GB947944A - New amine and process for preparing same - Google Patents

New amine and process for preparing same

Info

Publication number
GB947944A
GB947944A GB4367162A GB4367162A GB947944A GB 947944 A GB947944 A GB 947944A GB 4367162 A GB4367162 A GB 4367162A GB 4367162 A GB4367162 A GB 4367162A GB 947944 A GB947944 A GB 947944A
Authority
GB
United Kingdom
Prior art keywords
acid
ethano
anthracene
dihydro
free base
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB4367162A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BASF Schweiz AG
Original Assignee
Ciba AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CH1335960A external-priority patent/CH395972A/en
Application filed by Ciba AG filed Critical Ciba AG
Priority claimed from CH1343463A external-priority patent/CH433333A/en
Publication of GB947944A publication Critical patent/GB947944A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C47/00—Compounds having —CHO groups
    • C07C47/38—Unsaturated compounds having —CHO groups bound to carbon atoms of rings other than six—membered aromatic rings
    • C07C47/44—Unsaturated compounds having —CHO groups bound to carbon atoms of rings other than six—membered aromatic rings polycyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms

Abstract

The invention comprises 9-diethylaminomethyl -9, 10-dihydro -9, 10-ethano-(1, 2)-anthracene and its acid addition salts, and their preparation by reducing 9, 10-dihydro-9, 10-ethano-(1, 2)-anthracene -9-carboxylic acid diethylamide with lithium aluminium hydride followed by conversion of any resulting free base into an acid addition salt or of acid addition salt into free base, as required. 9, 10-Dihydro -9, 10-ethano-(1, 2)-anthracene-9-carboxylic acid diethylamide is made by treating the free acid with thionyl chloride and reacting the resulting acid chloride with diethylamine. Pharmaceutical preparations for use as tranquilizers comprise the above compounds of the invention, i.e. the free base or the salts with organic or inorganic acids, including therapeutically useful substances such as salicylic, aminosalicylic or ascorbic acid, tryptophan, lysine or arginine, in admixture or conjunction with a solid or liquid carrier suitable for enteral (e.g. oral) or parenteral administration. The preparations may take the form of tablets, dragees, capsules, suspensions or emulsions and may contain preserving, stabilizing, wetting or emulsifying agents, salts for regulating osmotic pressure or buffers.
GB4367162A 1960-11-29 1961-11-29 New amine and process for preparing same Expired GB947944A (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
CH1335960A CH395972A (en) 1960-11-29 1960-11-29 Process for the preparation of new 9-aminoalkyl-9,10-dihydro-9,10-ethano- (1,2) -anthracenes
CH1171061 1961-10-10
CH1343463A CH433333A (en) 1961-10-10 1963-11-01 Process for the preparation of a new amine
CH1663764A CH451923A (en) 1961-10-10 1964-12-23 Process for the preparation of a new amine
CH1617765 1965-11-24

Publications (1)

Publication Number Publication Date
GB947944A true GB947944A (en) 1964-01-29

Family

ID=27509426

Family Applications (4)

Application Number Title Priority Date Filing Date
GB962163A Expired GB947945A (en) 1960-11-29 1961-11-29 New dihydro-ethano-anthracenes
GB4276361A Expired GB947943A (en) 1960-11-29 1961-11-29 Aminoalkyl-dihydroethanoanthracenes
GB962263A Expired GB947946A (en) 1960-11-29 1961-11-29 New dihydro-ethano-anthracenes
GB4367162A Expired GB947944A (en) 1960-11-29 1961-11-29 New amine and process for preparing same

Family Applications Before (3)

Application Number Title Priority Date Filing Date
GB962163A Expired GB947945A (en) 1960-11-29 1961-11-29 New dihydro-ethano-anthracenes
GB4276361A Expired GB947943A (en) 1960-11-29 1961-11-29 Aminoalkyl-dihydroethanoanthracenes
GB962263A Expired GB947946A (en) 1960-11-29 1961-11-29 New dihydro-ethano-anthracenes

Country Status (2)

Country Link
GB (4) GB947945A (en)
SE (3) SE354274B (en)

Also Published As

Publication number Publication date
GB947945A (en) 1964-01-29
SE345442B (en) 1972-05-29
GB947946A (en) 1964-01-29
SE354274B (en) 1973-03-05
SE354273B (en) 1973-03-05
GB947943A (en) 1964-01-29

Similar Documents

Publication Publication Date Title
GB909279A (en) Pharmaceutical preparations containing d-glucofuranosides
GB970886A (en) New pyridines and process for the manufacture thereof
GB824908A (en) Improvements in or relating to triazine derivatives
GB947944A (en) New amine and process for preparing same
GB972672A (en) Pharmaceutical preparations containing compounds of the androstane series
GB1343917A (en) Benzenesulphonyl semicarbazides and a process for their preparation
GB914008A (en) New ª--piperidinopropane derivatives, their preparation and anti-tussive compositinscontaining them
CH610876A5 (en) Process for the preparation of 4-chlorophenoxyisobutyrylsalicylic acid
GB903162A (en) Kanamycin 3-phenyl salicylate and therapeutic compositions containing it
GB955989A (en) 2-[1:1-diphenyl-propyl-(3)-amino]-3-phenyl-propanegluconate and process of preparing it
GB1215152A (en) Biguanide derivatives and pharmaceutical preparations containing them
GB984362A (en) New isoquinoline derivatives and method of preparing the same
GB914455A (en) Novel sulphonamides and a process for the manufacture thereof
JPS5283429A (en) Preparation of aromatic unsaturated carboxylic acid amide derivatives
GB1009426A (en) Improvements in or relating to a basic ester of a di-alkoxy benzoic acid and acid addition salts
GB964561A (en) New sulphonamides and process for preparing them
GB908634A (en) Pharmaceutical compositions containing pararosaniline or derivatives thereof
GB735082A (en) Improvements in or relating to oxytetracycline compositions
GB884120A (en) A new tetrahydro-dioxopyridazine and process for its manufacture
JPS51123834A (en) A medicine against the headache
GB992956A (en) Pharmaceutical preparations containing pyrrolidone carboxylic acid and salts and esters thereof
GB929797A (en) Sulphonamides
GB933605A (en) Pharmaceutical preparations containing cyclopropane carboxylic acid and the salts thereof
GB1047911A (en) Glutamine salts
GB704038A (en) Improvements in or relating to medicines containing antibiotics