GB914008A - New ª--piperidinopropane derivatives, their preparation and anti-tussive compositinscontaining them - Google Patents

New ª--piperidinopropane derivatives, their preparation and anti-tussive compositinscontaining them

Info

Publication number
GB914008A
GB914008A GB1552861A GB1552861A GB914008A GB 914008 A GB914008 A GB 914008A GB 1552861 A GB1552861 A GB 1552861A GB 1552861 A GB1552861 A GB 1552861A GB 914008 A GB914008 A GB 914008A
Authority
GB
United Kingdom
Prior art keywords
benzylphenoxy
piperidinopropane
tussive
preparation
compositinscontaining
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB1552861A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia AS
Original Assignee
Pharmacia AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia AS filed Critical Pharmacia AS
Publication of GB914008A publication Critical patent/GB914008A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

The invention comprises a - (o - benzylphenoxy) - b - N-piperidinopropane and its pharmaceutically acceptable salts, together with anti - tussive compositions containing them and a process for the preparation of the compound and its salts by reacting a -(o-benzylphenoxy)-b -chloropropane with piperidine and isolating the a -(o-benzylphenoxy)-b -N-piperidinopropane either as the free base, or as a salt by reaction with a pharmaceutically acceptable acid. Specified acids include 2,6-ditertiary butyl naphthalene-1,7-disulphonic and 4,4-methylenebis-(3-hydroxy-2-naphthoic) acids. The anti-tussive compositions may be in the form of tablets, capsules, or suspensions and incorporate standard carriers and adjuvants for oral administration. Examples of a tablet and a liquid cough mixture are given. a -(o-benzylphenoxy)-b -chloropropane is prepared by treatment of a -(o-benzylphenoxy)-b -hydroxypropane with thionyl chloride. U.S.A. Specification 2,703,324 is referred to.
GB1552861A 1960-04-28 1961-04-28 New ª--piperidinopropane derivatives, their preparation and anti-tussive compositinscontaining them Expired GB914008A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DK165360A DK96113C (en) 1960-04-28 1960-04-28 Process for the preparation of o-benzylphenoxy-β-1-piperidinopropane or acid addition salts thereof.

Publications (1)

Publication Number Publication Date
GB914008A true GB914008A (en) 1962-12-28

Family

ID=8106917

Family Applications (1)

Application Number Title Priority Date Filing Date
GB1552861A Expired GB914008A (en) 1960-04-28 1961-04-28 New ª--piperidinopropane derivatives, their preparation and anti-tussive compositinscontaining them

Country Status (5)

Country Link
BE (1) BE602929A (en)
DK (1) DK96113C (en)
FI (1) FI42213B (en)
GB (1) GB914008A (en)
SE (2) SE304514B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105287554A (en) * 2014-12-10 2016-02-03 沈阳药科大学 Compound anti-cold medicine combination and application thereof

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105287554A (en) * 2014-12-10 2016-02-03 沈阳药科大学 Compound anti-cold medicine combination and application thereof
CN105287554B (en) * 2014-12-10 2018-10-30 沈阳药科大学 Compounded anti-cold drug composition and application thereof

Also Published As

Publication number Publication date
SE304514B (en) 1968-09-30
BE602929A (en) 1961-11-24
DK96113C (en) 1963-06-04
SE336790B (en) 1971-07-19
FI42213B (en) 1970-03-02

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