GB947945A - New dihydro-ethano-anthracenes - Google Patents

New dihydro-ethano-anthracenes

Info

Publication number
GB947945A
GB947945A GB962163A GB962163A GB947945A GB 947945 A GB947945 A GB 947945A GB 962163 A GB962163 A GB 962163A GB 962163 A GB962163 A GB 962163A GB 947945 A GB947945 A GB 947945A
Authority
GB
United Kingdom
Prior art keywords
ethano
piperazino
dihydro
carboxylic acid
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB962163A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BASF Schweiz AG
Original Assignee
Ciba AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CH1335960A external-priority patent/CH395972A/en
Application filed by Ciba AG filed Critical Ciba AG
Priority claimed from CH1343463A external-priority patent/CH433333A/en
Publication of GB947945A publication Critical patent/GB947945A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C47/00—Compounds having —CHO groups
    • C07C47/38—Unsaturated compounds having —CHO groups bound to carbon atoms of rings other than six—membered aromatic rings
    • C07C47/44—Unsaturated compounds having —CHO groups bound to carbon atoms of rings other than six—membered aromatic rings polycyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

The invention comprises 9, 10-dihydro -9, 10-ethano-1, 2-anthracenes having a nucleus of the formula: <FORM:0947945/C2/1> which are substituted in the 9-position by an amide group A.CO.(CH2)nwherein A is an amino group and n is an integer from 1 to 4, and may be further substituted in the 1- to 8-positions by C1-4 alkyl, alkoxy or halogen substituents. Suitably A is a mono- or di-alkylamino, alkenylamino, cycloalkylamino, aralkylamino or arylamino group or as pyrrolidino, piperidino, morpholino, piperazino, N-methyl-piperazino, N-ethyl-piperazino or N-b -hydroxyethyl-piperazino group. The compounds are prepared by treating the appropriate carboxylic acid chloride (obtainable by the action of thionyl chloride on the free acid) with ammonia or an amine AH. b -[9, 10-Dihydro-9, 10-ethano-(1, 2)-9-anthryl]-propionic acid and 1, 5-dichloro-9, 10-dihydro -9, 10-ethano-(1, 2)-anthracene 9-carboxylic acid are made by addition of ethylene to the appropriate anthracene-carboxylic acid. Specification 947,944 also is referred to.
GB962163A 1960-11-29 1961-11-29 New dihydro-ethano-anthracenes Expired GB947945A (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
CH1335960A CH395972A (en) 1960-11-29 1960-11-29 Process for the preparation of new 9-aminoalkyl-9,10-dihydro-9,10-ethano- (1,2) -anthracenes
CH1171061 1961-10-10
CH1343463A CH433333A (en) 1961-10-10 1963-11-01 Process for the preparation of a new amine
CH1663764A CH451923A (en) 1961-10-10 1964-12-23 Process for the preparation of a new amine
CH1617765 1965-11-24

Publications (1)

Publication Number Publication Date
GB947945A true GB947945A (en) 1964-01-29

Family

ID=27509426

Family Applications (4)

Application Number Title Priority Date Filing Date
GB4367162A Expired GB947944A (en) 1960-11-29 1961-11-29 New amine and process for preparing same
GB962263A Expired GB947946A (en) 1960-11-29 1961-11-29 New dihydro-ethano-anthracenes
GB4276361A Expired GB947943A (en) 1960-11-29 1961-11-29 Aminoalkyl-dihydroethanoanthracenes
GB962163A Expired GB947945A (en) 1960-11-29 1961-11-29 New dihydro-ethano-anthracenes

Family Applications Before (3)

Application Number Title Priority Date Filing Date
GB4367162A Expired GB947944A (en) 1960-11-29 1961-11-29 New amine and process for preparing same
GB962263A Expired GB947946A (en) 1960-11-29 1961-11-29 New dihydro-ethano-anthracenes
GB4276361A Expired GB947943A (en) 1960-11-29 1961-11-29 Aminoalkyl-dihydroethanoanthracenes

Country Status (2)

Country Link
GB (4) GB947944A (en)
SE (3) SE354273B (en)

Also Published As

Publication number Publication date
SE354273B (en) 1973-03-05
GB947944A (en) 1964-01-29
SE354274B (en) 1973-03-05
GB947943A (en) 1964-01-29
GB947946A (en) 1964-01-29
SE345442B (en) 1972-05-29

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