GEP20043181B - Cyclothiocarbamate Derivatives as Progesterone Receptor Modulators, Composition Containing Them and Their Use for Treatment Progesterone-Related Maladies - Google Patents
Cyclothiocarbamate Derivatives as Progesterone Receptor Modulators, Composition Containing Them and Their Use for Treatment Progesterone-Related MaladiesInfo
- Publication number
- GEP20043181B GEP20043181B GEAP20006120A GEAP2000006120A GEP20043181B GE P20043181 B GEP20043181 B GE P20043181B GE AP20006120 A GEAP20006120 A GE AP20006120A GE AP2000006120 A GEAP2000006120 A GE AP2000006120A GE P20043181 B GEP20043181 B GE P20043181B
- Authority
- GE
- Georgia
- Prior art keywords
- alkyl
- optionally substituted
- progesterone
- treatment
- aryl
- Prior art date
Links
- 239000002379 progesterone receptor modulator Substances 0.000 title 1
- 229940095745 sex hormone and modulator of the genital system progesterone receptor modulator Drugs 0.000 title 1
- RJKFOVLPORLFTN-LEKSSAKUSA-N Progesterone Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](C(=O)C)[C@@]1(C)CC2 RJKFOVLPORLFTN-LEKSSAKUSA-N 0.000 abstract 4
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 125000003118 aryl group Chemical group 0.000 abstract 3
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000004103 aminoalkyl group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000004122 cyclic group Chemical group 0.000 abstract 2
- 125000005842 heteroatom Chemical group 0.000 abstract 2
- 125000000623 heterocyclic group Chemical group 0.000 abstract 2
- 125000004051 hexyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 abstract 2
- 229960003387 progesterone Drugs 0.000 abstract 2
- 239000000186 progesterone Substances 0.000 abstract 2
- 125000003003 spiro group Chemical group 0.000 abstract 2
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 abstract 1
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 abstract 1
- 241000689227 Cora <basidiomycete fungus> Species 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
- C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
- C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
- C07D265/14—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D265/18—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with hetero atoms directly attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Chemical Or Physical Treatment Of Fibers (AREA)
- Detergent Compositions (AREA)
- Treatments For Attaching Organic Compounds To Fibrous Goods (AREA)
- Steroid Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US18301399P | 1999-05-04 | 1999-05-04 | |
| US09/552,354 US6436929B1 (en) | 1999-05-04 | 2000-04-19 | Cyclothiocarbamate derivatives as progesterone receptor modulators |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GEP20043181B true GEP20043181B (en) | 2004-02-25 |
Family
ID=26878649
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GEAP20006120A GEP20043181B (en) | 1999-05-04 | 2000-05-01 | Cyclothiocarbamate Derivatives as Progesterone Receptor Modulators, Composition Containing Them and Their Use for Treatment Progesterone-Related Maladies |
Country Status (24)
| Country | Link |
|---|---|
| EP (1) | EP1175411B1 (enExample) |
| JP (2) | JP4958338B2 (enExample) |
| KR (1) | KR100732692B1 (enExample) |
| CN (1) | CN1131856C (enExample) |
| AT (1) | ATE386729T1 (enExample) |
| AU (1) | AU766801B2 (enExample) |
| BG (1) | BG65277B1 (enExample) |
| BR (1) | BR0010214A (enExample) |
| CA (1) | CA2371712C (enExample) |
| CZ (1) | CZ20013952A3 (enExample) |
| DE (1) | DE60038108T2 (enExample) |
| DK (1) | DK1175411T3 (enExample) |
| EA (1) | EA004511B1 (enExample) |
| ES (1) | ES2301482T3 (enExample) |
| GE (1) | GEP20043181B (enExample) |
| HU (1) | HUP0203332A3 (enExample) |
| IL (1) | IL146298A0 (enExample) |
| MX (1) | MXPA01011287A (enExample) |
| NO (1) | NO321370B1 (enExample) |
| NZ (1) | NZ515353A (enExample) |
| PL (1) | PL351083A1 (enExample) |
| SG (1) | SG120970A1 (enExample) |
| SK (1) | SK15922001A3 (enExample) |
| TR (1) | TR200103285T2 (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1131856C (zh) * | 1999-05-04 | 2003-12-24 | 美国家庭用品有限公司 | 作为黄体酮受体调节剂的环硫代氨基甲酸酯衍生物 |
| US6407101B1 (en) * | 1999-05-04 | 2002-06-18 | American Home Products Corporation | Cyanopyrroles |
| CA2561313C (en) * | 2004-04-08 | 2012-12-04 | Wyeth | Methods for minimizing thioamide impurities |
| BRPI0509209A (pt) * | 2004-04-08 | 2007-08-28 | Wyeth Corp | composto, métodos para contracepção, terapia de reposição hormonal, tratamento ou prevenção de doença neoplásica dependente de hormÈnios; tratamento de sangramento disfuncional ou da sìndrome de ovários policìsticos; sincronização do estro; tratamento da acne ou tratamento do hirsutismo, e para preparação do composto, composição farmacêutica, kit farmacêutico, e, uso de um composto |
| ATE396189T1 (de) * | 2004-04-27 | 2008-06-15 | Wyeth Corp | Cyanopyrrolhaltige cyclische carbamat- und thiocarbamatbiaryle und verfahren zu deren herstellung |
| AU2005237520B2 (en) | 2004-04-27 | 2012-01-19 | Wyeth | Purification of progesterone receptor modulators |
| JP5288796B2 (ja) * | 2004-07-07 | 2013-09-11 | ワイス・エルエルシー | 周期的プロゲスチンレジメン及びキット |
| WO2006020712A1 (en) * | 2004-08-13 | 2006-02-23 | Wyeth | Tanaproget derivatives, metabolites, and uses thereof |
| PL1896034T3 (pl) * | 2005-04-28 | 2010-07-30 | Wyeth Llc | Mikronizowane kompozycje tanaprogetu i sposoby ich wytwarzania |
| SI1877059T1 (sl) | 2005-04-28 | 2010-07-30 | Wyeth Llc | Mikroniziran tanaproget in sestavki, ki ga vsebujejo |
| BRPI0610438A2 (pt) | 2005-04-28 | 2012-10-23 | Wyeth Corp | composição farmacêutica, cápsula, conjunto farmacêutico, e, processo para preparar uma composição |
| MX2007013469A (es) * | 2005-04-28 | 2008-01-22 | Wyeth Corp | Forma ii polimorfa de tanaproget. |
| CN101184738B (zh) * | 2005-04-28 | 2012-05-23 | 惠氏公司 | 纯化型的tanaproget |
| US20060280800A1 (en) * | 2005-06-09 | 2006-12-14 | Wyeth | Tanaproget compositions containing ethinyl estradiol |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0510235A1 (en) * | 1991-04-26 | 1992-10-28 | Dong-A Pharm. Co., Ltd. | Novel benzoxazine or benzothiazine derivatives and process for the preparation of the same |
| JPH0510235A (ja) * | 1991-07-05 | 1993-01-19 | Nippondenso Co Ltd | 内燃機関の点火時期制御装置 |
| AU1694295A (en) * | 1994-01-28 | 1995-08-15 | Merck & Co., Inc. | Benzoxazinones as inhibitors of hiv reverse transcriptase |
| NZ300739A (en) * | 1994-12-22 | 2000-05-26 | Ligand Pharm Inc | Steroid receptor modulator compounds |
| US5688808A (en) * | 1994-12-22 | 1997-11-18 | Ligand Pharmaceuticals Incorporated | Steroid receptor modulator compounds and methods |
| EP0929533B1 (en) * | 1996-10-02 | 2003-09-03 | Bristol-Myers Squibb Pharma Company | 4,4-disubstituted-1,4-dihydro-2h-3,1-benzoxazin-2-ones useful as hiv reverse transcriptase inhibitors and intermediates and processes for making the same |
| CN1131856C (zh) * | 1999-05-04 | 2003-12-24 | 美国家庭用品有限公司 | 作为黄体酮受体调节剂的环硫代氨基甲酸酯衍生物 |
| SI1877059T1 (sl) * | 2005-04-28 | 2010-07-30 | Wyeth Llc | Mikroniziran tanaproget in sestavki, ki ga vsebujejo |
| US20060280800A1 (en) * | 2005-06-09 | 2006-12-14 | Wyeth | Tanaproget compositions containing ethinyl estradiol |
-
2000
- 2000-05-01 CN CN008070997A patent/CN1131856C/zh not_active Expired - Fee Related
- 2000-05-01 EP EP00930266A patent/EP1175411B1/en not_active Expired - Lifetime
- 2000-05-01 DK DK00930266T patent/DK1175411T3/da active
- 2000-05-01 AT AT00930266T patent/ATE386729T1/de not_active IP Right Cessation
- 2000-05-01 BR BR0010214-8A patent/BR0010214A/pt active Search and Examination
- 2000-05-01 JP JP2000615600A patent/JP4958338B2/ja not_active Expired - Fee Related
- 2000-05-01 SG SG200400081A patent/SG120970A1/en unknown
- 2000-05-01 GE GEAP20006120A patent/GEP20043181B/en unknown
- 2000-05-01 SK SK1592-2001A patent/SK15922001A3/sk unknown
- 2000-05-01 IL IL14629800A patent/IL146298A0/xx unknown
- 2000-05-01 MX MXPA01011287A patent/MXPA01011287A/es active IP Right Grant
- 2000-05-01 KR KR1020017014085A patent/KR100732692B1/ko not_active Expired - Fee Related
- 2000-05-01 CA CA002371712A patent/CA2371712C/en not_active Expired - Fee Related
- 2000-05-01 DE DE60038108T patent/DE60038108T2/de not_active Expired - Lifetime
- 2000-05-01 AU AU48119/00A patent/AU766801B2/en not_active Ceased
- 2000-05-01 HU HU0203332A patent/HUP0203332A3/hu unknown
- 2000-05-01 NZ NZ515353A patent/NZ515353A/xx unknown
- 2000-05-01 EA EA200101181A patent/EA004511B1/ru not_active IP Right Cessation
- 2000-05-01 CZ CZ20013952A patent/CZ20013952A3/cs unknown
- 2000-05-01 PL PL00351083A patent/PL351083A1/xx not_active Application Discontinuation
- 2000-05-01 TR TR2001/03285T patent/TR200103285T2/xx unknown
- 2000-05-01 ES ES00930266T patent/ES2301482T3/es not_active Expired - Lifetime
-
2001
- 2001-11-02 NO NO20015381A patent/NO321370B1/no unknown
- 2001-11-02 BG BG106080A patent/BG65277B1/bg unknown
-
2011
- 2011-11-14 JP JP2011249051A patent/JP5523430B2/ja not_active Expired - Fee Related
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