GR1000381B - Μεθοδος καταψυξεως ερυθρων αιμοσφαιριων. - Google Patents
Μεθοδος καταψυξεως ερυθρων αιμοσφαιριων.Info
- Publication number
- GR1000381B GR1000381B GR900100082A GR900100082A GR1000381B GR 1000381 B GR1000381 B GR 1000381B GR 900100082 A GR900100082 A GR 900100082A GR 900100082 A GR900100082 A GR 900100082A GR 1000381 B GR1000381 B GR 1000381B
- Authority
- GR
- Greece
- Prior art keywords
- blood cells
- red blood
- freezing
- bag
- frame
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/02—Preservation of living parts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/18—Erythrocytes
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/02—Preservation of living parts
- A01N1/0205—Chemical aspects
- A01N1/021—Preservation or perfusion media, liquids, solids or gases used in the preservation of cells, tissue, organs or bodily fluids
- A01N1/0221—Freeze-process protecting agents, i.e. substances protecting cells from effects of the physical process, e.g. cryoprotectants, osmolarity regulators like oncotic agents
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/02—Preservation of living parts
- A01N1/0236—Mechanical aspects
- A01N1/0263—Non-refrigerated containers specially adapted for transporting or storing living parts whilst preserving, e.g. cool boxes, blood bags or "straws" for cryopreservation
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N1/00—Preservation of bodies of humans or animals, or parts thereof
- A01N1/02—Preservation of living parts
- A01N1/0236—Mechanical aspects
- A01N1/0263—Non-refrigerated containers specially adapted for transporting or storing living parts whilst preserving, e.g. cool boxes, blood bags or "straws" for cryopreservation
- A01N1/0268—Carriers for immersion in cryogenic fluid, both for slow-freezing and vitrification, e.g. open or closed "straws" for embryos, oocytes or semen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
- A61J1/14—Details; Accessories therefor
- A61J1/16—Holders for containers
- A61J1/165—Cooled holders, e.g. for medications, insulin, blood, plasma
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/02—Blood transfusion apparatus
- A61M1/0272—Apparatus for treatment of blood or blood constituents prior to or for conservation, e.g. freezing, drying or centrifuging
- A61M1/0277—Frames constraining or supporting bags, e.g. during freezing
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F25—REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
- F25D—REFRIGERATORS; COLD ROOMS; ICE-BOXES; COOLING OR FREEZING APPARATUS NOT OTHERWISE PROVIDED FOR
- F25D25/00—Charging, supporting, and discharging the articles to be cooled
- F25D25/005—Charging, supporting, and discharging the articles to be cooled using containers
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F25—REFRIGERATION OR COOLING; COMBINED HEATING AND REFRIGERATION SYSTEMS; HEAT PUMP SYSTEMS; MANUFACTURE OR STORAGE OF ICE; LIQUEFACTION SOLIDIFICATION OF GASES
- F25D—REFRIGERATORS; COLD ROOMS; ICE-BOXES; COOLING OR FREEZING APPARATUS NOT OTHERWISE PROVIDED FOR
- F25D2331/00—Details or arrangements of other cooling or freezing apparatus not provided for in other groups of this subclass
- F25D2331/80—Type of cooled receptacles
- F25D2331/801—Bags
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Hematology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Wood Science & Technology (AREA)
- Dentistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Mechanical Engineering (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Pharmacology & Pharmacy (AREA)
- Heart & Thoracic Surgery (AREA)
- Biotechnology (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Virology (AREA)
- Immunology (AREA)
- Developmental Biology & Embryology (AREA)
- Cell Biology (AREA)
- Combustion & Propulsion (AREA)
- Anesthesiology (AREA)
- Physics & Mathematics (AREA)
- Vascular Medicine (AREA)
- Thermal Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medical Preparation Storing Or Oral Administration Devices (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Steroid Compounds (AREA)
- Crystals, And After-Treatments Of Crystals (AREA)
- Compounds Of Unknown Constitution (AREA)
- Disintegrating Or Milling (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Μέθοδος κατάψυξης τυποποιημένης μονάδας δότου ερυθρών αιμοσφαιρίων, που να μπορεί να αποθηκευθεί επί μακρές περιόδους και στη συνέχεια να ανακτηθεί υπό μορφή αρκούντως καθαρή, για σκοπούς μετάγγισης, περιλαμβάνει φυγοκέντρηση μονάδας αίματος για την απομάκρυνση του πλάσματος και των αιμοπεταλίων, και παροχή 'Ογκου Συσσωρευμένων Κυττάρων (Packed Cell Volume) των ερυθρών αιμοσφαιρίων, όχι λιγότερο του 90%, προσθήκη των ερυθρών αιμοσφαιρίων σε σάκκο κατάψυξης (13), ο οποίος περιέχει διάλυμα HES (Υδροξυαιθυλοαμύλου, Hydroxyethyl starch-HES) τέτοιο ώστε η αναλογία HES/ερυθρά αιμοσφαίρια να μην είναι μεγαλύτερη από 7% (κατά προτίμηση 6%) βάρος/όγκο, τοποθέτηση του σάκκου κατάψυξης (13) σε κλωβό (20,21) προσαρμοσμένο έτσι ώστε να διατηρεί σταθερό το πάχος του περιεχομένου του σάκκου, και τοποθέτηση του κλωβού (20,21) χωρίς ανατάραξη, μέσα σε υγρό άζωτο. ω
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB898902791A GB8902791D0 (en) | 1989-02-08 | 1989-02-08 | A method of freezing blood |
Publications (2)
Publication Number | Publication Date |
---|---|
GR900100082A GR900100082A (en) | 1991-06-28 |
GR1000381B true GR1000381B (el) | 1992-06-30 |
Family
ID=10651316
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GR900100082A GR1000381B (el) | 1989-02-08 | 1990-02-08 | Μεθοδος καταψυξεως ερυθρων αιμοσφαιριων. |
Country Status (22)
Country | Link |
---|---|
US (1) | US5309723A (el) |
EP (2) | EP0564880A1 (el) |
JP (1) | JP2747114B2 (el) |
KR (1) | KR0148223B1 (el) |
CN (1) | CN1049103A (el) |
AT (1) | ATE99948T1 (el) |
AU (1) | AU638229B2 (el) |
BR (1) | BR9007103A (el) |
CA (1) | CA2046627A1 (el) |
DE (1) | DE69006014T2 (el) |
DK (1) | DK0457782T3 (el) |
ES (1) | ES2062509T3 (el) |
FI (1) | FI100382B (el) |
GB (2) | GB8902791D0 (el) |
GR (1) | GR1000381B (el) |
HU (1) | HU211079B (el) |
IE (1) | IE63695B1 (el) |
NO (1) | NO179435C (el) |
NZ (1) | NZ232347A (el) |
PT (1) | PT93099B (el) |
RU (1) | RU2073972C1 (el) |
WO (1) | WO1990009184A1 (el) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9212622D0 (en) * | 1992-06-15 | 1992-07-29 | Secr Defence | Freezing bags |
GB9218538D0 (en) * | 1992-09-02 | 1992-10-14 | Secr Defence | Infusievloeistoffen freezing bags |
ES2051649B1 (es) * | 1992-12-11 | 1995-01-01 | Grifols Grupo Sa | Procedimiento y su dispositivo para la congelacion transporte y almac enamiento de bolsas de sangre, plasma y similares. |
GB9320373D0 (en) * | 1993-10-02 | 1993-11-24 | Secr Defence | Freezing frames |
GB2296080B (en) * | 1993-10-02 | 1997-08-13 | Secr Defence | Freezing frames for blood bags |
DE4439480C1 (de) * | 1994-11-08 | 1996-06-05 | Asta Medica Ag | Verwendung von D,L- alpha-Liponsäure und/oder ihren Enantiomeren, und/oder ihren Derivaten als Zusatz bei Erythrozyten-Flüssigkonserven für homologe und autologe Erythrozyten-Konzentrate und als Zusatz bei Erythrozyten-Kryokonserven für homologe und autologe Erythrozytenkonzentrate |
CA2146098A1 (en) * | 1995-01-12 | 1996-07-13 | Ray V. Rajotte | Bulk cryopreservation of biological materials and uses for cryopreserved and encapsulated biological materials |
US6436705B1 (en) | 1997-02-18 | 2002-08-20 | The United States Of America As Represented By The Secretary Of The Navy | Shape stabilized erythrocytes |
US6358678B1 (en) | 1998-02-11 | 2002-03-19 | The United States Of America As Represented By The Secretary Of The Navy | Applications of reversible crosslinking and co-treatment in stabilization and viral inactivations of erythrocytes |
US6302327B1 (en) * | 1997-06-16 | 2001-10-16 | Thermogenesis, Corp. | Method and apparatus for cryogenic storage of thermolabile products |
CA2301025C (en) * | 1997-08-20 | 2004-03-30 | Biopore, Inc. | Cryoprotectant removal method and apparatus |
DE19736372A1 (de) | 1997-08-21 | 1999-02-25 | Ingo Dipl Ing Heschel | Verfahren und Vorrichtung zum Kühlen, insbesondere Gefrieren eines Kühlgutes |
CA2332986C (en) | 1998-05-26 | 2009-09-08 | Lifecell Corporation | Cryopreservation of human red blood cells |
DE10056181C1 (de) | 2000-11-13 | 2002-03-07 | Hiberna Ag | Blutbeutel-Kassette, Blut-Kryokonserve und Verfahren zu deren Herstellung |
AU2003230955A1 (en) * | 2002-05-01 | 2003-11-17 | Cryoglass Llc | Cryopreservation system for liquid substances |
AU2006294654B2 (en) * | 2005-09-26 | 2012-05-24 | Lifecell Corporation | Dry platelet composition |
EP2063706A2 (en) * | 2006-09-11 | 2009-06-03 | I.M.T. Interface Multigrad Technology Ltd. | Systems, devices and methods for freezing and thawing biological materials |
US9301520B2 (en) | 2007-12-21 | 2016-04-05 | Sartorius Stedim North America Inc. | Systems and methods for freezing, storing and thawing biopharmaceutical materials |
US8177123B2 (en) * | 2008-09-24 | 2012-05-15 | Sartorius Stedim North America Inc. | Systems and methods for freezing, storing and thawing biopharmaceutical materials |
KR102207030B1 (ko) * | 2012-09-28 | 2021-01-22 | 세키스이 메디칼 가부시키가이샤 | 비희석계 면역 크로마토그래피법 시약에 있어서 희석 시료를 측정하기 위한 첨가물 |
CN103120153A (zh) * | 2012-11-26 | 2013-05-29 | 刘召宏 | 一种脱落细胞保存液 |
US10448631B2 (en) | 2015-09-22 | 2019-10-22 | East Carolina University | Cryopreservation using sucralose |
FR3064608B1 (fr) * | 2017-03-30 | 2020-08-07 | Sartorius Stedim Fmt Sas | Boitier de protection d’une poche de liquide biopharmaceutique, ensemble de protection et procede d’assemblage associes |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3758382A (en) * | 1968-07-26 | 1973-09-11 | Us Navy | Ve agent process of freezing blood using a hydroxyalkyl starch as cryoprotecti |
US3729947A (en) * | 1970-12-04 | 1973-05-01 | Alza Corp | Process for storing blood platelets |
BE788135A (fr) * | 1971-08-30 | 1973-02-28 | Union Carbide Corp | Procede et dispositif de congelation rapide |
CA1003232A (en) * | 1973-03-02 | 1977-01-11 | Clifford C. Faust | Expandable holder apparatus for flattening and freezing fluid-containing flexible pouches |
US3898023A (en) * | 1974-05-28 | 1975-08-05 | Union Carbide Corp | Expandable holder apparatus for flattening and freezing fluid-containing flexible pouches |
US4018911A (en) * | 1975-11-10 | 1977-04-19 | The United States Of America As Represented By The Secretary Of The Navy | Method for large volume freezing and thawing of packed erythrocytes |
US4004975A (en) * | 1975-12-30 | 1977-01-25 | The United States Of America As Represented By The Secretary Of The Navy | Method of isolating and cryopreserving human white cells from whole blood |
US4059967A (en) * | 1976-02-19 | 1977-11-29 | The Community Blood Council Of Greater New York, Inc. | Process for freezing blood platelets |
DE2908436A1 (de) * | 1979-03-05 | 1980-09-25 | Fresenius Chem Pharm Ind | Kolloidales gefrierschutzmittel |
US4251995A (en) * | 1979-04-25 | 1981-02-24 | Hedbergska Stiftelsen | Method of freezing human blood platelets in glycerol-glucose using a statically controlled cooling rate device |
-
1989
- 1989-02-08 GB GB898902791A patent/GB8902791D0/en active Pending
-
1990
- 1990-01-31 DK DK90902326.9T patent/DK0457782T3/da active
- 1990-01-31 WO PCT/GB1990/000140 patent/WO1990009184A1/en active IP Right Grant
- 1990-01-31 EP EP93104628A patent/EP0564880A1/en not_active Ceased
- 1990-01-31 ES ES90902326T patent/ES2062509T3/es not_active Expired - Lifetime
- 1990-01-31 JP JP2502381A patent/JP2747114B2/ja not_active Expired - Lifetime
- 1990-01-31 DE DE90902326T patent/DE69006014T2/de not_active Expired - Fee Related
- 1990-01-31 BR BR909007103A patent/BR9007103A/pt not_active IP Right Cessation
- 1990-01-31 CA CA002046627A patent/CA2046627A1/en not_active Abandoned
- 1990-01-31 AT AT90902326T patent/ATE99948T1/de not_active IP Right Cessation
- 1990-01-31 AU AU49504/90A patent/AU638229B2/en not_active Ceased
- 1990-01-31 EP EP90902326A patent/EP0457782B1/en not_active Expired - Lifetime
- 1990-01-31 RU SU905001485A patent/RU2073972C1/ru active
- 1990-01-31 US US07/741,485 patent/US5309723A/en not_active Expired - Fee Related
- 1990-01-31 KR KR1019910700858A patent/KR0148223B1/ko not_active IP Right Cessation
- 1990-01-31 HU HU901677A patent/HU211079B/hu not_active IP Right Cessation
- 1990-02-02 NZ NZ232347A patent/NZ232347A/xx unknown
- 1990-02-07 IE IE43790A patent/IE63695B1/en not_active IP Right Cessation
- 1990-02-08 GR GR900100082A patent/GR1000381B/el unknown
- 1990-02-08 PT PT93099A patent/PT93099B/pt not_active IP Right Cessation
- 1990-02-08 CN CN90101409A patent/CN1049103A/zh active Pending
-
1991
- 1991-07-25 GB GB9116136A patent/GB2245144B/en not_active Expired
- 1991-08-06 FI FI913735A patent/FI100382B/fi active
- 1991-08-07 NO NO913070A patent/NO179435C/no unknown
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