GR3022871T3 - Direct esterification of mycophenolic acid. - Google Patents

Direct esterification of mycophenolic acid.

Info

Publication number
GR3022871T3
GR3022871T3 GR960402772T GR960402772T GR3022871T3 GR 3022871 T3 GR3022871 T3 GR 3022871T3 GR 960402772 T GR960402772 T GR 960402772T GR 960402772 T GR960402772 T GR 960402772T GR 3022871 T3 GR3022871 T3 GR 3022871T3
Authority
GR
Greece
Prior art keywords
mycophenolic acid
direct esterification
morpholinoethanol
refluxing
catalytically
Prior art date
Application number
GR960402772T
Other languages
English (en)
Inventor
Martin Barntick Knox
Gregory Donegan
Dennis A Smith
Original Assignee
Syntex Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Syntex Inc filed Critical Syntex Inc
Publication of GR3022871T3 publication Critical patent/GR3022871T3/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
    • C07D307/88—Benzo [c] furans; Hydrogenated benzo [c] furans with one oxygen atom directly attached in position 1 or 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
GR960402772T 1992-07-10 1997-03-20 Direct esterification of mycophenolic acid. GR3022871T3 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US91163592A 1992-07-10 1992-07-10
US07/993,146 US5247083A (en) 1992-07-10 1992-12-18 Direct esterification of mycophenolic acid
PCT/US1993/006390 WO1994001427A1 (en) 1992-07-10 1993-07-09 Direct esterification of mycophenolic acid

Publications (1)

Publication Number Publication Date
GR3022871T3 true GR3022871T3 (en) 1997-06-30

Family

ID=27129579

Family Applications (1)

Application Number Title Priority Date Filing Date
GR960402772T GR3022871T3 (en) 1992-07-10 1997-03-20 Direct esterification of mycophenolic acid.

Country Status (12)

Country Link
US (1) US5247083A (el)
EP (1) EP0649422B1 (el)
JP (1) JP3199741B2 (el)
AT (1) ATE150460T1 (el)
CY (1) CY2131B1 (el)
DE (1) DE69309065T2 (el)
DK (1) DK0649422T3 (el)
ES (1) ES2098763T3 (el)
GR (1) GR3022871T3 (el)
HK (1) HK1000248A1 (el)
MX (1) MX9304153A (el)
WO (1) WO1994001427A1 (el)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5455045A (en) * 1993-05-13 1995-10-03 Syntex (U.S.A.) Inc. High dose formulations
JP3844491B2 (ja) 1993-10-01 2006-11-15 シンテックス（ユー・エス・エイ）インコーポレイテッド ミコフェノール酸モフェチル高用量経口用懸濁剤
US5493030A (en) * 1994-02-18 1996-02-20 Syntex (U.S.A.) Inc. 5-substituted derivatives of mycophenolic acid
US5525602A (en) * 1994-02-18 1996-06-11 Syntex (U.S.A.) Inc. Method of using 4-amino 6-substituted mycophenolic acid and derivatives
US5444072A (en) * 1994-02-18 1995-08-22 Syntex (U.S.A.) Inc. 6-substituted mycophenolic acid and derivatives
US5512568A (en) * 1994-02-18 1996-04-30 Syntex (U.S.A.) Inc. Method of using 4-amino derivatives of 5-substituted mycophenolic acid
US5380879A (en) * 1994-02-18 1995-01-10 Syntex (U.S.A.) Inc. Derivatives of mycophenolic acid
AU1707700A (en) * 1998-10-29 2000-05-22 Bristol-Myers Squibb Company Novel inhibitors of impdh enzyme
US6596747B2 (en) 1998-10-29 2003-07-22 Bristol-Myers Squibb Company Compounds derived from an amine nucleus and pharmaceutical compositions comprising same
JP2002528499A (ja) 1998-10-29 2002-09-03 ブリストル−マイヤーズ スクイブ カンパニー Ｉｍｐｄｈ酵素のインヒビターであるアミノ核誘導化合物
US6420403B1 (en) 1998-10-29 2002-07-16 Edwin J. Iwanowicz Inhibitors of IMPDH enzyme
IN188985B (el) 1998-12-09 2002-11-30 Biocon Ltd
US6410758B2 (en) 1999-05-24 2002-06-25 Mcneil-Ppc, Inc. Preparation of sterol and stanol-esters
AU5553801A (en) 2000-04-24 2001-11-07 Bristol Myers Squibb Co Heterocycles that are inhibitors of impdh enzyme
CZ292123B6 (cs) * 2001-06-08 2003-08-13 Ivax Pharmaceuticals S.R.O. Způsob přípravy mykofenolátu mofetilu
WO2003042393A1 (en) * 2001-11-16 2003-05-22 Biocon Limited Enzymatic preparation of mycophenolate mofetil
TW200301698A (en) * 2001-12-21 2003-07-16 Bristol Myers Squibb Co Acridone inhibitors of IMPDH enzyme
TWI221414B (en) * 2003-02-21 2004-10-01 Chunghwa Chemical Synthesis & Method of making mycophenolate mofetil using transesterification
US20050187170A1 (en) * 2003-06-16 2005-08-25 Biocryst Pharmaceuticals, Inc. Enhancing the efficiency of RNA polymerase inhibitors by using inosine monophosphate dehydrogenase inhibitors
ES2308226T3 (es) * 2003-09-11 2008-12-01 Sandoz Ag Proceso para la produccion de micofenolato mofetil.
WO2005105768A2 (en) * 2004-04-26 2005-11-10 Teva Gyógyszergyár Zàrtköruen Muködo Rèszvènytàrsasàg Process for preparation of mycophenolic acid and ester derivatives thereof
WO2005105769A2 (en) * 2004-04-27 2005-11-10 Teva Gyógyszergyár Zàrtköruen Muködo Rèszvènytàrsasàg - Mycophenolate mofetil impurity
CA2573781A1 (en) * 2004-07-20 2006-02-02 Teva Gyogyszergyar Zartkoruen Mukodo Reszvenytarsasag Processes for preparation of crystalline mycophenolate sodium
EP1844041A4 (en) * 2005-01-20 2009-08-05 Apotex Fermentation Inc IMPROVED PROCESS FOR THE PREPARATION OF MYCOPHENOLATE MOFETIL
US20080280977A1 (en) * 2005-04-26 2008-11-13 Sandor Molnar Process for preparation of mycophenolate mofetil and other esters of mycophenolic acid
CN1328272C (zh) * 2005-08-22 2007-07-25 鲁南制药集团股份有限公司 一种工业化生产霉酚酸莫啡酯的方法
CN100402516C (zh) * 2005-10-18 2008-07-16 深圳市东阳光实业发展有限公司 一种霉酚酸莫啡酯的制备方法
WO2008015693A2 (en) * 2006-06-02 2008-02-07 Concord Biotech Limited Process for the preparation of mycophenolate mofetil
WO2008003637A2 (en) * 2006-07-05 2008-01-10 Dsm Ip Assets B.V. Isolation and use of amine salts of mycophenolic acid
CN1974564B (zh) * 2006-12-15 2010-05-12 丽珠集团新北江制药股份有限公司 一种霉酚酸莫啡酯的制备方法
US20080188653A1 (en) 2007-02-04 2008-08-07 Formosa Laboratories, Inc. Process for Preparation of Mycophenolate Mofetil
CN100484930C (zh) * 2007-03-16 2009-05-06 重庆大新药业股份有限公司 一种吗替麦考酚酯的制备方法
US8273739B2 (en) * 2007-06-27 2012-09-25 Dsm Sinochem Pharmaceuticals Netherlands B.V. Method for the purification of mycophenolate mofetil
WO2009003878A1 (en) * 2007-06-29 2009-01-08 Dsm Ip Assets B.V. Method for the preparation of mycophenolate mofetil
WO2009010503A1 (en) * 2007-07-18 2009-01-22 Dsm Ip Assets B.V. Mycophenolic acid recycling in a method for the preparation of mycophenolate mofetil
KR100975520B1 (ko) * 2008-02-01 2010-08-12 종근당바이오 주식회사 마이코페놀레이트 모페틸의 개선된 제조방법
WO2010041269A1 (en) * 2008-09-10 2010-04-15 Ipca Laboratories Limited Process for preparation of mycophenolic acid, its salt and ester derivatives
KR101668811B1 (ko) 2015-06-01 2016-10-25 라원택 안전 표시장치
AU2018254577B2 (en) 2017-04-21 2024-06-13 Epizyme, Inc. Combination therapies with EHMT2 inhibitors

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4727069A (en) * 1987-01-30 1988-02-23 Syntex (U.S.A.) Inc. Heterocyclic aminoalkyl esters of mycophenolic acid, derivatives thereof and pharmaceutical compositions
US4753935A (en) * 1987-01-30 1988-06-28 Syntex (U.S.A.) Inc. Morpholinoethylesters of mycophenolic acid and pharmaceutical compositions

Also Published As

Publication number Publication date
JP3199741B2 (ja) 2001-08-20
US5247083A (en) 1993-09-21
JPH08500340A (ja) 1996-01-16
MX9304153A (es) 1994-04-29
WO1994001427A1 (en) 1994-01-20
EP0649422B1 (en) 1997-03-19
DE69309065T2 (de) 1997-06-26
DK0649422T3 (da) 1997-04-14
ATE150460T1 (de) 1997-04-15
DE69309065D1 (de) 1997-04-24
HK1000248A1 (en) 1998-02-13
CY2131B1 (en) 2002-06-21
ES2098763T3 (es) 1997-05-01
EP0649422A1 (en) 1995-04-26

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