GT201600208A - Dispersión sólida amorfa que comprende taxano, comprimido que comprende la misma, y método para su preparación - Google Patents
Dispersión sólida amorfa que comprende taxano, comprimido que comprende la misma, y método para su preparaciónInfo
- Publication number
- GT201600208A GT201600208A GT201600208A GT201600208A GT201600208A GT 201600208 A GT201600208 A GT 201600208A GT 201600208 A GT201600208 A GT 201600208A GT 201600208 A GT201600208 A GT 201600208A GT 201600208 A GT201600208 A GT 201600208A
- Authority
- GT
- Guatemala
- Prior art keywords
- understanding
- solid dispersion
- preparation
- same
- amorphes
- Prior art date
Links
- 239000007962 solid dispersion Substances 0.000 title abstract 4
- 229940123237 Taxane Drugs 0.000 title 1
- DKPFODGZWDEEBT-QFIAKTPHSA-N taxane Chemical class C([C@]1(C)CCC[C@@H](C)[C@H]1C1)C[C@H]2[C@H](C)CC[C@@H]1C2(C)C DKPFODGZWDEEBT-QFIAKTPHSA-N 0.000 title 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 2
- 239000008180 pharmaceutical surfactant Substances 0.000 abstract 1
- 229920000642 polymer Polymers 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
- A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Dispersion Chemistry (AREA)
- Inorganic Chemistry (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
LA PRESENTE INVENCIÓN PROVEE UNA DISPERSIÓN SÓLIDA AMORFA QUE COMPRENDE UN TAXANO O UNA SAL FARMACÉUTICAMENTE ACEPATBLE DEL MISMO, UN POLÍMERO FARMACÉUTICAMENTE ACEPATBLE Y UN SURFACTANTE FARMACÉUTICAMENTE ACEPATBLE, QUE TIENE UNA SOLUBILIDAD MEJORADA. TAMBIÉN SE SUMINISTRA UN MÉTODO PARA LA PREPARACIÓN DE LA DISPERSIÓN SÓLIDA. LA PRESENTE INVENCIÓN TAMBIÉN SUMINISTRA UN COMPRIMIDO QUE TIENE BUENA SOLUBILIDAD, BIODISPONIBILIDAD Y ESTABILIDAD, EL CUAL COMPRENDE LA DISPERSIÓN SÓLIDA AMORFA, UN EXCIPIENTE INTRAGRANULAR, Y UN EXCIPIENTE EXTRAGRANULAR.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/KR2014/002734 WO2015152433A1 (en) | 2014-03-31 | 2014-03-31 | Amorphous solid dispersion comprising paclitaxel, tablet comprising the same, and method for preparing the same |
Publications (1)
Publication Number | Publication Date |
---|---|
GT201600208A true GT201600208A (es) | 2018-11-27 |
Family
ID=54240734
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GT201600208A GT201600208A (es) | 2014-03-31 | 2016-09-30 | Dispersión sólida amorfa que comprende taxano, comprimido que comprende la misma, y método para su preparación |
Country Status (33)
Country | Link |
---|---|
US (1) | US9867801B2 (es) |
EP (1) | EP3125872B1 (es) |
JP (1) | JP6539675B2 (es) |
KR (1) | KR101851571B1 (es) |
CN (1) | CN106255496B (es) |
AR (1) | AR099886A1 (es) |
AU (1) | AU2015242738B2 (es) |
BR (1) | BR112016022528B1 (es) |
CA (1) | CA2944438C (es) |
CL (1) | CL2016002441A1 (es) |
CU (1) | CU24486B1 (es) |
DK (1) | DK3125872T3 (es) |
DO (1) | DOP2016000262A (es) |
ES (1) | ES2748686T3 (es) |
GT (1) | GT201600208A (es) |
HU (1) | HUE046616T2 (es) |
IL (1) | IL247977B (es) |
LT (1) | LT3125872T (es) |
MA (1) | MA39361B1 (es) |
MX (1) | MX2016012596A (es) |
MY (1) | MY175387A (es) |
PE (1) | PE20161477A1 (es) |
PH (1) | PH12016501825A1 (es) |
PL (1) | PL3125872T3 (es) |
PT (1) | PT3125872T (es) |
RU (1) | RU2684632C2 (es) |
SA (1) | SA516371952B1 (es) |
SG (1) | SG11201607456RA (es) |
SI (1) | SI3125872T1 (es) |
TW (1) | TWI706793B (es) |
UA (1) | UA117610C2 (es) |
UY (1) | UY36055A (es) |
WO (2) | WO2015152433A1 (es) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
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US20180344646A1 (en) * | 2015-11-25 | 2018-12-06 | Patheon Development Services Inc. | Amorphous dispersion granules and oral dosage forms |
MA44987A (fr) * | 2016-05-09 | 2019-03-20 | Dispersol Technologies Llc | Formulations de médicaments améliorées |
CN110742895A (zh) * | 2017-03-30 | 2020-02-04 | 复旦大学附属中山医院 | Fxr激动剂在制备治疗脂肪肉瘤药物中的用途 |
TWI833710B (zh) * | 2017-10-06 | 2024-03-01 | 香港商慧源香港創新有限公司 | 高單位含量口服型紫杉烷組合物及方法 |
CA3081358A1 (en) * | 2017-11-10 | 2019-05-16 | Dispersol Technologies, Llc | Improved drug formulations |
CA3123476A1 (en) * | 2019-01-25 | 2020-07-30 | Beigene, Ltd. | Stable solid dispersions of b-raf kinase dimer inhibitor, methods of preparation, and uses therefor |
CN109851593B (zh) * | 2019-02-01 | 2021-04-16 | 沈阳药科大学 | 基于淋巴介导转运的甘油三酯前药及其制备方法 |
CN110105368B (zh) * | 2019-05-09 | 2022-01-07 | 上海大学 | 去氧紫杉烷类似物及其制备方法 |
WO2021177930A1 (en) * | 2020-03-06 | 2021-09-10 | Vyshnevskyy Ihor Anatoliyovych | Pharmaceutical composition with increased solubility of gesperidine and method of its preparation |
TW202233593A (zh) | 2020-10-07 | 2022-09-01 | 美商亞瑟尼克斯公司 | 乙醯胺基-苯基四唑衍生物及其使用方法 |
JP2024525206A (ja) * | 2021-06-23 | 2024-07-10 | ブループリント メディシンズ コーポレイション | 上皮成長因子受容体阻害剤の医薬組成物 |
WO2023154171A1 (en) * | 2022-02-14 | 2023-08-17 | Purdue Research Foundation | Polymer salts for improved drug delivery from amorphous solid dispersions |
AU2022368370A1 (en) * | 2022-03-08 | 2023-09-28 | Cnpharm Co., Ltd. | Pharmaceutical composition containing docetaxel or pharmaceutically acceptable salt thereof and preparation method therefor |
CN115429766B (zh) * | 2022-09-08 | 2023-10-27 | 江苏集萃新型药物制剂技术研究所有限公司 | 淫羊藿苷固体分散体、复方药物双层片剂及其制备方法与应用 |
Family Cites Families (19)
Publication number | Priority date | Publication date | Assignee | Title |
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IL133672A0 (en) * | 1997-06-27 | 2001-04-30 | Vivorx Pharmaceuticals Inc | Novel formulations of pharmacological agents, methods for the preparation thereof and methods for the use thereof |
US6610317B2 (en) * | 1999-05-27 | 2003-08-26 | Acusphere, Inc. | Porous paclitaxel matrices and methods of manufacture thereof |
KR20030041577A (ko) * | 2001-11-20 | 2003-05-27 | 디디에스텍주식회사 | 난용성 약물과 치환된 시클로덱스트린을 함유하는고체분산체 및 이를 함유하는 약제학적 조성물 |
WO2005030257A2 (en) * | 2003-09-30 | 2005-04-07 | Solubest Ltd. | Water soluble nanoparticles inclusion complexes |
KR20070072888A (ko) * | 2004-10-25 | 2007-07-06 | 니뽄 다바코 산교 가부시키가이샤 | 용해성 및 안정성이 개선된 고형 제제 및 그의 제조 방법 |
CN1840196A (zh) * | 2006-01-27 | 2006-10-04 | 无锡杰西医药科技有限公司 | 一种适用于难溶性药物的分散剂 |
CA2626234A1 (en) * | 2005-12-22 | 2007-06-28 | Teva Pharmaceutical Industries Ltd. | Compressed solid dosage forms with drugs of low solubility and process for making the same |
US9833510B2 (en) * | 2007-06-12 | 2017-12-05 | Johnson & Johnson Consumer Inc. | Modified release solid or semi-solid dosage forms |
US9089544B2 (en) * | 2007-08-24 | 2015-07-28 | Slotervaart Participaties Bv | Composition |
EP2190413B1 (en) * | 2007-08-24 | 2015-01-28 | Stichting Het Nederlands Kanker Instituut | Compositions for the treatment of neoplastic diseases |
GB0716591D0 (en) | 2007-08-24 | 2007-10-03 | Vereniging Het Nl Kanker I | Composition |
EP2249811A1 (en) * | 2008-01-25 | 2010-11-17 | Grünenthal GmbH | Pharmaceutical dosage form |
CN101632630A (zh) * | 2008-07-24 | 2010-01-27 | 北京诺美医药科技有限公司 | 一种普罗布考固体分散体 |
EP2328555A2 (en) * | 2008-08-22 | 2011-06-08 | Slotervaart Participaties BV | Compositions for the treatment of neoplastic diseases |
JP5751868B2 (ja) * | 2010-03-30 | 2015-07-22 | 日東電工株式会社 | フィルム状製剤及びその製造方法 |
KR20130109092A (ko) * | 2010-06-09 | 2013-10-07 | 아보트 러보러터리즈 | 키나제 억제제를 함유하는 고체 분산물 |
CN106511357A (zh) * | 2010-11-19 | 2017-03-22 | 吉利德科学公司 | 包含利匹韦林HCl和富马酸替诺福韦酯的治疗组合物 |
EP2755637B1 (en) * | 2011-09-13 | 2020-08-12 | ISP Investments LLC | Solid dispersion of poorly soluble compounds comprising crospovidone and at least one water-soluble polymer |
CN102357075A (zh) * | 2011-09-30 | 2012-02-22 | 武汉平华生物医药科技有限公司 | 一种多西他赛纳米制剂及其制备方法 |
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2014
- 2014-03-31 WO PCT/KR2014/002734 patent/WO2015152433A1/en active Application Filing
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2015
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- 2015-03-20 UA UAA201609267A patent/UA117610C2/uk unknown
- 2015-03-20 RU RU2016136636A patent/RU2684632C2/ru active
- 2015-03-20 PE PE2016001849A patent/PE20161477A1/es unknown
- 2015-03-20 SG SG11201607456RA patent/SG11201607456RA/en unknown
- 2015-03-20 JP JP2016559161A patent/JP6539675B2/ja active Active
- 2015-03-20 PT PT157733544T patent/PT3125872T/pt unknown
- 2015-03-20 CA CA2944438A patent/CA2944438C/en active Active
- 2015-03-20 CN CN201580016355.2A patent/CN106255496B/zh active Active
- 2015-03-20 LT LTEP15773354.4T patent/LT3125872T/lt unknown
- 2015-03-20 EP EP15773354.4A patent/EP3125872B1/en active Active
- 2015-03-20 CU CU2016000144A patent/CU24486B1/es unknown
- 2015-03-20 ES ES15773354T patent/ES2748686T3/es active Active
- 2015-03-20 MA MA39361A patent/MA39361B1/fr unknown
- 2015-03-20 KR KR1020167027373A patent/KR101851571B1/ko active IP Right Grant
- 2015-03-20 MX MX2016012596A patent/MX2016012596A/es active IP Right Grant
- 2015-03-20 PL PL15773354T patent/PL3125872T3/pl unknown
- 2015-03-20 BR BR112016022528-7A patent/BR112016022528B1/pt active IP Right Grant
- 2015-03-20 US US15/300,515 patent/US9867801B2/en active Active
- 2015-03-20 HU HUE15773354A patent/HUE046616T2/hu unknown
- 2015-03-20 SI SI201530891T patent/SI3125872T1/sl unknown
- 2015-03-20 DK DK15773354.4T patent/DK3125872T3/da active
- 2015-03-20 MY MYPI2016001721A patent/MY175387A/en unknown
- 2015-03-20 AU AU2015242738A patent/AU2015242738B2/en active Active
- 2015-03-27 UY UY0001036055A patent/UY36055A/es not_active Application Discontinuation
- 2015-03-30 TW TW104110283A patent/TWI706793B/zh active
- 2015-03-30 AR ARP150100942A patent/AR099886A1/es unknown
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2016
- 2016-09-19 PH PH12016501825A patent/PH12016501825A1/en unknown
- 2016-09-22 IL IL247977A patent/IL247977B/en active IP Right Grant
- 2016-09-27 DO DO2016000262A patent/DOP2016000262A/es unknown
- 2016-09-28 CL CL2016002441A patent/CL2016002441A1/es unknown
- 2016-09-29 SA SA516371952A patent/SA516371952B1/ar unknown
- 2016-09-30 GT GT201600208A patent/GT201600208A/es unknown
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