GB9309621D0 - Amide derivatives and their therapeutic use - Google Patents

Amide derivatives and their therapeutic use

Info

Publication number
GB9309621D0
GB9309621D0 GB939309621A GB9309621A GB9309621D0 GB 9309621 D0 GB9309621 D0 GB 9309621D0 GB 939309621 A GB939309621 A GB 939309621A GB 9309621 A GB9309621 A GB 9309621A GB 9309621 D0 GB9309621 D0 GB 9309621D0
Authority
GB
United Kingdom
Prior art keywords
therapeutic use
amide derivatives
solvates
chem
medicine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
GB939309621A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wellcome Foundation Ltd
Original Assignee
Wellcome Foundation Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wellcome Foundation Ltd filed Critical Wellcome Foundation Ltd
Priority to GB939309621A priority Critical patent/GB9309621D0/en
Publication of GB9309621D0 publication Critical patent/GB9309621D0/en
Priority to CN94192558A priority patent/CN1041720C/zh
Priority to DE69426327T priority patent/DE69426327T2/de
Priority to ES94914500T priority patent/ES2153420T3/es
Priority to JP52514194A priority patent/JP3241734B2/ja
Priority to HK98103107.7A priority patent/HK1003934B/en
Priority to DE69431316T priority patent/DE69431316T2/de
Priority to DK94914500T priority patent/DK0699180T3/da
Priority to EP99204317A priority patent/EP0987248B1/en
Priority to PCT/GB1994/001002 priority patent/WO1994026692A1/en
Priority to CA002162708A priority patent/CA2162708C/en
Priority to PCT/GB1994/001003 priority patent/WO1994026693A1/en
Priority to ES99204317T priority patent/ES2182454T3/es
Priority to AU66848/94A priority patent/AU6684894A/en
Priority to HU9501882A priority patent/HUT72419A/hu
Priority to US08/549,686 priority patent/US5872118A/en
Priority to PT94914500T priority patent/PT699180E/pt
Priority to EP94914500A priority patent/EP0699180B1/en
Priority to AT99204317T priority patent/ATE223373T1/de
Priority to AT94914500T priority patent/ATE197704T1/de
Priority to AU66849/94A priority patent/AU684778C/en
Priority to NZ265677A priority patent/NZ265677A/en
Priority to IL10961094A priority patent/IL109610A0/xx
Priority to CA002355987A priority patent/CA2355987C/en
Priority to RU95122284A priority patent/RU2143422C1/ru
Priority to FI955430A priority patent/FI955430L/fi
Priority to KR1019950705013A priority patent/KR100417670B1/ko
Priority to ZA943269A priority patent/ZA943269B/xx
Priority to TW083104243A priority patent/TW275615B/zh
Priority to NO19954519A priority patent/NO310409B1/no
Priority to JP19062998A priority patent/JP3302928B2/ja
Priority to GR20000402870T priority patent/GR3035180T3/el
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/02—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • C07C233/11—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to carbon atoms of an unsaturated carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C07C233/17—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
    • C07C233/22—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to an acyclic carbon atom of a carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/32—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C07C235/34—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/32—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C07C235/36—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/70—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/72—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atoms of the carboxamide groups bound to acyclic carbon atoms
    • C07C235/76—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton
    • C07C235/78—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton the carbon skeleton containing rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/49—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C255/57—Carboxylic acid nitriles having cyano groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing cyano groups and carboxyl groups, other than cyano groups, bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
    • C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
    • C07C259/06—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D215/14—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/04—Systems containing only non-condensed rings with a four-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Anesthesiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyrane Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
GB939309621A 1993-05-11 1993-05-11 Amide derivatives and their therapeutic use Pending GB9309621D0 (en)

Priority Applications (32)

Application Number Priority Date Filing Date Title
GB939309621A GB9309621D0 (en) 1993-05-11 1993-05-11 Amide derivatives and their therapeutic use
KR1019950705013A KR100417670B1 (ko) 1993-05-11 1994-05-10 비시클릭아미드유도체및근이완제로서의이의용도
HU9501882A HUT72419A (en) 1993-05-11 1994-05-10 Bicyclic amide derivatives pharmaceutical compns. contg. them and process for preparing the said compds.
US08/549,686 US5872118A (en) 1993-05-11 1994-05-10 Bicyclic amide derivatives and their use as muscle relaxants
ES94914500T ES2153420T3 (es) 1993-05-11 1994-05-10 Derivados de amida biciclica y uso como relajantes musculares de los mismos.
JP52514194A JP3241734B2 (ja) 1993-05-11 1994-05-10 二環式アミド誘導体及びこれらの筋弛緩剤としての使用
HK98103107.7A HK1003934B (en) 1993-05-11 1994-05-10 Bicyclic amide derivatives and their use as muscle relaxants
DE69431316T DE69431316T2 (de) 1993-05-11 1994-05-10 Amidderivate und ihre therapeutische Verwendung
DK94914500T DK0699180T3 (da) 1993-05-11 1994-05-10 Bicykliske amidderivater og anvendelse af disse som muskelafspændende midler
EP99204317A EP0987248B1 (en) 1993-05-11 1994-05-10 Amide derivatives and their therapeutic use
EP94914500A EP0699180B1 (en) 1993-05-11 1994-05-10 Bicyclic amide derivatives and their use as muscle relaxants
CA002162708A CA2162708C (en) 1993-05-11 1994-05-10 Bicyclic amide derivatives and their use as muscle relaxants
PCT/GB1994/001003 WO1994026693A1 (en) 1993-05-11 1994-05-10 Bicyclic amide derivatives and their use as muscle relaxants
ES99204317T ES2182454T3 (es) 1993-05-11 1994-05-10 Derivados de amida y su uso terapeutico.
AU66848/94A AU6684894A (en) 1993-05-11 1994-05-10 Bicyclic amide derivatives and their use as muscle relaxants
CN94192558A CN1041720C (zh) 1993-05-11 1994-05-10 双环酰胺类衍生物、其制法、药物组合物和制药应用
PT94914500T PT699180E (pt) 1993-05-11 1994-05-10 Derivados amida biciclicos e sua utilizacao como relaxantes musculares
AT99204317T ATE223373T1 (de) 1993-05-11 1994-05-10 Amidderivate und ihre therapeutische verwendung
PCT/GB1994/001002 WO1994026692A1 (en) 1993-05-11 1994-05-10 Bicyclic amide derivatives and their use as muscle relaxants
DE69426327T DE69426327T2 (de) 1993-05-11 1994-05-10 Bicyclische amid-derivate und ihre verwendung als muskel entspannende verbindungen
AT94914500T ATE197704T1 (de) 1993-05-11 1994-05-10 Bicyclische amid-derivate und ihre verwendung als muskel entspannende verbindungen
AU66849/94A AU684778C (en) 1993-05-11 1994-05-10 Bicyclic amide derivatives and their use as muscle relaxants
NZ265677A NZ265677A (en) 1993-05-11 1994-05-10 Indanylidene-, naphthylidene- and chromanylidene- acetamide derivatives; pharmaceutical compositions
IL10961094A IL109610A0 (en) 1993-05-11 1994-05-10 Amide derivatives, their preparation and pharmaceutical compositions containing them
CA002355987A CA2355987C (en) 1993-05-11 1994-05-10 Bicyclic amide derivatives and their use as muscle relaxants
RU95122284A RU2143422C1 (ru) 1993-05-11 1994-05-10 Производные бициклических амидов, фармацевтическая композиция и способ лечения патологических и воспалительных состояний
FI955430A FI955430L (fi) 1993-05-11 1994-05-10 Bisyklisiä amidijohdannaisia ja niiden käyttö lihasten jännitystä laukaisevina aineena
TW083104243A TW275615B (enExample) 1993-05-11 1994-05-11
ZA943269A ZA943269B (en) 1993-05-11 1994-05-11 Amide derivatives and their therapeutic use
NO19954519A NO310409B1 (no) 1993-05-11 1995-11-09 Bisykliske amidderivater, fremstilling og anvendelse derav
JP19062998A JP3302928B2 (ja) 1993-05-11 1998-07-06 二環式アミド誘導体及びこれらの筋弛緩剤としての使用
GR20000402870T GR3035180T3 (en) 1993-05-11 2000-12-29 Bicyclic amide derivatives and their use as muscle relaxants

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB939309621A GB9309621D0 (en) 1993-05-11 1993-05-11 Amide derivatives and their therapeutic use

Publications (1)

Publication Number Publication Date
GB9309621D0 true GB9309621D0 (en) 1993-06-23

Family

ID=10735231

Family Applications (1)

Application Number Title Priority Date Filing Date
GB939309621A Pending GB9309621D0 (en) 1993-05-11 1993-05-11 Amide derivatives and their therapeutic use

Country Status (23)

Country Link
US (1) US5872118A (enExample)
EP (2) EP0987248B1 (enExample)
JP (2) JP3241734B2 (enExample)
KR (1) KR100417670B1 (enExample)
CN (1) CN1041720C (enExample)
AT (2) ATE197704T1 (enExample)
AU (1) AU6684894A (enExample)
CA (2) CA2162708C (enExample)
DE (2) DE69426327T2 (enExample)
DK (1) DK0699180T3 (enExample)
ES (2) ES2153420T3 (enExample)
FI (1) FI955430L (enExample)
GB (1) GB9309621D0 (enExample)
GR (1) GR3035180T3 (enExample)
HU (1) HUT72419A (enExample)
IL (1) IL109610A0 (enExample)
NO (1) NO310409B1 (enExample)
NZ (1) NZ265677A (enExample)
PT (1) PT699180E (enExample)
RU (1) RU2143422C1 (enExample)
TW (1) TW275615B (enExample)
WO (2) WO1994026693A1 (enExample)
ZA (1) ZA943269B (enExample)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY113062A (en) * 1994-05-10 2001-11-30 The Wellcome Foundation Ltd Amide derivatives and their therapeutic use
US5719186A (en) * 1994-05-10 1998-02-17 Glaxo Wellcome Inc. Amide derivatives and their therapeutic use
US5661186A (en) * 1995-02-24 1997-08-26 Bristol-Myers Squibb Co. Tetralinyl-and indanyl-ethylamides
US6124284A (en) * 1998-07-16 2000-09-26 Glaxo Wellcome Inc. Bicyclic amide derivatives and their use as muscle relaxants
GB9907234D0 (en) * 1999-03-29 1999-05-26 Isis Innovation Drug assay
GB9926630D0 (en) * 1999-11-10 2000-01-12 Glaxo Group Ltd Pharmacologically active compounds
GB0013487D0 (en) * 2000-06-02 2000-07-26 Astrazeneca Ab Novel process
JP2004532188A (ja) * 2001-02-06 2004-10-21 グラクソ　グループ　リミテッド 増強したカリウムチャネル活性に応答する疾患の治療のための二環式エステルまたはアミドの使用
US6956129B2 (en) * 2001-02-16 2005-10-18 Bayer Aktiengesellschaft Polyhalogen-substituted cinnamic acids and cinnamic acid derivatives and a process for the preparation of polyhalogen-substituted cinnamic acids and cinnamic acid derivatives
DE10145780B4 (de) 2001-09-17 2012-10-04 Merck Patent Gmbh Fluorierte Cyclopenta[a]naphthaline und ihre Verwendung in Flüssigkristallmischungen und Displays
DE10145779B4 (de) 2001-09-17 2012-11-15 Merck Patent Gmbh Fluorierte Cyclopenta[b]naphthaline und ihre Verwendung in Flüssigkristallmischungen
JP4754566B2 (ja) 2005-07-22 2011-08-24 持田製薬株式会社 新規なヘテロシクリデンアセトアミド誘導体
PE20081692A1 (es) 2007-01-24 2008-12-18 Mochida Pharm Co Ltd Nuevo derivado de heterocicliden acetamida
CN102258508A (zh) * 2011-04-14 2011-11-30 威海迪素制药有限公司 芳基丙烯酸衍生物抗癫痫的用途
CN106631989B (zh) * 2016-11-26 2019-07-16 威海迪素制药有限公司 一种盐酸多奈哌齐有关物质e的制备方法
US12534623B2 (en) 2018-03-02 2026-01-27 Johnson & Johnson Vision Care, Inc. Contact lens with improved tear film optical quality
US11993037B1 (en) 2018-03-02 2024-05-28 Johnson & Johnson Vision Care, Inc. Contact lens displaying improved vision attributes
US12595370B2 (en) 2018-03-02 2026-04-07 Johnson & Johnson Vision Care, Inc. Polymerizable absorbers of UV and high energy visible light
US10935695B2 (en) 2018-03-02 2021-03-02 Johnson & Johnson Vision Care, Inc. Polymerizable absorbers of UV and high energy visible light
US12486348B2 (en) 2019-08-30 2025-12-02 Johnson & Johnson Vision Care, Inc. Contact lens displaying improved vision attributes
US12486403B2 (en) 2018-03-02 2025-12-02 Johnson & Johnson Vision Care, Inc. Polymerizable absorbers of UV and high energy visible light
US12595371B2 (en) 2018-03-02 2026-04-07 Johnson & Johnson Vision Care, Inc. Contact lens with improved vision break-up time
US11543683B2 (en) 2019-08-30 2023-01-03 Johnson & Johnson Vision Care, Inc. Multifocal contact lens displaying improved vision attributes
US12509428B2 (en) 2019-06-28 2025-12-30 Johnson & Johnson Vision Care, Inc. Polymerizable fused tricyclic compounds as absorbers of UV and visible light
US11958824B2 (en) 2019-06-28 2024-04-16 Johnson & Johnson Vision Care, Inc. Photostable mimics of macular pigment
US12674032B2 (en) 2019-06-28 2026-07-07 Johnson & Johnson Vision Care, Inc. Polymerizable fused tricyclic compounds as absorbers of UV and visible light

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE371190B (enExample) * 1972-03-24 1974-11-11 Kabi Ab
DE1241438B (de) * 1963-05-02 1967-06-01 Emil Frese Dipl Chem Verfahren zur Herstellung von beta, beta-disubstituierten Acrylsaeureestern und den entsprechenden Acrylsaeuren
NL7200059A (enExample) * 1971-01-21 1972-07-25
DE3300004A1 (de) * 1983-01-03 1984-07-12 Bayer Ag, 5090 Leverkusen Substituierte 4-aminomethylenchromane bzw. -chromene, verfahren zu ihrer herstellung sowie ihre verwendung in arzneimitteln
DE3669317D1 (de) * 1985-09-11 1990-04-12 Beecham Group Plc Chromanderivate und aehnliche verbindungen mit blutdrucksenkender wirkung.
GB8610911D0 (en) * 1986-05-03 1986-06-11 Beecham Group Plc Active compounds
JP2727183B2 (ja) * 1987-03-04 1998-03-11 富士重工業 株式会社 自動変速機の変速制御装置
US5075337A (en) * 1989-07-26 1991-12-24 G. D. Searle & Co. Alpha-deuterated 2-alkylaminoacetamide derivatives having reduced toxicity for treatment of CNS disorders

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JPH08509973A (ja) 1996-10-22
DE69431316D1 (de) 2002-10-10
WO1994026692A1 (en) 1994-11-24
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HK1003934A1 (en) 1998-11-13
ATE197704T1 (de) 2000-12-15
DE69426327D1 (de) 2000-12-28
HUT72419A (en) 1996-04-29
ZA943269B (en) 1995-11-13
IL109610A0 (en) 1994-08-26
KR100417670B1 (ko) 2004-09-10
NZ265677A (en) 1997-06-24
ES2182454T3 (es) 2003-03-01
GR3035180T3 (en) 2001-04-30
FI955430A7 (fi) 1995-12-13
CA2355987C (en) 2004-02-03
AU6684894A (en) 1994-12-12
CN1125938A (zh) 1996-07-03
EP0987248B1 (en) 2002-09-04
DE69431316T2 (de) 2003-05-22
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AU684778B2 (en) 1998-01-08
NO954519D0 (no) 1995-11-09
RU2143422C1 (ru) 1999-12-27
EP0987248A1 (en) 2000-03-22
FI955430L (fi) 1995-12-13
CN1041720C (zh) 1999-01-20
JP3241734B2 (ja) 2001-12-25
FI955430A0 (fi) 1995-11-10
DE69426327T2 (de) 2001-04-12
NO954519L (no) 1995-12-19
ES2153420T3 (es) 2001-03-01
EP0699180A1 (en) 1996-03-06
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CA2162708C (en) 2003-03-18
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US5872118A (en) 1999-02-16
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JP3302928B2 (ja) 2002-07-15
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HU9501882D0 (en) 1995-08-28

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