GB903718A - Process for the production of basic derivatives of salicylamide which form salts which are easily soluble in water - Google Patents

Process for the production of basic derivatives of salicylamide which form salts which are easily soluble in water

Info

Publication number
GB903718A
GB903718A GB2916558A GB2916558A GB903718A GB 903718 A GB903718 A GB 903718A GB 2916558 A GB2916558 A GB 2916558A GB 2916558 A GB2916558 A GB 2916558A GB 903718 A GB903718 A GB 903718A
Authority
GB
United Kingdom
Prior art keywords
salicylamide
salts
production
water
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB2916558A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott GmbH and Co KG
Original Assignee
Knoll GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Knoll GmbH filed Critical Knoll GmbH
Publication of GB903718A publication Critical patent/GB903718A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
    • C07D211/58—Nitrogen atoms attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/18—Aralkyl radicals
    • C07D217/20—Aralkyl radicals with oxygen atoms directly attached to the aromatic ring of said aralkyl radical, e.g. papaverine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/22—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D277/28—Radicals substituted by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The substituted salicylamides of the parent Specification are prepared by reacting salicylic acid azide or salicylamide with a diamine of the formula R1NH.X.NR2R3 (wherein R1 is hydrogen or C1-C4 alkyl, X is alkylene of 2 or 3 carbon atoms and R2 and R3 are C1-C4 alkyl or, together with N, form a saturated heterocyclic ring). Examples are given and salts of the products with organic and inorganic acids are described. Salicylic acid azide is prepared by treating salicoyl hydrazide in hydrochloric acid with sodium nitrite. The substituted salicylamides, which are stated to have analgetic, antipyretic and antiphlogistic action, may be formulated as pharmaceutical compositions. Aqueous injection solutions of the salts are described, and tablets, suppositories and syrups are also referred to.
GB2916558A 1957-09-12 1958-09-11 Process for the production of basic derivatives of salicylamide which form salts which are easily soluble in water Expired GB903718A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DEK32913A DE1098001B (en) 1957-09-12 1957-09-12 Process for the preparation of N- (Diaethylaminoalkyl) -salicylamiden

Publications (1)

Publication Number Publication Date
GB903718A true GB903718A (en) 1962-08-15

Family

ID=7219583

Family Applications (1)

Application Number Title Priority Date Filing Date
GB2916558A Expired GB903718A (en) 1957-09-12 1958-09-11 Process for the production of basic derivatives of salicylamide which form salts which are easily soluble in water

Country Status (4)

Country Link
AT (1) AT210405B (en)
DE (1) DE1098001B (en)
FR (1) FR1238239A (en)
GB (1) GB903718A (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH399486A (en) * 1962-10-02 1965-09-30 Biosedra Lab Process for the preparation of new salicylamides
US3506758A (en) * 1964-03-10 1970-04-14 Colgate Palmolive Co Substantive sunscreening compositions
US3723416A (en) * 1967-04-03 1973-03-27 Ile De France Substituted 2-arylalkyloxy benzamides

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH93431A (en) * 1919-10-15 1922-03-01 Faust Edwin Stanton Dr Prof Process for the preparation of a soluble derivative of camphor.
CH107782A (en) * 1923-07-17 1924-11-17 Chem Ind Basel Process for the preparation of a unilaterally acylated derivative of ethylene diamine.
CH107776A (en) * 1923-07-17 1924-11-17 Chem Ind Basel Process for the preparation of a unilaterally acylated derivative of ethylene diamine.
CH107202A (en) * 1923-07-17 1924-10-01 Chem Ind Basel Process for the preparation of a unilaterally acylated derivative of ethylene diamine.
DE881946C (en) * 1950-06-14 1953-07-06 Basf Ag Process for the preparation of monoacyl derivatives of 1,2-alkylenediamines
US2691041A (en) * 1953-05-21 1954-10-05 Sterling Drug Inc N-(tertiary-aminoalkyl)-2-substituted-4-nitrobenzamides and their salts

Also Published As

Publication number Publication date
DE1098001B (en) 1961-01-26
AT210405B (en) 1960-08-10
FR1238239A (en) 1960-08-12

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