GB611098A - The manufacture of bile acid derivatives - Google Patents

The manufacture of bile acid derivatives

Info

Publication number
GB611098A
GB611098A GB2652246A GB2652246A GB611098A GB 611098 A GB611098 A GB 611098A GB 2652246 A GB2652246 A GB 2652246A GB 2652246 A GB2652246 A GB 2652246A GB 611098 A GB611098 A GB 611098A
Authority
GB
United Kingdom
Prior art keywords
bile acid
acid derivatives
manufacture
keto
reaction
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB2652246A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ALBERT RONALD MOSS
MARIANNE KOENIGSTEIN
WILLIAM HARCOURT KENNEDY
Roche Products Ltd
Original Assignee
ALBERT RONALD MOSS
MARIANNE KOENIGSTEIN
WILLIAM HARCOURT KENNEDY
Roche Products Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ALBERT RONALD MOSS, MARIANNE KOENIGSTEIN, WILLIAM HARCOURT KENNEDY, Roche Products Ltd filed Critical ALBERT RONALD MOSS
Priority to GB2652246A priority Critical patent/GB611098A/en
Publication of GB611098A publication Critical patent/GB611098A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Steroid Compounds (AREA)

Abstract

Bile acid derivatives of the general formula R-COO(CH2)nNR1R2 where R-COOH represents a keto-bile acid (e.g. dehydrodesoxy- or dehydro-cholic acid, n is a small integer and R1 and R2 are alkyl groups or together form the residue of a heterocyclic group which include the N-atom in a ring are obtained by esterifying a keto bile acid with a dialkylamino (including piperidino and morpholino) alkyl alcohol or halide while removing the water or hydrogen halide formed from the reaction, e.g. by distillation or by carrying the reaction in the presence of a basic substance. Detailed examples are given.
GB2652246A 1946-09-04 1946-09-04 The manufacture of bile acid derivatives Expired GB611098A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB2652246A GB611098A (en) 1946-09-04 1946-09-04 The manufacture of bile acid derivatives

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB2652246A GB611098A (en) 1946-09-04 1946-09-04 The manufacture of bile acid derivatives

Publications (1)

Publication Number Publication Date
GB611098A true GB611098A (en) 1948-10-25

Family

ID=10244945

Family Applications (1)

Application Number Title Priority Date Filing Date
GB2652246A Expired GB611098A (en) 1946-09-04 1946-09-04 The manufacture of bile acid derivatives

Country Status (1)

Country Link
GB (1) GB611098A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2935525A (en) * 1956-08-13 1960-05-03 Abbott Lab Esterification of organic acids

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2935525A (en) * 1956-08-13 1960-05-03 Abbott Lab Esterification of organic acids

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