) 2환성 아미노기로 치환된 피리돈카르복실산 유도체, 그의 에스테르 및 그의 염 및 이들의 중간체인 2환성 아민
JPH10195074A (ja) 新規なエリプティシン化合物、それらの製造方法及びそれらを含む医薬組成物
JP2002114785A (ja) １，８−ナフチリジン誘導体および抗腫瘍剤
ZA200306610B (en) 1,2,3,4-tetrahydroisoquinolines derivatives as urotensin II receptor antagonists.

Legal Events

Date Code Title Description
PF Patent in force
PE Patent expired

Effective date: 20150605