GB967715A - Improvements in the preparation of the nicotinic ester of dihydrocodeine and acid addition salts thereof - Google Patents
Improvements in the preparation of the nicotinic ester of dihydrocodeine and acid addition salts thereofInfo
- Publication number
- GB967715A GB967715A GB4286960A GB4286960A GB967715A GB 967715 A GB967715 A GB 967715A GB 4286960 A GB4286960 A GB 4286960A GB 4286960 A GB4286960 A GB 4286960A GB 967715 A GB967715 A GB 967715A
- Authority
- GB
- United Kingdom
- Prior art keywords
- dihydrocodeine
- acid
- nicotinic
- addition salts
- acid addition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000002253 acid Substances 0.000 title abstract 4
- RBOXVHNMENFORY-DNJOTXNNSA-N dihydrocodeine Chemical compound C([C@H]1[C@H](N(CC[C@@]112)C)C3)C[C@H](O)[C@@H]1OC1=C2C3=CC=C1OC RBOXVHNMENFORY-DNJOTXNNSA-N 0.000 title abstract 3
- 229960000920 dihydrocodeine Drugs 0.000 title abstract 3
- XYYVYLMBEZUESM-UHFFFAOYSA-N dihydrocodeine Natural products C1C(N(CCC234)C)C2C=CC(=O)C3OC2=C4C1=CC=C2OC XYYVYLMBEZUESM-UHFFFAOYSA-N 0.000 title abstract 3
- 150000002148 esters Chemical class 0.000 title abstract 3
- 150000003839 salts Chemical class 0.000 title abstract 3
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 abstract 3
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 abstract 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract 2
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 abstract 2
- OFOBLEOULBTSOW-UHFFFAOYSA-N Propanedioic acid Natural products OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 abstract 1
- 230000000202 analgesic effect Effects 0.000 abstract 1
- 230000000954 anitussive effect Effects 0.000 abstract 1
- 229940124584 antitussives Drugs 0.000 abstract 1
- 239000002775 capsule Substances 0.000 abstract 1
- 239000007795 chemical reaction product Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- PCHPORCSPXIHLZ-UHFFFAOYSA-N diphenhydramine hydrochloride Chemical compound [Cl-].C=1C=CC=CC=1C(OCC[NH+](C)C)C1=CC=CC=C1 PCHPORCSPXIHLZ-UHFFFAOYSA-N 0.000 abstract 1
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 abstract 1
- 239000011976 maleic acid Substances 0.000 abstract 1
- VPODXHOUBDCEHN-UHFFFAOYSA-N pyridine-3-carbonyl pyridine-3-carboxylate Chemical compound C=1C=CN=CC=1C(=O)OC(=O)C1=CC=CN=C1 VPODXHOUBDCEHN-UHFFFAOYSA-N 0.000 abstract 1
- 229910000029 sodium carbonate Inorganic materials 0.000 abstract 1
- 239000006188 syrup Substances 0.000 abstract 1
- 235000020357 syrup Nutrition 0.000 abstract 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR812944 | 1959-12-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB967715A true GB967715A (en) | 1964-08-26 |
Family
ID=8722542
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB4286960A Expired GB967715A (en) | 1959-12-14 | 1960-12-13 | Improvements in the preparation of the nicotinic ester of dihydrocodeine and acid addition salts thereof |
Country Status (3)
| Country | Link |
|---|---|
| BE (2) | BE597869A (fr) |
| DE (1) | DE1175246B (fr) |
| GB (1) | GB967715A (fr) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4122181A (en) | 1975-12-19 | 1978-10-24 | Pierre Fabre S.A. | Analgesic (3-micotinamido-N(quinolyl) anthranilates and method of use |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1143667B (it) * | 1977-05-30 | 1986-10-22 | Scharber Per L Ind Farmaceutic | Derivato paraverolinico ad azione duratura e procedimento per ottenerlo |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AT202282B (de) * | 1956-05-04 | 1959-02-25 | Lannacher Heilmittel | Verfahren zur Herstellung des neuen Morphin-bis-nicotinsäureesters |
-
1960
- 1960-03-07 DE DEL41277A patent/DE1175246B/de active Pending
- 1960-12-07 BE BE597869A patent/BE597869A/fr unknown
- 1960-12-07 BE BE597868A patent/BE597868A/fr unknown
- 1960-12-13 GB GB4286960A patent/GB967715A/en not_active Expired
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4122181A (en) | 1975-12-19 | 1978-10-24 | Pierre Fabre S.A. | Analgesic (3-micotinamido-N(quinolyl) anthranilates and method of use |
Also Published As
| Publication number | Publication date |
|---|---|
| BE597869A (fr) | 1961-03-31 |
| DE1175246B (de) | 1964-08-06 |
| BE597868A (fr) | 1961-03-31 |
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