GR3026222T3 - Novel mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace - Google Patents

Novel mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace

Info

Publication number
GR3026222T3
GR3026222T3 GR980400401T GR980400401T GR3026222T3 GR 3026222 T3 GR3026222 T3 GR 3026222T3 GR 980400401 T GR980400401 T GR 980400401T GR 980400401 T GR980400401 T GR 980400401T GR 3026222 T3 GR3026222 T3 GR 3026222T3
Authority
GR
Greece
Prior art keywords
enkephalinase
ace
inhibitors
derivatives useful
mercaptoacetylamide derivatives
Prior art date
Application number
GR980400401T
Other languages
Greek (el)
English (en)
Inventor
Gary A Flynn
Alan M Warshawsky
Shujaath Mehdi
Philippe Bey
Douglas W Beight
Eugene L Giroux
Timothy P Burkholder
Original Assignee
Merrell Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Pharma Inc filed Critical Merrell Pharma Inc
Publication of GR3026222T3 publication Critical patent/GR3026222T3/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Immunology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Transplantation (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Hydrogenated Pyridines (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
GR980400401T 1990-10-18 1998-02-25 Novel mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace GR3026222T3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US60005290A 1990-10-18 1990-10-18
US73549691A 1991-07-25 1991-07-25

Publications (1)

Publication Number Publication Date
GR3026222T3 true GR3026222T3 (en) 1998-05-29

Family

ID=27083513

Family Applications (1)

Application Number Title Priority Date Filing Date
GR980400401T GR3026222T3 (en) 1990-10-18 1998-02-25 Novel mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace

Country Status (18)

Country Link
EP (1) EP0481522B1 (fr)
JP (1) JP3181335B2 (fr)
KR (1) KR100372491B1 (fr)
CN (2) CN1036590C (fr)
AT (1) ATE161536T1 (fr)
AU (1) AU642535B2 (fr)
CA (1) CA2053340C (fr)
DE (1) DE69128516T2 (fr)
DK (1) DK0481522T3 (fr)
ES (1) ES2114870T3 (fr)
FI (2) FI95255C (fr)
GR (1) GR3026222T3 (fr)
HU (1) HU210008B (fr)
IE (1) IE913648A1 (fr)
IL (1) IL99769A (fr)
NO (1) NO180718C (fr)
NZ (1) NZ240230A (fr)
PT (1) PT99267B (fr)

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US5208230A (en) * 1990-12-21 1993-05-04 Merrell Dow Pharmaceuticals Amino and nitro containing tricyclic compounds useful as inhibitors of ACE
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US5455242A (en) * 1991-09-27 1995-10-03 Merrell Dow Pharmaceuticals Inc. Carboxyalkyl tricyclic derivatives useful as inhibitors of enkephalinase and ace
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ATE182892T1 (de) * 1992-05-15 1999-08-15 Merrell Pharma Inc Mercaptoacetylamide von pyridazo(1,2-a>(1,2>- diazepin -derivaten als eukephalinase und ace- inhibitoren
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US5238932A (en) * 1992-05-20 1993-08-24 Merrell Dow Pharmaceuticals Inc. Mercaptoacetylamide tricyclic derivatives useful as inhibitors of enkephalinase
US5298492A (en) * 1992-08-04 1994-03-29 Schering Corporation Diamino acid derivatives as antihypertensives
AU679452B2 (en) * 1992-08-24 1997-07-03 Merrell Dow Pharmaceuticals Inc. Novel 2-substituted indane-2-mercaptoacetylamide tricyclic derivatives useful as inhibitors of enkephalinase
US5208236A (en) * 1992-09-23 1993-05-04 Schering Corporation N-(acylaminomethyl)glutaryl amino acids and use
US5504080A (en) * 1992-10-28 1996-04-02 Bristol-Myers Squibb Co. Benzo-fused lactams
AU673857B2 (en) * 1992-10-30 1996-11-28 Aventisub Ii Inc. Mercaptoacetylamide bicyclic lactam derivatives
US5654294A (en) * 1993-05-13 1997-08-05 Bristol-Myers Squibb Spiro lactam dual action inhibitors
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WO1994028901A1 (fr) * 1993-06-11 1994-12-22 Eisai Co., Ltd. Derive aminoacide
AU680512B2 (en) * 1993-06-11 1997-07-31 Eisai Co. Ltd. Amino acid derivative
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ES2076096B1 (es) * 1993-07-14 1996-03-16 Squibb & Sons Inc Compuestos inhibidores de la enzima convertidora de angiotensinas y dela endopeptidasa neutra, y metodos para prepararlos.
US5362727A (en) * 1993-07-26 1994-11-08 Bristol-Myers Squibb Substituted azepino[2,1-a]isoquinoline compounds
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CA2183313C (fr) * 1994-02-14 2001-01-02 Gary A. Flynn Nouveaux derives de bisulfure d'indane-2-mercaptoacetylamide utiles en tant qu'inhibiteurs de l'encephalinase
PT750631E (pt) * 1994-02-14 2000-07-31 Merrell Pharma Inc Novos derivados de dissulfureto de mercapto-aacetilamido-1,3,4,5-tetra-hidro-benzo¬c)azepin-3-ona uteis como inibidores de encefalinase e ace
ATE177098T1 (de) * 1994-02-14 1999-03-15 Merrell Pharma Inc Mercaptoacetylamid disulfidderivate als enkephalinase und ace inhibitoren
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DE69514912T2 (de) * 1994-03-24 2000-10-05 Merrell Pharmaceuticals Inc., Cincinnati Hypocholesterolemische, antiatherosklerotische und hypotriglyceridemische verwendung von aminoacetylmercapto derivaten
US6013645A (en) * 1994-03-24 2000-01-11 Hoechst Marion Roussel, Inc. Hypocholesterolemic, antiatherosclerotic and hypotriglyceridemic mercaptoacetylamide disulfide derivatives
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US5641880A (en) * 1994-12-21 1997-06-24 Hoechst Marion Roussel, Inc. Processes for preparing intermediates of inhibitors of enkephalinase and angiotensin converting enzyme and intermediates thereof
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Also Published As

Publication number Publication date
EP0481522A1 (fr) 1992-04-22
FI95255B (fi) 1995-09-29
FI914905A0 (fi) 1991-10-17
HU210008B (en) 1995-01-30
NO914092L (no) 1992-04-21
FI95255C (fi) 1996-01-10
CN1166490A (zh) 1997-12-03
CN1061971A (zh) 1992-06-17
FI96691C (fi) 1996-08-12
AU642535B2 (en) 1993-10-21
ATE161536T1 (de) 1998-01-15
FI943363A (fi) 1994-07-14
ES2114870T3 (es) 1998-06-16
AU8581991A (en) 1992-04-30
HUT63419A (en) 1993-08-30
DK0481522T3 (da) 1998-03-09
JP3181335B2 (ja) 2001-07-03
PT99267B (pt) 1999-04-30
IL99769A0 (en) 1992-08-18
HU913282D0 (en) 1992-01-28
JPH04282382A (ja) 1992-10-07
DE69128516T2 (de) 1998-07-23
KR100372491B1 (ko) 2003-05-27
FI914905A (fi) 1992-04-19
PT99267A (pt) 1992-08-31
FI96691B (fi) 1996-04-30
CN1058013C (zh) 2000-11-01
FI943363A0 (fi) 1994-07-14
IE913648A1 (en) 1992-04-22
NZ240230A (en) 1993-01-27
NO180718C (no) 1997-06-04
IL99769A (en) 1998-12-27
DE69128516D1 (de) 1998-02-05
CN1036590C (zh) 1997-12-03
NO914092D0 (no) 1991-10-17
KR920008040A (ko) 1992-05-27
EP0481522B1 (fr) 1997-12-29
CA2053340A1 (fr) 1992-04-19
NO180718B (no) 1997-02-24
CA2053340C (fr) 2002-04-02

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