GB913866A - Improvements in or relating to amino-norcamphane compounds - Google Patents
Improvements in or relating to amino-norcamphane compoundsInfo
- Publication number
- GB913866A GB913866A GB2631360A GB2631360A GB913866A GB 913866 A GB913866 A GB 913866A GB 2631360 A GB2631360 A GB 2631360A GB 2631360 A GB2631360 A GB 2631360A GB 913866 A GB913866 A GB 913866A
- Authority
- GB
- United Kingdom
- Prior art keywords
- radicals
- alkyl
- hydrogen
- compounds
- general formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- VUFQYRAKSQTZEB-UHFFFAOYSA-N bicyclo[2.2.1]heptan-4-amine Chemical class C1CC2CCC1(N)C2 VUFQYRAKSQTZEB-UHFFFAOYSA-N 0.000 title 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- 239000001257 hydrogen Substances 0.000 abstract 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 4
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 239000002253 acid Substances 0.000 abstract 2
- 238000006243 chemical reaction Methods 0.000 abstract 2
- BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 abstract 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
- 239000007868 Raney catalyst Substances 0.000 abstract 1
- NPXOKRUENSOPAO-UHFFFAOYSA-N Raney nickel Chemical compound [Al].[Ni] NPXOKRUENSOPAO-UHFFFAOYSA-N 0.000 abstract 1
- 229910000564 Raney nickel Inorganic materials 0.000 abstract 1
- 230000002152 alkylating effect Effects 0.000 abstract 1
- 230000029936 alkylation Effects 0.000 abstract 1
- 238000005804 alkylation reaction Methods 0.000 abstract 1
- 230000003555 analeptic effect Effects 0.000 abstract 1
- -1 aralkyl halides Chemical class 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 238000009833 condensation Methods 0.000 abstract 1
- 230000005494 condensation Effects 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 235000019253 formic acid Nutrition 0.000 abstract 1
- 125000002485 formyl group Chemical class [H]C(*)=O 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 150000003141 primary amines Chemical class 0.000 abstract 1
- 150000003856 quaternary ammonium compounds Chemical class 0.000 abstract 1
- 125000001453 quaternary ammonium group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/02—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
- C07D295/027—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring
- C07D295/033—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring with the ring nitrogen atoms directly attached to carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/38—Radicals substituted by singly-bound nitrogen atoms having only hydrogen or hydrocarbon radicals attached to the substituent nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/02—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DEM42332A DE1110159B (de) | 1959-08-01 | 1959-08-01 | Verfahren zur Herstellung analeptisch wirksamer N-substituierter Aminonorcamphanderivate bzw. von deren Saeureadditionssalzen und quaternaeren Ammoniumverbindungen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB913866A true GB913866A (en) | 1962-12-28 |
Family
ID=7304304
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB2631360A Expired GB913866A (en) | 1959-08-01 | 1960-07-28 | Improvements in or relating to amino-norcamphane compounds |
Country Status (6)
| Country | Link |
|---|---|
| BE (1) | BE593463A (enrdf_load_stackoverflow) |
| CH (1) | CH385196A (enrdf_load_stackoverflow) |
| DE (1) | DE1110159B (enrdf_load_stackoverflow) |
| FR (1) | FR978M (enrdf_load_stackoverflow) |
| GB (1) | GB913866A (enrdf_load_stackoverflow) |
| SE (1) | SE302957B (enrdf_load_stackoverflow) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10662146B2 (en) | 2015-09-15 | 2020-05-26 | Praxis Bioresearch, LLC | Prodrugs of fencamfamine |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1201338B (de) | 1959-08-01 | 1965-09-23 | Merck Ag E | Verfahren zur Herstellung analeptisch wirksamer N-substituierter Aminobicyclo-heptanderivate bzw. von deren Saeureadditions-salzen und quaternaeren Ammonium-verbindungen |
| DE1219478B (de) | 1960-12-23 | 1966-06-23 | Merck Ag E | Verfahren zur Herstellung analeptisch wirksamer N-substituierter Aminonorcamphanderivate bzw. von deren Saeureadditionssalzen und quartaeren Ammoniumverbindungen |
| DE1298527B (de) * | 1962-06-09 | 1969-07-03 | Knoll Ag | Verfahren zur Herstellung bicyclisch substituierter Aminoalkane |
| DE1284421B (de) * | 1962-06-09 | 1968-12-05 | Knoll Ag | Bicyclisch substituierte Aminoalkane und Verfahren zu ihrer Herstellung |
| US3308160A (en) * | 1963-06-26 | 1967-03-07 | Du Pont | 4-phenylbicyclo[2.2.2]octane-1-amines and salts thereof |
| US3341402A (en) * | 1965-01-15 | 1967-09-12 | Smith Kline French Lab | Anti-viral composition and method |
| US3362878A (en) * | 1966-08-01 | 1968-01-09 | Du Pont | Pharmaceutical compositions and methods utilizing substituted bicyclo[2.2.2]-octanes |
| US3651142A (en) * | 1969-02-06 | 1972-03-21 | Colgate Palmolive Co | 3-amino-2-(3 4-dihalophenyl) bicyclo(2.2.2)octan-2-ol |
| DE19835766C2 (de) * | 1998-08-07 | 2003-07-03 | Bosch Gmbh Robert | Anordnung zum Beschalten eines elektrochemischen Sensors |
| RU2307826C1 (ru) * | 2006-05-30 | 2007-10-10 | Государственное образовательное учреждение высшего профессионального образования Волгоградский государственный технический университет (ВолгГТУ) | Способ получения n-(3-фенил-2-норкамфанил)-n-этиламина гидрохлорида |
| WO2022140677A1 (en) | 2020-12-23 | 2022-06-30 | The Broad Institute, Inc. | Compositions and methods related to di-substituted bicyclo[2.2.1] heptanamine-containing compounds |
-
1959
- 1959-08-01 DE DEM42332A patent/DE1110159B/de active Pending
-
1960
- 1960-07-08 CH CH779260A patent/CH385196A/de unknown
- 1960-07-27 BE BE593463A patent/BE593463A/fr unknown
- 1960-07-28 GB GB2631360A patent/GB913866A/en not_active Expired
- 1960-08-01 SE SE743760A patent/SE302957B/xx unknown
- 1960-10-24 FR FR834659A patent/FR978M/fr not_active Expired
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10662146B2 (en) | 2015-09-15 | 2020-05-26 | Praxis Bioresearch, LLC | Prodrugs of fencamfamine |
| US20200399203A1 (en) | 2015-09-15 | 2020-12-24 | Praxis Bioresearch, LLC | Prodrugs of fencamfamine |
| US11919836B2 (en) | 2015-09-15 | 2024-03-05 | Praxis Bioresearch, LLC | Prodrugs of fencamfamine |
Also Published As
| Publication number | Publication date |
|---|---|
| DE1110159B (de) | 1961-07-06 |
| FR978M (enrdf_load_stackoverflow) | 1961-12-04 |
| BE593463A (fr) | 1961-01-27 |
| SE302957B (enrdf_load_stackoverflow) | 1968-08-12 |
| CH385196A (de) | 1964-12-15 |
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