CU24486B1 - Dispersión sólida amorfa que comprende taxano, tabletas comprendiendo la misma y método para prepararla - Google Patents

Dispersión sólida amorfa que comprende taxano, tabletas comprendiendo la misma y método para prepararla

Info

Publication number
CU24486B1
CU24486B1 CU2016000144A CU20160144A CU24486B1 CU 24486 B1 CU24486 B1 CU 24486B1 CU 2016000144 A CU2016000144 A CU 2016000144A CU 20160144 A CU20160144 A CU 20160144A CU 24486 B1 CU24486 B1 CU 24486B1
Authority
CU
Cuba
Prior art keywords
tablets
prepare
understanding
same
solid dispersion
Prior art date
Application number
CU2016000144A
Other languages
English (en)
Inventor
Ho Taek Im
Yong Ii Kim
Jae Hyun Park
Shanmugam Srinivasan
Jong Soo Woo
Young Su Yoon
Original Assignee
Hanmi Pharm Ind Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=54240734&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CU24486(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Hanmi Pharm Ind Co Ltd filed Critical Hanmi Pharm Ind Co Ltd
Publication of CU24486B1 publication Critical patent/CU24486B1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

<p>La presente invención provee una dispersión sólida amorfa que comprende un taxano o una sal del mismo aceptable desde el punto de vista farmacéutico, un polímero aceptable desde el punto de vista farmacéutico, y un agente tensoactivo aceptable desde el punto de vista farmacéutico, Ia cual tiene solubilidad mejorada. También se provee un método para Ia preparación de Ia dispersión sólida. La presente invención también provee una tableta que tiene buena solubilidad, biodisponibilidad y estabilidad, que comprende Ia dispersión sólida amorfa, un excipiente intragranular, y un excipiente extragranular.</p>
CU2016000144A 2014-03-31 2015-03-20 Dispersión sólida amorfa que comprende taxano, tabletas comprendiendo la misma y método para prepararla CU24486B1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/KR2014/002734 WO2015152433A1 (en) 2014-03-31 2014-03-31 Amorphous solid dispersion comprising paclitaxel, tablet comprising the same, and method for preparing the same
PCT/KR2015/002756 WO2015152544A1 (en) 2014-03-31 2015-03-20 Amorphous solid dispersion comprising taxane, tablet comprising the same, and method for preparing the same

Publications (1)

Publication Number Publication Date
CU24486B1 true CU24486B1 (es) 2020-11-30

Family

ID=54240734

Family Applications (1)

Application Number Title Priority Date Filing Date
CU2016000144A CU24486B1 (es) 2014-03-31 2015-03-20 Dispersión sólida amorfa que comprende taxano, tabletas comprendiendo la misma y método para prepararla

Country Status (33)

Country Link
US (1) US9867801B2 (es)
EP (1) EP3125872B1 (es)
JP (1) JP6539675B2 (es)
KR (1) KR101851571B1 (es)
CN (1) CN106255496B (es)
AR (1) AR099886A1 (es)
AU (1) AU2015242738B2 (es)
BR (1) BR112016022528B1 (es)
CA (1) CA2944438C (es)
CL (1) CL2016002441A1 (es)
CU (1) CU24486B1 (es)
DK (1) DK3125872T3 (es)
DO (1) DOP2016000262A (es)
ES (1) ES2748686T3 (es)
GT (1) GT201600208A (es)
HU (1) HUE046616T2 (es)
IL (1) IL247977B (es)
LT (1) LT3125872T (es)
MA (1) MA39361B1 (es)
MX (1) MX2016012596A (es)
MY (1) MY175387A (es)
PE (1) PE20161477A1 (es)
PH (1) PH12016501825A1 (es)
PL (1) PL3125872T3 (es)
PT (1) PT3125872T (es)
RU (1) RU2684632C2 (es)
SA (1) SA516371952B1 (es)
SG (1) SG11201607456RA (es)
SI (1) SI3125872T1 (es)
TW (1) TWI706793B (es)
UA (1) UA117610C2 (es)
UY (1) UY36055A (es)
WO (2) WO2015152433A1 (es)

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CN116964044A (zh) 2020-10-07 2023-10-27 希华医药有限公司 乙酰胺基-苯基四唑衍生物及其使用方法
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Also Published As

Publication number Publication date
SA516371952B1 (ar) 2020-12-07
PL3125872T3 (pl) 2020-03-31
AR099886A1 (es) 2016-08-24
IL247977A0 (en) 2016-11-30
UA117610C2 (uk) 2018-08-27
US9867801B2 (en) 2018-01-16
SI3125872T1 (sl) 2019-11-29
GT201600208A (es) 2018-11-27
BR112016022528A2 (pt) 2017-08-15
SG11201607456RA (en) 2016-10-28
CA2944438C (en) 2021-10-26
LT3125872T (lt) 2019-10-10
PT3125872T (pt) 2019-10-24
ES2748686T3 (es) 2020-03-17
RU2016136636A3 (es) 2018-09-25
MA39361B1 (fr) 2018-06-29
PH12016501825B1 (en) 2016-11-07
EP3125872A1 (en) 2017-02-08
EP3125872A4 (en) 2017-10-11
KR101851571B1 (ko) 2018-04-26
MA39361A1 (fr) 2017-06-30
AU2015242738A1 (en) 2016-09-22
JP2017509653A (ja) 2017-04-06
HUE046616T2 (hu) 2020-03-30
CN106255496A (zh) 2016-12-21
CA2944438A1 (en) 2015-10-08
JP6539675B2 (ja) 2019-07-03
IL247977B (en) 2019-09-26
EP3125872B1 (en) 2019-08-14
RU2684632C2 (ru) 2019-04-11
WO2015152433A1 (en) 2015-10-08
WO2015152544A1 (en) 2015-10-08
PH12016501825A1 (en) 2016-11-07
MY175387A (en) 2020-06-23
KR20160124904A (ko) 2016-10-28
CN106255496B (zh) 2019-10-18
RU2016136636A (ru) 2018-05-03
TWI706793B (zh) 2020-10-11
TW201620506A (zh) 2016-06-16
CL2016002441A1 (es) 2017-02-17
DOP2016000262A (es) 2017-01-15
BR112016022528B1 (pt) 2023-04-11
AU2015242738B2 (en) 2019-09-26
DK3125872T3 (da) 2019-10-14
MX2016012596A (es) 2017-01-09
PE20161477A1 (es) 2017-01-29
NZ723991A (en) 2021-01-29
US20170112799A1 (en) 2017-04-27
UY36055A (es) 2016-09-30

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