GT201300160A - Inmunoglobulinas de dominio variable dual biespecificas de il-1 alfa y beta y su uso - Google Patents
Inmunoglobulinas de dominio variable dual biespecificas de il-1 alfa y beta y su usoInfo
- Publication number
- GT201300160A GT201300160A GT201300160A GT201300160A GT201300160A GT 201300160 A GT201300160 A GT 201300160A GT 201300160 A GT201300160 A GT 201300160A GT 201300160 A GT201300160 A GT 201300160A GT 201300160 A GT201300160 A GT 201300160A
- Authority
- GT
- Guatemala
- Prior art keywords
- immunoglobulinas
- bispecificas
- beta
- alpha
- variable domain
- Prior art date
Links
- 108010002352 Interleukin-1 Proteins 0.000 title 1
- 208000017667 Chronic Disease Diseases 0.000 abstract 1
- 230000001154 acute effect Effects 0.000 abstract 1
- 238000003745 diagnosis Methods 0.000 abstract 1
- 230000002757 inflammatory effect Effects 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- A61K2039/507—Comprising a combination of two or more separate antibodies
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/35—Valency
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/64—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising a combination of variable region and constant region components
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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-
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- 2011-12-20 EP EP11820904.8A patent/EP2655417A2/en not_active Withdrawn
- 2011-12-20 PH PH1/2013/501336A patent/PH12013501336A1/en unknown
- 2011-12-20 KR KR1020137018960A patent/KR20130133247A/ko not_active Withdrawn
- 2011-12-20 CN CN201180066566.9A patent/CN103517921B/zh active Active
- 2011-12-20 SG SG2013048483A patent/SG191312A1/en unknown
- 2011-12-20 RU RU2013133811A patent/RU2627171C2/ru active
- 2011-12-20 PE PE2013001458A patent/PE20141060A1/es not_active Application Discontinuation
- 2011-12-20 TW TW100147523A patent/TW201249865A/zh unknown
- 2011-12-20 MX MX2013007332A patent/MX2013007332A/es unknown
- 2011-12-20 WO PCT/US2011/066130 patent/WO2012121775A2/en not_active Ceased
- 2011-12-20 SG SG10201604699VA patent/SG10201604699VA/en unknown
- 2011-12-20 BR BR112013015944A patent/BR112013015944A2/pt not_active IP Right Cessation
- 2011-12-20 CA CA2821976A patent/CA2821976A1/en not_active Abandoned
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- 2011-12-20 JP JP2013546325A patent/JP6009455B2/ja not_active Expired - Fee Related
- 2011-12-20 US US13/331,422 patent/US8853365B2/en active Active
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2013
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- 2013-07-17 EC ECSP13012776 patent/ECSP13012776A/es unknown
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2014
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| Publication number | Publication date |
|---|---|
| AU2011361720A1 (en) | 2013-07-04 |
| US20150093387A1 (en) | 2015-04-02 |
| PE20141060A1 (es) | 2014-09-26 |
| RU2013133811A (ru) | 2015-01-27 |
| CR20130340A (es) | 2013-10-15 |
| TW201249865A (en) | 2012-12-16 |
| US8853365B2 (en) | 2014-10-07 |
| DOP2013000145A (es) | 2013-11-15 |
| WO2012121775A3 (en) | 2012-11-01 |
| MY163368A (en) | 2017-09-15 |
| AU2011361720B2 (en) | 2017-04-27 |
| KR20130133247A (ko) | 2013-12-06 |
| CN103517921A (zh) | 2014-01-15 |
| JP6009455B2 (ja) | 2016-10-19 |
| US20120189541A1 (en) | 2012-07-26 |
| JP2017029157A (ja) | 2017-02-09 |
| ECSP13012776A (es) | 2013-09-30 |
| RU2627171C2 (ru) | 2017-08-03 |
| WO2012121775A2 (en) | 2012-09-13 |
| JP2014504860A (ja) | 2014-02-27 |
| SG191312A1 (en) | 2013-07-31 |
| MX2013007332A (es) | 2014-01-23 |
| CO6771416A2 (es) | 2013-10-15 |
| CN103517921B (zh) | 2017-07-18 |
| CL2013001831A1 (es) | 2013-11-08 |
| SG10201604699VA (en) | 2016-07-28 |
| BR112013015944A2 (pt) | 2018-06-19 |
| WO2012121775A9 (en) | 2013-01-17 |
| EP2655417A2 (en) | 2013-10-30 |
| PH12013501336A1 (en) | 2013-08-28 |
| CA2821976A1 (en) | 2012-09-13 |
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