GB752332A - Improvements in or relating to n, mono substituted piperazines and process of preparing the same - Google Patents

Improvements in or relating to n, mono substituted piperazines and process of preparing the same

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Publication number
GB752332A
GB752332A GB22655/52A GB2265552A GB752332A GB 752332 A GB752332 A GB 752332A GB 22655/52 A GB22655/52 A GB 22655/52A GB 2265552 A GB2265552 A GB 2265552A GB 752332 A GB752332 A GB 752332A
Authority
GB
United Kingdom
Prior art keywords
piperazine
chlorobenzhydryl
carbethoxy
benzhydryl
give
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB22655/52A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott Laboratories
Original Assignee
Abbott Laboratories
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Laboratories filed Critical Abbott Laboratories
Publication of GB752332A publication Critical patent/GB752332A/en
Expired legal-status Critical Current

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Abstract

Piperazines of the formula <FORM:0752332/IV(a)/1> where R3 and R4 are aryl or substituted aryl groups and R2 is hydrogen, are made by hydrolysis and decarboxylation of the corresponding N1-carbalkoxy compounds, e.g. by refluxing with concentrated hydrochloric acid or alcoholic potash. The products are intermediates for the compounds of the parent Specification. In the examples: (1) p-chlorobenzhydryl chloride is condensed with N-carbethoxy-piperazine to give N-(p-chlorobenzhydryl) - N1 - carbethoxy - piperazine (isolated as dihydrochloride); the latter by acid hydrolysis yields N-(p-chlorobenzhydryl)-piperazine; (2) N-benzhydryl-N1-carbethoxypiperazine is made similarly and hydrolysed in alkaline solution to give N-benzhydryl-piperazine. The aryl groups may be substituted by halogen, alkyl or alkoxy. According to the Specification as open to inspection under Sect. 91, R2 may be an alkyl group containing up to 4 carbon atoms and R4 may be an alicyclic or heterocyclic group, e.g. pyrimidyl or furyl. This subject-matter does not appear in the Specification as accepted.
GB22655/52A 1948-09-30 1949-07-23 Improvements in or relating to n, mono substituted piperazines and process of preparing the same Expired GB752332A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US752332XA 1948-09-30 1948-09-30

Publications (1)

Publication Number Publication Date
GB752332A true GB752332A (en) 1956-07-11

Family

ID=22124392

Family Applications (1)

Application Number Title Priority Date Filing Date
GB22655/52A Expired GB752332A (en) 1948-09-30 1949-07-23 Improvements in or relating to n, mono substituted piperazines and process of preparing the same

Country Status (1)

Country Link
GB (1) GB752332A (en)

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